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Subramaniam Malarkannan PhD

Subramaniam Malarkannan PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Bone Marrow Transplant

Member of the Cancer Center
Member of the Center for Immunology
Member of the Mellowes Center for Genomic Sciences and Precision Medicine

View Curriculum Vitae

Publications (96)

  • Sequential therapy with supercharged NK cells with either chemotherapy drug cisplatin or anti-PD-1 antibody decreases the tumor size and significantly enhances the NK function in Hu-BLT mice. (Kaur K, Chen PC, Ko MW, Mei A, Senjor E, Malarkannan S, Kos J, Jewett A) Front Immunol 2023;14:1132807 PMID: 37197660 PMCID: PMC10183580 SCOPUS ID: 2-s2.0-85159769580 05/18/2023       4 Citations
  • Successes and challenges in taming the beast: Cytotoxic immune effectors in amyotrophic lateral sclerosis (Kaur K, Chen PC, Ko MW, Mei A, Huerta-Yepez S, Maharaj D, Malarkannan S, Jewetta A) Critical Reviews in Immunology 2023;43(1):1-11 SCOPUS ID: 2-s2.0-85160646811 01/01/2023    
  • The Potential Role of Cytotoxic Immune Effectors in Induction, Progression and Pathogenesis of Amyotrophic Lateral Sclerosis (ALS). (Kaur K, Chen PC, Ko MW, Mei A, Chovatiya N, Huerta-Yepez S, Ni W, Mackay S, Zhou J, Maharaj D, Malarkannan S, Jewett A) Cells 2022 Oct 31;11(21) PMID: 36359827 PMCID: PMC9656116 SCOPUS ID: 2-s2.0-85141563829 11/12/2022       11 Citations
  • Innatus immunis: Evolving paradigm of adaptive NK cells. (Khalil M, Malarkannan S) J Exp Med 2022 Nov 07;219(11) PMID: 36066493 PMCID: PMC9449531 SCOPUS ID: 2-s2.0-85137746091 09/07/2022    
  • Transcriptomic perspectives of memory-like NK cells and aging. (Wang D, Malarkannan S) Genome Med 2022 May 25;14(1):57 PMID: 35610660 PMCID: PMC9129893 SCOPUS ID: 2-s2.0-85130685503 05/25/2022    
  • Method to Study Adaptive NK Cells Following MCMV Infections. (Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S) Methods Mol Biol 2022;2463:195-204 PMID: 35344176 SCOPUS ID: 2-s2.0-85127680170 03/29/2022    
  • Methods for Isolating and Defining Single-Cell Transcriptomes of Tissue-Resident Human NK Cells. (Hashemi E, Mei A, Wang D, Khalil M, Malarkannan S) Methods Mol Biol 2022;2463:103-116 PMID: 35344170 SCOPUS ID: 2-s2.0-85127638330 03/29/2022    
  • Methods to Analyze the Developmental Trajectory of Human Primary NK Cells Using Monocle and SCENIC Analyses. (Wang D, Burns R, Khalil M, Mei A, Hashemi E, Malarkannan S) Methods Mol Biol 2022;2463:81-102 PMID: 35344169 SCOPUS ID: 2-s2.0-85127703540 03/29/2022       2 Citations
  • Isolation of Innate Lymphoid Cells from Murine Intestinal Lamina Propria. (Mei A, Hashemi E, Khalil M, Wang D, Malarkannan S) Methods Mol Biol 2022;2463:3-9 PMID: 35344163 SCOPUS ID: 2-s2.0-85127639536 03/29/2022       1 Citation
  • Implications of a 'Third Signal' in NK Cells. (Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S) Cells 2021 Jul 31;10(8) PMID: 34440725 PMCID: PMC8393955 SCOPUS ID: 2-s2.0-85115044374 08/28/2021       4 Citations
  • The Role of microRNAs in NK Cell Development and Function. (Nanbakhsh A, Malarkannan S) Cells 2021 Aug 07;10(8) PMID: 34440789 PMCID: PMC8391642 SCOPUS ID: 2-s2.0-85115193231 08/28/2021       10 Citations
