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Dara W. Frank PhD

Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Publications (112)

Identification and Verification of Ubiquitin-Activated Bacterial Phospholipases. (Tessmer MH, Anderson DM, Pickrum AM, Riegert MO, Frank DW) J Bacteriol 2019 Feb 15;201(4) PMID: 30455285 PMCID: PMC6351748 SCOPUS ID: 2-s2.0-85060624878 11/21/2018 9 Citations

Conformational Changes and Membrane Interaction of the Bacterial Phospholipase, ExoU: Characterization by Site-Directed Spin Labeling. (Feix JB, Kohn S, Tessmer MH, Anderson DM, Frank DW) Cell Biochem Biophys 2019 Mar;77(1):79-87 PMID: 30047043 PMCID: PMC6347562 SCOPUS ID: 2-s2.0-85050694302 07/27/2018 6 Citations

Identification of a ubiquitin-binding interface using Rosetta and DEER. (Tessmer MH, Anderson DM, Pickrum AM, Riegert MO, Moretti R, Meiler J, Feix JB, Frank DW) Proc Natl Acad Sci U S A 2018 Jan 16;115(3):525-530 PMID: 29295930 PMCID: PMC5776994 SCOPUS ID: 2-s2.0-85042128224 01/04/2018 22 Citations

Structure and Dynamics of Type III Secretion Effector Protein ExoU As determined by SDSL-EPR Spectroscopy in Conjunction with De Novo Protein Folding. (Fischer AW, Anderson DM, Tessmer MH, Frank DW, Feix JB, Meiler J) ACS Omega 2017 Jun 30;2(6):2977-2984 PMID: 28691114 PMCID: PMC5494639 SCOPUS ID: 2-s2.0-85028991891 07/12/2017 9 Citations

Pseudomonas aeruginosa infection liberates transmissible, cytotoxic prion amyloids. (Balczon R, Morrow KA, Zhou C, Edmonds B, Alexeyev M, Pittet JF, Wagener BM, Moser SA, Leavesley S, Zha X, Frank DW, Stevens T) FASEB J 2017 Jul;31(7):2785-2796 PMID: 28314768 PMCID: PMC5471513 SCOPUS ID: 2-s2.0-85021662814 03/21/2017 26 Citations

The Pseudomonas aeruginosa Exoenzyme Y: A Promiscuous Nucleotidyl Cyclase Edema Factor and Virulence Determinant. (Morrow KA, Frank DW, Balczon R, Stevens T) Handb Exp Pharmacol 2017;238:67-85 PMID: 28181005 PMCID: PMC6103630 SCOPUS ID: 2-s2.0-85018986099 02/10/2017 20 Citations

Cooperative Substrate-Cofactor Interactions and Membrane Localization of the Bacterial Phospholipase A₂ (PLA₂) Enzyme, ExoU. (Tessmer MH, Anderson DM, Buchaklian A, Frank DW, Feix JB) J Biol Chem 2017 Feb 24;292(8):3411-3419 PMID: 28069812 PMCID: PMC5336173 SCOPUS ID: 2-s2.0-85013836015 01/11/2017 23 Citations

Pseudomonas aeruginosa exoenzymes U and Y induce a transmissible endothelial proteinopathy. (Morrow KA, Ochoa CD, Balczon R, Zhou C, Cauthen L, Alexeyev M, Schmalzer KM, Frank DW, Stevens T) Am J Physiol Lung Cell Mol Physiol 2016 Feb 15;310(4):L337-53 PMID: 26637633 PMCID: PMC4754902 SCOPUS ID: 2-s2.0-84958559488 12/08/2015 33 Citations

Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection. (Morrow KA, Seifert R, Kaever V, Britain AL, Sayner SL, Ochoa CD, Cioffi EA, Frank DW, Rich TC, Stevens T) Am J Physiol Lung Cell Mol Physiol 2015 Nov 15;309(10):L1199-207 PMID: 26386118 PMCID: PMC4652153 SCOPUS ID: 2-s2.0-84947231546 09/20/2015 23 Citations

Cross Kingdom Activators of Five Classes of Bacterial Effectors. (Anderson DM, Feix JB, Frank DW) PLoS Pathog 2015 Jul;11(7):e1004944 PMID: 26203905 PMCID: PMC4512716 SCOPUS ID: 2-s2.0-84938811382 07/24/2015 10 Citations

Pseudomonas aeruginosa toxins (Rolsma S, Frank DW, Barbieri JT) The Comprehensive Sourcebook of Bacterial Protein Toxins 5 June 2015:133-160 SCOPUS ID: 2-s2.0-85053197841 06/05/2015 2 Citations

cCMP and cUMP occur in vivo. (Bähre H, Hartwig C, Munder A, Wolter S, Stelzer T, Schirmer B, Beckert U, Frank DW, Tümmler B, Kaever V, Seifert R) Biochem Biophys Res Commun 2015 May 15;460(4):909-14 PMID: 25838203 PMCID: PMC4765920 SCOPUS ID: 2-s2.0-84937760629 04/04/2015 29 Citations

