Medical College of Wisconsin
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Tyce J. Kearl MD, PhD

Tyce J. Kearl MD, PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Bone Marrow Transplant

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0002-9255-892X

Member of the Cancer Center
Member of the Center for Immunology


I am willing to collaborate on research projects.

View Curriculum Vitae

Research Experience

  • Immunotherapy

    • Clinical Expertise

  • Oncologists

    • Methodologies and Techniques

  • Cell Culture Techniques
  • Immune System
  • Sequence Analysis, RNA
  • Single-Cell Analysis

    • Leadership Positions

  • Research Director, BMT and Cell Therapy Laboratory
  • Co-Director, Cell Therapy and Immune Monitoring shared resource laboratory

    • MCW Program / Core Facilities

  • Pediatric Oncology

    • Publications (10)

  • Phase I/II Study of Adaptive Manufactured Lentiviral Anti-CD20/Anti-CD19 Chimeric Antigen Receptor T Cells for Relapsed, Refractory Mantle Cell Lymphoma (Shah NN, Colina AS, Johnson BD, Szabo A, Furqan F, Kearl T, Schneider D, Vargas-Cortes M, Schmeling JL, Dwinell MB, Palen K, Longo W, Hematti P, Zamora AE, Hari P, Bucklan D, Cunningham A, Hamadani M, Fenske TS.) Journal of Clinical Oncology 03/31/2025    
  • CAR T-cell therapy for B-cell lymphomas: outcomes and resistance mechanisms. (Kearl TJ, Furqan F, Shah NN) Cancer Metastasis Rev 2024 Dec 01;44(1):12 PMID: 39617795 SCOPUS ID: 2-s2.0-85211169496 12/02/2024       2 Citations
  • In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations (Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ) Oral Oncology September 2024;156 SCOPUS ID: 2-s2.0-85198374252 09/01/2024       1 Citation
  • TIM-3 blockade enhances ex vivo stimulated allogeneic NK cell therapy for relapsed murine neuroblastoma after hematopoietic cell transplant. (Quamine A, Mohrdieck NR, King CA, Griggs AA, Kline JM, Cho MM, Rinella SP, Tippins KE, Bates PD, Shi L, Song L, Hess NJ, Kearl TJ, Johnson BD, Capitini CM) bioRxiv 2024 Jul 12 PMID: 39026718 PMCID: PMC11257576 07/19/2024    
  • Corrigendum to Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture (Translational Oncology (2024) 42, (S1936523324000251), (10.1016/j.tranon.2024.101899)) (Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA) Translational Oncology June 2024;44 SCOPUS ID: 2-s2.0-85187349354 06/01/2024    
  • Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture. (Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA) Transl Oncol 2024 Apr;42:101899 PMID: 38320395 PMCID: PMC10851216 SCOPUS ID: 2-s2.0-85184507548 02/07/2024       2 Citations
  • Controlling Cytokine Release Syndrome to Harness the Full Potential of CAR-Based Cellular Therapy. (Thakar MS, Kearl TJ, Malarkannan S) Front Oncol 2019;9:1529 PMID: 32076597 PMCID: PMC7006459 SCOPUS ID: 2-s2.0-85079671509 02/23/2020       28 Citations
  • Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma. (Kearl TJ, Jing W, Gershan JA, Johnson BD) J Immunol 2013 Jun 01;190(11):5620-8 PMID: 23616570 PMCID: PMC3891840 SCOPUS ID: 2-s2.0-84878099006 04/26/2013       87 Citations
  • Phosphatidylethanolamine is externalized at the surface of microparticles. (Larson MC, Woodliff JE, Hillery CA, Kearl TJ, Zhao M) Biochim Biophys Acta 2012 Dec;1821(12):1501-7 PMID: 22960380 PMCID: PMC3809829 SCOPUS ID: 2-s2.0-84866500244 09/11/2012       53 Citations
  • Methods for studying voltage-gated sodium channels in heterologous expression systems. (Dice MS, Kearl T, Ruben PC) Methods Mol Med 2006;129:163-85 PMID: 17085811 SCOPUS ID: 2-s2.0-35548949165 11/07/2006       3 Citations
    • Last update: 07/03/2025