Angela Mathison PhD
MCW Program / Core Facilities
Mellowes Center for Genomic Sciences and Precision MedicinePublications (79)
In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations (Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ) Oral Oncology September 2024;156 SCOPUS ID: 2-s2.0-85198374252 09/01/2024 In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations. (Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ) Oral Oncol 2024 Sep;156:106947 PMID: 39009483 SCOPUS ID: 2-s2.0-85198374252 07/16/2024 Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas. (Pollin G, Mathison AJ, de Assuncao TM, Thomas A, Zeighami A, Salmonson A, Liu H, Urrutia G, Vankayala P, Pandol SJ, Hong JC, Zimmermann MT, Iovanna J, Jin VX, Urrutia R, Lomberk G) Front Genet 2024;15:1412767 PMID: 38948355 PMCID: PMC11211573 SCOPUS ID: 2-s2.0-85197408751 07/01/2024 Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation. (Kim J, Zimmermann MT, Mathison AJ, Lomberk G, Urrutia R, Hong JC) Ann Surg Open 2024 Jun;5(2):e444 PMID: 38911661 PMCID: PMC11191965 06/24/2024 Type I interferon signaling promotes radioresistance in head and neck cancer. (Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA) Transl Cancer Res 2024 May 31;13(5):2535-2543 PMID: 38881922 PMCID: PMC11170510 SCOPUS ID: 2-s2.0-85195040296 06/17/2024 1 CitationChanges in Daily Apparent Diffusion Coefficient on Fully Quantitative Magnetic Resonance Imaging Correlate With Established Genomic Pathways of Radiation Sensitivity and Reveal Novel Biologic Associations. (Hall WA, Mathison AJ, DeVoe E, Tschannen M, Wendt-Andrae J, Straza M, Awan M, Puckett LL, Lawton CAF, Schultz C, Urrutia R, Kerns S, Torres-Roca JF, Li XA, Erickson B, Nevalainen MT, Zimmermann MT, Paulson E) Int J Radiat Oncol Biol Phys 2024 Oct 01;120(2):570-578 PMID: 38819340 SCOPUS ID: 2-s2.0-85194948255 05/31/2024 EHMT2 Inactivation in Pancreatic Epithelial Cells Shapes the Transcriptional Landscape and Inflammation Response of the Whole Pancreas. (Pollin G, Mathison AJ, de Assuncao TM, Thomas A, Zeighami L, Salmonson A, Liu H, Urrutia G, Vankayala P, Pandol SJ, Zimmermann MT, Iovanna J, Jin VX, Urrutia R, Lomberk G) bioRxiv 2024 Mar 16 PMID: 38529489 PMCID: PMC10962735 03/26/2024 Verteporfin induces lipid peroxidation and ferroptosis in pancreatic cancer cells. (Zhou W, Lim A, Elmadbouh OHM, Edderkaoui M, Osipov A, Mathison AJ, Urrutia R, Liu T, Wang Q, Pandol SJ) Free Radic Biol Med 2024 Feb 20;212:493-504 PMID: 38184120 PMCID: PMC10906657 SCOPUS ID: 2-s2.0-85182384342 01/07/2024 3 CitationsType I interferon signaling promotes radioresistance in head and neck cancer (Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA) Translational Cancer Research 2024;13(5):2535-2543 SCOPUS ID: 2-s2.0-85195040296 01/01/2024 1 CitationDeep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction. (Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Front Genet 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023 A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1. (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Comput Struct Biotechnol J 2023;21:5249-5258 PMID: 37954151 PMCID: PMC10632586 SCOPUS ID: 2-s2.0-85174744984 11/13/2023 Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape. (Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT) Comput Struct Biotechnol J 2023;21:4790-4803 PMID: 37841325 PMCID: PMC10570560 SCOPUS ID: 2-s2.0-85173171942 10/16/2023 3 CitationsA Multi-Layered Computational Structural Genomics Approach Enhances Domain-Specific Interpretation of Kleefstra Syndrome Variants in EHMT1. (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) bioRxiv 