Platelet signaling. Handb Exp Pharmacol 2012(210):59-85
Date
08/25/2012Pubmed ID
22918727Pubmed Central ID
PMC4785017DOI
10.1007/978-3-642-29423-5_3Scopus ID
2-s2.0-84867167320 (requires institutional sign-in at Scopus site) 127 CitationsAbstract
This chapter summarizes current ideas about the intracellular signaling that drives platelet responses to vascular injury. After a brief overview of platelet activation intended to place the signaling pathways into context, the first section considers the early events of platelet activation leading up to integrin activation and platelet aggregation. The focus is on the G protein-mediated events utilized by agonists such as thrombin and ADP, and the tyrosine kinase-based signaling triggered by collagen. The second section considers the events that occur after integrin engagement, some of which are dependent on close physical contact between platelets. A third section addresses the regulatory events that help to avoid unprovoked or excessive platelet activation, after which the final section briefly considers individual variations in platelet reactivity and the role of platelet signaling in the innate immune response and embryonic development.
Author List
Stalker TJ, Newman DK, Ma P, Wannemacher KM, Brass LFAuthors
Debra K. Newman PhD Investigator in the Blood Research Institute department at BloodCenter of WisconsinDebra K. Newman PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBlood Platelets
Calcium
GTP-Binding Proteins
Humans
Platelet Activation
Platelet Adhesiveness
Signal Transduction