Ubiquitin activates patatin-like phospholipases from multiple bacterial species. (Anderson DM, Sato H, Dirck AT, Feix JB, Frank DW) J Bacteriol 2015 Feb;197(3):529-41 PMID: 25404699 PMCID: PMC4285982 SCOPUS ID: 2-s2.0-84920836378 11/19/2014 33 Citations

Reproducible and quantitative model of infection of Dermacentor variabilis with the live vaccine strain of Francisella tularensis. (Coburn J, Maier T, Casey M, Padmore L, Sato H, Frank DW) Appl Environ Microbiol 2015 Jan;81(1):386-95 PMID: 25362054 PMCID: PMC4272728 SCOPUS ID: 2-s2.0-84917707073 11/02/2014 7 Citations

Intoxication of host cells by the T3SS phospholipase ExoU: PI(4,5)P2-associated, cytoskeletal collapse and late phase membrane blebbing. (Sato H, Frank DW) PLoS One 2014;9(7):e103127 PMID: 25061861 PMCID: PMC4111512 SCOPUS ID: 2-s2.0-84904896550 07/26/2014 29 Citations

ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation. (Beckert U, Wolter S, Hartwig C, Bähre H, Kaever V, Ladant D, Frank DW, Seifert R) Biochem Biophys Res Commun 2014 Jul 18;450(1):870-4 PMID: 24971548 PMCID: PMC4764875 SCOPUS ID: 2-s2.0-84904719123 06/28/2014 52 Citations

In vitro assays to monitor the activity of Pseudomonas aeruginosa Type III secreted proteins. (Rolsma SL, Frank DW) Methods Mol Biol 2014;1149:171-84 PMID: 24818904 PMCID: PMC5860653 SCOPUS ID: 2-s2.0-84927145450 05/14/2014 7 Citations

The Pseudomonas aeruginosa exoenzyme Y impairs endothelial cell proliferation and vascular repair following lung injury. (Stevens TC, Ochoa CD, Morrow KA, Robson MJ, Prasain N, Zhou C, Alvarez DF, Frank DW, Balczon R, Stevens T) Am J Physiol Lung Cell Mol Physiol 2014 May 15;306(10):L915-24 PMID: 24705722 PMCID: PMC4025060 SCOPUS ID: 2-s2.0-84900807344 04/08/2014 62 Citations

In the absence of effector proteins, the Pseudomonas aeruginosa type three secretion system needle tip complex contributes to lung injury and systemic inflammatory responses. (Audia JP, Lindsey AS, Housley NA, Ochoa CR, Zhou C, Toba M, Oka M, Annamdevula NS, Fitzgerald MS, Frank DW, Alvarez DF) PLoS One 2013;8(11):e81792 PMID: 24312357 PMCID: PMC3842252 SCOPUS ID: 2-s2.0-84896716494 12/07/2013 24 Citations

Pseudomonas aeruginosa exotoxin Y-mediated tau hyperphosphorylation impairs microtubule assembly in pulmonary microvascular endothelial cells. (Balczon R, Prasain N, Ochoa C, Prater J, Zhu B, Alexeyev M, Sayner S, Frank DW, Stevens T) PLoS One 2013;8(9):e74343 PMID: 24023939 PMCID: PMC3762819 SCOPUS ID: 2-s2.0-84883383682 09/12/2013 39 Citations

Identification of the major ubiquitin-binding domain of the Pseudomonas aeruginosa ExoU A2 phospholipase. (Anderson DM, Feix JB, Monroe AL, Peterson FC, Volkman BF, Haas AL, Frank DW) J Biol Chem 2013 Sep 13;288(37):26741-52 PMID: 23908356 PMCID: PMC3772220 SCOPUS ID: 2-s2.0-84884182244 08/03/2013 27 Citations

Five mechanisms of manipulation by bacterial effectors: a ubiquitous theme. (Anderson DM, Frank DW) PLoS Pathog 2012;8(8):e1002823 PMID: 22927812 PMCID: PMC3426537 SCOPUS ID: 2-s2.0-84866183655 08/29/2012 20 Citations

Treating bacterial virulence systems: we are not there yet. (Huang YJ, Bittner EA, Frank D, Wiener-Kronish J) Intensive Care Med 2012 Jul;38(7):1087-8 PMID: 22527077 PMCID: PMC5178826 SCOPUS ID: 2-s2.0-84862705219 04/25/2012

Research Topic on Pseudomonas aeruginosa, Biology, Genetics, and Host-Pathogen Interactions. (Frank DW) Front Microbiol 2012;3:20 PMID: 22347214 PMCID: PMC3270588 02/22/2012

Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU. (Anderson DM, Schmalzer KM, Sato H, Casey M, Terhune SS, Haas AL, Feix JB, Frank DW) Mol Microbiol 2011 Dec;82(6):1454-67 PMID: 22040088 PMCID: PMC3237844 SCOPUS ID: 2-s2.0-83355166268 11/02/2011 71 Citations

