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Free radical-mediated activation of hydrazine derivatives. Environ Health Perspect 1985 Dec;64:179-84

Date

12/01/1985

Pubmed ID

3007088

Pubmed Central ID

PMC1568606

DOI

10.1289/ehp.8564179

Scopus ID

2-s2.0-0022272164 (requires institutional sign-in at Scopus site)   52 Citations

Abstract

Hydrazines are known to undergo oxidative activation in several enzymatic systems in vitro. Free radicals or carbonium ions have been proposed as active intermediates during such activation. The toxic effects elicited by hydrazines have also been linked to free radical-mediated activation. In this report, we have reviewed the identification of organic free radicals from hydrazines by direct ESR and ESR-spin trapping.

Author List

Kalyanaraman B, Sinha BK

Author

Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Arachidonic Acid
Arachidonic Acids
Biotransformation
Cytochrome P-450 Enzyme System
Electron Spin Resonance Spectroscopy
Erythrocytes
Free Radicals
Hemoglobins
Hemolysis
Horseradish Peroxidase
Humans
Hydrazines
Oxidation-Reduction
Phenylhydrazines
Prostaglandin-Endoperoxide Synthases