Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. Bioorg Med Chem Lett 2003 Jun 16;13(12):1977-80
Date
06/05/2003Pubmed ID
12781177DOI
10.1016/s0960-894x(03)00348-2Scopus ID
2-s2.0-0038440634 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both alpha-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated.
Author List
El Fangour S, Balas L, Rossi JC, Fedenyuk A, Gretskaya N, Bobrov M, Bezuglov V, Hillard CJ, Durand TAuthor
Cecilia J. Hillard PhD Associate Dean, Center Director, Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AmidohydrolasesAnimals
Arachidonic Acids
Binding, Competitive
Cannabinoid Receptor Modulators
Endocannabinoids
Enzyme Inhibitors
Ethylene Glycols
Polyunsaturated Alkamides
Radioligand Assay
Rats
Receptor, Cannabinoid, CB1