Medical College of Wisconsin
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Carol L. Williams PhD

Carol L. Williams PhD

Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Cancer Center


Publications

  • SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers. (Schuld NJ, Hauser AD, Gastonguay AJ, Wilson JM, Lorimer EL, Williams CL) Cell Cycle 2014 Mar 15;13(6):941-52 PMID 24552806
  • The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. (Schuld NJ, Vervacke JS, Lorimer EL, Simon NC, Hauser AD, Barbieri JT, Distefano MD, Williams CL) J Biol Chem 2014 Mar 7;289(10):6862-76 PMID 24415755
  • The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer. (Hauser AD, Bergom C, Schuld NJ, Chen X, Lorimer EL, Huang J, Mackinnon AC, Williams CL) Mol Cancer Res 2014 Jan;12(1):130-42 PMID 24197117
  • Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. (Zimmerman NP, Roy I, Hauser AD, Wilson JM, Williams CL, Dwinell MB) Mol Carcinog 2013 Sep 24: PMID 24115212
  • A new signaling paradigm to control the prenylation and trafficking of small GTPases. (Williams CL) Cell Cycle 2013 Sep 15;12(18):2933-4 PMID 23974087
  • An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. (Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL) Sci Signal 2013 May 28;6(277):ra39 PMID 23716716
  • Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation. (Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H) Arterioscler Thromb Vasc Biol 2013 Jul;33(7):1591-600 PMID 23640485
  • The role of Rac1 in the regulation of NF-κB activity, cell proliferation, and cell migration in non-small cell lung carcinoma. (Gastonguay A, Berg T, Hauser AD, Schuld N, Lorimer E, Williams CL) Cancer Biol Ther 2012 Jun;13(8):647-56 PMID 22549160
  • Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells. (Nithipatikom K, Gomez-Granados AD, Tang AT, Pfeiffer AW, Williams CL, Campbell WB) Endocrinology 2012 Jan;153(1):29-41 PMID 22087025
  • Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. (Cheng G, Lopez M, Zielonka J, Hauser AD, Joseph J, McAllister D, Rowe JJ, Sugg SL, Williams CL, Kalyanaraman B) Cancer Biol Ther 2011 Oct 15;12(8):707-17 PMID 21799303
  • Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells. (Bongard RD, Krenz GS, Gastonguay AJ, Williams CL, Lindemer BJ, Merker MP) Free Radic Biol Med 2011 Apr 15;50(8):953-62 PMID 21238579
  • Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists. (Nithipatikom K, Brody DM, Tang AT, Manthati VL, Falck JR, Williams CL, Campbell WB) Cancer Sci 2010 Dec;101(12):2629-36 PMID 20804500
  • Splice variants of SmgGDS control small GTPase prenylation and membrane localization. (Berg TJ, Gastonguay AJ, Lorimer EL, Kuhnmuench JR, Li R, Fields AP, Williams CL) J Biol Chem 2010 Nov 12;285(46):35255-66 PMID 20709748
  • SmgGDS is up-regulated in prostate carcinoma and promotes tumour phenotypes in prostate cancer cells. (Zhi H, Yang XJ, Kuhnmuench J, Berg T, Thill R, Yang H, See WA, Becker CG, Williams CL, Li R) J Pathol 2009 Feb;217(3):389-97 PMID 18973191
  • Expression and function of fatty acid amide hydrolase in prostate cancer. (Endsley MP, Thill R, Choudhry I, Williams CL, Kajdacsy-Balla A, Campbell WB, Nithipatikom K) Int J Cancer 2008 Sep 15;123(6):1318-26 PMID 18566995
  • Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells. (Thill R, Campbell WB, Williams CL) J Cell Biochem 2008 Aug 1;104(5):1760-70 PMID 18348285
  • SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma. (Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL) J Biol Chem 2008 Jan 11;283(2):963-76 PMID 17951244
  • Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. (Kotamraju S, Williams CL, Kalyanaraman B) Cancer Res 2007 Aug 1;67(15):7386-94 PMID 17671209
  • Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS. (Zhang Y, Deng Q, Porath JA, Williams CL, Pederson-Gulrud KJ, Barbieri JT) Cell Microbiol 2007 Sep;9(9):2192-201 PMID 17490406
  • The Rac1 C-terminal polybasic region regulates the nuclear localization and protein degradation of Rac1. (Lanning CC, Daddona JL, Ruiz-Velasco R, Shafer SH, Williams CL) J Biol Chem 2004 Oct 15;279(42):44197-210 PMID 15304504
  • Elevated Rac1 activity changes the M3 muscarinic acetylcholine receptor-mediated inhibition of proliferation to induction of cell death. (Shafer SH, Williams CL) Mol Pharmacol 2004 May;65(5):1080-91 PMID 15102936
  • Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment. (Shafer SH, Williams CL) Int J Oncol 2003 Aug;23(2):389-400 PMID 12851688
  • Muscarinic signaling in carcinoma cells. (Williams CL) Life Sci 2003 Mar 28;72(18-19):2173-82 PMID 12628476
  • The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies. (Varker KA, Phelps SH, King MM, Williams CL) Int J Oncol 2003 Mar;22(3):671-81 PMID 12579323
  • Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1. (Lanning CC, Ruiz-Velasco R, Williams CL) J Biol Chem 2003 Apr 4;278(14):12495-506 PMID 12551911
  • The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1, IQGAP1, and actin. (Ruiz-Velasco R, Lanning CC, Williams CL) J Biol Chem 2002 Sep 6;277(36):33081-91 PMID 12070151
  • Involvement of the muscarinic acetylcholine receptor in inhibition of cell migration. (Varker KA, Williams CL) Biochem Pharmacol 2002 Feb 15;63(4):597-605 PMID 11992627
  • Reduced expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. (Williams CL, Noti JD) Int J Oncol 2001 Dec;19(6):1227-33 PMID 11713593
  • P2Y2 purinergic and M3 muscarinic acetylcholine receptors activate different phospholipase C-beta isoforms that are uniquely susceptible to protein kinase C-dependent phosphorylation and inactivation. (Strassheim D, Williams CL) J Biol Chem 2000 Dec 15;275(50):39767-72 PMID 10995776
  • Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma. (Strassheim D, Shafer SH, Phelps SH, Williams CL) Cancer Res 2000 May 15;60(10):2730-6 PMID 10825148
  • Unique in vivo associations with SmgGDS and RhoGDI and different guanine nucleotide exchange activities exhibited by RhoA, dominant negative RhoA(Asn-19), and activated RhoA(Val-14). (Strassheim D, Porter RA, Phelps SH, Williams CL) J Biol Chem 2000 Mar 10;275(10):6699-702 PMID 10702222
  • Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5. (Carey I, Williams CL, Ways DK, Noti JD) Int J Oncol 1999 Jul;15(1):127-36 PMID 10375605
  • M3 muscarinic acetylcholine receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein kinase C isoforms. (Strassheim D, May LG, Varker KA, Puhl HL, Phelps SH, Porter RA, Aronstam RS, Noti JD, Williams CL) J Biol Chem 1999 Jun 25;274(26):18675-85 PMID 10373480
  • Activation of transfected M1 or M3 muscarinic acetylcholine receptors induces cell-cell adhesion of Chinese hamster ovary cells expressing endogenous cadherins. (Shafer SH, Puhl HL, Phelps SH, Williams CL) Exp Cell Res 1999 Apr 10;248(1):148-59 PMID 10094822
  • Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. (Shafer SH, Phelps SH, Williams CL) Biochem Pharmacol 1998 Nov 1;56(9):1229-36 PMID 9802335
  • Regulation of integrin-mediated adhesion by muscarinic acetylcholine receptors and protein kinase C in small cell lung carcinoma. (Quigley RL, Shafer SH, Williams CL) Chest 1998 Sep;114(3):839-46 PMID 9743176