2023 Sep 07 PMID: 37786696 PMCID: PMC10541560 10/03/2023 IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma. (Pisano MD, Sun F, Cheng Y, Parashar D, Zhou V, Jing X, Sompallae R, Abrudan J, Zimmermann MT, Mathison A, Janz S, Pufall MA) Haematologica 2023 Dec 01;108(12):3372-3383 PMID: 37439384 PMCID: PMC10690922 SCOPUS ID: 2-s2.0-85178652041 07/13/2023 Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape. (Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Esparza GV, Leverence EN, De Assuncao TM, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT) bioRxiv 2023 Apr 28 PMID: 37207265 PMCID: PMC10189839 05/19/2023 A timeline of genetic variant enrichment: from multiple myeloma diagnosis to myeloma-associated myeloid malignancy. (Kleman A, Singavi A, Pommert L, Mathison AJ, Hari P, Dhakal B, Mohan M, Janz S, Knight JM, Shah MV, Schinke C, Burns R, Steinhardt GF, Rao S, Carlson K) Blood Adv 2023 Sep 26;7(18):5549-5553 PMID: 36724511 PMCID: PMC10514068 SCOPUS ID: 2-s2.0-85164933174 02/02/2023 1 CitationThe splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. (Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G) Nat Commun 2023 Jan 03;14(1):1 PMID: 36596776 PMCID: PMC9810714 SCOPUS ID: 2-s2.0-85145429848 01/04/2023 23 CitationsBeyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape (Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT) Computational and Structural Biotechnology Journal January 2023;21:4790-4803 SCOPUS ID: 2-s2.0-85173171942 01/01/2023 3 CitationsA multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1 (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Computational and Structural Biotechnology Journal January 2023;21:5249-5258 SCOPUS ID: 2-s2.0-85174744984 01/01/2023 Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function. (Stancill JS, Hansen PA, Mathison AJ, Schmidt EE, Corbett JA) Function (Oxf) 2022;3(4):zqac034 PMID: 35873655 PMCID: PMC9301323 SCOPUS ID: 2-s2.0-85138214139 07/26/2022 14 CitationsStructural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Comput Struct Biotechnol J 2022;20:2200-2211 PMID: 35615018 PMCID: PMC9111933 SCOPUS ID: 2-s2.0-85130080827 05/27/2022 5 CitationsRho-related BTB Domain-containing Protein 1 Reverses Established Arterial Stiffness in Angiotensin II-treated Mice. (Fang S, Wu J, Reho J, Lu KT, Brozoski D, Werthman A, Kumar G, Silva SD, Muskus P, Wackman K, Mathison A, Urrutia RA, Teng BQ, Lin CW, Quelle FW, Sigmund CD) FASEB J 2022 May;36 Suppl 1 PMID: 35557171 SCOPUS ID: 2-s2.0-85130011716 05/14/2022 To ChIP, or to CUT, that is the question: Comparative Evaluation of NextGen Methodologies for Studying the genome-wide distribution of Histone H3 Lysine 9 di-methyl mark in pancreatic cells. (Urrutia G, Abrudan JL, Du M, de Assuncao TM, Mathison AJ, Zimmermann MT, Lomberk G, Urrutia R) FASEB J 2022 May;36 Suppl 1 PMID: 35556470 SCOPUS ID: 2-s2.0-85130072518 05/14/2022 Transcriptional Landscape Established by the Euchromatic Histone-lysine N-methyltransferase Pathway During Pancreas Ontogenesis and Pancreatitis. (Urrutia R, Salmonson A, Urrutia G, de Assuncao TM, Zimmermann MT, Mathison AJ, Lomberk G) FASEB J 2022 May;36 Suppl 1 PMID: 35556469 SCOPUS ID: 2-s2.0-85130010001 05/14/2022 Defining the Mutational Landscape That Affects the Histone Demethylase KDM6A/UTX in Human Cancer. (Chi YI, Stodola TJ, de Assuncao TM, Volkman B, Smith B, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) FASEB J 2022 May;36 Suppl 1 PMID: 35555661 SCOPUS ID: 2-s2.0-85130046941 05/14/2022 Integrative Modeling, Molecular Mechanics, and Molecular Dynamics Evaluation of Genomics Variants in KMT2C (MLL3), a Gene