miRNA-Mediated RNA Activation in Mammalian Cells. Adv Exp Med Biol 2017;983:81-89
Date
06/24/2017Pubmed ID
28639193DOI
10.1007/978-981-10-4310-9_6Scopus ID
2-s2.0-85021314316 10 CitationsAbstract
MicroRNA (miRNA or miR) is a small noncoding RNA molecule ~22 nucleotides in size, which is found in plants, animals, and some viruses. miRNAs are thought to primarily down regulate gene expression by binding to 3' untranslated regions of target transcripts, thereby triggering mRNA cleavage or repression of translation. Recently, evidence has emerged that miRNAs can interact with the promoter and activate gene expression. This mechanism, called RNA activation (RNAa), is a process of transcriptional activation where the direct interaction of miRNA on the promoter triggers the recruitment of transcription factors and RNA-Polymerase-II on the promoter to activate gene transcription. To date, very little is known about the mechanism by which miRNA regulates RNA activation (RNAa) and their role in tumor progression. This is an emerging field in RNA biology. In this chapter, we describe the mechanisms utilized by miRNAs to activate transcription.
Author List
Ramchandran R, Chaluvally-Raghavan PAuthors
Pradeep Chaluvally-Raghavan PhD Associate Professor in the Obstetrics and Gynecology department at Medical College of WisconsinRamani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
3' Untranslated RegionsAnimals
MicroRNAs
Promoter Regions, Genetic
Transcriptional Activation
