Tyrosine kinases EnAbling adaptor molecules for chemokine-induced Rap1 activation in T cells. Sci Signal 2012 Jul 31;5(235):pe33
Date
08/03/2012Pubmed ID
22855504Pubmed Central ID
PMC4307919DOI
10.1126/scisignal.2003383Scopus ID
2-s2.0-84864554527 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Chemokines regulate T cell trafficking into secondary lymphoid organs and migration across endothelial cells in response to inflammatory signals. The small guanosine triphosphatase Rap1 is a critical regulator of chemokine signaling in T cells, but how chemokines activate Rap1 has been unclear. A study showed that Abl family tyrosine kinases were essential for chemokine-induced Rap1 activation, T cell polarization, and migration. Abl family kinases promoted Rap1 activation by phosphorylating the adaptor protein human enhancer of filamentation 1 (HEF1), thus establishing a critical Abl-HEF1-Rap1 signaling axis for chemokine-induced T cell migration.
Author List
Malherbe LP, Wang DAuthor
Demin Wang PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adaptor Proteins, Signal TransducingCell Movement
Chemokines
Humans
Lymphocyte Activation
Models, Immunological
Phosphoproteins
Phosphorylation
Protein-Tyrosine Kinases
Signal Transduction
T-Lymphocytes
rap1 GTP-Binding Proteins