Involved in Kleefstra Syndrome Type 2. (Jorge SD, Chi YI, de Assuncao TM, Mathison AJ, Volkman B, Smith B, Lomberk G, Zimmermann MT, Urrutia R) FASEB J 2022 May;36 Suppl 1 PMID: 35553749 SCOPUS ID: 2-s2.0-85130006059 05/14/2022 Epigenomic mechanisms used by KrasG12D to regulate inflammatory gene clusters in epithelial pancreatic cancer cells, which are critical for reprogramming the tumor microenvironment. (Du M, Abrudan JL, Urrutia G, de Assuncao TM, Mathison AJ, Zimmermann MT, Lomberk G, Urrutia R) FASEB J 2022 May;36 Suppl 1 PMID: 35552230 SCOPUS ID: 2-s2.0-85130057842 05/14/2022 NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. (Xie Y, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zimmermann MT, Wilcox DA, Gutterman DD, Shen Y, Zhang DX) Basic Res Cardiol 2022 Apr 25;117(1):24 PMID: 35469044 PMCID: PMC9119129 SCOPUS ID: 2-s2.0-85128849246 04/27/2022 5 CitationsRhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerization. (Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD Jr, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD) JCI Insight 2022 May 09;7(9) PMID: 35358093 PMCID: PMC9090250 SCOPUS ID: 2-s2.0-85129954550 04/01/2022 10 CitationsPepsinogen/Proton Pump Co-Expression in Barrett's Esophageal Cells Induces Cancer-Associated Changes. (Stabenau KA, Samuels TL, Lam TK, Mathison AJ, Wells C, Altman KW, Battle MA, Johnston N) Laryngoscope 2023 Jan;133(1):59-69 PMID: 35315085 SCOPUS ID: 2-s2.0-85126774243 03/23/2022 5 CitationsMicroglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons. (Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD) Genes (Basel) 2022 Jan 27;13(2) PMID: 35205286 PMCID: PMC8871895 SCOPUS ID: 2-s2.0-85124092767 02/26/2022 6 CitationsMicroglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons (Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD) Genes February 2022;13(2) SCOPUS ID: 2-s2.0-85124092767 02/01/2022 6 CitationsEnhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics. (Tripathi S, Dsouza NR, Mathison AJ, Leverence E, Urrutia R, Zimmermann MT) Comput Struct Biotechnol J 2022;20:117-127 PMID: 34976316 PMCID: PMC8688876 SCOPUS ID: 2-s2.0-85121238740 01/04/2022 3 CitationsEnhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics (Tripathi S, Dsouza NR, Mathison AJ, Leverence E, Urrutia R, Zimmermann MT) Computational and Structural Biotechnology Journal January 2022;20:117-127 SCOPUS ID: 2-s2.0-85121238740 01/01/2022 3 CitationsKrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells. (Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R) Genome Biol 2021 Oct 14;22(1):289 PMID: 34649604 PMCID: PMC8518179 SCOPUS ID: 2-s2.0-85117299300 10/16/2021 6 CitationsComputational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis. (Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Proteins 2022 Jan;90(1):282-298 PMID: 34414607 PMCID: PMC8671179 SCOPUS ID: 2-s2.0-85114677469 08/21/2021 2 CitationsEffects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model. (Kim J, Zimmerman MA, Shin WY, Boettcher BT, Lee JS, Park JI, Ali M, Yang M, Mishra J, Hagen CE, McGraw JE, Mathison A, Woehlck HJ, Lomberk G, Camara AKS, Urrutia RA, Stowe DF, Hong JC) Ann Surg 2023 Feb 01;277(2):e366-e375 PMID: 34387201 PMCID: PMC8840998 SCOPUS ID: 2-s2.0-85146161896 08/14/2021 8 CitationsInactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks. (Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G) Front Cell Dev Biol 2021;9:681153 PMID: 34249932 PMCID: PMC8261250 SCOPUS ID: 2-s2.0-85116952280 07/13/2021 5 CitationsBMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease. (Gonzalez MM, Bamidele AO, Svingen PA, Sagstetter MR, Smyrk