Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents. Learn Mem 2015 Sep;22(9):472-93
Date
08/20/2015Pubmed ID
26286657Pubmed Central ID
PMC4561402DOI
10.1101/lm.037267.114Scopus ID
2-s2.0-84942106437 (requires institutional sign-in at Scopus site) 145 CitationsAbstract
Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen 17β-estradiol (E2), affect hippocampal morphology, plasticity, and memory in male and female rodents. Yet relatively few investigators who work with male subjects consider the effects of these hormones on learning and memory. This review describes the effects of E2 on hippocampal spinogenesis, neurogenesis, physiology, and memory, with particular attention paid to the effects of E2 in male rodents. The estrogen receptors, cell-signaling pathways, and epigenetic processes necessary for E2 to enhance memory in female rodents are also discussed in detail. Finally, practical considerations for working with female rodents are described for those investigators thinking of adding females to their experimental designs.
Author List
Frick KM, Kim J, Tuscher JJ, Fortress AMAuthors
Karyn Frick BA,MA,PhD Professor in the Psychology department at University of Wisconsin - MilwaukeeJennifer J. Tuscher PhD Assistant Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsEstradiol
Female
Hippocampus
Learning
Male
Memory
Rodentia
