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Major components of endogenous neurotransmission underlying the discharge activity of hypoglossal motoneurons in vivo. Adv Exp Med Biol 2008;605:279-84

Date

12/19/2007

Pubmed ID

18085286

DOI

10.1007/978-0-387-73693-8_49

Scopus ID

2-s2.0-38449120437 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

Multibarrel micropipettes were used to simultaneously record unit activity and apply antagonists on individual inspiratory hypoglossal motoneurons (IHMNs) to determine the endogenous activation levels of NMDA, non-NMDA, GABA(A) and serotonin receptors responsible for the IHMN spontaneous discharge patterns in decerebrate dogs. IHMN activity is highly dependent on glutamatergic phasic and tonic drives, which are differentially mediated by the receptor subtypes. Endogenous serotonin significantly amplifies IHMN activity, while GABAergic gain modulation acts to attenuate activity. Thus, alterations in the neurotransmission of any of these systems could markedly alter neuronal output to target muscles.

Author List

Zuperku EJ, Brandes IF, Stucke AG, Sanchez A, Hopp FA, Stuth EA

Authors

Astrid G. Stucke MD Professor in the Anesthesiology department at Medical College of Wisconsin
Eckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin
Edward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

2-Amino-5-phosphonovalerate
Animals
Bicuculline
Decerebrate State
Dogs
Excitatory Amino Acid Antagonists
Hypoglossal Nerve
Ketanserin
Models, Animal
Models, Neurological
Motor Neurons
Quinoxalines
Synaptic Transmission
Tongue