  • Role of GATA2 in Human NK Cell Development. (Wang D, Uyemura B, Hashemi E, Bjorgaard S, Riese M, Verbsky J, Thakar MS, Malarkannan S) Crit Rev Immunol 2021;41(2):21-33 PMID: 34348000 SCOPUS ID: 2-s2.0-85113414587 08/05/2021       4 Citations
  • NK Cell Development and Function in Patients with Fanconi Anemia. (Hashemi E, Bjorgaard S, Wang D, Uyemura B, Riese M, Thakar MS, Malarkannan S) Crit Rev Immunol 2021;41(2):35-44 PMID: 34348001 SCOPUS ID: 2-s2.0-85113381824 08/05/2021    
  • MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection. (Dixon KJ, Siebert JR, Wang D, Abel AM, Johnson KE, Riese MJ, Terhune SS, Tarakanova VL, Thakar MS, Malarkannan S) Mol Immunol 2021 Sep;137:94-104 PMID: 34242922 SCOPUS ID: 2-s2.0-85109126048 07/10/2021       1 Citation
  • NK cell-mediated immunotherapy: The exquisite role of PGC-1a in metabolic reprogramming (Gerbec Z, Malarkannan S) Successes and Challenges of NK Immunotherapy: Breaking Tolerance to Cancer Resistance 1 January 2021:121-142 SCOPUS ID: 2-s2.0-85138332303 01/01/2021    
  • Transcriptional Regulation of NK Cell Development by mTOR Complexes. (Yang C, Malarkannan S) Front Cell Dev Biol 2020;8:566090 PMID: 33240877 PMCID: PMC7683515 SCOPUS ID: 2-s2.0-85096677591 11/27/2020       14 Citations
  • Molecular mechanisms of FasL-mediated 'reverse-signaling'. (Malarkannan S) Mol Immunol 2020 Nov;127:31-37 PMID: 32905906 PMCID: PMC7606657 SCOPUS ID: 2-s2.0-85090199863 09/10/2020       15 Citations
  • Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells. (Gerbec ZJ, Hashemi E, Nanbakhsh A, Holzhauer S, Yang C, Mei A, Tsaih SW, Lemke A, Flister MJ, Riese MJ, Thakar MS, Malarkannan S) iScience 2020 Sep 25;23(9):101454 PMID: 32858341 PMCID: PMC7474003 SCOPUS ID: 2-s2.0-85089821937 08/29/2020       9 Citations
  • NKG7 makes a better killer. (Malarkannan S) Nat Immunol 2020 Oct;21(10):1139-1140 PMID: 32839609 SCOPUS ID: 2-s2.0-85089783013 08/26/2020       14 Citations
  • Transcriptional Regulation of Natural Killer Cell Development and Functions. (Wang D, Malarkannan S) Cancers (Basel) 2020 Jun 16;12(6) PMID: 32560225 PMCID: PMC7352776 SCOPUS ID: 2-s2.0-85088411457 06/21/2020       34 Citations
  • Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance. (Hashemi E, Malarkannan S) Cancers (Basel) 2020 Jun 12;12(6) PMID: 32545516 PMCID: PMC7352973 SCOPUS ID: 2-s2.0-85088494621 06/18/2020       51 Citations
  • Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway. (Idso JM, Lao S, Schloemer NJ, Knipstein J, Burns R, Thakar MS, Malarkannan S) Oncotarget 2020 May 19;11(20):1799-1815 PMID: 32499867 PMCID: PMC7244011 SCOPUS ID: 2-s2.0-85086126995 06/06/2020       20 Citations
  • Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature. (Yang C, Siebert JR, Burns R, Zheng Y, Mei A, Bonacci B, Wang D, Urrutia RA, Riese MJ, Rao S, Carlson KS, Thakar MS, Malarkannan S) Elife 2020 May 14;9 PMID: 32406817 PMCID: PMC7255804 SCOPUS ID: 2-s2.0-85085630468 05/15/2020       17 Citations
  • Controlling Cytokine Release Syndrome to Harness the Full Potential of CAR-Based Cellular Therapy. (Thakar MS, Kearl TJ, Malarkannan S) Front Oncol 2019;9:1529 PMID: 32076597 PMCID: PMC7006459 SCOPUS ID: 2-s2.0-85079671509 02/23/2020       22 Citations
