Faculty Collaboration Database

Modulators of endocannabinoid enzymic hydrolysis and membrane transport. Handb Exp Pharmacol 2005(168):187-207

Date

04/07/2006

Pubmed ID

16596775

DOI

10.1007/3-540-26573-2_6

Scopus ID

2-s2.0-27644514002 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

Tissue concentrations of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) are regulated by both synthesis and inactivation. The purpose of this review is to compile available data regarding three inactivation processes: fatty acid amide hydrolase, monoacylglycerol lipase, and cellular membrane transport. In particular, we have focused on mechanisms by which these processes are modulated. We describe the in vitro and in vivo effects of inhibitors of these processes as well as available evidence regarding their modulation by other factors.

Author List

Ho WS, Hillard CJ

Author

Cecilia J. Hillard PhD Associate Dean, Center Director, Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Amidohydrolases
Animals
Arachidonic Acids
Biological Transport
Cannabinoid Receptor Modulators
Cell Membrane
Endocannabinoids
Humans
Hydrolysis
Monoacylglycerol Lipases
Polyunsaturated Alkamides
Substrate Specificity