Kajana Satkunendrarajah PhD

Research Areas of Interest
Cervical CordDiaphragmElectrophysiologyForelimbInterneuronsNeuroanatomyNeuroprotective AgentsOptogeneticsPhrenic NerveRecovery of FunctionRespirationSpinal CordSpinal Cord CompressionSpondylosisResearch Experience
Cervical CordElectrophysiologyForelimbGait Disorders, NeurologicLocomotionMiceMice, TransgenicMotor ActivityNeuroanatomyNeuronal PlasticityOptogeneticsRespirationSensorimotor CortexSpinal Cord CompressionSpinal Cord InjuriesMethodologies and Techniques
Disease Models, AnimalElectrophysiologyEvoked Potentials, MotorPlethysmography, Whole BodyRecovery of FunctionEducational Expertise
Disease Models, AnimalElectrophysiologyEvoked Potentials, MotorImmunohistochemistryNeuroprotective AgentsRecovery of FunctionSpinal CordSpinal Cord CompressionPublications (28)
Subclinical respiratory dysfunction and impaired ventilatory adaptation in degenerative cervical myelopathy. (Sweetman H, Rahman M, Vedantam A, Satkunendrarajah K) Exp Neurol 2024 Jan;371:114600 PMID: 37907124 SCOPUS ID: 2-s2.0-85175540178 11/01/2023 Spinal cord injury and degenerative cervical myelopathy. (Satkunendrarajah K, Karadimas SK, Fehlings MG) Handb Clin Neurol 2022;189:241-257 PMID: 36031307 SCOPUS ID: 2-s2.0-85136594983 08/29/2022 4 CitationsViral tools for mapping and modulating neural networks after spinal cord injury. (Schrank S, Satkunendrarajah K) Exp Neurol 2022 May;351:113995 PMID: 35123955 SCOPUS ID: 2-s2.0-85124103217 02/07/2022 Mir21 modulates inflammation and sensorimotor deficits in cervical myelopathy: data from humans and animal models. (Laliberte AM, Karadimas SK, Vidal PM, Satkunendrarajah K, Fehlings MG) Brain Commun 2021;3(1):fcaa234 PMID: 33604572 PMCID: PMC7878254 SCOPUS ID: 2-s2.0-85112157010 02/20/2021 28 CitationsSpinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease. (Zholudeva LV, Abraira VE, Satkunendrarajah K, McDevitt TC, Goulding MD, Magnuson DSK, Lane MA) J Neurosci 2021 Feb 03;41(5):845-854 PMID: 33472820 PMCID: PMC7880285 SCOPUS ID: 2-s2.0-85101994444 01/22/2021 46 CitationsBilateral cervical contusion spinal cord injury: A mouse model to evaluate sensorimotor function. (Reinhardt DR, Stehlik KE, Satkunendrarajah K, Kroner A) Exp Neurol 2020 Sep;331:113381 PMID: 32561411 SCOPUS ID: 2-s2.0-85086575731 06/21/2020 15 CitationsSensory cortical control of movement. (Karadimas SK, Satkunendrarajah K, Laliberte AM, Ringuette D, Weisspapir I, Li L, Gosgnach S, Fehlings MG) Nat Neurosci 2020 Jan;23(1):75-84 PMID: 31740813 SCOPUS ID: 2-s2.0-85075146992 11/20/2019 41 CitationsCervical excitatory neurons sustain breathing after spinal cord injury. (Satkunendrarajah K, Karadimas SK, Laliberte AM, Montandon G, Fehlings MG) Nature 2018 Oct;562(7727):419-422 PMID: 30305735 SCOPUS ID: 2-s2.0-85055018424 10/12/2018 57 CitationsNeural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury. (Suzuki H, Ahuja CS, Salewski RP, Li L, Satkunendrarajah K, Nagoshi N, Shibata S, Fehlings MG) PLoS One 2017;12(8):e0182339 PMID: 28771534 PMCID: PMC5542671 SCOPUS ID: 2-s2.0-85026755609 08/05/2017 81 CitationsGenerating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function. (Wilcox JT, Satkunendrarajah K, Nasirzadeh Y, Laliberte AM, Lip A, Cadotte DW, Foltz WD, Fehlings MG) Neurobiol Dis 2017 Sep;105:194-212 PMID: 28578003 SCOPUS ID: 2-s2.0-85020764778 06/05/2017 31 CitationsA New Acute Impact-Compression Lumbar Spinal Cord Injury Model in the Rodent. (Moonen G, Satkunendrarajah K, Wilcox JT, Badner A, Mothe A, Foltz W, Fehlings MG, Tator CH) J Neurotrauma 2016 Feb 01;33(3):278-89 PMID: 26414192 PMCID: PMC4744888 SCOPUS ID: 2-s2.0-84957714901 09/29/2015 32 CitationsRiluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection. (Satkunendrarajah K, Nassiri F, Karadimas SK, Lip A, Yao G, Fehlings MG) Exp Neurol 2016 Feb;276:59-71 PMID: 26394202 SCOPUS ID: 2-s2.0-84954402665 09/24/2015 38 CitationsNeural precursor cell transplantation enhances functional recovery and reduces astrogliosis in bilateral compressive/contusive cervical spinal cord injury. (Wilcox JT, Satkunendrarajah K, Zuccato JA, Nassiri F, Fehlings MG) Stem Cells Transl Med 2014 Oct;3(10):1148-59 PMID: 25107585 PMCID: PMC4181397 SCOPUS ID: 2-s2.0-84908040537 08/12/2014 43 CitationsBilateral contusion-compression model of incomplete traumatic cervical spinal cord injury. (Forgione