  • Beyond the cell surface: Targeting intracellular negative regulators to enhance t cell anti-tumor activity (Sitaram P, Uyemura B, Malarkannan S, Riese MJ) International Journal of Molecular Sciences 1 December 2019;20(23) SCOPUS ID: 2-s2.0-85075296555 12/01/2019       22 Citations
  • Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells. (Nanbakhsh A, Malarkannan S) Methods Mol Biol 2020;2097:107-113 PMID: 31776922 SCOPUS ID: 2-s2.0-85075740556 11/30/2019    
  • In Vivo Assessment of NK Cell-Mediated Cytotoxicity by Adoptively Transferred Splenocyte Rejection. (Schloemer NJ, Abel AM, Thakar MS, Malarkannan S) Methods Mol Biol 2020;2097:115-123 PMID: 31776923 SCOPUS ID: 2-s2.0-85075755837 11/30/2019    
  • Beyond the Cell Surface: Targeting Intracellular Negative Regulators to Enhance T cell Anti-Tumor Activity. (Sitaram P, Uyemura B, Malarkannan S, Riese MJ) Int J Mol Sci 2019 Nov 20;20(23) PMID: 31756921 PMCID: PMC6929154 SCOPUS ID: 2-s2.0-85075296555 11/24/2019       22 Citations
  • Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. (Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL) Circ Res 2019 Dec 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019       108 Citations
  • Mirc11 Disrupts Inflammatory but Not Cytotoxic Responses of NK Cells. (Nanbakhsh A, Srinivasamani A, Holzhauer S, Riese MJ, Zheng Y, Wang D, Burns R, Reimer MH, Rao S, Lemke A, Tsaih SW, Flister MJ, Lao S, Dahl R, Thakar MS, Malarkannan S) Cancer Immunol Res 2019 Oct;7(10):1647-1662 PMID: 31515257 PMCID: PMC7428857 SCOPUS ID: 2-s2.0-85072848720 09/14/2019       10 Citations
  • Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome. (Yang C, Siebert JR, Burns R, Gerbec ZJ, Bonacci B, Rymaszewski A, Rau M, Riese MJ, Rao S, Carlson KS, Routes JM, Verbsky JW, Thakar MS, Malarkannan S) Nat Commun 2019 Sep 02;10(1):3931 PMID: 31477722 PMCID: PMC6718415 SCOPUS ID: 2-s2.0-85071610251 09/04/2019       150 Citations
  • Single-center experience suggests donor lymphocyte infusion may promote long-term survival in children with high-risk acute lymphoblastic leukemia. (Liberio N, Robinson H, Nugent M, Simpson P, Margolis DA, Malarkannan S, Keever-Taylor C, Thakar MS) Pediatr Blood Cancer 2019 Nov;66(11):e27950 PMID: 31368194 PMCID: PMC6754268 SCOPUS ID: 2-s2.0-85070087706 08/02/2019       8 Citations
  • Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression. (Xu W, Dong J, Zheng Y, Zhou J, Yuan Y, Ta HM, Miller HE, Olson M, Rajasekaran K, Ernstoff MS, Wang D, Malarkannan S, Wang L) Cancer Immunol Res 2019 Sep;7(9):1497-1510 PMID: 31340983 PMCID: PMC6726548 SCOPUS ID: 2-s2.0-85071783703 07/26/2019       91 Citations
  • Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression. (Reimer M Jr, Pulakanti K, Shi L, Abel A, Liang M, Malarkannan S, Rao S) BMC Dev Biol 2019 Jul 08;19(1):16 PMID: 31286885 PMCID: PMC6615237 SCOPUS ID: 2-s2.0-85068878011 07/10/2019       7 Citations
  • IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection. (Kumar P, Rajasekaran K, Nanbakhsh A, Gorski J, Thakar MS, Malarkannan S) Sci Rep 2019 Mar 21;9(1):4984 PMID: 30899058 PMCID: PMC6428861 SCOPUS ID: 2-s2.0-85063320720 03/23/2019       19 Citations
