Medical College of Wisconsin
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Allison D. Ebert PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cardiovascular Center
Member of the Neuroscience Research Center


Publications

  • Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy. (Sison SL, Patitucci TN, Seminary ER, Villalon E, Lorson CL, Ebert AD) Hum Mol Genet 2017 Sep 01;26(17):3409-3420 PMID: 28637335 06/24/2017
  • Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy. (Osman EY, Washington CW 3rd, Kaifer KA, Mazzasette C, Patitucci TN, Florea KM, Simon ME, Ko CP, Ebert AD, Lorson CL) Mol Ther 2016 Sep;24(9):1592-601 PMID: 27401142 PMCID: PMC5113110 07/13/2016
  • Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy. (Afzal MZ, Reiter M, Gastonguay C, McGivern JV, Guan X, Ge ZD, Mack DL, Childers MK, Ebert AD, Strande JL) J Cardiovasc Pharmacol Ther 2016 Nov;21(6):549-562 PMID: 26940570 PMCID: PMC5010518 03/05/2016
  • Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation. (Bigley TM, McGivern JV, Ebert AD, Terhune SS) Antiviral Res 2016 May;129:67-73 PMID: 26875788 PMCID: PMC4957402 02/16/2016
  • Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. (Schwab AJ, Ebert AD) Stem Cell Reports 2015 Dec 08;5(6):1039-52 PMID: 26651604 PMCID: PMC4682343 12/15/2015
  • SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons. (Patitucci TN, Ebert AD) Hum Mol Genet 2016 Feb 01;25(3):514-23 PMID: 26643950 12/09/2015
  • Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. (Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R) Stem Cell Reports 2015 Dec 08;5(6):933-45 PMID: 26610635 PMCID: PMC4881284 11/28/2015
  • Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease. (Rivero-Ríos P, Gómez-Suaga P, Fernández B, Madero-Pérez J, Schwab AJ, Ebert AD, Hilfiker S) Biochem Soc Trans 2015 Jun;43(3):390-5 PMID: 26009181 05/27/2015
  • Astrocytes influence the severity of spinal muscular atrophy. (Rindt H, Feng Z, Mazzasette C, Glascock JJ, Valdivia D, Pyles N, Crawford TO, Swoboda KJ, Patitucci TN, Ebert AD, Sumner CJ, Ko CP, Lorson CL) Hum Mol Genet 2015 Jul 15;24(14):4094-102 PMID: 25911676 PMCID: PMC5007659 04/26/2015
  • Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results. (Yu H, Fischer G, Ebert AD, Wu HE, Bai X, Hogan QH) Mol Pain 2015 Feb 12;11:5 PMID: 25888914 PMCID: PMC4331376 04/19/2015
  • Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results. (Yu H, Fischer G, Ebert AD, Wu HE, Bai X, Hogan QH) Mol Pain 2015 Dec;11(1):2 PMID: 25775959 03/18/2015
  • Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. (Park AK, Liegel RP, Ronchetti A, Ebert AD, Geurts A, Sidjanin DJ) BMC Genet 2014 Dec 05;15:135 PMID: 25476608 PMCID: PMC4266191 12/06/2014
  • Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy. (Schwab AJ, Ebert AD) PLoS One 2014;9(7):e103112 PMID: 25054590 PMCID: PMC4108398 07/24/2014
  • Derivation of myogenic progenitors directly from human pluripotent stem cells using a sphere-based culture. (Hosoyama T, McGivern JV, Van Dyke JM, Ebert AD, Suzuki M) Stem Cells Transl Med 2014 May;3(5):564-74 PMID: 24657962 PMCID: PMC4006483 03/25/2014
  • Exploiting pluripotent stem cell technology for drug discovery, screening, safety, and toxicology assessments. (McGivern JV, Ebert AD) Adv Drug Deliv Rev 2014 Apr;69-70:170-8 PMID: 24309014 12/07/2013
  • Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. (Liegel RP, Handley MT, Ronchetti A, Brown S, Langemeyer L, Linford A, Chang B, Morris-Rosendahl DJ, Carpanini S, Posmyk R, Harthill V, Sheridan E, Abdel-Salam GM, Terhal PA, Faravelli F, Accorsi P, Giordano L, Pinelli L, Hartmann B, Ebert AD, Barr FA, Aligianis IA, Sidjanin DJ) Am J Hum Genet 2013 Dec 05;93(6):1001-14 PMID: 24239381 PMCID: PMC3852926 11/19/2013
  • Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production. (McGivern JV, Patitucci TN, Nord JA, Barabas MA, Stucky CL, Ebert AD) Glia 2013 Sep;61(9):1418-1428 PMID: 23839956 PMCID: PMC3941074 07/11/2013
  • EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. (Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, Kim HW, Cattaneo E, Svendsen CN) Stem Cell Res 2013 May;10(3):417-427 PMID: 23474892 PMCID: PMC3786426 03/12/2013
  • COPI transport complexes bind to specific RNAs in neuronal cells. (Todd AG, Lin H, Ebert AD, Liu Y, Androphy EJ) Hum Mol Genet 2013 Feb 15;22(4):729-36 PMID: 23175440 PMCID: PMC3988478 11/24/2012
  • The future of neurodegenerative diseases: emerging targets, treatments and technologies. (Voss J, Ebert A, Wolfe M, Lindsley C, Cookson M, Deane R) Future Med Chem 2012 Sep;4(13):1661-9 PMID: 22924504 08/29/2012
  • Modeling neurodegenerative diseases using stem cells: is it accelerating drug discovery? (Ebert AD) Future Med Chem 2012 Sep;4(13):1651-3 PMID: 22924501 08/29/2012
  • Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. (HD iPSC Consortium) Cell Stem Cell 2012 Aug 03;11(2):264-78 PMID: 22748968 PMCID: PMC3804072 07/04/2012
  • Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. (Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN) PLoS One 2012;7(6):e39113 PMID: 22723941 PMCID: PMC3378532 06/23/2012
  • A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. (Jodelka FM, Ebert AD, Duelli DM, Hastings ML) Hum Mol Genet 2010 Dec 15;19(24):4906-17 PMID: 20884664 PMCID: PMC2989896 10/05/2010
  • Stem cell model of spinal muscular atrophy. (Ebert AD, Svendsen CN) Arch Neurol 2010 Jun;67(6):665-9 PMID: 20558385 PMCID: PMC3140872 06/19/2010
  • Human stem cells and drug screening: opportunities and challenges. (Ebert AD, Svendsen CN) Nat Rev Drug Discov 2010 05;9(5):367-72 PMID: 20339370 03/27/2010
  • Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease. (Ebert AD, Barber AE, Heins BM, Svendsen CN) Exp Neurol 2010 Jul;224(1):155-62 PMID: 20227407 03/17/2010
  • Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. (Sareen D, McMillan E, Ebert AD, Shelley BC, Johnson JA, Meisner LF, Svendsen CN) PLoS One 2009 Oct 29;4(10):e7630 PMID: 19898616 PMCID: PMC2765070 11/10/2009
  • Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF. (Emborg ME, Moirano J, Raschke J, Bondarenko V, Zufferey R, Peng S, Ebert AD, Joers V, Roitberg B, Holden JE, Koprich J, Lipton J, Kordower JH, Aebischer P) Neurobiol Dis 2009 Nov;36(2):303-11 PMID: 19660547 PMCID: PMC2989601 08/08/2009
  • Delivery of a read-through inducing compound, TC007, lessens the severity of a spinal muscular atrophy animal model. (Mattis VB, Ebert AD, Fosso MY, Chang CW, Lorson CL) Hum Mol Genet 2009 Oct 15;18(20):3906-13 PMID: 19625298 PMCID: PMC2748896 07/25/2009
  • Induced pluripotent stem cells from a spinal muscular atrophy patient. (Ebert AD, Yu J, Rose FF Jr, Mattis VB, Lorson CL, Thomson JA, Svendsen CN) Nature 2009 Jan 15;457(7227):277-80 PMID: 19098894 PMCID: PMC2659408 12/23/2008
  • Lesion-induced increase in survival and migration of human neural progenitor cells releasing GDNF. (Behrstock S, Ebert AD, Klein S, Schmitt M, Moore JM, Svendsen CN) Cell Transplant 2008;17(7):753-62 PMID: 19044202 PMCID: PMC2650839 12/03/2008
  • Isolating, expanding, and infecting human and rodent fetal neural progenitor cells. (Ebert AD, McMillan EL, Svendsen CN) Curr Protoc Stem Cell Biol 2008 Sep;Chapter 2:Unit 2D.2 PMID: 18819085 09/27/2008
  • GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys. (Emborg ME, Ebert AD, Moirano J, Peng S, Suzuki M, Capowski E, Joers V, Roitberg BZ, Aebischer P, Svendsen CN) Cell Transplant 2008;17(4):383-95 PMID: 18522241 06/05/2008
  • Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. (Ebert AD, Beres AJ, Barber AE, Svendsen CN) Exp Neurol 2008 Jan;209(1):213-23 PMID: 18061591 12/07/2007
  • Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of Parkinson's disease does not involve activation of caspase-9 and caspase-3. (Ebert AD, Hann HJ, Bohn MC) J Neurosci Res 2008 Feb 01;86(2):317-25 PMID: 17787016 09/06/2007
  • Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. (Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN) J Neurosci Methods 2007 Jul 30;163(2):338-49 PMID: 17397931 04/03/2007
  • Differentiated dopaminergic MN9D cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons. (Rick CE, Ebert A, Virag T, Bohn MC, Surmeier DJ) Dev Neurosci 2006;28(6):528-37 PMID: 17028430 10/10/2006
  • Lentiviral Delivery of Glial Cell Line-derived Neurotrophic Factor in Aged 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Rhesus Monkeys 883. (Emborg ME, Roitberg BZ, Moirano J, Zufferey R, Ebert AD, Joers V, Holden J, Converse AK, Koprich JB, Kordower JH, Aebischer P) Neurosurgery 2006 Aug 01;59(2):481-482 PMID: 28180727 08/01/2006
  • Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. (Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN) Gene Ther 2006 Mar;13(5):379-88 PMID: 16355116 12/16/2005
  • A new tool in the battle against Alzheimer's disease and aging: ex vivo gene therapy. (Ebert AD, Svendsen CN) Rejuvenation Res 2005;8(3):131-4 PMID: 16144466 09/08/2005
  • A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo. (Ebert AD, Chen F, He X, Cryns VL, Bohn MC) Exp Neurol 2005 Feb;191 Suppl 1:S80-94 PMID: 15629764 01/05/2005
  • Comparative pharmacokinetics of 14C-sucrose in RG-2 rat gliomas after intravenous and convection-enhanced delivery. (Vavra M, Ali MJ, Kang EW, Navalitloha Y, Ebert A, Allen CV, Groothuis DR) Neuro Oncol 2004 Apr;6(2):104-12 PMID: 15134624 PMCID: PMC1871980 05/12/2004
  • Last update: 06/24/2017
    jenkins-FCD Prod-130 96200611f8481f0aa4f84230b11dd74d063847a3