Major components of endogenous neurotransmission underlying the discharge activity of hypoglossal motoneurons in vivo. Adv Exp Med Biol 2008;605:279-84
Date
12/19/2007Pubmed ID
18085286DOI
10.1007/978-0-387-73693-8_49Scopus ID
2-s2.0-38449120437 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Multibarrel micropipettes were used to simultaneously record unit activity and apply antagonists on individual inspiratory hypoglossal motoneurons (IHMNs) to determine the endogenous activation levels of NMDA, non-NMDA, GABA(A) and serotonin receptors responsible for the IHMN spontaneous discharge patterns in decerebrate dogs. IHMN activity is highly dependent on glutamatergic phasic and tonic drives, which are differentially mediated by the receptor subtypes. Endogenous serotonin significantly amplifies IHMN activity, while GABAergic gain modulation acts to attenuate activity. Thus, alterations in the neurotransmission of any of these systems could markedly alter neuronal output to target muscles.
Author List
Zuperku EJ, Brandes IF, Stucke AG, Sanchez A, Hopp FA, Stuth EAAuthors
Astrid G. Stucke MD Professor in the Anesthesiology department at Medical College of WisconsinEckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin
Edward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
2-Amino-5-phosphonovalerateAnimals
Bicuculline
Decerebrate State
Dogs
Excitatory Amino Acid Antagonists
Hypoglossal Nerve
Ketanserin
Models, Animal
Models, Neurological
Motor Neurons
Quinoxalines
Synaptic Transmission
Tongue