  • Platelet Gene Therapy Promotes Targeted Peripheral Tolerance by Clonal Deletion and Induction of Antigen-Specific Regulatory T Cells. (Luo X, Chen J, Schroeder JA, Allen KP, Baumgartner CK, Malarkannan S, Hu J, Williams CB, Shi Q) Front Immunol 2018;9:1950 PMID: 30237796 PMCID: PMC6136275 SCOPUS ID: 2-s2.0-85053056830 09/22/2018       12 Citations
  • Natural Killer Cells: Development, Maturation, and Clinical Utilization. (Abel AM, Yang C, Thakar MS, Malarkannan S) Front Immunol 2018;9:1869 PMID: 30150991 PMCID: PMC6099181 SCOPUS ID: 2-s2.0-85051533232 08/29/2018       655 Citations
  • Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance. (Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ) Immunohorizons 2018 Apr 01;2(4):107-118 PMID: 30027154 PMCID: PMC6048965 SCOPUS ID: 2-s2.0-85075290149 07/22/2018       12 Citations
  • IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells. (Abel AM, Tiwari AA, Gerbec ZJ, Siebert JR, Yang C, Schloemer NJ, Dixon KJ, Thakar MS, Malarkannan S) Front Immunol 2018;9:1168 PMID: 29892299 PMCID: PMC5985319 SCOPUS ID: 2-s2.0-85047552130 06/13/2018       12 Citations
  • mTORC1 and mTORC2 differentially promote natural killer cell development. (Yang C, Tsaih SW, Lemke A, Flister MJ, Thakar MS, Malarkannan S) Elife 2018 May 29;7 PMID: 29809146 PMCID: PMC5976438 SCOPUS ID: 2-s2.0-85051988950 05/29/2018       49 Citations
  • Author Correction: Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis. (Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L) Sci Rep 2018 Mar 01;8(1):4054 PMID: 29497089 PMCID: PMC5832769 SCOPUS ID: 2-s2.0-85070438329 03/03/2018    
  • Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection. (Jang Y, Gerbec ZJ, Won T, Choi B, Podsiad A, B Moore B, Malarkannan S, Laouar Y) J Immunol 2018 Mar 15;200(6):1982-1987 PMID: 29440507 PMCID: PMC5840015 SCOPUS ID: 2-s2.0-85044713946 02/15/2018       24 Citations
  • The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. (Xu W, Hiếu T, Malarkannan S, Wang L) Cell Mol Immunol 2018 May;15(5):438-446 PMID: 29375120 PMCID: PMC6068175 SCOPUS ID: 2-s2.0-85050984306 01/30/2018       87 Citations
  • Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells. (Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S) J Vis Exp 2018 Jan 15(131) PMID: 29364266 PMCID: PMC5908645 SCOPUS ID: 2-s2.0-85041082468 01/25/2018       11 Citations
  • Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis. (Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L) Sci Rep 2017 May 03;7(1):1485 PMID: 28469254 PMCID: PMC5431161 SCOPUS ID: 2-s2.0-85018759710 05/05/2017       67 Citations
  • The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9. (Fisher JB, Peterson J, Reimer M, Stelloh C, Pulakanti K, Gerbec ZJ, Abel AM, Strouse JM, Strouse C, McNulty M, Malarkannan S, Crispino JD, Milanovich S, Rao S) Leukemia 2017 Mar;31(3):712-719 PMID: 27554164 PMCID: PMC5332284 SCOPUS ID: 2-s2.0-84989244308 08/25/2016       41 Citations
  • Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy. (Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S) Front Immunol 2016;7:176 PMID: 27242783 PMCID: PMC4863891 SCOPUS ID: 2-s2.0-84973571081 06/01/2016       26 Citations
  • The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells. (Gerbec ZJ, Thakar MS, Malarkannan S) Front Immunol 2015;6:472 PMID: 26441977 PMCID: PMC4584950 SCOPUS ID: 2-s2.0-84946558476 10/07/2015       23 Citations
  • TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β. (Arumugam V, Bluemn T, Wesley E, Schmidt AM, Kambayashi T, Malarkannan S, Riese MJ) J Leukoc Biol 2015 Nov;98(5):703-12 PMID: 26153417 PMCID: PMC4600064 SCOPUS ID: 2-s2.0-84946053957 07/15/2015       22 Citations
  • IQGAP1: insights into the function of a molecular puppeteer. (Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S) Mol Immunol 2015 Jun;65(2):336-49 PMID: 25733387 PMCID: PMC4480615 SCOPUS ID: 2-s2.0-84923604300 03/04/2015       57 Citations
  • Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner. (Milanovich S, Peterson J, Allred J, Stelloh C, Rajasekaran K, Fisher J, Duncan SA, Malarkannan S, Rao S) Exp Hematol 2015 Jan;43(1):53-64.e1-8 PMID: 25246269 PMCID: PMC4268405 SCOPUS ID: 2-s2.0-84961288383 09/24/2014       16 Citations
  • Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. (Yea SS, So L, Mallya S, Lee J, Rajasekaran K, Malarkannan S, Fruman DA) PLoS One 2014;9(6):e99486 PMID: 24915189 PMCID: PMC4051752 SCOPUS ID: 2-s2.0-84902578296 06/11/2014       11 Citations
  • Erratum: Signaling by Fyn-ADAP via the carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells (Nature Immunology (2013) DOI 10.1038/ni2708)) (Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S) Nature Immunology February 2014;15(2):205 SCOPUS ID: 2-s2.0-84892740524 02/01/2014       1 Citation
  • Corrigendum: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. (Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S) Nat Immunol 2014 Jan 21;15(2):205 PMID: 24448581 01/23/2014    
  • Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. (Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S) Nat Immunol 2013 Nov;14(11):1127-36 PMID: 24036998 PMCID: PMC3855032 SCOPUS ID: 2-s2.0-84886663499 09/17/2013       77 Citations
  • Clinical relevance of natural killer cells following hematopoietic stem cell transplantation. (Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S) J Cancer 2013;4(1):25-35 PMID: 23386902 PMCID: PMC3564244 SCOPUS ID: 2-s2.0-84882940191 02/07/2013       43 Citations
  • IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration. (Kumar P, Rajasekaran K, Palmer JM, Thakar MS, Malarkannan S) J Cancer 2013;4(1):57-65 PMID: 23386905 PMCID: PMC3564247 SCOPUS ID: 2-s2.0-84880829571 02/07/2013       35 Citations
  • IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. (Kumar P, Thakar MS, Ouyang W, Malarkannan S) Mucosal Immunol 2013 Jan;6(1):69-82 PMID: 22739232 PMCID: PMC3835350 SCOPUS ID: 2-s2.0-84867658823 06/29/2012       153 Citations
  • IQGAP1: a regulator of intracellular spacetime relativity. (Malarkannan S, Awasthi A, Rajasekaran K, Kumar P, Schuldt KM, Bartoszek A, Manoharan N, Goldner NK, Umhoefer CM, Thakar MS) J Immunol 2012 Mar 01;188(5):2057-63 PMID: 22345702 PMCID: PMC3286039 SCOPUS ID: 2-s2.0-84857476097 02/22/2012       39 Citations
