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Genetic and environmental cofactors of Myc translocations in plasma cell tumor development in mice. J Natl Cancer Inst Monogr 2008(39):37-40

Date

07/24/2008

Pubmed ID

18648000

DOI

10.1093/jncimonographs/lgn015

Scopus ID

2-s2.0-52149120771   6 Citations

Abstract

Peritoneal plasmacytomagenesis in inbred BALB/c mice affords an experimental model system for the study of the mechanism by which naturally occurring Myc (c-myc) translocations collaborate with host susceptibility factors and environmental influences in tumor development. Mouse plasmacytoma is initiated in approximately 80% of cases by a balanced chromosomal T(12;15)(Igh-Myc) translocation that results in a mode of Myc deregulation that renders the survival and outgrowth of the translocation-bearing tumor precursor exquisitely dependent upon factors provided by sustained inflammation (IL-6) and gut flora microbes. Tumor susceptibility genes of BALB/c, such as weak efficiency alleles of genes encoding p16(Ink4a) and Frap (mTOR), are also required for plasmacytoma, although the pathways linking these genes with deregulated Myc and the environment have not yet been elucidated. The findings in mouse plasmacytoma may be relevant for hematopoietic neoplasms in human beings, in which leukemia- and lymphoma-associated chromosomal translocation (LLA-CT) is much more frequent than subsequent neoplasia. Just like T(12;15)-carrying B-lymphocytes and plasma cells in mice, the malignant transformation of LLA-CT-bearing blood cells in humans may be a rare occurrence that requires several genetic and environmental cofactors to take place.

Author List

Janz S

Author

Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Environment
Genes, myc
Mice
Plasmacytoma
Translocation, Genetic