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Multicenter Evaluation of the Solana Group A Streptococcus Assay: Comparison with Culture. J Clin Microbiol 2016 Sep;54(9):2388-90

Date

07/01/2016

Pubmed ID

27358464

Pubmed Central ID

PMC5005512

DOI

10.1128/JCM.01268-16

Scopus ID

2-s2.0-84983593764 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

We compared group A Streptococcus (GAS) culture with a rapid helicase-dependent amplification (HDA) method using 1,082 throat swab specimens. The HDA method demonstrated 98.2% sensitivity and 97.2% specificity. GAS prevalence by culture was 20.7%, and it was 22.6% using the HDA method. In 35 min, the HDA method provided rapid, sensitive GAS detection, making culture confirmation unnecessary.

Author List

Uphoff TS, Buchan BW, Ledeboer NA, Granato PA, Daly JA, Marti TN

Authors

Blake W. Buchan PhD Professor in the Pathology department at Medical College of Wisconsin
Nathan A. Ledeboer PhD Vice Chair, Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Aged, 80 and over
Bacteriological Techniques
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Molecular Diagnostic Techniques
Nucleic Acid Amplification Techniques
Pharynx
Prospective Studies
Sensitivity and Specificity
Streptococcal Infections
Streptococcus pyogenes
Time Factors
Young Adult