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Pablo Nakagawa PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Physiology
Program: Cardiovascular Research Center

Member of the Cardiovascular Research Center
Member of the Center for Immunology

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Publications (42)

Definitive Evidence for the Identification and Function of Renin-Expressing Cholinergic Neurons in the Nucleus Ambiguus. (Fekete ÉM, Gomez J, Ghobrial M, Kaminski K, Muskus PC, Boychuk CR, Hantke Guixa A, Vazirabad I, Xie M, Ganiyu A, Golosova D, Mathieu NM, Wang YB, Lu KT, Wackman KK, Brozoski DT, Mouradian GC, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P) Hypertension 2025 Feb;82(2):282-292 PMID: 39618396 PMCID: PMC11735315 SCOPUS ID: 2-s2.0-85210962734 12/02/2024 1 Citation

Early-life sodium restriction programs autonomic dysfunction and salt sensitivity in male C57BL/6J mice. (Ziegler AA, Lawton SBR, Fekete EM, Brozoski DT, Wagner VA, Grobe CC, Sigmund CD, Nakagawa P, Grobe JL, Segar JL) Am J Physiol Regul Integr Comp Physiol 2025 Jan 01;328(1):R109-R120 PMID: 39548798 PMCID: PMC11905802 SCOPUS ID: 2-s2.0-85213215949 11/16/2024

Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence. (Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL) Hypertension 2024 Nov;81(11):2209-2217 PMID: 39315447 PMCID: PMC11483214 SCOPUS ID: 2-s2.0-85205521844 09/24/2024 3 Citations

Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure. (Mathieu NM, Tan EE, Reho JJ, Brozoski DT, Muskus PC, Lu KT, Wackman KK, Grobe JL, Nakagawa P, Sigmund CD) Hypertension 2024 Jun;81(6):1332-1344 PMID: 38629290 PMCID: PMC11096025 SCOPUS ID: 2-s2.0-85193429264 04/17/2024 2 Citations

Modulatory effects of estrous cycle on ingestive behaviors and energy balance in young adult C57BL/6J mice maintained on a phytoestrogen-free diet. (Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2024 Mar 01;326(3):R242-R253 PMID: 38284128 PMCID: PMC11213288 SCOPUS ID: 2-s2.0-85186271298 01/29/2024 3 Citations

Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice. (Ziegler AA, Lawton SBR, Grobe CC, Reho JJ, Freudinger BP, Burnett CML, Nakagawa P, Grobe JL, Segar JL) Am J Physiol Regul Integr Comp Physiol 2023 Nov 01;325(5):R576-R592 PMID: 37720996 PMCID: PMC10866575 SCOPUS ID: 2-s2.0-85174752582 09/18/2023 3 Citations

Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension. (Mathieu NM, Fekete EM, Muskus PC, Brozoski DT, Lu KT, Wackman KK, Gomez J, Fang S, Reho JJ, Grobe CC, Vazirabad I, Mouradian GC Jr, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P) Function (Oxf) 2023;4(5):zqad043 PMID: 37609445 PMCID: PMC10440998 SCOPUS ID: 2-s2.0-85168790693 08/23/2023 3 Citations

Angiotensin AT_1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity. (Balapattabi K, Yavuz Y, Jiang J, Deng G, Mathieu NM, Ritter ML, Opichka MA, Reho JJ, McCorvy JD, Nakagawa P, Morselli LL, Mouradian GC Jr, Atasoy D, Cui H, Hodges MR, Sigmund CD, Grobe JL) Cell Rep 2023 Aug 29;42(8):112935 PMID: 37540598 PMCID: PMC10530419 SCOPUS ID: 2-s2.0-85169503465 08/04/2023 7 Citations

Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature. (Grobe CC, Reho JJ, Brown-Williams D, Ziegler AA, Mathieu NM, Lawton SBR, Fekete EM, Brozoski DT, Wackman KK, Burnett CML, Nakagawa P, Sigmund CD, Segar JL, Grobe JL) Hypertension 2023 Sep;80(9):1871-1880 PMID: 37470185 PMCID: PMC10528934 SCOPUS ID: 2-s2.0-85168254483 07/20/2023 1 Citation

