Medical College of Wisconsin
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Pradeep Chaluvally-Raghavan PhD

Pradeep Chaluvally-Raghavan PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Obstetrics and Gynecology
Division: Obstetrics and Gynecology Research and Advanced Education

Member of the Cancer Center
Member of the Center for Disease Prevention Research (CDPR)
Member of the Center for Immunology

Publications (40)

  • The transcription factor Rlm1 couples the MAPK Slt2/ERK1 pathway to the IRE1-driven unfolded protein response. (Chakraborty A, Chakrabarty S, Uppala JK, Mayer KA, Evans AJ, George J, Ghosh C, Dey R, Ohikhuare F, Mirza S, Nguyen APT, Gouignard N, Chaluvally-Raghavan P, Dey M) Commun Biol 2026 Apr 21 PMID: 42014513 04/22/2026    
  • MRPL47 as a Novel Mitochondrial Biomarker for Early Detection and Therapeutic Response in Ovarian Cancer. (Pradeep M, Kadamberi IP, George J, Gao Y, Dagum C, Nair A, Tsaih SW, Geethadevi A, Nair A, Hopp E, Uyar D, Bradley W, Rader J, Li Y, Chaluvally-Raghavan P, Ojesina AI) bioRxiv 2026 Mar 09 PMID: 41959452 PMCID: PMC13060964 04/10/2026    
  • IL-1-mediated inflammation promotes metastatic dissemination and resistance to EGFR-targeted therapy. (Pagano F, Girone C, Borrelli F, Romaniello D, Gelfo V, Filippini DM, Morselli A, Mazzeschi M, Querzoli G, Ambrosi F, Miano C, D'Uva G, Fazi F, Chaluvally-Raghavan P, Sgarzi M, Győrffy B, Ardizzoni A, Lauriola M) NPJ Precis Oncol 2026 Apr 08 PMID: 41951719 04/09/2026    
  • Single-cell transcriptomics reveals FXR1 as an actionable target for siRNA therapy in ovarian cancer. (George J, Ma X, Kadamberi IP, Nair A, Mittal S, Hashemi E, Kumar S, Singh M, Geethadevi A, Pradeep M, Nair A, Tsaih SW, Jorns JM, Malarkannan S, Dietlein F, Lin CW, Pradeep S, Chaluvally-Raghavan P) Nat Commun 2026 Apr 03 PMID: 41932914 04/04/2026    
  • Coupling the MAPK Slt2/ERK1 Pathway and IRE1-driven UPR Through Transcription Factor Rlm1/MEF2. (Chakraborty A, Chakrabarty S, Uppala JK, Mayer KA, Evans AJ, George J, Ghosh C, Dey R, Nguyen APT, Gouignard N, Chaluvally-Raghavan P, Dey M) Res Sq 2025 Dec 11 PMID: 41510289 PMCID: PMC12776503 01/09/2026    
  • Natural history of SPP1 signaling in NF1 tumors. (Njoya K, Zayed H, Sun L, Alson D, Aina O, Khan S, Veneklasen X, Lytle N, Chaluvally-Raghavan P, Sun D) NPJ Precis Oncol 2025 Oct 06;9(1):320 PMID: 41053414 PMCID: PMC12501028 SCOPUS ID: 2-s2.0-105018220877 10/07/2025       2 Citations
  • eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR-Mediated Metabolic Rewiring. (Mittal S, Nenwani M, Pulikkal Kadamberi I, Kumar S, Animasahun O, George J, Tsaih SW, Gupta P, Singh M, Geethadevi A, Dey C, Meurs N, Shankaran A, Chaluvally Raghavan P, Nagrath D, Pradeep S) Adv Sci (Weinh) 2025 Nov;12(42):e06307 PMID: 40820860 PMCID: PMC12622447 SCOPUS ID: 2-s2.0-105013566484 08/18/2025       3 Citations
  • Protocol for the isolation of tumor cell-derived extracellular vesicles followed by in vivo metastasis assessment in a murine ovarian cancer model (Mittal S, Kumar S, Gupta P, Singh M, Chaluvally-Raghavan P, Pradeep S) STAR Protocols 21 June 2024;5(2) SCOPUS ID: 2-s2.0-85187377383 06/21/2024       3 Citations