Multi-Functional Characteristics of the Pseudomonas aeruginosa Type III Needle-Tip Protein, PcrV; Comparison to Orthologs in other Gram-negative Bacteria. (Sato H, Frank DW) Front Microbiol 2011;2:142 PMID: 21772833 PMCID: PMC3131520 SCOPUS ID: 2-s2.0-84857946668 07/21/2011 57 Citations

Modified needle-tip PcrV proteins reveal distinct phenotypes relevant to the control of type III secretion and intoxication by Pseudomonas aeruginosa. (Sato H, Hunt ML, Weiner JJ, Hansen AT, Frank DW) PLoS One 2011 Mar 29;6(3):e18356 PMID: 21479247 PMCID: PMC3066235 SCOPUS ID: 2-s2.0-79953167847 04/12/2011 24 Citations

Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity. (Sayner SL, Balczon R, Frank DW, Cooper DM, Stevens T) Am J Physiol Lung Cell Mol Physiol 2011 Jul;301(1):L117-24 PMID: 21478251 PMCID: PMC3129906 SCOPUS ID: 2-s2.0-79959985241 04/12/2011 34 Citations

Induced conformational changes in the activation of the Pseudomonas aeruginosa type III toxin, ExoU. (Benson MA, Komas SM, Schmalzer KM, Casey MS, Frank DW, Feix JB) Biophys J 2011 Mar 02;100(5):1335-43 PMID: 21354407 PMCID: PMC3043214 SCOPUS ID: 2-s2.0-79953903080 03/01/2011 16 Citations

Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis. (Apicella MA, Post DM, Fowler AC, Jones BD, Rasmussen JA, Hunt JR, Imagawa S, Choudhury B, Inzana TJ, Maier TM, Frank DW, Zahrt TC, Chaloner K, Jennings MP, McLendon MK, Gibson BW) PLoS One 2010 Jul 06;5(7):e11060 PMID: 20625403 PMCID: PMC2897883 SCOPUS ID: 2-s2.0-77955411445 07/14/2010 70 Citations

Activation of ExoU phospholipase activity requires specific C-terminal regions. (Schmalzer KM, Benson MA, Frank DW) J Bacteriol 2010 Apr;192(7):1801-12 PMID: 20097856 PMCID: PMC2838045 SCOPUS ID: 2-s2.0-77949694407 01/26/2010 23 Citations

A sensitive fluorescence-based assay for the detection of ExoU-mediated PLA(2) activity. (Benson MA, Schmalzer KM, Frank DW) Clin Chim Acta 2010 Feb;411(3-4):190-7 PMID: 19900431 PMCID: PMC2812683 SCOPUS ID: 2-s2.0-72449131834 11/11/2009 23 Citations

A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge. (Pechous RD, McCarthy TR, Mohapatra NP, Soni S, Penoske RM, Salzman NH, Frank DW, Gunn JS, Zahrt TC) PLoS One 2008 Jun 25;3(6):e2487 PMID: 18575611 PMCID: PMC2429968 SCOPUS ID: 2-s2.0-49649100202 06/26/2008 63 Citations

Type IV pili in Francisella tularensis: roles of pilF and pilT in fiber assembly, host cell adherence, and virulence. (Chakraborty S, Monfett M, Maier TM, Benach JL, Frank DW, Thanassi DG) Infect Immun 2008 Jul;76(7):2852-61 PMID: 18426883 PMCID: PMC2446743 SCOPUS ID: 2-s2.0-46449114418 04/23/2008 65 Citations

Identification of Francisella tularensis Himar1-based transposon mutants defective for replication in macrophages. (Maier TM, Casey MS, Becker RH, Dorsey CW, Glass EM, Maltsev N, Zahrt TC, Frank DW) Infect Immun 2007 Nov;75(11):5376-89 PMID: 17682043 PMCID: PMC2168294 SCOPUS ID: 2-s2.0-35648989527 08/08/2007 74 Citations

Genetics and genetic manipulation in Francisella tularensis. (Frank DW, Zahrt TC) Ann N Y Acad Sci 2007 Jun;1105:67-97 PMID: 17395725 SCOPUS ID: 2-s2.0-34748901912 03/31/2007 22 Citations

Pseudolipasin A is a specific inhibitor for phospholipase A2 activity of Pseudomonas aeruginosa cytotoxin ExoU. (Lee VT, Pukatzki S, Sato H, Kikawada E, Kazimirova AA, Huang J, Li X, Arm JP, Frank DW, Lory S) Infect Immun 2007 Mar;75(3):1089-98 PMID: 17178785 PMCID: PMC1828555 SCOPUS ID: 2-s2.0-33847704986 12/21/2006 63 Citations

Pseudomonas aeruginosa toxins (Maresso AW, Frank DW, Barbieri JT) The Comprehensive Sourcebook of Bacterial Protein Toxins 2006:257-269 SCOPUS ID: 2-s2.0-35348958777 12/01/2006 5 Citations