  • Ethanol disrupts carbamylcholine-stimulated release of arachidonic acid from Chinese hamster ovary cells expressing different subtypes of human muscarinic receptor. (Stair SM, May LG, Puhl HL, Phelps SH, Williams CL, Aronstam RS) Alcohol Clin Exp Res 1998 Apr;22(2):409-15 PMID 9581647
  • Nicotinic acetylcholine receptors of muscle and neuronal (alpha7) types coexpressed in a small cell lung carcinoma. (Sciamanna MA, Griesmann GE, Williams CL, Lennon VA) J Neurochem 1997 Dec;69(6):2302-11 PMID 9375661
  • Influence of acute and chronic ethanol treatment on muscarinic responses and receptor expression in Chinese hamster ovary cells. (Chang ZL, Puhl HL, May LG, Williams CL, Aronstam RS) Biochem Pharmacol 1997 Oct 1;54(7):833-9 PMID 9353138
  • Regulation of cadherin-mediated adhesion by the small GTP-binding protein Rho in small cell lung carcinoma cells. (Tokman MG, Porter RA, Williams CL) Cancer Res 1997 May 1;57(9):1785-93 PMID 9135023
  • Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpiperazin e (KN-62). (Puhl HL, Raman PS, Williams CL, Aronstam RS) Biochem Pharmacol 1997 Apr 25;53(8):1107-14 PMID 9175715
  • Basic science of small cell lung cancer. (Williams CL) Chest Surg Clin N Am 1997 Feb;7(1):1-19 PMID 9001753
  • Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma. (Williams CL, Phelps SH, Porter RA) Biochem Pharmacol 1996 Mar 8;51(5):707-15 PMID 8615909
  • Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) . (Williams CL, Porter RA, Phelps SH) Biochem Pharmacol 1995 Dec 22;50(12):1979-85 PMID 8849323
  • Enteric GABA-containing nerves projecting to the guinea-pig inferior mesenteric ganglion modulate acetylcholine release. (Parkman HP, Stapelfeldt WH, Williams CL, Lennon VA, Szurszewski JH) J Physiol 1993 Nov;471:191-207 PMID 8120803
  • Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma. (Williams CL, Hayes VY, Hummel AM, Tarara JE, Halsey TJ) J Cell Biol 1993 May;121(3):643-54 PMID 8387530
  • Human monoclonal striational autoantibodies isolated from thymic B lymphocytes of patients with myasthenia gravis use VH and VL gene segments associated with the autoimmune repertoire. (Victor KD, Pascual V, Williams CL, Lennon VA, Capra JD) Eur J Immunol 1992 Sep;22(9):2231-6 PMID 1516616
  • Paraneoplastic cerebellar autoantibodies associated with gynecological cancer bind to myenteric plexus neurons. (Altermatt HJ, Williams CL, Lennon VA) Ann Neurol 1991 Jun;29(6):687-8 PMID 1892373
  • Activation of muscarinic acetylcholine receptors inhibits cell cycle progression of small cell lung carcinoma. (Williams CL, Lennon VA) Cell Regul 1991 May;2(5):373-81 PMID 1654127
  • Activation of M3 muscarinic acetylcholine receptors inhibits voltage-dependent calcium influx in small cell lung carcinoma. (Williams CL, Lennon VA) J Biol Chem 1990 Jan 25;265(3):1443-7 PMID 2153134
  • Grants and Awards

  • Mechanisms, Treatment and Prevention of Metastasis in Breast Cancer (#9305804 07/01/2012 - 12/31/2014) Sponsor: Cancer Center
  • Prognostic Significance of SmgGDS-Mediated Signaling Pathways in Breast Cancer (#9305864 11/01/2012 - 01/01/2014) Sponsor: Cancer Center
  • Regulation of Ras and Rho Family GTPases in Lung Cancer (#9206091 01/01/2010 - 12/31/2014) Sponsor: NIH Cancer Institute
  • Translational Breast Cancer Biomarker Research Project (#9208682 04/01/2014 - 03/31/2018) Sponsor: Froedtert Hospital Foundation
  • Small GTPase Polybasic Regions: Function and Regulation (#9203656 04/01/2005 - 03/30/2010) Sponsor: NIH General Medical Sciences