  • High-throughput detection method for influenza virus. (Kumar P, Bartoszek AE, Moran TM, Gorski J, Bhattacharyya S, Navidad JF, Thakar MS, Malarkannan S) J Vis Exp 2012 Feb 04(60) PMID: 22331038 PMCID: PMC3369630 SCOPUS ID: 2-s2.0-84856989933 02/15/2012       11 Citations
  • Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation. (Kwun J, Malarkannan S, Burlingham WJ, Knechtle SJ) J Immunol 2011 Oct 15;187(8):3997-4006 PMID: 21900176 PMCID: PMC3357205 SCOPUS ID: 2-s2.0-80054733899 09/09/2011       15 Citations
  • Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production. (Rajasekaran K, Chu H, Kumar P, Xiao Y, Tinguely M, Samarakoon A, Kim TW, Li X, Thakar MS, Zhang J, Malarkannan S) J Biol Chem 2011 Sep 09;286(36):31213-24 PMID: 21771792 PMCID: PMC3173069 SCOPUS ID: 2-s2.0-80052400379 07/21/2011       29 Citations
  • Functional dichotomy between NKG2D and CD28-mediated co-stimulation in human CD8+ T cells. (Rajasekaran K, Xiong V, Fong L, Gorski J, Malarkannan S) PLoS One 2010 Sep 09;5(9) PMID: 20844584 PMCID: PMC2936560 SCOPUS ID: 2-s2.0-77958581426 09/17/2010       35 Citations
  • Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. (Awasthi A, Samarakoon A, Chu H, Kamalakannan R, Quilliam LA, Chrzanowska-Wodnicka M, White GC 2nd, Malarkannan S) J Exp Med 2010 Aug 30;207(9):1923-38 PMID: 20733035 PMCID: PMC2931159 SCOPUS ID: 2-s2.0-77956248916 08/25/2010       46 Citations
  • Evasion of natural killer cells by influenza virus. (Guo H, Kumar P, Malarkannan S) J Leukoc Biol 2011 Feb;89(2):189-94 PMID: 20682623 PMCID: PMC3024901 SCOPUS ID: 2-s2.0-79951894460 08/05/2010       28 Citations
  • The functional impairment of natural killer cells during influenza virus infection. (Guo H, Kumar P, Moran TM, Garcia-Sastre A, Zhou Y, Malarkannan S) Immunol Cell Biol 2009;87(8):579-89 PMID: 19721456 PMCID: PMC2882241 SCOPUS ID: 2-s2.0-70450250036 09/02/2009       60 Citations
  • Murine NKG2D ligands: "double, double toil and trouble". (Samarakoon A, Chu H, Malarkannan S) Mol Immunol 2009 Mar;46(6):1011-9 PMID: 19081632 PMCID: PMC2764959 SCOPUS ID: 2-s2.0-61449189831 12/17/2008       37 Citations
  • The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation. (Guo H, Samarakoon A, Vanhaesebroeck B, Malarkannan S) J Exp Med 2008 Sep 29;205(10):2419-35 PMID: 18809712 PMCID: PMC2556795 SCOPUS ID: 2-s2.0-53349143413 09/24/2008       90 Citations
  • Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. (Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, Weiler H) Blood 2008 Dec 15;112(13):4905-14 PMID: 18796632 PMCID: PMC2597598 SCOPUS ID: 2-s2.0-58149376483 09/18/2008       54 Citations
  • Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. (Chu H, Awasthi A, White GC 2nd, Chrzanowska-Wodnicka M, Malarkannan S) J Immunol 2008 Sep 01;181(5):3373-83 PMID: 18714009 PMCID: PMC4571460 SCOPUS ID: 2-s2.0-51549097602 08/21/2008       51 Citations
  • Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells. (Awasthi A, Samarakoon A, Dai X, Wen R, Wang D, Malarkannan S) Genes Immun 2008 Sep;9(6):522-35 PMID: 18548087 PMCID: PMC4623703 SCOPUS ID: 2-s2.0-51249121801 06/13/2008       28 Citations
