Medical College of Wisconsin
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Yiliang Chen PhD

Yiliang Chen PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Endocrinology
Program: Research

Member of the Cancer Center
Member of the Cardiovascular Research Center


I am willing to collaborate on research projects.

View Curriculum Vitae

Publications (30)

  • Oxidized LDL stimulates PKM2-mediated mtROS production and phagocytosis. (Zhang J, Chang J, Chen V, Beg MA, Huang W, Vick L, Wang Y, Zhang H, Yttre E, Gupta A, Castleberry M, Zhang Z, Dai W, Zhu J, Song S, Yang M, Brown AK, Xu Z, Ma YQ, Smith BC, Zielonka J, Traylor JG Jr, Ben Dhaou C, Orr AW, Cui W, Chen Y) J Lipid Res 2025 May;66(5):100809 PMID: 40250804 PMCID: PMC12142535 SCOPUS ID: 2-s2.0-105006766220 04/19/2025       6 Citations
  • CD36 restricts lipid-associated macrophages accumulation in white adipose tissues during atherogenesis. (Chen V, Zhang J, Chang J, Beg MA, Vick L, Wang D, Gupta A, Wang Y, Zhang Z, Dai W, Kim M, Song S, Pereira D, Zheng Z, Sodhi K, Shapiro JI, Silverstein RL, Malarkannan S, Chen Y) Front Cardiovasc Med 2024;11:1436865 PMID: 39156133 PMCID: PMC11327822 SCOPUS ID: 2-s2.0-85201434395 08/19/2024       4 Citations
  • Targeting mitochondrial dynamics and redox regulation in cardiovascular diseases. (Beg MA, Huang M, Vick L, Rao KNS, Zhang J, Chen Y) Trends Pharmacol Sci 2024 Apr;45(4):290-303 PMID: 38458847 PMCID: PMC11837222 SCOPUS ID: 2-s2.0-85187360123 03/09/2024       17 Citations
  • Plasma tissue-type plasminogen activator is associated with lipoprotein(a) and clinical outcomes in hospitalized patients with COVID-19 (Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z) Research and Practice in Thrombosis and Haemostasis August 2023;7(6) SCOPUS ID: 2-s2.0-85169507694 08/01/2023       6 Citations
  • Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL. (Pillai SS, Pereira DG, Zhang J, Huang W, Beg MA, Knaack DA, de Souza Goncalves B, Sahoo D, Silverstein RL, Shapiro JI, Sodhi K, Chen Y) Front Cardiovasc Med 2023;10:1046495 PMID: 37180782 PMCID: PMC10174328 SCOPUS ID: 2-s2.0-85159873988 05/14/2023       13 Citations
  • Na/K-ATPase signaling tonically inhibits sodium reabsorption in the renal proximal tubule. (Mukherji ST, Brambilla L, Stuart KB, Mayes I, Kutz LC, Chen Y, Barbosa LA, Elmadbouh I, McDermott JP, Haller ST, Romero MF, Soleimani M, Liu J, Shapiro JI, Blanco GV, Xie Z, Pierre SV) FASEB J 2023 Apr;37(4):e22835 PMID: 36856735 PMCID: PMC10028530 SCOPUS ID: 2-s2.0-85149427345 03/02/2023       4 Citations
  • Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn. (Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y) iScience 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022       16 Citations
  • Editorial: The Roles of Lipids in Immunometabolism: The Crosstalk Between Lipid Metabolisms and Inflammation. (Zhang J, Dai W, Chen Y) Front Cardiovasc Med 2022;9:938535 PMID: 35811702 PMCID: PMC9257247 SCOPUS ID: 2-s2.0-85139113119 07/12/2022       9 Citations
  • CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate. (Chen Y, Zhang J, Cui W, Silverstein RL) J Exp Med 2022 Jun 06;219(6) PMID: 35438721 PMCID: PMC9022290 SCOPUS ID: 2-s2.0-85128794972 04/20/2022       307 Citations
  • AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism. (Palma FR, Ratti BA, Paviani V, Coelho DR, Miguel R, Danes JM, Zaichik SV, de Abreu AL, Silva SO, Chen Y, Silverstein RL, Karan U, Jones DP, Bonini MG) Oncogene 2021 Sep;40(36):5455-5467 PMID: 34290400 PMCID: PMC8669831 SCOPUS ID: 2-s2.0-85110982210 07/23/2021       16 Citations
  • CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys. (Hou Y, Wang Q, Han B, Chen Y, Qiao X, Wang L) Cell Death Dis 2021 May 21;12(6):523 PMID: 34021126 PMCID: PMC8140121 SCOPUS ID: 2-s2.0-85106615244 05/23/2021       128 Citations
  • Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer. (Xin G, Chen Y, Topchyan P, Kasmani MY, Burns R, Volberding PJ, Wu X, Cohn A, Chen Y, Lin CW, Ho PC, Silverstein R, Dwinell MB, Cui W) Cancer Immunol Res 2021 Apr;9(4):454-469 PMID: 33579728 PMCID: PMC8137571 SCOPUS ID: 2-s2.0-85104420312 02/14/2021       46 Citations
  • Regulation of Na/K-ATPase expression by cholesterol: isoform specificity and the molecular mechanism. (Zhang J, Li X, Yu H, Larre I, Dube PR, Kennedy DJ, Tang WHW, Westfall K, Pierre SV, Xie Z, Chen Y) Am J Physiol Cell Physiol 2020 Dec 01;319(6):C1107-C1119 PMID: 32997514 PMCID: PMC7792677 SCOPUS ID: 2-s2.0-85098226317 10/01/2020       10 Citations