Identification of superoxide dismutase as a cofactor for the pseudomonas type III toxin, ExoU. (Sato H, Feix JB, Frank DW) Biochemistry 2006 Aug 29;45(34):10368-75 PMID: 16922513 SCOPUS ID: 2-s2.0-33748672064 08/23/2006 63 Citations

Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain. (Pechous R, Celli J, Penoske R, Hayes SF, Frank DW, Zahrt TC) Infect Immun 2006 Aug;74(8):4452-61 PMID: 16861631 PMCID: PMC1539594 SCOPUS ID: 2-s2.0-33746596554 07/25/2006 66 Citations

Acquisition and evolution of the exoU locus in Pseudomonas aeruginosa. (Kulasekara BR, Kulasekara HD, Wolfgang MC, Stevens L, Frank DW, Lory S) J Bacteriol 2006 Jun;188(11):4037-50 PMID: 16707695 PMCID: PMC1482899 SCOPUS ID: 2-s2.0-33744728373 05/19/2006 91 Citations

In vivo Himar1-based transposon mutagenesis of Francisella tularensis. (Maier TM, Pechous R, Casey M, Zahrt TC, Frank DW) Appl Environ Microbiol 2006 Mar;72(3):1878-85 PMID: 16517634 PMCID: PMC1393221 SCOPUS ID: 2-s2.0-33644941364 03/07/2006 75 Citations

Characterization of phospholipase activity of the Pseudomonas aeruginosa type III cytotoxin, ExoU. (Sato H, Feix JB, Hillard CJ, Frank DW) J Bacteriol 2005 Feb;187(3):1192-5 PMID: 15659695 PMCID: PMC545705 SCOPUS ID: 2-s2.0-13244295376 01/22/2005 53 Citations

Construction and characterization of a highly efficient Francisella shuttle plasmid. (Maier TM, Havig A, Casey M, Nano FE, Frank DW, Zahrt TC) Appl Environ Microbiol 2004 Dec;70(12):7511-9 PMID: 15574954 PMCID: PMC535190 SCOPUS ID: 2-s2.0-10444282165 12/03/2004 136 Citations

ExoU is a potent intracellular phospholipase. (Sato H, Frank DW) Mol Microbiol 2004 Sep;53(5):1279-90 PMID: 15387809 SCOPUS ID: 2-s2.0-4444342607 09/25/2004 235 Citations

Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY. (Sayner SL, Frank DW, King J, Chen H, VandeWaa J, Stevens T) Circ Res 2004 Jul 23;95(2):196-203 PMID: 15192021 SCOPUS ID: 2-s2.0-3343017244 06/12/2004 104 Citations

The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. (Sato H, Frank DW, Hillard CJ, Feix JB, Pankhaniya RR, Moriyama K, Finck-Barbançon V, Buchaklian A, Lei M, Long RM, Wiener-Kronish J, Sawa T) EMBO J 2003 Jun 16;22(12):2959-69 PMID: 12805211 PMCID: PMC162142 SCOPUS ID: 2-s2.0-0038376087 06/14/2003 281 Citations

Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis. (Miyata S, Casey M, Frank DW, Ausubel FM, Drenkard E) Infect Immun 2003 May;71(5):2404-13 PMID: 12704110 PMCID: PMC153283 SCOPUS ID: 2-s2.0-0242500352 04/22/2003 204 Citations

Generation and characterization of a protective monoclonal antibody to Pseudomonas aeruginosa PcrV. (Frank DW, Vallis A, Wiener-Kronish JP, Roy-Burman A, Spack EG, Mullaney BP, Megdoud M, Marks JD, Fritz R, Sawa T) J Infect Dis 2002 Jul 01;186(1):64-73 PMID: 12089663 SCOPUS ID: 2-s2.0-0036642461 06/29/2002 129 Citations

Children with cystic fibrosis produce an immune response against exoenzyme S, a type III cytotoxin of Pseudomonas aeruginosa. (Banwart B, Splaingard ML, Farrell PM, Rock MJ, Havens PL, Moss J, Ehrmantraut ME, Frank DW, Barbieri JT) J Infect Dis 2002 Jan 15;185(2):269-70 PMID: 11807706 SCOPUS ID: 2-s2.0-0037080359 01/25/2002 20 Citations

PcrV immunization enhances survival of burned Pseudomonas aeruginosa-infected mice. (Holder IA, Neely AN, Frank DW) Infect Immun 2001 Sep;69(9):5908-10 PMID: 11500471 PMCID: PMC98711 SCOPUS ID: 2-s2.0-0034877753 08/14/2001 74 Citations

Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU. (Finck-Barbançon V, Frank DW) J Bacteriol 2001 Jul;183(14):4330-44 PMID: 11418575 PMCID: PMC95324 SCOPUS ID: 2-s2.0-0034977803 06/22/2001 57 Citations

Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections. (Roy-Burman A, Savel RH, Racine S, Swanson BL, Revadigar NS, Fujimoto J, Sawa T, Frank DW, Wiener-Kronish JP) J Infect Dis 2001 Jun 15;183(12):1767-74 PMID: 11372029 SCOPUS ID: 2-s2.0-0035877065 05/24/2001 378 Citations

Type III secretion/intoxication system important in virulence of Pseudomonas aeruginosa infections in burns. (Holder IA, Neely AN, Frank DW) Burns 2001 Mar;27(2):129-30 PMID: 11226648 SCOPUS ID: 2-s2.0-0035137564 02/28/2001 68 Citations

Sera from adult patients with cystic fibrosis contain antibodies to Pseudomonas aeruginosa type III apparatus. (Moss J, Ehrmantraut ME, Banwart BD, Frank DW, Barbieri JT) Infect Immun 2001 Feb;69(2):1185-8 PMID: 11160019 PMCID: PMC98003 SCOPUS ID: 2-s2.0-0035143703 02/13/2001 40 Citations

Intracellular localization and processing of Pseudomonas aeruginosa ExoS in eukaryotic cells. (Pederson KJ, Pal S, Vallis AJ, Frank DW, Barbieri JT) Mol Microbiol 2000 Jul;37(2):287-99 PMID: 10931325 SCOPUS ID: 2-s2.0-0033913828 08/10/2000 33 Citations

ExoT of cytotoxic Pseudomonas aeruginosa prevents uptake by corneal epithelial cells. (Cowell BA, Chen DY, Frank DW, Vallis AJ, Fleiszig SM) Infect Immun 2000 Jan;68(1):403-6 PMID: 10603417 PMCID: PMC97150 SCOPUS ID: 2-s2.0-0033961448 12/22/1999 84 Citations

Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. (Kurahashi K, Kajikawa O, Sawa T, Ohara M, Gropper MA, Frank DW, Martin TR, Wiener-Kronish JP) J Clin Invest 1999 Sep;104(6):743-50 PMID: 10491409 PMCID: PMC408437 SCOPUS ID: 2-s2.0-0032699215 09/24/1999 286 Citations

Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system. (Coburn J, Frank DW) Infect Immun 1999 Jun;67(6):3151-4 PMID: 10338535 PMCID: PMC96636 SCOPUS ID: 2-s2.0-0033031869 05/25/1999 64 Citations

Interruption of multiple cellular processes in HT-29 epithelial cells by Pseudomonas aeruginosa exoenzyme S. (Olson JC, Fraylick JE, McGuffie EM, Dolan KM, Yahr TL, Frank DW, Vincent TS) Infect Immun 1999 Jun;67(6):2847-54 PMID: 10338490 PMCID: PMC96591 SCOPUS ID: 2-s2.0-0033023632 05/25/1999 48 Citations

The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins. (Pederson KJ, Vallis AJ, Aktories K, Frank DW, Barbieri JT) Mol Microbiol 1999 Apr;32(2):393-401 PMID: 10231494 SCOPUS ID: 2-s2.0-0032931551 05/07/1999 121 Citations

Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury. (Sawa T, Yahr TL, Ohara M, Kurahashi K, Gropper MA, Wiener-Kronish JP, Frank DW) Nat Med 1999 Apr;5(4):392-8 PMID: 10202927 SCOPUS ID: 2-s2.0-0032907634 04/15/1999 297 Citations

Biological effects of Pseudomonas aeruginosa type III-secreted proteins on CHO cells. (Vallis AJ, Finck-Barbançon V, Yahr TL, Frank DW) Infect Immun 1999 Apr;67(4):2040-4 PMID: 10085057 PMCID: PMC96567 SCOPUS ID: 2-s2.0-0033066577 03/20/1999 113 Citations

Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions. (Vallis AJ, Yahr TL, Barbieri JT, Frank DW) Infect Immun 1999 Feb;67(2):914-20 PMID: 9916108 PMCID: PMC96404 SCOPUS ID: 2-s2.0-0032962344 01/23/1999 121 Citations

Identification and characterization of SpcU, a chaperone required for efficient secretion of the ExoU cytotoxin. (Finck-Barbançon V, Yahr TL, Frank DW) J Bacteriol 1998 Dec;180(23):6224-31 PMID: 9829931 PMCID: PMC107707 SCOPUS ID: 2-s2.0-0031785949 11/26/1998 54 Citations

ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system. (Yahr TL, Vallis AJ, Hancock MK, Barbieri JT, Frank DW) Proc Natl Acad Sci U S A 1998 Nov 10;95(23):13899-904 PMID: 9811898 PMCID: PMC24955 SCOPUS ID: 2-s2.0-0032506004 11/13/1998 369 Citations

In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections. (Sawa T, Ohara M, Kurahashi K, Twining SS, Frank DW, Doroques DB, Long T, Gropper MA, Wiener-Kronish JP) Infect Immun 1998 Jul;66(7):3242-9 PMID: 9632591 PMCID: PMC108338 SCOPUS ID: 2-s2.0-0031867030 06/25/1998 103 Citations