TC, Gaballa JM, Hamdan FH, Kosinsky RL, Gibbons HR, Sun Z, Ye Z, Nair A, Ramos GP, Braga Neto MB, Wixom AQ, Mathison AJ, Johnsen SA, Urrutia R, Faubion WA Jr) J Clin Invest 2021 Jun 15;131(12) PMID: 34128475 PMCID: PMC8203461 SCOPUS ID: 2-s2.0-85108220626 06/16/2021 13 CitationsCorrection to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Orphanet J Rare Dis 2021 Jun 01;16(1):247 PMID: 34074320 PMCID: PMC8170813 SCOPUS ID: 2-s2.0-85107273180 06/03/2021 RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media. (Stabenau KA, Zimmermann MT, Mathison A, Zeighami A, Samuels TL, Chun RH, Papsin BC, McCormick ME, Johnston N, Kerschner JE) Laryngoscope 2021 Nov;131(11):2590-2597 PMID: 33844317 SCOPUS ID: 2-s2.0-85104152095 04/13/2021 9 CitationsInterpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level. (Zimmermann MT, Mathison AJ, Stodola T, Evans DB, Abrudan JL, Demos W, Tschannen M, Aldakkak M, Geurts J, Lomberk G, Tsai S, Urrutia R) Front Oncol 2021;11:606820 PMID: 33747920 PMCID: PMC7973372 SCOPUS ID: 2-s2.0-85102941394 03/23/2021 5 CitationsMolecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Orphanet J Rare Dis 2021 Feb 05;16(1):66 PMID: 33546721 PMCID: PMC7866879 SCOPUS ID: 2-s2.0-85100579633 02/07/2021 11 CitationsInorganic arsenic promotes luminal to basal transition and metastasis of breast cancer. (Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG) FASEB J 2020 Dec;34(12):16034-16048 PMID: 33047385 PMCID: PMC8289339 SCOPUS ID: 2-s2.0-85092336914 10/14/2020 12 CitationsDiscovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain. (Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G) PLoS One 2020;15(2):e0217452 PMID: 32027651 PMCID: PMC7004349 SCOPUS ID: 2-s2.0-85079081692 02/07/2020 5 CitationsCombined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse. (Urrutia G, Salmonson A, Toro-Zapata J, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G) Mol Cancer Res 2020 Mar;18(3):448-462 PMID: 31822519 PMCID: PMC7056528 SCOPUS ID: 2-s2.0-85081130002 12/12/2019 11 CitationsSOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. (He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG) Proc Natl Acad Sci U S A 2019 Nov 19;116(47):23534-23541 PMID: 31591207 PMCID: PMC6876149 SCOPUS ID: 2-s2.0-85075260452 10/09/2019 56 CitationsAurora kinase B-phosphorylated HP1α functions in chromosomal instability. (Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA) Cell Cycle 2019 Jun;18(12):1407-1421 PMID: 31130069 PMCID: PMC6592258 SCOPUS ID: 2-s2.0-85067316375 05/28/2019 7 CitationsEnhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis. (Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH) Cell Mol Gastroenterol Hepatol 2019;7(1):197-209 PMID: 30539787 PMCID: PMC6282644 SCOPUS ID: 2-s2.0-85057853914 12/13/2018 56 CitationsMechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway. (Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R) Sci Rep 2018 Oct 10;8(1):15077 PMID: 30305677 PMCID: PMC6180112 SCOPUS ID: 2-s2.0-85054625299 10/12/2018 5 CitationsDistinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes. (Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, Armenoult L, Ayadi M, Ordog T, Lee JH, Oliver G, Klee E, Moutardier V, Gayet O, Bian B, Duconseil P, Gilabert M, Bigonnet M, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Secq V, De Reyniès A, Dusetti N, Iovanna J, Urrutia R) Nat Commun 2018 May 17;9(1):1978 PMID: 29773832 PMCID: PMC5958058 SCOPUS ID: 2-s2.0-85047248746 05/19/2018 166 CitationsFunctional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signaling. (Cousin MA, Zimmermann MT, Mathison AJ, Blackburn PR, Boczek NJ, Oliver