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Allison D. Ebert PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cardiovascular Center
Member of the Center for Immunology
Member of the Neuroscience Research Center

View Curriculum Vitae

Research Areas of Interest

  • Alzheimer Disease
  • Amyotrophic Lateral Sclerosis
  • Astrocytes
  • Cell Survival
  • Cytomegalovirus
  • Induced Pluripotent Stem Cells
  • Microglia
  • Motor Neurons
  • Muscular Atrophy, Spinal
  • Neurodegenerative Diseases
  • Organoids
  • Stem Cell Transplantation

    • Publications (75)

  • Sickle cell disease iPSC-derived sensory neurons exhibit increased excitability and sensitization to patient plasma. (Allison R, Welby E, Ehlers V, Burand A Jr, Isaeva O, Nieves Torres DD, Highland J, Brandow AM, Stucky CL, Ebert AD) Blood 2024 Mar 01 PMID: 38427938 SCOPUS ID: 2-s2.0-85189689054 03/01/2024    
  • ALS iPSC-derived microglia and motor neurons respond to astrocyte-targeted IL-10 and CCL2 modulation. (Allison RL, Ebert AD) Hum Mol Genet 2024 Feb 28;33(6):530-542 PMID: 38129120 SCOPUS ID: 2-s2.0-85186709230 12/22/2023       1 Citation
  • Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy. (Miller N, Xu Z, Quinlan KA, Ji A, McGivern JV, Feng Z, Shi H, Ko CP, Tsai LH, Heckman CJ, Ebert AD, Ma YC) Proc Natl Acad Sci U S A 2023 Nov 21;120(47):e2300308120 PMID: 37976261 PMCID: PMC10666147 SCOPUS ID: 2-s2.0-85177422314 11/17/2023    
  • Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons. (Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD) mBio 2023 Nov 15;14(6):e0225123 PMID: 37966250 PMCID: PMC10746155 SCOPUS ID: 2-s2.0-85183165409 11/15/2023       1 Citation
  • Neutralizing antibodies with neurotropic factor treatment maintain neurodevelopmental gene expression upon exposure to human cytomegalovirus. (O'Brien BS, Mokry RL, Schumacher ML, Rosas-Rogers S, Terhune SS, Ebert AD) J Virol 2023 Oct 31;97(10):e0069623 PMID: 37796129 PMCID: PMC10653813 SCOPUS ID: 2-s2.0-85175819477 10/05/2023       1 Citation
  • Viral vector gene delivery of the novel chaperone protein SRCP1 to modify insoluble protein in in vitro and in vivo models of ALS (Luecke IW, Lin G, Santarriaga S, Scaglione KM, Ebert AD) Gene Therapy June 2023;30(6):528-533 SCOPUS ID: 2-s2.0-85109959996 06/01/2023       3 Citations
  • Human Cytomegalovirus Induces Significant Structural and Functional Changes in Terminally Differentiated Human Cortical Neurons. (Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD) bioRxiv 2023 Mar 06 PMID: 36945635 PMCID: PMC10028818 03/23/2023    
  • A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses. (Kim JK, Jha NN, Awano T, Caine C, Gollapalli K, Welby E, Kim SS, Fuentes-Moliz A, Wang X, Feng Z, Sera F, Takeda T, Homma S, Ko CP, Tabares L, Ebert AD, Rich MM, Monani UR) Neuron 2023 May 03;111(9):1423-1439.e4 PMID: 36863345 PMCID: PMC10164130 SCOPUS ID: 2-s2.0-85150290633 03/03/2023       9 Citations
  • Sickle cell disease patient plasma sensitizes iPSC-derived sensory neurons from sickle cell disease patients. (Allison RL, Burand A, Torres DN, Brandow AM, Stucky CL, Ebert AD) bioRxiv 2023 Jan 10 PMID: 36711992 PMCID: PMC9882050 01/31/2023    
  • Diminished motor neuron activity driven by abnormal astrocytic EAAT1 glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery. (Welby E, Ebert AD) Glia 2023 May;71(5):1311-1332 PMID: 36655314 SCOPUS ID: 2-s2.0-85146442117 01/20/2023       3 Citations
  • Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization. (Mokry RL, O'Brien BS, Adelman JW, Rosas S, Schumacher ML, Ebert AD, Terhune SS) J Virol 2022 Jul 27;96(14):e0012622 PMID: 35862705 PMCID: PMC9327702 SCOPUS ID: 2-s2.0-85135227929 07/22/2022       7 Citations
  • Detection of Soluble and Insoluble Protein Species in Patient-Derived iPSCs. (Santarriaga S, Luecke I, Ebert AD) Methods Mol Biol 2022;2429:73-84 PMID: 35507156 SCOPUS ID: 2-s2.0-85124109057 05/05/2022       1 Citation
  • Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus. (O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD) iScience 2022 Apr 15;25(4):104098 PMID: 35391828 PMCID: PMC8980761 SCOPUS ID: 2-s2.0-85127531399 04/09/2022       11 Citations
  • Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons. (Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD) Genes (Basel) 2022 Jan 27;13(2) PMID: 35205286 PMCID: PMC8871895 SCOPUS ID: 2-s2.0-85124092767 02/26/2022       6 Citations
  • Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons (Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD) Genes February 2022;13(2) SCOPUS ID: 2-s2.0-85124092767 02/01/2022       6 Citations
  • Viral mediated knockdown of GATA6 in SMA iPSC-derived astrocytes prevents motor neuron loss and microglial activation. (Allison RL, Welby E, Khayrullina G, Burnett BG, Ebert AD) Glia 2022 May;70(5):989-1004 PMID: 35088910 PMCID: PMC9303278 SCOPUS ID: 2-s2.0-85123783848 01/29/2022       12 Citations
  • Assessment of cerebral spinal fluid biomarkers and microRNA-mediated disease mechanisms in spinal muscular atrophy patient samples. (Welby E, Rehborg RJ, Harmelink M, Ebert AD) Hum Mol Genet 2022 Jun 04;31(11):1830-1843 PMID: 34919695 SCOPUS ID: 2-s2.0-85123796645 12/18/2021       5 Citations
  • Viral vector gene delivery of the novel chaperone protein SRCP1 to modify insoluble protein in in vitro and in vivo models of ALS. (Luecke IW, Lin G, Santarriaga S, Scaglione KM, Ebert AD) Gene Ther 2023 Jun;30(6):528-533 PMID: 34239068 PMCID: PMC8741877 SCOPUS ID: 2-s2.0-85109959996 07/10/2021       3 Citations
  • Human cells and networks of pain: Transforming pain target identification and therapeutic development. (Renthal W, Chamessian A, Curatolo M, Davidson S, Burton M, Dib-Hajj S, Dougherty PM, Ebert AD, Gereau RW 4th, Ghetti A, Gold MS, Hoben G, Menichella DM, Mercier P, Ray WZ, Salvemini D, Seal RP, Waxman S, Woolf CJ, Stucky CL, Price TJ) Neuron 2021 May 05;109(9):1426-1429 PMID: 33957072 PMCID: PMC9208579 SCOPUS ID: 2-s2.0-85105020162 05/07/2021       36 Citations
  • Induced pluripotent stem cells for modeling of spinal muscular atrophy (Welby E, Ebert AD) iPSCs for Modeling Central Nervous System Disorders, Volume 6 1 January 2021:147-170 SCOPUS ID: 2-s2.0-85128048942 01/01/2021    
  • Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis. (Seminary ER, Santarriaga S, Wheeler L, Mejaki M, Abrudan J, Demos W, Zimmermann MT, Urrutia RA, Fee D, Barkhaus PE, Ebert AD) Cells 2020 Feb 28;9(3) PMID: 32121108 PMCID: PMC7140469 SCOPUS ID: 2-s2.0-85092221701 03/04/2020       10 Citations
  • Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids. (Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD) J Virol 2019 Sep 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019       38 Citations