Modification of Ras in eukaryotic cells by Pseudomonas aeruginosa exoenzyme S. (McGuffie EM, Frank DW, Vincent TS, Olson JC) Infect Immun 1998 Jun;66(6):2607-13 PMID: 9596723 PMCID: PMC108245 SCOPUS ID: 2-s2.0-0031811812 05/29/1998 68 Citations

Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites. (Ganesan AK, Frank DW, Misra RP, Schmidt G, Barbieri JT) J Biol Chem 1998 Mar 27;273(13):7332-7 PMID: 9516428 SCOPUS ID: 2-s2.0-0032571385 04/29/1998 101 Citations

Pseudomonas aeruginosa invasion and cytotoxicity are independent events, both of which involve protein tyrosine kinase activity. (Evans DJ, Frank DW, Finck-Barbançon V, Wu C, Fleiszig SM) Infect Immun 1998 Apr;66(4):1453-9 PMID: 9529067 PMCID: PMC108074 SCOPUS ID: 2-s2.0-0032036504 04/07/1998 92 Citations

Rapid IL-10 upregulation in lung in cytotoxic Pseudomonas aeruginosa pneumonia (Sawa T, Ohara M, Kurahashi K, Gropper MA, Frank DW, Wiener-Kronish JP) FASEB Journal 20 March 1998;12(5) SCOPUS ID: 2-s2.0-33749322243 03/20/1998

Cytotoxic strains of Pseudomonas aeruginosa can damage the intact corneal surface in vitro. (Fleiszig SM, Lee EJ, Wu C, Andika RC, Vallas V, Portoles M, Frank DW) CLAO J 1998 Jan;24(1):41-7 PMID: 9474453 SCOPUS ID: 2-s2.0-0031891691 02/25/1998 49 Citations

The exoenzyme S regulon of Pseudomonas aeruginosa. (Frank DW) Mol Microbiol 1997 Nov;26(4):621-9 PMID: 9427393 SCOPUS ID: 2-s2.0-0030726075 01/14/1998 315 Citations

Resistance of strains of pseudomonas aeruginosa to contact lens disinfectants (Lakkis C, Frank DW, Bruce AS, Fleiszig SMJ) Investigative Ophthalmology and Visual Science 1997;38(4) SCOPUS ID: 2-s2.0-0006769951 12/01/1997

Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon. (Yahr TL, Mende-Mueller LM, Friese MB, Frank DW) J Bacteriol 1997 Nov;179(22):7165-8 PMID: 9371466 PMCID: PMC179660 SCOPUS ID: 2-s2.0-0030731178 11/26/1997 183 Citations

ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury. (Finck-Barbançon V, Goranson J, Zhu L, Sawa T, Wiener-Kronish JP, Fleiszig SM, Wu C, Mende-Mueller L, Frank DW) Mol Microbiol 1997 Aug;25(3):547-57 PMID: 9302017 SCOPUS ID: 2-s2.0-0030868998 08/01/1997 425 Citations

Isolation and characterization of an attenuated strain of Pseudomonas aeruginosa AC869, a 3,5-dichlorobenzoate degrader. (Zhou X, George SE, Frank DW, Utley M, Gilmour I, Krogfelt KA, Claxton LD, Laux DC, Cohen PS) Appl Environ Microbiol 1997 Apr;63(4):1389-95 PMID: 9097436 PMCID: PMC168433 SCOPUS ID: 2-s2.0-0030908977 04/01/1997 7 Citations

Functional analysis of exsC and exsB in regulation of exoenzyme S production by Pseudomonas aeruginosa. (Goranson J, Hovey AK, Frank DW) J Bacteriol 1997 Mar;179(5):1646-54 PMID: 9045825 PMCID: PMC178878 SCOPUS ID: 2-s2.0-0031047135 03/01/1997 17 Citations

Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa. (Liu S, Yahr TL, Frank DW, Barbieri JT) J Bacteriol 1997 Mar;179(5):1609-13 PMID: 9045820 PMCID: PMC178873 SCOPUS ID: 2-s2.0-0031046668 03/01/1997 46 Citations

Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S. (Fleiszig SM, Wiener-Kronish JP, Miyazaki H, Vallas V, Mostov KE, Kanada D, Sawa T, Yen TS, Frank DW) Infect Immun 1997 Feb;65(2):579-86 PMID: 9009316 PMCID: PMC176099 SCOPUS ID: 2-s2.0-0031020233 02/01/1997 262 Citations

Effects of differential expression of the 49-kilodalton exoenzyme S by Pseudomonas aeruginosa on cultured eukaryotic cells. (Olson JC, McGuffie EM, Frank DW) Infect Immun 1997 Jan;65(1):248-56 PMID: 8975919 PMCID: PMC174583 SCOPUS ID: 2-s2.0-0031016010 01/01/1997 56 Citations