N, Karadimas SK, Foltz WD, Satkunendrarajah K, Lip A, Fehlings MG) J Neurotrauma 2014 Nov 01;31(21):1776-88 PMID: 24949719 PMCID: PMC4186801 SCOPUS ID: 2-s2.0-84912114112 06/21/2014 38 CitationsDelayed administration of a bio-engineered zinc-finger VEGF-A gene therapy is neuroprotective and attenuates allodynia following traumatic spinal cord injury. (Figley SA, Liu Y, Karadimas SK, Satkunendrarajah K, Fettes P, Spratt SK, Lee G, Ando D, Surosky R, Giedlin M, Fehlings MG) PLoS One 2014;9(5):e96137 PMID: 24846143 PMCID: PMC4028194 SCOPUS ID: 2-s2.0-84901372372 05/23/2014 32 CitationsRiluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia. (Wu Y, Satkunendrarajah K, Fehlings MG) Neuroscience 2014 Apr 18;265:302-12 PMID: 24508749 SCOPUS ID: 2-s2.0-84894657597 02/11/2014 41 CitationsThe role of neural precursor cells and self assembling peptides in nerve regeneration. (Zhao X, Yao GS, Liu Y, Wang J, Satkunendrarajah K, Fehlings M) J Otolaryngol Head Neck Surg 2013 Dec 19;42(1):60 PMID: 24351041 PMCID: PMC3878249 SCOPUS ID: 2-s2.0-84896987191 12/20/2013 8 CitationsDo omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27. (Satkunendrarajah K, Fehlings MG) Exp Neurol 2013 Nov;249:104-10 PMID: 23994716 SCOPUS ID: 2-s2.0-84884278859 09/03/2013 10 CitationsA self-assembling peptide reduces glial scarring, attenuates post-traumatic inflammation and promotes neurological recovery following spinal cord injury. (Liu Y, Ye H, Satkunendrarajah K, Yao GS, Bayon Y, Fehlings MG) Acta Biomater 2013 Sep;9(9):8075-88 PMID: 23770224 SCOPUS ID: 2-s2.0-84880916642 06/19/2013 95 CitationsDelayed post-injury administration of riluzole is neuroprotective in a preclinical rodent model of cervical spinal cord injury. (Wu Y, Satkunendrarajah K, Teng Y, Chow DS, Buttigieg J, Fehlings MG) J Neurotrauma 2013 Mar 15;30(6):441-52 PMID: 23517137 PMCID: PMC3696918 SCOPUS ID: 2-s2.0-84876270838 03/23/2013 78 CitationsA novel experimental model of cervical spondylotic myelopathy (CSM) to facilitate translational research. (Karadimas SK, Moon ES, Yu WR, Satkunendrarajah K, Kallitsis JK, Gatzounis G, Fehlings MG) Neurobiol Dis 2013 Jun;54:43-58 PMID: 23466695 SCOPUS ID: 2-s2.0-84875333402 03/08/2013 113 CitationsImmunoglobulin G (IgG) attenuates neuroinflammation and improves neurobehavioral recovery after cervical spinal cord injury. (Nguyen DH, Cho N, Satkunendrarajah K, Austin JW, Wang J, Fehlings MG) J Neuroinflammation 2012 Sep 21;9:224 PMID: 22998664 PMCID: PMC3503837 SCOPUS ID: 2-s2.0-84866478622 09/25/2012 58 CitationsEvaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury. (Cho N, Nguyen DH, Satkunendrarajah K, Branch DR, Fehlings MG) J Neuroinflammation 2012 Jun 20;9:134 PMID: 22715999 PMCID: PMC3410772 SCOPUS ID: 2-s2.0-84862311781 06/22/2012 26 CitationsThe effects of intrathecal injection of a hyaluronan-based hydrogel on inflammation, scarring and neurobehavioural outcomes in a rat model of severe spinal cord injury associated with arachnoiditis. (Austin JW, Kang CE, Baumann MD, DiDiodato L, Satkunendrarajah K, Wilson JR, Stanisz GJ, Shoichet MS, Fehlings MG) Biomaterials 2012 Jun;33(18):4555-64 PMID: 22459192 SCOPUS ID: 2-s2.0-84862819061 03/31/2012 87 CitationsDevelopment and characterization of a novel rat model of cervical spondylotic myelopathy: the impact of chronic cord compression on clinical, neuroanatomical, and neurophysiological outcomes. (Lee J, Satkunendrarajah K, Fehlings MG) J Neurotrauma 2012 Mar 20;29(5):1012-27 PMID: 21561323 SCOPUS ID: 2-s2.0-84863369604 05/13/2011 44 CitationsSystemic administration of rolipram increases medullary and spinal cAMP and activates a latent respiratory motor pathway after high cervical spinal cord injury. (Kajana S, Goshgarian HG) J Spinal Cord Med 2009;32(2):175-82 PMID: 19569465 PMCID: PMC2678289 SCOPUS ID: 2-s2.0-66449106384 07/03/2009 26 CitationsSpinal activation of the cAMP-PKA pathway induces respiratory motor recovery following high cervical spinal cord injury. (Kajana S, Goshgarian HG) Brain Res 2008 Sep 26;1232:206-13 PMID: 18656458 PMCID: PMC2573999 SCOPUS ID: 2-s2.0-51049089530 07/29/2008 20 CitationsAdministration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats. (Kajana S, Goshgarian HG) Exp Neurol 2008 Apr;210(2):671-80 PMID: 18289533 PMCID: PMC2377457 SCOPUS ID: 2-s2.0-41149094934 02/22/2008 41 Citations Last update: 11/19/2024