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miRNA-Mediated RNA Activation in Mammalian Cells. Adv Exp Med Biol 2017;983:81-89

Date

06/24/2017

Pubmed ID

28639193

DOI

10.1007/978-981-10-4310-9_6

Scopus ID

2-s2.0-85021314316   10 Citations

Abstract

MicroRNA (miRNA or miR) is a small noncoding RNA molecule ~22 nucleotides in size, which is found in plants, animals, and some viruses. miRNAs are thought to primarily down regulate gene expression by binding to 3' untranslated regions of target transcripts, thereby triggering mRNA cleavage or repression of translation. Recently, evidence has emerged that miRNAs can interact with the promoter and activate gene expression. This mechanism, called RNA activation (RNAa), is a process of transcriptional activation where the direct interaction of miRNA on the promoter triggers the recruitment of transcription factors and RNA-Polymerase-II on the promoter to activate gene transcription. To date, very little is known about the mechanism by which miRNA regulates RNA activation (RNAa) and their role in tumor progression. This is an emerging field in RNA biology. In this chapter, we describe the mechanisms utilized by miRNAs to activate transcription.

Author List

Ramchandran R, Chaluvally-Raghavan P

Authors

Pradeep Chaluvally-Raghavan PhD Associate Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin
Ramani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

3' Untranslated Regions
Animals
MicroRNAs
Promoter Regions, Genetic
Transcriptional Activation
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