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Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. Bioorg Med Chem Lett 2003 Jun 16;13(12):1977-80

Date

06/05/2003

Pubmed ID

12781177

DOI

10.1016/s0960-894x(03)00348-2

Scopus ID

2-s2.0-0038440634 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both alpha-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated.

Author List

El Fangour S, Balas L, Rossi JC, Fedenyuk A, Gretskaya N, Bobrov M, Bezuglov V, Hillard CJ, Durand T

Author

Cecilia J. Hillard PhD Associate Dean, Center Director, Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Amidohydrolases
Animals
Arachidonic Acids
Binding, Competitive
Cannabinoid Receptor Modulators
Endocannabinoids
Enzyme Inhibitors
Ethylene Glycols
Polyunsaturated Alkamides
Radioligand Assay
Rats
Receptor, Cannabinoid, CB1