GR, Lomberk GA, Urrutia RA, Deyle DR, Klee EW) Cold Spring Harb Mol Case Stud 2017 Jul;3(4) PMID: 28679693 PMCID: PMC5495030 SCOPUS ID: 2-s2.0-85037598912 07/07/2017 7 CitationsCombined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. (Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G) Mol Cancer Res 2017 Aug;15(8):984-997 PMID: 28442587 PMCID: PMC5705946 SCOPUS ID: 2-s2.0-85026643394 04/27/2017 16 CitationsThe Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD). (Sarmento OF, Svingen PA, Xiong Y, Sun Z, Bamidele AO, Mathison AJ, Smyrk TC, Nair AA, Gonzalez MM, Sagstetter MR, Baheti S, McGovern DP, Friton JJ, Papadakis KA, Gautam G, Xavier RJ, Urrutia RA, Faubion WA) J Biol Chem 2017 Jan 13;292(2):706-722 PMID: 27909059 PMCID: PMC5241744 SCOPUS ID: 2-s2.0-85009804809 12/03/2016 54 CitationsAsymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body. (Campoy EM, Laurito SR, Branham MT, Urrutia G, Mathison A, Gago F, Orozco J, Urrutia R, Mayorga LS, Roqué M) PLoS One 2016;11(7):e0157416 PMID: 27383829 PMCID: PMC4934783 SCOPUS ID: 2-s2.0-84978159641 07/08/2016 7 CitationsPerhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. (Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE) J Clin Invest 2015 Oct 01;125(10):3819-30 PMID: 26368306 PMCID: PMC4607137 SCOPUS ID: 2-s2.0-84943222952 09/15/2015 65 CitationsPhenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. (Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R) Endocrinology 2015 Oct;156(10):3581-95 PMID: 26248217 PMCID: PMC4588811 SCOPUS ID: 2-s2.0-84943616432 08/08/2015 10 CitationsThe Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. (Leonard PH, Grzenda A, Mathison A, Morbeck DE, Fredrickson JR, de Assuncao TM, Christensen T, Salisbury J, Calvo E, Iovanna J, Coddington CC, Urrutia R, Lomberk G) BMC Dev Biol 2015 May 29;15:23 PMID: 26021315 PMCID: PMC4448908 SCOPUS ID: 2-s2.0-84930204241 05/30/2015 6 CitationsBrowning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers. (Loft A, Forss I, Siersbæk MS, Schmidt SF, Larsen AS, Madsen JG, Pisani DF, Nielsen R, Aagaard MM, Mathison A, Neville MJ, Urrutia R, Karpe F, Amri EZ, Mandrup S) Genes Dev 2015 Jan 01;29(1):7-22 PMID: 25504365 PMCID: PMC4281566 SCOPUS ID: 2-s2.0-84920403959 12/17/2014 125 CitationsDeleted in Breast Cancer 1 regulates cellular senescence during obesity. (Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN) Aging Cell 2014 Oct;13(5):951-3 PMID: 24992635 PMCID: PMC4172532 SCOPUS ID: 2-s2.0-84940363648 07/06/2014 23 CitationsSingle and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks. (Calvo E, Grzenda A, Lomberk G, Mathison A, Iovanna J, Urrutia R) BMC Mol Biol 2014 May 25;15:10 PMID: 24885560 PMCID: PMC4049485 SCOPUS ID: 2-s2.0-84902078010 06/03/2014 6 CitationsNew role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. (de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH) J Biol Chem 2014 May 30;289(22):15798-809 PMID: 24759103 PMCID: PMC4140934 SCOPUS ID: 2-s2.0-84901702509 04/25/2014 44 CitationsMembrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. (Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ, Kendrick ML, Shen KR, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Farrugia G, Urrutia RA, Ordog T) PLoS One 2013;8(10):e76822 PMID: 24116170 PMCID: PMC3792098 SCOPUS ID: 2-s2.0-84885041041 10/12/2013 14 CitationsRole for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis. (Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, Hendrickson H, Liebl A, Xiong YY, Gores G, Fernandez-Zapico M, Larusso NF, Faubion W, Shah VH, Urrutia R) PLoS One 2013;8(9):e75311 PMID: 24069400 PMCID: PMC3775729 SCOPUS ID: 