Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Allison D. Ebert PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cardiovascular Center
Member of the Neuroscience Research Center


  • Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson's Disease-Relevant Phenotypes. (Sison SL, Vermilyea SC, Emborg ME, Ebert AD) Curr Neurol Neurosci Rep 2018 Oct 04;18(12):84 PMID: 30284665 10/05/2018    
  • SRCP1 Conveys Resistance to Polyglutamine Aggregation. (Santarriaga S, Haver HN, Kanack AJ, Fikejs AS, Sison SL, Egner JM, Bostrom JR, Seminary ER, Hill RB, Link BA, Ebert AD, Scaglione KM) Mol Cell 2018 Jul 19;71(2):216-228.e7 PMID: 30029002 PMCID: PMC6091221 07/22/2018    
  • Decreased NAD+ in dopaminergic neurons. (Sison SL, Ebert AD) Aging (Albany NY) 2018 Apr 28;10(4):526-527 PMID: 29706611 PMCID: PMC5940114 05/01/2018    
  • Modeling Protein Aggregation and the Heat Shock Response in ALS iPSC-Derived Motor Neurons. (Seminary ER, Sison SL, Ebert AD) Front Neurosci 2018;12:86 PMID: 29515358 PMCID: PMC5826239 03/09/2018    
  • Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCF degron. (Gray KM, Kaifer KA, Baillat D, Wen Y, Bonacci TR, Ebert AD, Raimer AC, Spring AM, Have ST, Glascock JJ, Gupta K, Van Duyne GD, Emanuele MJ, Lamond AI, Wagner EJ, Lorson CL, Matera AG) Mol Biol Cell 2018 01 15;29(2):96-110 PMID: 29167380 PMCID: PMC5909936 11/24/2017       2 Citations
  • Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons. (Schwab AJ, Sison SL, Meade MR, Broniowska KA, Corbett JA, Ebert AD) Stem Cell Reports 2017 12 12;9(6):1839-1852 PMID: 29129681 PMCID: PMC5785678 11/14/2017       11 Citations
  • Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy. (Sison SL, Patitucci TN, Seminary ER, Villalon E, Lorson CL, Ebert AD) Hum Mol Genet 2017 09 01;26(17):3409-3420 PMID: 28637335 06/24/2017       3 Citations
  • Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy. (Osman EY, Washington CW 3rd, Kaifer KA, Mazzasette C, Patitucci TN, Florea KM, Simon ME, Ko CP, Ebert AD, Lorson CL) Mol Ther 2016 09;24(9):1592-601 PMID: 27401142 PMCID: PMC5113110 07/13/2016       7 Citations
  • Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy. (Afzal MZ, Reiter M, Gastonguay C, McGivern JV, Guan X, Ge ZD, Mack DL, Childers MK, Ebert AD, Strande JL) J Cardiovasc Pharmacol Ther 2016 11;21(6):549-562 PMID: 26940570 PMCID: PMC5010518 03/05/2016       13 Citations
  • Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation. (Bigley TM, McGivern JV, Ebert AD, Terhune SS) Antiviral Res 2016 May;129:67-73 PMID: 26875788 PMCID: PMC4957402 02/16/2016       1 Citations
  • Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. (Schwab AJ, Ebert AD) Stem Cell Reports 2015 Dec 08;5(6):1039-1052 PMID: 26651604 PMCID: PMC4682343 12/15/2015       23 Citations
  • SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons. (Patitucci TN, Ebert AD) Hum Mol Genet 2016 Feb 01;25(3):514-23 PMID: 26643950 12/09/2015       14 Citations
  • Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. (Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R) Stem Cell Reports 2015 Dec 08;5(6):933-945 PMID: 26610635 PMCID: PMC4881284 11/28/2015       40 Citations
  • Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease. (Rivero-Ríos P, Gómez-Suaga P, Fernández B, Madero-Pérez J, Schwab AJ, Ebert AD, Hilfiker S) Biochem Soc Trans 2015 Jun;43(3):390-5 PMID: 26009181 05/27/2015       9 Citations
  • Astrocytes influence the severity of spinal muscular atrophy. (Rindt H, Feng Z, Mazzasette C, Glascock JJ, Valdivia D, Pyles N, Crawford TO, Swoboda KJ, Patitucci TN, Ebert AD, Sumner CJ, Ko CP, Lorson CL) Hum Mol Genet 2015 Jul 15;24(14):4094-102 PMID: 25911676 PMCID: PMC5007659 04/26/2015       42 Citations
  • Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results. (Yu H, Fischer G, Ebert AD, Wu HE, Bai X, Hogan QH) Mol Pain 2015 Feb 12;11:5 PMID: 25888914 PMCID: PMC4331376 04/19/2015       11 Citations
  • Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results. (Yu H, Fischer G, Ebert AD, Wu HE, Bai X, Hogan QH) Mol Pain 2015 Dec;11(1):2 PMID: 25775959 03/18/2015    
  • Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. (Park AK, Liegel RP, Ronchetti A, Ebert AD, Geurts A, Sidjanin DJ) BMC Genet 2014 Dec 05;15:135 PMID: 25476608 PMCID: PMC4266191 12/06/2014       8 Citations
  • Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy. (Schwab AJ, Ebert AD) PLoS One 2014;9(7):e103112 PMID: 25054590 PMCID: PMC4108398 07/24/2014       7 Citations
  • Derivation of myogenic progenitors directly from human pluripotent stem cells using a sphere-based culture. (Hosoyama T, McGivern JV, Van Dyke JM, Ebert AD, Suzuki M) Stem Cells Transl Med 2014 May;3(5):564-74 PMID: 24657962 PMCID: PMC4006483 03/25/2014       45 Citations
  • Exploiting pluripotent stem cell technology for drug discovery, screening, safety, and toxicology assessments. (McGivern JV, Ebert AD) Adv Drug Deliv Rev 2014 Apr;69-70:170-8 PMID: 24309014 12/07/2013       20 Citations
  • Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. (Liegel RP, Handley MT, Ronchetti A, Brown S, Langemeyer L, Linford A, Chang B, Morris-Rosendahl DJ, Carpanini S, Posmyk R, Harthill V, Sheridan E, Abdel-Salam GM, Terhal PA, Faravelli F, Accorsi P, Giordano L, Pinelli L, Hartmann B, Ebert AD, Barr FA, Aligianis IA, Sidjanin DJ) Am J Hum Genet 2013 Dec 05;93(6):1001-14 PMID: 24239381 PMCID: PMC3852926 11/19/2013       46 Citations
  • Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production. (McGivern JV, Patitucci TN, Nord JA, Barabas MA, Stucky CL, Ebert AD) Glia 2013 Sep;61(9):1418-1428 PMID: 23839956 PMCID: PMC3941074 07/11/2013    
  • EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. (Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, Kim HW, Cattaneo E, Svendsen CN) Stem Cell Res 2013 May;10(3):417-427 PMID: 23474892 PMCID: PMC3786426 03/12/2013       53 Citations
  • COPI transport complexes bind to specific RNAs in neuronal cells. (Todd AG, Lin H, Ebert AD, Liu Y, Androphy EJ) Hum Mol Genet 2013 Feb 15;22(4):729-36 PMID: 23175440 PMCID: PMC3988478 11/24/2012       25 Citations
  • Modeling neurodegenerative diseases using stem cells: is it accelerating drug discovery? (Ebert AD) Future Med Chem 2012 Sep;4(13):1651-3 PMID: 22924501 08/29/2012       1 Citations
  • The future of neurodegenerative diseases: emerging targets, treatments and technologies. (Voss J, Ebert A, Wolfe M, Lindsley C, Cookson M, Deane R) Future Med Chem 2012 Sep;4(13):1661-9 PMID: 22924504 08/29/2012       2 Citations
  • Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. (HD iPSC Consortium) Cell Stem Cell 2012 Aug 03;11(2):264-78 PMID: 22748968 PMCID: PMC3804072 07/04/2012    
  • Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. (Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN) PLoS One 2012;7(6):e39113 PMID: 22723941 PMCID: PMC3378532 06/23/2012       82 Citations
  • A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. (Jodelka FM, Ebert AD, Duelli DM, Hastings ML) Hum Mol Genet 2010 Dec 15;19(24):4906-17 PMID: 20884664 PMCID: PMC2989896 10/05/2010       51 Citations
  • Stem cell model of spinal muscular atrophy. (Ebert AD, Svendsen CN) Arch Neurol 2010 Jun;67(6):665-9 PMID: 20558385 PMCID: PMC3140872 06/19/2010       16 Citations
  • Human stem cells and drug screening: opportunities and challenges. (Ebert AD, Svendsen CN) Nat Rev Drug Discov 2010 05;9(5):367-72 PMID: 20339370 03/27/2010       99 Citations
  • Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease. (Ebert AD, Barber AE, Heins BM, Svendsen CN) Exp Neurol 2010 Jul;224(1):155-62 PMID: 20227407 03/17/2010       56 Citations
  • Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. (Sareen D, McMillan E, Ebert AD, Shelley BC, Johnson JA, Meisner LF, Svendsen CN) PLoS One 2009 Oct 29;4(10):e7630 PMID: 19898616 PMCID: PMC2765070 11/10/2009       48 Citations
  • Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF. (Emborg ME, Moirano J, Raschke J, Bondarenko V, Zufferey R, Peng S, Ebert AD, Joers V, Roitberg B, Holden JE, Koprich J, Lipton J, Kordower JH, Aebischer P) Neurobiol Dis 2009 Nov;36(2):303-11 PMID: 19660547 PMCID: PMC2989601 08/08/2009       31 Citations
  • Delivery of a read-through inducing compound, TC007, lessens the severity of a spinal muscular atrophy animal model. (Mattis VB, Ebert AD, Fosso MY, Chang CW, Lorson CL) Hum Mol Genet 2009 Oct 15;18(20):3906-13 PMID: 19625298 PMCID: PMC2748896 07/25/2009       64 Citations
  • Induced pluripotent stem cells from a spinal muscular atrophy patient. (Ebert AD, Yu J, Rose FF Jr, Mattis VB, Lorson CL, Thomson JA, Svendsen CN) Nature 2009 Jan 15;457(7227):277-80 PMID: 19098894 PMCID: PMC2659408 12/23/2008       1015 Citations
  • Lesion-induced increase in survival and migration of human neural progenitor cells releasing GDNF. (Behrstock S, Ebert AD, Klein S, Schmitt M, Moore JM, Svendsen CN) Cell Transplant 2008;17(7):753-62 PMID: 19044202 PMCID: PMC2650839 12/03/2008       37 Citations
  • Isolating, expanding, and infecting human and rodent fetal neural progenitor cells. (Ebert AD, McMillan EL, Svendsen CN) Curr Protoc Stem Cell Biol 2008 Sep;Chapter 2:Unit 2D.2 PMID: 18819085 09/27/2008       20 Citations
  • GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys. (Emborg ME, Ebert AD, Moirano J, Peng S, Suzuki M, Capowski E, Joers V, Roitberg BZ, Aebischer P, Svendsen CN) Cell Transplant 2008;17(4):383-95 PMID: 18522241 06/05/2008       57 Citations
  • Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. (Ebert AD, Beres AJ, Barber AE, Svendsen CN) Exp Neurol 2008 Jan;209(1):213-23 PMID: 18061591 12/07/2007       106 Citations
  • Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of Parkinson's disease does not involve activation of caspase-9 and caspase-3. (Ebert AD, Hann HJ, Bohn MC) J Neurosci Res 2008 Feb 01;86(2):317-25 PMID: 17787016 09/06/2007       11 Citations
  • Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. (Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN) J Neurosci Methods 2007 Jul 30;163(2):338-49 PMID: 17397931 04/03/2007       61 Citations
  • Differentiated dopaminergic MN9D cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons. (Rick CE, Ebert A, Virag T, Bohn MC, Surmeier DJ) Dev Neurosci 2006;28(6):528-37 PMID: 17028430 10/10/2006       20 Citations
  • Lentiviral Delivery of Glial Cell Line-derived Neurotrophic Factor in Aged 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Rhesus Monkeys 883. (Emborg ME, Roitberg BZ, Moirano J, Zufferey R, Ebert AD, Joers V, Holden J, Converse AK, Koprich JB, Kordower JH, Aebischer P) Neurosurgery 2006 Aug 01;59(2):481-482 PMID: 28180727 08/01/2006    
  • Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. (Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN) Gene Ther 2006 Mar;13(5):379-88 PMID: 16355116 12/16/2005       131 Citations
  • A new tool in the battle against Alzheimer's disease and aging: ex vivo gene therapy. (Ebert AD, Svendsen CN) Rejuvenation Res 2005;8(3):131-4 PMID: 16144466 09/08/2005       19 Citations
  • A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo. (Ebert AD, Chen F, He X, Cryns VL, Bohn MC) Exp Neurol 2005 Feb;191 Suppl 1:S80-94 PMID: 15629764 01/05/2005       16 Citations
  • Comparative pharmacokinetics of 14C-sucrose in RG-2 rat gliomas after intravenous and convection-enhanced delivery. (Vavra M, Ali MJ, Kang EW, Navalitloha Y, Ebert A, Allen CV, Groothuis DR) Neuro Oncol 2004 Apr;6(2):104-12 PMID: 15134624 PMCID: PMC1871980 05/12/2004       35 Citations
  • Last update: 12/13/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796