  • Blocking Oncostatin M receptor abrogates STAT3 mediated integrin signaling and overcomes chemoresistance in ovarian cancer. (Geethadevi A, Ku Z, Tsaih SW, Parashar D, Kadamberi IP, Xiong W, Deng H, George J, Kumar S, Mittal S, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P) NPJ Precis Oncol 2024 Jun 05;8(1):127 PMID: 38839865 PMCID: PMC11153533 SCOPUS ID: 2-s2.0-85195471255 06/06/2024       12 Citations
  • Protocol for the isolation of tumor cell-derived extracellular vesicles followed by in vivo metastasis assessment in a murine ovarian cancer model. (Mittal S, Kumar S, Gupta P, Singh M, Chaluvally-Raghavan P, Pradeep S) STAR Protoc 2024 Jun 21;5(2):102943 PMID: 38470912 PMCID: PMC10945248 SCOPUS ID: 2-s2.0-85187377383 03/12/2024       3 Citations
  • Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma. (Mittal S, Kadamberi IP, Chang H, Wang F, Kumar S, Tsaih SW, Walker CJ, Chaluvally-Raghavan P, Charlson J, Landesman Y, Pradeep S) Exp Hematol Oncol 2023 Sep 15;12(1):78 PMID: 37715291 PMCID: PMC10503035 SCOPUS ID: 2-s2.0-85171339411 09/16/2023       4 Citations
  • Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin. (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB) iScience 2022 Dec 22;25(12):105670 PMID: 36567718 PMCID: PMC9768319 SCOPUS ID: 2-s2.0-85143723525 12/27/2022       10 Citations
  • Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB) Iscience 22 December 2022;25(12) SCOPUS ID: 2-s2.0-85143723525 12/22/2022       10 Citations
  • Metabolic Reprogramming in Tumor-Associated Macrophages in the Ovarian Tumor Microenvironment. (Kumar S, Mittal S, Gupta P, Singh M, Chaluvally-Raghavan P, Pradeep S) Cancers (Basel) 2022 Oct 25;14(21) PMID: 36358644 PMCID: PMC9656653 SCOPUS ID: 2-s2.0-85141848301 11/12/2022       27 Citations
  • Extracellular vesicle contents as non-invasive biomarkers in ovarian malignancies (McAlarnen LA, Gupta P, Singh R, Pradeep S, Chaluvally-Raghavan P) Molecular Therapy Oncolytics 15 September 2022;26:347-359 SCOPUS ID: 2-s2.0-85136664501 09/15/2022       7 Citations
  • Extracellular vesicle contents as non-invasive biomarkers in ovarian malignancies. (McAlarnen LA, Gupta P, Singh R, Pradeep S, Chaluvally-Raghavan P) Mol Ther Oncolytics 2022 Sep 15;26:347-359 PMID: 36090475 PMCID: PMC9420349 SCOPUS ID: 2-s2.0-85136664501 09/13/2022       7 Citations
  • Correction: Parashar et al. Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance. Cancers 2022, 14, 958. (Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P) Cancers (Basel) 2022 May 16;14(10) PMID: 35626175 PMCID: PMC9140135 SCOPUS ID: 2-s2.0-85129951244 05/29/2022       2 Citations
  • Optimized proximity ligation assay (PLA) for detection of RNA-protein complex interactions in cell lines. (George J, Mittal S, Kadamberi IP, Pradeep S, Chaluvally-Raghavan P) STAR Protoc 2022 Jun 17;3(2):101340 PMID: 35620072 PMCID: PMC9127197 SCOPUS ID: 2-s2.0-85130357879 05/28/2022       15 Citations
  • Correction to: Parashar et al. Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance (Cancers, (2022), 14, 958) (Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P) Cancers May-2 2022;14(10) SCOPUS ID: 2-s2.0-85129951244 05/01/2022       2 Citations
  • Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer. (Gupta P, Kadamberi IP, Mittal S, Tsaih SW, George J, Kumar S, Vijayan DK, Geethadevi A, Parashar D, Topchyan P, McAlarnen L, Volkman BF, Cui W, Zhang KYJ, Di Vizio D, Chaluvally-Raghavan P, Pradeep S) Adv Sci (Weinh) 2022 May;9(14):e2104452 PMID: 35289120 PMCID: PMC9108620 SCOPUS ID: 2-s2.0-85126251446 03/16/2022       63 Citations
  • Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance. (Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P) Cancers (Basel) 2022 Feb 15;14(4) PMID: 35205706 PMCID: PMC8870411 SCOPUS ID: 2-s2.0-85124460063 02/26/2022       18 Citations
  • Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance (Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P) Cancers February-2 2022;14(4) SCOPUS ID: 2-s2.0-85124460063 02/01/2022       18 Citations
  • Establishment of In Vivo Ovarian Cancer Mouse Models Using Intraperitoneal Tumor Cell Injection. (Mittal S, Gupta P, Chaluvally-Raghavan P, Pradeep S) Methods Mol Biol 2022;2424:247-254 PMID: 34918299 SCOPUS ID: 2-s2.0-85121752492 12/18/2021       5 Citations
  • RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2021 Nov 02;37(5):109934 PMID: 34731628 PMCID: PMC8675433 SCOPUS ID: 2-s2.0-85118477211 11/04/2021       50 Citations
  • Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth. (Geethadevi A, Nair A, Parashar D, Ku Z, Xiong W, Deng H, Li Y, George J, McAllister DM, Sun Y, Kadamberi IP, Gupta P, Dwinell MB, Bradley WH, Rader JS, Rui H, Schwabe RF, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P) Cancer Res 2021 Oct 15;81(20):5336-5352 PMID: 34380633 PMCID: PMC8530981 SCOPUS ID: 2-s2.0-85116424540 08/13/2021       55 Citations
  • Targeted biologic inhibition of both tumor cell-intrinsic and intercellular CLPTM1L/CRR9-mediated chemotherapeutic drug resistance. (Parashar D, Geethadevi A, McAllister D, Ebben J, Peterson FC, Jensen DR, Bishop E, Pradeep S, Volkman BF, Dwinell MB, Chaluvally-Raghavan P, James MA) NPJ Precis Oncol 2021 Mar 02;5(1):16 PMID: 33654182 PMCID: PMC7925570 SCOPUS ID: 2-s2.0-85109651282 03/04/2021       23 Citations
  • Emerging Role of Extracellular Vesicles in Immune Regulation and Cancer Progression. (Mittal S, Gupta P, Chaluvally-Raghavan P, Pradeep S) Cancers (Basel) 2020 Nov 28;12(12) PMID: 33260606 PMCID: PMC7760253 SCOPUS ID: 2-s2.0-85096847824 12/03/2020       61 Citations
  • Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling. (Parashar D, Nair B, Geethadevi A, George J, Nair A, Tsaih SW, Kadamberi IP, Gopinadhan Nair GK, Lu Y, Ramchandran R, Uyar DS, Rader JS, Ram PT, Mills GB, Pradeep S, Chaluvally-Raghavan P) Cancer Res 2020 Dec 15;80(24):5554-5568 PMID: 33087324 PMCID: PMC7744365 SCOPUS ID: 2-s2.0-85100331032 10/23/2020       37 Citations
  • Anticancer effect of physical activity is mediated by modulation of extracellular microRNA in blood. (Pulliero A, You M, Chaluvally-Raghavan P, Marengo B, Domenicotti C, Banelli B, Degan P, Molfetta L, Gianiorio F, Izzotti A) Oncotarget 2020 Jun 02;11(22):2106-2119 PMID: 32547708 PMCID: PMC7275780 SCOPUS ID: 2-s2.0-85090283897 06/18/2020       13 Citations
  • Anticancer effect of physical activity is mediated by modulation of extracellular microRNA in blood (Pulliero A, You M, Chaluvally-Raghavan P, Marengo B, Domenicotti C, Banelli B, Degan P, Molfetta L, Gianiorio F, Izzotti A) Oncotarget 1 June 2020;11(22):2106-2119 SCOPUS ID: 2-s2.0-85090283897 06/01/2020       13 Citations
  • ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis. (Chen C, Gupta P, Parashar D, Nair GG, George J, Geethadevi A, Wang W, Tsaih SW, Bradley W, Ramchandran R, Rader JS, Chaluvally-Raghavan P, Pradeep S) Oncogene 2020 Apr;39(14):2921-2933 PMID: 32029900 PMCID: PMC7346970 SCOPUS ID: 2-s2.0-85079196544 02/08/2020       41 Citations
  • miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer. (Parashar D, Geethadevi A, Aure MR, Mishra J, George J, Chen C, Mishra MK, Tahiri A, Zhao W, Nair B, Lu Y, Mangala LS, Rodriguez-Aguayo C, Lopez-Berestein G, Camara AKS, Liang M, Rader JS, Ramchandran R, You M, Sood AK, Kristensen VN, Mills GB, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2019 Dec 24;29(13):4389-4406.e10 PMID: 31875548 PMCID: PMC7380555 SCOPUS ID: 2-s2.0-85076674271 12/26/2019       66 Citations
  • Interaction of tumor cells and astrocytes promotes breast cancer brain metastases through TGF-β2/ANGPTL4 axes. (Gong X, Hou Z, Endsley MP, Gronseth EI, Rarick KR, Jorns JM, Yang Q, Du Z, Yan K, Bordas ML, Gershan J, Deepak P, Geethadevi A, Chaluvally-Raghavan P, Fan Y, Harder DR, Ramchandran R, Wang L) NPJ Precis Oncol 2019;3:24 PMID: 31602400 PMCID: PMC6776663 SCOPUS ID: 2-s2.0-85079332436 10/12/2019       77 Citations
  • B Cells as an Immune-Regulatory Signature in Ovarian Cancer. (Gupta P, Chen C, Chaluvally-Raghavan P, Pradeep S) Cancers (Basel) 2019 Jun 26;11(7) PMID: 31248034 PMCID: PMC6678944 SCOPUS ID: 2-s2.0-85068665327 06/30/2019       43 Citations
  • ERBB signaling in CTCs of ovarian cancer and glioblastoma. (Geethadevi A, Parashar D, Bishop E, Pradeep S, Chaluvally-Raghavan P) Genes Cancer 2017 Nov;8(11-12):746-751 PMID: 29321816 PMCID: PMC5755720 SCOPUS ID: 2-s2.0-85042923599 01/13/2018       20 Citations
  • miRNA-Mediated RNA Activation in Mammalian Cells. (Ramchandran R, Chaluvally-Raghavan P) Adv Exp Med Biol 2017;983:81-89 PMID: 28639193 SCOPUS ID: 2-s2.0-85021314316 06/24/2017       49 Citations
  • Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer. (Chaluvally-Raghavan P, Jeong KJ, Pradeep S, Silva AM, Yu S, Liu W, Moss T, Rodriguez-Aguayo C, Zhang D, Ram P, Liu J, Lu Y, Lopez-Berestein G, Calin GA, Sood AK, Mills GB) Cell Rep 2016 May 17;15(7):1493-1504 PMID: 27160903 PMCID: PMC4914391 SCOPUS ID: 2-s2.0-84964941322 05/11/2016       87 Citations
  • Targeting ncRNAs in the 3q26.2 amplicon. (Chaluvally-Raghavan P, Mills GB) Oncoscience 2015;2(8):671-2 PMID: 26425652 PMCID: PMC4580054 SCOPUS ID: 2-s2.0-84959273567 10/02/2015       2 Citations
  • Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers. (Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ, McGuire SE, Flores ER, Sood AK, Mills GB) Cancer Cell 2014 Dec 08;26(6):863-879 PMID: 25490449 PMCID: PMC4261159 SCOPUS ID: 2-s2.0-84919477596 12/10/2014       49 Citations
  • Hematogenous metastasis of ovarian cancer: rethinking mode of spread. (Pradeep S, Kim SW, Wu SY, Nishimura M, Chaluvally-Raghavan P, Miyake T, Pecot CV, Kim SJ, Choi HJ, Bischoff FZ, Mayer JA, Huang L, Nick AM, Hall CS, Rodriguez-Aguayo C, Zand B, Dalton HJ, Arumugam T, Lee HJ, Han HD, Cho MS, Rupaimoole R, Mangala LS, Sehgal V, Oh SC, Liu J, Lee JS, Coleman RL, Ram P, Lopez-Berestein G, Fidler IJ, Sood AK) Cancer Cell 2014 Jul 14;26(1):77-91 PMID: 25026212 PMCID: PMC4100212 SCOPUS ID: 2-s2.0-84904265681 07/16/2014       273 Citations
    • Last update: 05/02/2026