Insights Into the Role of Angiotensin-II AT₁ Receptor-Dependent β-Arrestin Signaling in Cardiovascular Disease. (Mathieu NM, Nakagawa P, Grobe JL, Sigmund CD) Hypertension 2024 Jan;81(1):6-16 PMID: 37449411 PMCID: PMC10787814 SCOPUS ID: 2-s2.0-85180800778 07/14/2023 9 Citations

Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension. (Wagner VA, Deng G, Claflin KE, Ritter ML, Cui H, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL, Kwitek AE) Front Cell Neurosci 2023;17:1207350 PMID: 37293629 PMCID: PMC10244568 SCOPUS ID: 2-s2.0-85161193387 06/09/2023 4 Citations

Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice. (Ritter ML, Deng G, Reho JJ, Deng Y, Sapouckey SA, Opichka MA, Balapattabi K, Wackman KK, Brozoski DT, Lu KT, Paradee WJ, Gibson-Corley KN, Cui H, Nakagawa P, Morselli LL, Sigmund CD, Grobe JL) Hypertension 2022 Dec;79(12):2843-2853 PMID: 36259376 PMCID: PMC9649888 SCOPUS ID: 2-s2.0-85141891708 10/20/2022 2 Citations

ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation. (Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD) Hypertension 2022 Nov;79(11):2480-2492 PMID: 36215165 PMCID: PMC9669141 SCOPUS ID: 2-s2.0-85140375825 10/11/2022 13 Citations

Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons. (Mouradian GC Jr, Liu P, Nakagawa P, Duffy E, Gomez Vargas J, Balapattabi K, Grobe JL, Sigmund CD, Hodges MR) Front Synaptic Neurosci 2022;14:910820 PMID: 35844900 PMCID: PMC9280690 SCOPUS ID: 2-s2.0-85134237459 07/19/2022 3 Citations

Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice. (Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2022 Oct 01;323(4):R410-R421 PMID: 35816717 PMCID: PMC9512112 SCOPUS ID: 2-s2.0-85138457982 07/12/2022 7 Citations

Melanocortin MC₄R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. (Oliveira V, Riedl RA, Claflin KE, Mathieu NM, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL) Physiol Genomics 2022 Jun 01;54(6):196-205 PMID: 35476598 PMCID: PMC9131927 SCOPUS ID: 2-s2.0-85131018208 04/28/2022 6 Citations

Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. (Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2022 Jun 01;322(6):R467-R485 PMID: 35348007 PMCID: PMC9054347 SCOPUS ID: 2-s2.0-85129779185 03/30/2022 11 Citations

Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents. (Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL) Front Physiol 2022;13:855054 PMID: 35283781 PMCID: PMC8914175 SCOPUS ID: 2-s2.0-85126220642 03/15/2022 23 Citations

Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice. (Nakagawa P, Gomez J, Lu KT, Grobe JL, Sigmund CD) PLoS One 2021;16(7):e0250807 PMID: 34319999 PMCID: PMC8318244 SCOPUS ID: 2-s2.0-85111564742 07/29/2021 3 Citations

Under Pressure: A Baroreceptor Mechanism in the Renal Renin Cell Controlling Renin. (Nakagawa P, Sigmund CD) Circ Res 2021 Jul 09;129(2):277-279 PMID: 34236885 PMCID: PMC8274374 SCOPUS ID: 2-s2.0-85110022097 07/09/2021 1 Citation

Role of the Peroxisome Proliferator Activated Receptors in Hypertension. (Fang S, Livergood MC, Nakagawa P, Wu J, Sigmund CD) Circ Res 2021 Apr 02;128(7):1021-1039 PMID: 33793338 PMCID: PMC8020861 SCOPUS ID: 2-s2.0-85103807023 04/02/2021 35 Citations

