Faculty Collaboration Database

Insights Into the Role of Angiotensin-II AT₁ Receptor-Dependent β-Arrestin Signaling in Cardiovascular Disease. Hypertension 2024 Jan;81(1):6-16

Date

07/14/2023

Pubmed ID

37449411

Pubmed Central ID

PMC10787814

DOI

10.1161/HYPERTENSIONAHA.123.19419

Scopus ID

2-s2.0-85180800778 (requires institutional sign-in at Scopus site)

Abstract

β-arrestins are a family of intracellular signaling proteins that play a key role in regulating the activity of G protein-coupled receptors. The angiotensin-II type 1 receptor is an important G protein-coupled receptor involved in the regulation of cardiovascular function and has been implicated in the progression of cardiovascular diseases. In addition to canonical G protein signaling, G protein-coupled receptors including the angiotensin-II type 1 receptor can signal via β-arrestin. Dysregulation of β-arrestin signaling has been linked to several cardiovascular diseases including hypertension, atherosclerosis, and heart failure. Understanding the role of β-arrestins in these conditions is critical to provide new therapeutic targets for the treatment of cardiovascular disease. In this review, we will discuss the beneficial and maladaptive physiological outcomes of angiotensin-II type 1 receptor-dependent β-arrestin activation in different cardiovascular diseases.

Author List

Mathieu NM, Nakagawa P, Grobe JL, Sigmund CD

Authors

Justin L. Grobe PhD Professor in the Physiology department at Medical College of Wisconsin
Pablo Nakagawa PhD Assistant Professor in the Physiology department at Medical College of Wisconsin
Curt Sigmund PhD Chair, Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Angiotensin II
Angiotensins
Arrestins
Cardiovascular Diseases
Humans
Receptor, Angiotensin, Type 1
Signal Transduction
beta-Arrestin 1
beta-Arrestin 2
beta-Arrestins