  • Recognition of allo-peptide is governed by novel anchor imposition and limited variations in TCR contact residues. (Reinbold CJ, Malarkannan S) Mol Immunol 2008 Mar;45(5):1318-26 PMID: 17981332 PMCID: PMC3835348 SCOPUS ID: 2-s2.0-37349020964 11/06/2007       3 Citations
  • Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation. (Malarkannan S, Regunathan J, Chu H, Kutlesa S, Chen Y, Zeng H, Wen R, Wang D) J Immunol 2007 Sep 15;179(6):3752-62 PMID: 17785812 SCOPUS ID: 2-s2.0-35748981185 09/06/2007       37 Citations
  • Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells. (Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, Wang D, Malarkannan S) J Immunol 2006 Oct 15;177(8):5365-76 PMID: 17015722 SCOPUS ID: 2-s2.0-33749524546 10/04/2006       42 Citations
  • The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions. (Malarkannan S) Semin Immunol 2006 Jun;18(3):186-92 PMID: 16737823 PMCID: PMC2752866 SCOPUS ID: 2-s2.0-33744549755 06/02/2006       21 Citations
  • Missing-self: Revisited (Malarkannan S) Seminars in Immunology June 2006;18(3):143-144 SCOPUS ID: 2-s2.0-33744513345 06/01/2006    
  • Minor histocompatibility antigens: Molecular targets for immunomodulation in tissue transplantation and tumor therapy (Malarkannan S, Regunathan J, Timler AM) Clinical and Applied Immunology Reviews March 2005;5(2):95-109 SCOPUS ID: 2-s2.0-17044432574 03/01/2005       9 Citations
  • Minor histocompatibility antigens: Time for a paradigm shift? (Malarkannan S) Transplantation Reviews January 2005;19(1):1-19 SCOPUS ID: 2-s2.0-17444395601 01/01/2005       4 Citations
  • Unanticipated antigens: translation initiation at CUG with leucine. (Schwab SR, Shugart JA, Horng T, Malarkannan S, Shastri N) PLoS Biol 2004 Nov;2(11):e366 PMID: 15510226 PMCID: PMC524250 SCOPUS ID: 2-s2.0-14044254752 10/29/2004       89 Citations
  • NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. (Regunathan J, Chen Y, Wang D, Malarkannan S) Blood 2005 Jan 01;105(1):233-40 PMID: 15328154 PMCID: PMC3889208 SCOPUS ID: 2-s2.0-11144236862 08/26/2004       53 Citations
  • A single nucleotide polymorphism in the Emp3 gene defines the H4 minor histocompatibility antigen. (Luedtke B, Pooler LM, Choi EY, Tranchita AM, Reinbold CJ, Brown AC, Shaffer DJ, Roopenian DC, Malarkannan S) Immunogenetics 2003 Aug;55(5):284-95 PMID: 12845499 SCOPUS ID: 2-s2.0-0042330076 07/08/2003       12 Citations
  • Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease. (Choi EY, Christianson GJ, Yoshimura Y, Jung N, Sproule TJ, Malarkannan S, Joyce S, Roopenian DC) Blood 2002 Dec 15;100(13):4259-65 PMID: 12393464 SCOPUS ID: 2-s2.0-0037114627 10/24/2002       62 Citations
  • Minor histocompatibility antigens: Molecular targets for adoptive cellular immunotherapy (Malarkannan S) Current Opinion in Organ Transplantation September 2002;7(3):299-304 SCOPUS ID: 2-s2.0-0036741359 09/01/2002       3 Citations
  • Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others. (Choi EY, Yoshimura Y, Christianson GJ, Sproule TJ, Malarkannan S, Shastri N, Joyce S, Roopenian DC) J Immunol 2001 Apr 01;166(7):4370-9 PMID: 11254691 SCOPUS ID: 2-s2.0-0035313052 03/20/2001       69 Citations