β-Arrestin-Biased Agonist Targeting the Brain AT₁R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension. (Zanaty M, Seara FAC, Nakagawa P, Deng G, Mathieu NM, Balapattabi K, Karnik SS, Grobe JL, Sigmund CD) Hypertension 2021 Feb;77(2):420-431 PMID: 33249862 PMCID: PMC7855825 SCOPUS ID: 2-s2.0-85100070274 12/01/2020 20 Citations

Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. (Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD) Hypertension 2020 Aug;76(2):468-477 PMID: 32507043 PMCID: PMC7347438 SCOPUS ID: 2-s2.0-85087872461 06/09/2020 9 Citations

Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension. (Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD) Cardiovasc Res 2021 Jan 01;117(1):308-319 PMID: 32428209 PMCID: PMC7797211 SCOPUS ID: 2-s2.0-85097807979 05/20/2020 23 Citations

The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation. (Nakagawa P, Gomez J, Grobe JL, Sigmund CD) Curr Hypertens Rep 2020 Jan 10;22(1):7 PMID: 31925571 PMCID: PMC7101821 SCOPUS ID: 2-s2.0-85077710193 01/12/2020 74 Citations

Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. (Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD) Hypertension 2019 Jul;74(1):173-183 PMID: 31104564 PMCID: PMC6561821 SCOPUS ID: 2-s2.0-85068196613 05/21/2019 25 Citations

Renal release of N-acetyl-seryl-aspartyl-lysyl-proline is part of an antifibrotic peptidergic system in the kidney. (Romero CA, Kumar N, Nakagawa P, Worou ME, Liao TD, Peterson EL, Carretero OA) Am J Physiol Renal Physiol 2019 Jan 01;316(1):F195-F203 PMID: 30403163 PMCID: PMC6383198 SCOPUS ID: 2-s2.0-85059797487 11/08/2018 17 Citations

Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction. (Nakagawa P, Romero CA, Jiang X, D'Ambrosio M, Bordcoch G, Peterson EL, Harding P, Yang XP, Carretero OA) PLoS One 2018;13(1):e0190300 PMID: 29364896 PMCID: PMC5783348 SCOPUS ID: 2-s2.0-85041122447 01/25/2018 17 Citations

Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. (Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD) Hypertension 2017 Nov;70(5):990-997 PMID: 28874461 PMCID: PMC5679092 SCOPUS ID: 2-s2.0-85031820971 09/07/2017 19 Citations

How Is the Brain Renin-Angiotensin System Regulated? (Nakagawa P, Sigmund CD) Hypertension 2017 Jul;70(1):10-18 PMID: 28559391 PMCID: PMC5511499 SCOPUS ID: 2-s2.0-85020147188 06/01/2017 63 Citations

Effects of N-acetyl-seryl-asparyl-lysyl-proline on blood pressure, renal damage, and mortality in systemic lupus erythematosus. (Nakagawa P, Masjoan-Juncos JX, Basha H, Janic B, Worou ME, Liao TD, Romero CA, Peterson EL, Carretero OA) Physiol Rep 2017 Jan;5(2) PMID: 28126732 PMCID: PMC5269407 SCOPUS ID: 2-s2.0-85010660805 01/28/2017 11 Citations

Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension. (González GE, Rhaleb NE, D'Ambrosio MA, Nakagawa P, Liao TD, Peterson EL, Leung P, Dai X, Janic B, Liu YH, Yang XP, Carretero OA) Am J Physiol Heart Circ Physiol 2016 Nov 01;311(5):H1287-H1296 PMID: 27496875 PMCID: PMC5130499 SCOPUS ID: 2-s2.0-84994627883 11/03/2016 64 Citations

The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase. (Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Monu SR, Peterson EL, Shaw J, Valeriote F, Ongeri EM, Niyitegeka JM, Rhaleb NE, Carretero OA) Am J Physiol Renal Physiol 2016 May 15;310(10):F1026-34 PMID: 26962108 PMCID: PMC4889319 SCOPUS ID: 2-s2.0-84984633347 03/11/2016 46 Citations