  • A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals and C. elegans. (Wang X, Cai L, Xie JX, Cui X, Zhang J, Wang J, Chen Y, Larre I, Shapiro JI, Pierre SV, Wu D, Zhu GZ, Xie Z) Sci Adv 2020 May;6(22):eaaw5851 PMID: 32537485 PMCID: PMC7253156 SCOPUS ID: 2-s2.0-85086625763 06/17/2020       14 Citations
  • Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na+/K+-ATPase-α-1. (Khalaf FK, Tassavvor I, Mohamed A, Chen Y, Malhotra D, Xie Z, Tian J, Haller ST, Westfall K, Tang WHW, Kennedy DJ) J Am Heart Assoc 2020 Feb 04;9(3):e013933 PMID: 32013704 PMCID: PMC7033897 SCOPUS ID: 2-s2.0-85078888113 02/06/2020       13 Citations
  • Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. (Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL) Circ Res 2019 Dec 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019       205 Citations
  • Modification of HDL by reactive aldehydes alters select cardioprotective functions of HDL in macrophages. (Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D) FEBS J 2020 Feb;287(4):695-707 PMID: 31386799 PMCID: PMC7002295 SCOPUS ID: 2-s2.0-85070750063 08/07/2019       14 Citations
  • Platelet metabolism meets thrombosis. (Chen Y, Silverstein RL) Blood 2018 Sep 13;132(11):1089-1091 PMID: 30213838 SCOPUS ID: 2-s2.0-85053125219 09/15/2018       3 Citations
  • Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase. (Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL) Arterioscler Thromb Vasc Biol 2017 Aug;37(8):1462-1469 PMID: 28619997 PMCID: PMC5532064 SCOPUS ID: 2-s2.0-85020518621 06/18/2017       29 Citations
  • Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions. (Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL) Blood 2017 May 25;129(21):2917-2927 PMID: 28336528 PMCID: PMC5445574 SCOPUS ID: 2-s2.0-85019661296 03/25/2017       87 Citations
  • Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling. (Dong L, Yuan Y, Opansky C, Chen Y, Aguilera-Barrantes I, Wu S, Yuan R, Cao Q, Cheng YC, Sahoo D, Silverstein RL, Ren B) Oncotarget 2017 Apr 04;8(14):22550-22562 PMID: 28186980 PMCID: PMC5410244 SCOPUS ID: 2-s2.0-85016933174 02/12/2017       32 Citations
  • Extracellular Vesicles Activate a CD36-Dependent Signaling Pathway to Inhibit Microvascular Endothelial Cell Migration and Tube Formation. (Ramakrishnan DP, Hajj-Ali RA, Chen Y, Silverstein RL) Arterioscler Thromb Vasc Biol 2016 Mar;36(3):534-44 PMID: 26821945 PMCID: PMC4767682 SCOPUS ID: 2-s2.0-84959464380 01/30/2016       55 Citations
  • Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis. (Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, Li Z, Xie Z, Chadwick AC, Sahoo D, Silverstein RL) Sci Signal 2015 Sep 08;8(393):ra91 PMID: 26350901 PMCID: PMC4852751 SCOPUS ID: 2-s2.0-84941034207 09/10/2015       84 Citations
  • Acrolein impairs the cholesterol transport functions of high density lipoproteins. (Chadwick AC, Holme RL, Chen Y, Thomas MJ, Sorci-Thomas MG, Silverstein RL, Pritchard KA Jr, Sahoo D) PLoS One 2015;10(4):e0123138 PMID: 25849485 PMCID: PMC4388475 SCOPUS ID: 2-s2.0-84927672521 04/08/2015       38 Citations
  • Regulation of angiogenesis by phospholipid lysophosphatidic acid. (Chen Y, Ramakrishnan DP, Ren B) Front Biosci (Landmark Ed) 2013 Jun 01;18(3):852-61 PMID: 23747852 SCOPUS ID: 2-s2.0-84880398679 06/12/2013       26 Citations
  • CD36 and Na/K-ATPase-α1 form a proinflammatory signaling loop in kidney. (Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL) Hypertension 2013 Jan;61(1):216-24 PMID: 23172921 PMCID: PMC3521864 SCOPUS ID: 2-s2.0-84871620197 11/23/2012       94 Citations
  • Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. (Liu C, Bai Y, Chen Y, Wang Y, Sottejeau Y, Liu L, Li X, Lingrel JB, Malhotra D, Cooper CJ, Shapiro JI, Xie ZJ, Tian J) J Biol Chem 2012 May 11;287(20):16390-8 PMID: 22451662 PMCID: PMC3351339 SCOPUS ID: 2-s2.0-84860849880 03/28/2012       46 Citations
  • Regulation of alpha1 Na/K-ATPase expression by cholesterol. (Chen Y, Li X, Ye Q, Tian J, Jing R, Xie Z) J Biol Chem 2011 Apr 29;286(17):15517-24 PMID: 21362623 PMCID: PMC3083216 SCOPUS ID: 2-s2.0-79955368568 03/03/2011       40 Citations
  • Regulation of intracellular cholesterol distribution by Na/K-ATPase. (Chen Y, Cai T, Wang H, Li Z, Loreaux E, Lingrel JB, Xie Z) J Biol Chem 2009 May 29;284(22):14881-90 PMID: 19363037 PMCID: PMC2685670 SCOPUS ID: 2-s2.0-67649382187 04/14/2009       53 Citations
  • Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase. (Cai T, Wang H, Chen Y, Liu L, Gunning WT, Quintas LE, Xie ZJ) J Cell Biol 2008 Sep 22;182(6):1153-69 PMID: 18794328 PMCID: PMC2542476 SCOPUS ID: 2-s2.0-52249104702 09/17/2008       108 Citations
    • Last update: 01/22/2026