  • Generation of antigen-specific, lacZ-inducible T-cell hybrids. (Malarkannan S, Mendoza LM, Shastri N) Methods Mol Biol 2001;156:265-72 PMID: 11068767 SCOPUS ID: 2-s2.0-0035219683 11/09/2000       18 Citations
  • Identification of CD8+ T-cell-stimulating antigen genes in cDNA libraries. (Mendoza LM, Malarkannan S, Shastri N) Methods Mol Biol 2001;156:255-63 PMID: 11068766 SCOPUS ID: 2-s2.0-0035219703 11/09/2000       3 Citations
  • Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens. (Malarkannan S, Horng T, Eden P, Gonzalez F, Shih P, Brouwenstijn N, Klinge H, Christianson G, Roopenian D, Shastri N) Immunity 2000 Sep;13(3):333-44 PMID: 11021531 SCOPUS ID: 2-s2.0-0033662243 10/06/2000       76 Citations
  • Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism. (Malarkannan S, Horng T, Shih PP, Schwab S, Shastri N) Immunity 1999 Jun;10(6):681-90 PMID: 10403643 SCOPUS ID: 2-s2.0-0033151592 07/14/1999       92 Citations
  • The molecular and functional characterization of a dominant minor H antigen, H60. (Malarkannan S, Shih PP, Eden PA, Horng T, Zuberi AR, Christianson G, Roopenian D, Shastri N) J Immunol 1998 Oct 01;161(7):3501-9 PMID: 9759870 SCOPUS ID: 2-s2.0-0032193663 10/06/1998       212 Citations
  • The mouse mammary tumor virus env gene is the source of a CD8+ T-cell-stimulating peptide presented by a major histocompatibility complex class I molecule in a murine thymoma. (Malarkannan S, Serwold T, Nguyen V, Sherman LA, Shastri N) Proc Natl Acad Sci U S A 1996 Nov 26;93(24):13991-6 PMID: 8943048 PMCID: PMC19482 SCOPUS ID: 2-s2.0-0030475228 11/26/1996       23 Citations
  • Alloreactive CD8+ T cells can recognize unusual, rare, and unique processed peptide/MHC complexes. (Malarkannan S, Gonzalez F, Nguyen V, Adair G, Shastri N) J Immunol 1996 Nov 15;157(10):4464-73 PMID: 8906823 SCOPUS ID: 2-s2.0-0030588548 11/15/1996       36 Citations
  • A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells. (Malarkannan S, Afkarian M, Shastri N) J Exp Med 1995 Dec 01;182(6):1739-50 PMID: 7500018 PMCID: PMC2192241 SCOPUS ID: 2-s2.0-0028817871 12/01/1995       63 Citations
  • The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes. (Malarkannan S, Goth S, Buchholz DR, Shastri N) J Immunol 1995 Jan 15;154(2):585-98 PMID: 7814870 SCOPUS ID: 2-s2.0-0028889987 01/15/1995       38 Citations
  • Immunodetection of biotinylated lymphocyte-surface proteins by enhanced chemiluminescence: a nonradioactive method for cell-surface protein analysis. (Meier T, Arni S, Malarkannan S, Poincelet M, Hoessli D) Anal Biochem 1992 Jul;204(1):220-6 PMID: 1514691 SCOPUS ID: 2-s2.0-0026691177 07/01/1992       100 Citations
  • Impairment of alternate pathway (CD2) of T cell activation in leprosy (Malarkannan S, Chakkalath HR, Muthukkaruppan VR) Journal of Biosciences March 1989;14(1):29-36 SCOPUS ID: 2-s2.0-51649151233 03/01/1989    
  • The classical and alternate pathways of T cell activation are impaired in leprosy. (Muthukkaruppan V, Chakkalath HR, Malarkannan S) Immunol Lett 1988 Sep;19(1):55-8 PMID: 2903849 SCOPUS ID: 2-s2.0-0023687271 09/01/1988       4 Citations
    • Last update: 09/17/2023