Pseudomonas aeruginosa nucleic acids encoding exoenzymes activity and use thereof in detecting pseudomonas aeruginosa infection (Barbieri JT, Frank DW, Kulich SM) Biotechnology Advances 1997;15(3-4):723 SCOPUS ID: 2-s2.0-0030662886 01/01/1997

Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway. (Yahr TL, Goranson J, Frank DW) Mol Microbiol 1996 Dec;22(5):991-1003 PMID: 8971719 SCOPUS ID: 2-s2.0-0029801248 12/01/1996 240 Citations

Genetic relationship between the 53- and 49-kilodalton forms of exoenzyme S from Pseudomonas aeruginosa. (Yahr TL, Barbieri JT, Frank DW) J Bacteriol 1996 Mar;178(5):1412-9 PMID: 8631719 PMCID: PMC177816 SCOPUS ID: 2-s2.0-0029914812 03/01/1996 107 Citations

Evidence that all Pseudomonas aeruginosa strains may be inherently capable of invading corneal epithelial cells and that cytotoxicity is regulated by ExsA (Fleiszig SMJ, Wiener-Kronish JP, Vallas V, Mostov KE, Frank DW) Investigative Ophthalmology and Visual Science 15 February 1996;37(3) SCOPUS ID: 2-s2.0-24444466303 02/15/1996 2 Citations

Genetic analysis of exoenzyme S expression by Pseudomonas aeruginosa. (Goranson J, Frank DW) FEMS Microbiol Lett 1996 Jan 15;135(2-3):149-55 PMID: 8595851 SCOPUS ID: 2-s2.0-0030044151 01/15/1996 20 Citations

Analyses of the DNA-binding and transcriptional activation properties of ExsA, the transcriptional activator of the Pseudomonas aeruginosa exoenzyme S regulon. (Hovey AK, Frank DW) J Bacteriol 1995 Aug;177(15):4427-36 PMID: 7635828 PMCID: PMC177193 SCOPUS ID: 2-s2.0-0029162189 08/01/1995 112 Citations

Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: glycosylation-defective host cells are resistant to bacterial killing. (Apodaca G, Bomsel M, Lindstedt R, Engel J, Frank D, Mostov KE, Wiener-Kronish J) Infect Immun 1995 Apr;63(4):1541-51 PMID: 7890421 PMCID: PMC173187 SCOPUS ID: 2-s2.0-0028949289 04/01/1995 101 Citations

Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene. (Yahr TL, Hovey AK, Kulich SM, Frank DW) J Bacteriol 1995 Mar;177(5):1169-78 PMID: 7868588 PMCID: PMC176720 SCOPUS ID: 2-s2.0-0028944578 03/01/1995 87 Citations

Expression of recombinant exoenzyme S of Pseudomonas aeruginosa. (Kulich SM, Frank DW, Barbieri JT) Infect Immun 1995 Jan;63(1):1-8 PMID: 7806344 PMCID: PMC172950 SCOPUS ID: 2-s2.0-0028796549 01/01/1995 47 Citations

Exoproduct secretions of Pseudomonas aeruginosa strains influence severity of alveolar epithelial injury. (Kudoh I, Wiener-Kronish JP, Hashimoto S, Pittet JF, Frank D) Am J Physiol 1994 Nov;267(5 Pt 1):L551-6 PMID: 7977765 SCOPUS ID: 2-s2.0-0028050672 11/01/1994 122 Citations

Transcriptional organization of the trans-regulatory locus which controls exoenzyme S synthesis in Pseudomonas aeruginosa. (Yahr TL, Frank DW) J Bacteriol 1994 Jul;176(13):3832-38 PMID: 8021164 PMCID: PMC205579 SCOPUS ID: 2-s2.0-0028332195 07/01/1994 75 Citations

Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388. (Kulich SM, Yahr TL, Mende-Mueller LM, Barbieri JT, Frank DW) J Biol Chem 1994 Apr 08;269(14):10431-7 PMID: 8144626 SCOPUS ID: 2-s2.0-0028308703 04/08/1994 78 Citations

Construction and characterization of chromosomal insertional mutations of the Pseudomonas aeruginosa exoenzyme S trans-regulatory locus. (Frank DW, Nair G, Schweizer HP) Infect Immun 1994 Feb;62(2):554-63 PMID: 8300213 PMCID: PMC186141 SCOPUS ID: 2-s2.0-0028157289 02/01/1994 67 Citations

Regulation of expression of Pseudomonas exotoxin A by iron. (Frank DW, Storey DG) Methods Enzymol 1994;235:502-17 PMID: 8057922 SCOPUS ID: 2-s2.0-0028240366 01/01/1994 4 Citations

Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. (Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay MA) J Appl Physiol (1985) 1993 Oct;75(4):1661-9 PMID: 8282618 SCOPUS ID: 2-s2.0-0027491593 10/01/1993 109 Citations