  • AAV9-mediated delivery of miR-23a reduces disease severity in Smn2B/-SMA model mice. (Kaifer KA, Villalón E, O'Brien BS, Sison SL, Smith CE, Simon ME, Marquez J, O'Day S, Hopkins AE, Neff R, Rindt H, Ebert AD, Lorson CL) Hum Mol Genet 2019 Oct 01;28(19):3199-3210 PMID: 31211843 PMCID: PMC6859438 SCOPUS ID: 2-s2.0-85073460598 06/19/2019       30 Citations
  • Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models. (Logan S, Arzua T, Canfield SG, Seminary ER, Sison SL, Ebert AD, Bai X) Compr Physiol 2019 Mar 14;9(2):565-611 PMID: 30873582 PMCID: PMC6705133 SCOPUS ID: 2-s2.0-85062970410 03/16/2019       87 Citations
  • Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson's Disease-Relevant Phenotypes. (Sison SL, Vermilyea SC, Emborg ME, Ebert AD) Curr Neurol Neurosci Rep 2018 Oct 04;18(12):84 PMID: 30284665 PMCID: PMC6739862 SCOPUS ID: 2-s2.0-85054424244 10/05/2018       35 Citations
  • SRCP1 Conveys Resistance to Polyglutamine Aggregation. (Santarriaga S, Haver HN, Kanack AJ, Fikejs AS, Sison SL, Egner JM, Bostrom JR, Seminary ER, Hill RB, Link BA, Ebert AD, Scaglione KM) Mol Cell 2018 Jul 19;71(2):216-228.e7 PMID: 30029002 PMCID: PMC6091221 SCOPUS ID: 2-s2.0-85049861465 07/22/2018       12 Citations
  • Decreased NAD+ in dopaminergic neurons. (Sison SL, Ebert AD) Aging (Albany NY) 2018 Apr 28;10(4):526-527 PMID: 29706611 PMCID: PMC5940114 SCOPUS ID: 2-s2.0-85046882276 05/01/2018       5 Citations
  • Modeling Protein Aggregation and the Heat Shock Response in ALS iPSC-Derived Motor Neurons. (Seminary ER, Sison SL, Ebert AD) Front Neurosci 2018;12:86 PMID: 29515358 PMCID: PMC5826239 SCOPUS ID: 2-s2.0-85042415692 03/09/2018       35 Citations
  • Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron. (Gray KM, Kaifer KA, Baillat D, Wen Y, Bonacci TR, Ebert AD, Raimer AC, Spring AM, Have ST, Glascock JJ, Gupta K, Van Duyne GD, Emanuele MJ, Lamond AI, Wagner EJ, Lorson CL, Matera AG) Mol Biol Cell 2018 Jan 15;29(2):96-110 PMID: 29167380 PMCID: PMC5909936 SCOPUS ID: 2-s2.0-85040975387 11/24/2017       18 Citations
  • Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons. (Schwab AJ, Sison SL, Meade MR, Broniowska KA, Corbett JA, Ebert AD) Stem Cell Reports 2017 Dec 12;9(6):1839-1852 PMID: 29129681 PMCID: PMC5785678 SCOPUS ID: 2-s2.0-85033362137 11/14/2017       67 Citations
  • Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy. (Sison SL, Patitucci TN, Seminary ER, Villalon E, Lorson CL, Ebert AD) Hum Mol Genet 2017 Sep 01;26(17):3409-3420 PMID: 28637335 SCOPUS ID: 2-s2.0-85040601550 06/24/2017       55 Citations
  • Contributions of Different Cell Types to Spinal Muscular Atrophy Pathogenesis (Deguise MO, Patitucci TN, Ebert AD, Lorson CL, Kothary R) Spinal Muscular Atrophy: Disease Mechanisms and Therapy 2017:167-181 SCOPUS ID: 2-s2.0-85027277085 01/01/2017       7 Citations
  • Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy. (Osman EY, Washington CW 3rd, Kaifer KA, Mazzasette C, Patitucci TN, Florea KM, Simon ME, Ko CP, Ebert AD, Lorson CL) Mol Ther 2016 Sep;24(9):1592-601 PMID: 27401142 PMCID: PMC5113110 SCOPUS ID: 2-s2.0-84981277292 07/13/2016       30 Citations
  • Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy. (Afzal MZ, Reiter M, Gastonguay C, McGivern JV, Guan X, Ge ZD, Mack DL, Childers MK, Ebert AD, Strande JL) J Cardiovasc Pharmacol Ther 2016 Nov;21(6):549-562 PMID: 26940570 PMCID: PMC5010518 SCOPUS ID: 2-s2.0-84990055894 03/05/2016       44 Citations
  • Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation. (Bigley TM, McGivern JV, Ebert AD, Terhune SS) Antiviral Res 2016 May;129:67-73 PMID: 26875788 PMCID: PMC4957402 SCOPUS ID: 2-s2.0-84959527703 02/16/2016       7 Citations
  • Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. (Schwab AJ, Ebert AD) Stem Cell Reports 2015 Dec 08;5(6):1039-1052 PMID: 26651604 PMCID: PMC4682343 SCOPUS ID: 2-s2.0-84949513552 12/15/2015       73 Citations
  • SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons. (Patitucci TN, Ebert AD) Hum Mol Genet 2016 Feb 01;25(3):514-23 PMID: 26643950 SCOPUS ID: 2-s2.0-84960888922 12/09/2015       30 Citations
  • Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. (Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R) Stem Cell Reports 2015 Dec 08;5(6):933-945 PMID: 26610635 PMCID: PMC4881284 SCOPUS ID: 2-s2.0-84949526040 11/28/2015       66 Citations
  • Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease. (Rivero-Ríos P, Gómez-Suaga P, Fernández B, Madero-Pérez J, Schwab AJ, Ebert AD, Hilfiker S) Biochem Soc Trans 2015 Jun;43(3):390-5 PMID: 26009181 SCOPUS ID: 2-s2.0-84934967144 05/27/2015       26 Citations
  • Astrocytes influence the severity of spinal muscular atrophy. (Rindt H, Feng Z, Mazzasette C, Glascock JJ, Valdivia D, Pyles N, Crawford TO, Swoboda KJ, Patitucci TN, Ebert AD, Sumner CJ, Ko CP, Lorson CL) Hum Mol Genet 2015 Jul 15;24(14):4094-102 PMID: 25911676 PMCID: PMC5007659 SCOPUS ID: 2-s2.0-84936741397 04/26/2015       91 Citations
  • Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results. (Yu H, Fischer G, Ebert AD, Wu HE, Bai X, Hogan QH) Mol Pain 2015 Feb 12;11:5 PMID: 25888914 PMCID: PMC4331376 SCOPUS ID: 2-s2.0-84924280629 04/19/2015       25 Citations
  • Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results. (Yu H, Fischer G, Ebert AD, Wu HE, Bai X, Hogan QH) Mol Pain 2015 Dec;11(1):2 PMID: 25775959 03/18/2015    
  • Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. (Park AK, Liegel RP, Ronchetti A, Ebert AD, Geurts A, Sidjanin DJ) BMC Genet 2014 Dec 05;15:135 PMID: 25476608 PMCID: PMC4266191 SCOPUS ID: 2-s2.0-84964313193 12/06/2014       17 Citations
  • Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy. (Schwab AJ, Ebert AD) PLoS One 2014;9(7):e103112 PMID: 25054590 PMCID: PMC4108398 SCOPUS ID: 2-s2.0-84904700148 07/24/2014       14 Citations
  • Derivation of myogenic progenitors directly from human pluripotent stem cells using a sphere-based culture. (Hosoyama T, McGivern JV, Van Dyke JM, Ebert AD, Suzuki M) Stem Cells Transl Med 2014 May;3(5):564-74 PMID: 24657962 PMCID: PMC4006483 SCOPUS ID: 2-s2.0-84899668462 03/25/2014       96 Citations
  • Exploiting pluripotent stem cell technology for drug discovery, screening, safety, and toxicology assessments. (McGivern JV, Ebert AD) Adv Drug Deliv Rev 2014 Apr;69-70:170-8 PMID: 24309014 SCOPUS ID: 2-s2.0-84899971912 12/07/2013       23 Citations
  • Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. (Liegel RP, Handley MT, Ronchetti A, Brown S, Langemeyer L, Linford A, Chang B, Morris-Rosendahl DJ, Carpanini S, Posmyk R, Harthill V, Sheridan E, Abdel-Salam GM, Terhal PA, Faravelli F, Accorsi P, Giordano L, Pinelli L, Hartmann B, Ebert AD, Barr FA, Aligianis IA, Sidjanin DJ) Am J Hum Genet 2013 Dec 05;93(6):1001-14 PMID: 24239381 PMCID: PMC3852926 SCOPUS ID: 2-s2.0-84890310034 11/19/2013       104 Citations
  • Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production. (McGivern JV, Patitucci TN, Nord JA, Barabas MA, Stucky CL, Ebert AD) Glia 2013 Sep;61(9):1418-1428 PMID: 23839956 PMCID: PMC3941074 SCOPUS ID: 2-s2.0-84880836806 07/11/2013       115 Citations
  • EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. (Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, Kim HW, Cattaneo E, Svendsen CN) Stem Cell Res 2013 May;10(3):417-427 PMID: 23474892 PMCID: PMC3786426 SCOPUS ID: 2-s2.0-84874795685 03/12/2013       88 Citations
  • COPI transport complexes bind to specific RNAs in neuronal cells. (Todd AG, Lin H, Ebert AD, Liu Y, Androphy EJ) Hum Mol Genet 2013 Feb 15;22(4):729-36 PMID: 23175440 PMCID: PMC3988478 SCOPUS ID: 2-s2.0-84873034506 11/24/2012       40 Citations
  • Modeling neurodegenerative diseases using stem cells: is it accelerating drug discovery? (Ebert AD) Future Med Chem 2012 Sep;4(13):1651-3 PMID: 22924501 SCOPUS ID: 2-s2.0-84865765635 08/29/2012       1 Citation
  • The future of neurodegenerative diseases: emerging targets, treatments and technologies. (Voss J, Ebert A, Wolfe M, Lindsley C, Cookson M, Deane R) Future Med Chem 2012 Sep;4(13):1661-9 PMID: 22924504 SCOPUS ID: 2-s2.0-84865747110 08/29/2012       2 Citations
  • Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. (HD iPSC Consortium) Cell Stem Cell 2012 Aug 03;11(2):264-78 PMID: 22748968 PMCID: PMC3804072 SCOPUS ID: 2-s2.0-84864628471 07/04/2012       404 Citations
  • Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. (Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN) PLoS One 2012;7(6):e39113 PMID: 22723941 PMCID: PMC3378532 SCOPUS ID: 2-s2.0-84862518720 06/23/2012       120 Citations
  • Modelling neurodegenerative diseases using pluripotent stem cells (McGivern JV, Ebert AD) Stem Cells and Cancer Stem Cells 1 January 2012:421-430 SCOPUS ID: 2-s2.0-85030998190 01/01/2012    
  • A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. (Jodelka FM, Ebert AD, Duelli DM, Hastings ML) Hum Mol Genet 2010 Dec 15;19(24):4906-17 PMID: 20884664 PMCID: PMC2989896 SCOPUS ID: 2-s2.0-78649461312 10/05/2010       71 Citations
  • Stem cell model of spinal muscular atrophy. (Ebert AD, Svendsen CN) Arch Neurol 2010 Jun;67(6):665-9 PMID: 20558385 PMCID: PMC3140872 SCOPUS ID: 2-s2.0-77953623111 06/19/2010       22 Citations
  • Human stem cells and drug screening: opportunities and challenges. (Ebert AD, Svendsen CN) Nat Rev Drug Discov 2010 May;9(5):367-72 PMID: 20339370 SCOPUS ID: 2-s2.0-77951879452 03/27/2010       141 Citations
  • Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease. (Ebert AD, Barber AE, Heins BM, Svendsen CN) Exp Neurol 2010 Jul;224(1):155-62 PMID: 20227407 SCOPUS ID: 2-s2.0-77953701829 03/17/2010       67 Citations
  • Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. (Sareen D, McMillan E, Ebert AD, Shelley BC, Johnson JA, Meisner LF, Svendsen CN) PLoS One 2009 Oct 29;4(10):e7630 PMID: 19898616 PMCID: PMC2765070 SCOPUS ID: 2-s2.0-70449562730 11/10/2009       59 Citations
  • Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF. (Emborg ME, Moirano J, Raschke J, Bondarenko V, Zufferey R, Peng S, Ebert AD, Joers V, Roitberg B, Holden JE, Koprich J, Lipton J, Kordower JH, Aebischer P) Neurobiol Dis 2009 Nov;36(2):303-11 PMID: 19660547 PMCID: PMC2989601 SCOPUS ID: 2-s2.0-70349762432 08/08/2009       42 Citations
  • Delivery of a read-through inducing compound, TC007, lessens the severity of a spinal muscular atrophy animal model. (Mattis VB, Ebert AD, Fosso MY, Chang CW, Lorson CL) Hum Mol Genet 2009 Oct 15;18(20):3906-13 PMID: 19625298 PMCID: PMC2748896 SCOPUS ID: 2-s2.0-70349575755 07/25/2009       80 Citations
  • Induced pluripotent stem cells from a spinal muscular atrophy patient. (Ebert AD, Yu J, Rose FF Jr, Mattis VB, Lorson CL, Thomson JA, Svendsen CN) Nature 2009 Jan 15;457(7227):277-80 PMID: 19098894 PMCID: PMC2659408 SCOPUS ID: 2-s2.0-58249110796 12/23/2008       1214 Citations
  • Lesion-induced increase in survival and migration of human neural progenitor cells releasing GDNF. (Behrstock S, Ebert AD, Klein S, Schmitt M, Moore JM, Svendsen CN) Cell Transplant 2008;17(7):753-62 PMID: 19044202 PMCID: PMC2650839 SCOPUS ID: 2-s2.0-58149198246 12/03/2008       44 Citations
  • Isolating, expanding, and infecting human and rodent fetal neural progenitor cells. (Ebert AD, McMillan EL, Svendsen CN) Curr Protoc Stem Cell Biol 2008 Sep;Chapter 2:Unit 2D.2 PMID: 18819085 SCOPUS ID: 2-s2.0-60849133362 09/27/2008       24 Citations
  • GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys. (Emborg ME, Ebert AD, Moirano J, Peng S, Suzuki M, Capowski E, Joers V, Roitberg BZ, Aebischer P, Svendsen CN) Cell Transplant 2008;17(4):383-95 PMID: 18522241 SCOPUS ID: 2-s2.0-44149085940 06/05/2008       65 Citations
  • Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. (Ebert AD, Beres AJ, Barber AE, Svendsen CN) Exp Neurol 2008 Jan;209(1):213-23 PMID: 18061591 SCOPUS ID: 2-s2.0-37549042851 12/07/2007       130 Citations
  • Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of Parkinson's disease does not involve activation of caspase-9 and caspase-3. (Ebert AD, Hann HJ, Bohn MC) J Neurosci Res 2008 Feb 01;86(2):317-25 PMID: 17787016 SCOPUS ID: 2-s2.0-38849087433 09/06/2007       17 Citations
  • Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. (Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN) J Neurosci Methods 2007 Jul 30;163(2):338-49 PMID: 17397931 SCOPUS ID: 2-s2.0-34249900697 04/03/2007       68 Citations
  • Differentiated dopaminergic MN9D cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons. (Rick CE, Ebert A, Virag T, Bohn MC, Surmeier DJ) Dev Neurosci 2006;28(6):528-37 PMID: 17028430 SCOPUS ID: 2-s2.0-33749560870 10/10/2006       26 Citations
  • Lentiviral Delivery of Glial Cell Line-derived Neurotrophic Factor in Aged 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Rhesus Monkeys 883. (Emborg ME, Roitberg BZ, Moirano J, Zufferey R, Ebert AD, Joers V, Holden J, Converse AK, Koprich JB, Kordower JH, Aebischer P) Neurosurgery 2006 Aug 01;59(2):481-482 PMID: 28180727 08/01/2006    
  • Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. (Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN) Gene Ther 2006 Mar;13(5):379-88 PMID: 16355116 SCOPUS ID: 2-s2.0-33645140627 12/16/2005       147 Citations
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