Multicenter Evaluation of the Solana Group A Streptococcus Assay: Comparison with Culture. J Clin Microbiol 2016 Sep;54(9):2388-90
Date
07/01/2016Pubmed ID
27358464Pubmed Central ID
PMC5005512DOI
10.1128/JCM.01268-16Scopus ID
2-s2.0-84983593764 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
We compared group A Streptococcus (GAS) culture with a rapid helicase-dependent amplification (HDA) method using 1,082 throat swab specimens. The HDA method demonstrated 98.2% sensitivity and 97.2% specificity. GAS prevalence by culture was 20.7%, and it was 22.6% using the HDA method. In 35 min, the HDA method provided rapid, sensitive GAS detection, making culture confirmation unnecessary.
Author List
Uphoff TS, Buchan BW, Ledeboer NA, Granato PA, Daly JA, Marti TNAuthors
Blake W. Buchan PhD Professor in the Pathology department at Medical College of WisconsinNathan A. Ledeboer PhD Vice Chair, Professor in the Pathology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Bacteriological Techniques
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Molecular Diagnostic Techniques
Nucleic Acid Amplification Techniques
Pharynx
Prospective Studies
Sensitivity and Specificity
Streptococcal Infections
Streptococcus pyogenes
Time Factors
Young Adult