Effect of Pseudomonas aeruginosa elastase, alkaline protease, and exotoxin A on corneal proteinases and proteins. (Twining SS, Kirschner SE, Mahnke LA, Frank DW) Invest Ophthalmol Vis Sci 1993 Aug;34(9):2699-712 PMID: 8344792 SCOPUS ID: 2-s2.0-0027179622 08/01/1993 129 Citations

Purification and characterization of exoenzyme S from Pseudomonas aeruginosa 388. (Kulich SM, Frank DW, Barbieri JT) Infect Immun 1993 Jan;61(1):307-13 PMID: 8418052 PMCID: PMC302720 SCOPUS ID: 2-s2.0-0027464118 01/01/1993 44 Citations

Effect of regB on expression from the P1 and P2 promoters of the Pseudomonas aeruginosa regAB operon. (Storey DG, Raivio TL, Frank DW, Wick MJ, Kaye S, Iglewski BH) J Bacteriol 1991 Oct;173(19):6088-94 PMID: 1917842 PMCID: PMC208355 SCOPUS ID: 2-s2.0-0025954284 10/01/1991 21 Citations

Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. (Frank DW, Iglewski BH) J Bacteriol 1991 Oct;173(20):6460-8 PMID: 1655713 PMCID: PMC208981 SCOPUS ID: 2-s2.0-0025948303 10/01/1991 84 Citations

Identification of regB, a gene required for optimal exotoxin A yields in Pseudomonas aeruginosa. (Wick MJ, Frank DW, Storey DG, Iglewski BH) Mol Microbiol 1990 Mar;4(3):489-97 PMID: 2113155 SCOPUS ID: 2-s2.0-0025342389 03/01/1990 21 Citations

Multiple promoters control the regulation of the Pseudomonas aeruginosa regA gene. (Storey DG, Frank DW, Farinha MA, Kropinski AM, Iglewski BH) Mol Microbiol 1990 Mar;4(3):499-503 PMID: 2113156 SCOPUS ID: 2-s2.0-0025373544 03/01/1990 36 Citations

Structure, function, and regulation of Pseudomonas aeruginosa exotoxin A. (Wick MJ, Frank DW, Storey DG, Iglewski BH) Annu Rev Microbiol 1990;44:335-63 PMID: 2123620 SCOPUS ID: 2-s2.0-0025185583 01/01/1990 67 Citations

Differential regulation by iron of regA and toxA transcript accumulation in Pseudomonas aeruginosa. (Frank DW, Storey DG, Hindahl MS, Iglewski BH) J Bacteriol 1989 Oct;171(10):5304-13 PMID: 2507519 PMCID: PMC210366 SCOPUS ID: 2-s2.0-0024463456 10/01/1989 49 Citations

Kinetics of toxA and regA mRNA accumulation in Pseudomonas aeruginosa. (Frank DW, Iglewski BH) J Bacteriol 1988 Oct;170(10):4477-83 PMID: 3139628 PMCID: PMC211479 SCOPUS ID: 2-s2.0-0023759078 10/01/1988 46 Citations

Characterization of a gene that regulates toxin A synthesis in Pseudomonas aeruginosa. (Hindahl MS, Frank DW, Hamood A, Iglewski BH) Nucleic Acids Res 1988 Jun 24;16(12):5699 PMID: 3133641 PMCID: PMC336806 SCOPUS ID: 2-s2.0-0023902438 06/24/1988 15 Citations

Molecular studies of a positive regulator of toxin A synthesis in Pseudomonas aeruginosa. (Hindahl MS, Frank DW, Iglewski BH) Antibiot Chemother (1971) 1987;39:279-89 PMID: 3118790 SCOPUS ID: 2-s2.0-0023085670 01/01/1987 19 Citations

Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections. (Nicas TI, Frank DW, Stenzel P, Lile JD, Iglewski BH) Eur J Clin Microbiol 1985 Apr;4(2):175-9 PMID: 2988945 SCOPUS ID: 2-s2.0-0021795933 04/01/1985 52 Citations

Cell surface antigens of Bordetella pertussis. (Parker CD, Branes LV, Armstrong SK, Frank DW, Cole A) Dev Biol Stand 1985;61:123-36 PMID: 2872098 SCOPUS ID: 2-s2.0-0022293254 01/01/1985 2 Citations

Surface antigens of Bordetella pertussis. (Parker CD, Armstrong SK, Frank DW) Adv Exp Med Biol 1985;185:117-27 PMID: 2866677 SCOPUS ID: 2-s2.0-0022317379 01/01/1985

Isolation and characterization of monoclonal antibodies to Bordetella pertussis. (Frank DW, Parker CD) J Biol Stand 1984 Oct;12(4):353-65 PMID: 6098581 SCOPUS ID: 2-s2.0-0021708285 10/01/1984 11 Citations

Interaction of monoclonal antibodies with pertussis toxin and its subunits. (Frank DW, Parker CD) Infect Immun 1984 Oct;46(1):195-201 PMID: 6207108 PMCID: PMC261448 SCOPUS ID: 2-s2.0-0021176155 10/01/1984 18 Citations

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Dara W. Frank PhD

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