Ac-SDKP suppresses TNF-α-induced ICAM-1 expression in endothelial cells via inhibition of IκB kinase and NF-κB activation. (Zhu L, Yang XP, Janic B, Rhaleb NE, Harding P, Nakagawa P, Peterson EL, Carretero OA) Am J Physiol Heart Circ Physiol 2016 May 01;310(9):H1176-83 PMID: 26945075 PMCID: PMC5243213 SCOPUS ID: 2-s2.0-84983751551 03/06/2016 25 Citations

Renal protective effect of N-acetyl-seryl-aspartyl-lysyl-proline in dahl salt-sensitive rats. (Worou ME, Liao TD, D'Ambrosio M, Nakagawa P, Janic B, Peterson EL, Rhaleb NE, Carretero OA) Hypertension 2015 Oct;66(4):816-22 PMID: 26324505 PMCID: PMC4658233 SCOPUS ID: 2-s2.0-84941207515 09/02/2015 23 Citations

N-Acetyl-Seryl-Aspartyl-Lysyl-Proline: mechanisms of renal protection in mouse model of systemic lupus erythematosus. (Liao TD, Nakagawa P, Janic B, D'Ambrosio M, Worou ME, Peterson EL, Rhaleb NE, Yang XP, Carretero OA) Am J Physiol Renal Physiol 2015 May 15;308(10):F1146-54 PMID: 25740596 PMCID: PMC4436999 SCOPUS ID: 2-s2.0-84930863328 03/06/2015 14 Citations

Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension. (González GE, Rhaleb NE, D'Ambrosio MA, Nakagawa P, Liu Y, Leung P, Dai X, Yang XP, Peterson EL, Carretero OA) J Hypertens 2015 Jan;33(1):144-52 PMID: 25304471 PMCID: PMC4256143 SCOPUS ID: 2-s2.0-84916897951 10/12/2014 90 Citations

N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats. (González GE, Rhaleb NE, Nakagawa P, Liao TD, Liu Y, Leung P, Dai X, Yang XP, Carretero OA) Clin Sci (Lond) 2014 Jan 01;126(1):85-94 PMID: 23834332 PMCID: PMC4240015 SCOPUS ID: 2-s2.0-84885062062 07/10/2013 44 Citations

Treatment with N-acetyl-seryl-aspartyl-lysyl-proline prevents experimental autoimmune myocarditis in rats. (Nakagawa P, Liu Y, Liao TD, Chen X, González GE, Bobbitt KR, Smolarek D, Peterson EL, Kedl R, Yang XP, Rhaleb NE, Carretero OA) Am J Physiol Heart Circ Physiol 2012 Nov 01;303(9):H1114-27 PMID: 22923621 PMCID: PMC3517643 SCOPUS ID: 2-s2.0-84868352552 08/28/2012 30 Citations

Angiotensin-(1-7) upregulates central nitric oxide synthase in spontaneously hypertensive rats. (Cerrato BD, Frasch AP, Nakagawa P, Longo-Carbajosa N, Peña C, Höcht C, Gironacci MM) Brain Res 2012 May 09;1453:1-7 PMID: 22483959 SCOPUS ID: 2-s2.0-84859804254 04/10/2012 26 Citations

Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice. (Peng H, Yang XP, Carretero OA, Nakagawa P, D'Ambrosio M, Leung P, Xu J, Peterson EL, González GE, Harding P, Rhaleb NE) Exp Physiol 2011 Aug;96(8):756-64 PMID: 21602297 PMCID: PMC3256574 SCOPUS ID: 2-s2.0-79960699648 05/24/2011 58 Citations

Angiotensin-(1-7) upregulates cardiac nitric oxide synthase in spontaneously hypertensive rats. (Costa MA, Lopez Verrilli MA, Gomez KA, Nakagawa P, Peña C, Arranz C, Gironacci MM) Am J Physiol Heart Circ Physiol 2010 Oct;299(4):H1205-11 PMID: 20675563 SCOPUS ID: 2-s2.0-77958055381 08/03/2010 58 Citations

Last update: 07/01/2025

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Pablo Nakagawa PhD

Assistant Professor

Publications (42)