2-s2.0-84884265835 09/27/2013 24 CitationsFunctional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression. (Grzenda A, Leonard P, Seo S, Mathison AJ, Urrutia G, Calvo E, Iovanna J, Urrutia R, Lomberk G) Epigenetics Chromatin 2013 Jul 05;6(1):21 PMID: 23829974 PMCID: PMC3707784 SCOPUS ID: 2-s2.0-84879835428 07/09/2013 18 CitationsKrüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. (Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R) J Biol Chem 2013 Jun 14;288(24):17745-58 PMID: 23589285 PMCID: PMC3682574 SCOPUS ID: 2-s2.0-84879068306 04/17/2013 26 CitationsA novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis. (Daftary GS, Zheng Y, Tabbaa ZM, Schoolmeester JK, Gada RP, Grzenda AL, Mathison AJ, Keeney GL, Lomberk GA, Urrutia R) PLoS One 2013;8(3):e60165 PMID: 23555910 PMCID: PMC3610699 SCOPUS ID: 2-s2.0-84875516286 04/05/2013 39 CitationsFunctional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression. (Grzenda A, Lomberk G, Svingen P, Mathison A, Calvo E, Iovanna J, Xiong Y, Faubion W, Urrutia R) Epigenetics Chromatin 2013 Feb 28;6(1):3 PMID: 23448518 PMCID: PMC3606351 SCOPUS ID: 2-s2.0-84874345376 03/02/2013 27 CitationsKrüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells. (Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R) J Biol Chem 2012 Apr 13;287(16):12723-35 PMID: 22375010 PMCID: PMC3339994 SCOPUS ID: 2-s2.0-84859776104 03/01/2012 33 CitationsSequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. (Lomberk G, Mathison AJ, Grzenda A, Seo S, DeMars CJ, Ilyas SI, Bonilla-Velez J, Calvo E, Fernandez-Zapico ME, Iovanna J, Buttar NS, Urrutia R) J Biol Chem 2012 Apr 13;287(16):13026-39 PMID: 22318730 PMCID: PMC3339955 SCOPUS ID: 2-s2.0-84859753082 02/10/2012 45 CitationsDetailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology. (Daftary GS, Lomberk GA, Buttar NS, Allen TW, Grzenda A, Zhang J, Zheng Y, Mathison AJ, Gada RP, Calvo E, Iovanna JL, Billadeau DD, Prendergast FG, Urrutia R) J Biol Chem 2012 Mar 02;287(10):7010-25 PMID: 22203677 PMCID: PMC3293586 SCOPUS ID: 2-s2.0-84863280739 12/29/2011 37 CitationsPancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes. (Mathison A, Liebl A, Bharucha J, Mukhopadhyay D, Lomberk G, Shah V, Urrutia R) Pancreatology 2010;10(4):505-16 PMID: 20847583 PMCID: PMC3214918 09/18/2010 Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes (Mathison A, Liebl A, Bharucha J, Mukhopadhyay D, Lomberk G, Shah V, Urrutia R) Pancreatology October 2010;10(4):505-516 SCOPUS ID: 2-s2.0-77956593984 01/01/2010 41 CitationsBrucella melitensis, B. neotomae and B. ovis elicit common and distinctive macrophage defense transcriptional responses. (Covert J, Mathison AJ, Eskra L, Banai M, Splitter G) Exp Biol Med (Maywood) 2009 Dec;234(12):1450-67 PMID: 19934366 PMCID: PMC2880867 SCOPUS ID: 2-s2.0-72449175964 11/26/2009 30 CitationsThe sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research. (Lomberk G, Mathison AJ, Grzenda A, Urrutia R) Curr Opin Gastroenterol 2008 Sep;24(5):597-602 PMID: 19122501 PMCID: PMC2941574 SCOPUS ID: 2-s2.0-55549090720 01/06/2009 19 CitationsBrucella: functional genomics and host-pathogen interactions. (Rajashekara G, Eskra L, Mathison A, Petersen E, Yu Q, Harms J, Splitter G) Anim Health Res Rev 2006;7(1-2):1-11 PMID: 17389050 SCOPUS ID: 2-s2.0-34447509539 03/29/2007 27 CitationsUnraveling Brucella genomics and pathogenesis in immunocompromised IRF-1-/- mice. (Rajashekara G, Krepps M, Eskra L, Mathison A, Montgomery A, Ishii Y, Splitter G) Am J Reprod Immunol 2005 Dec;54(6):358-68 PMID: 16305661 SCOPUS ID: 2-s2.0-28644431555 11/25/2005 16 CitationsMicroarray analysis of mRNA levels from RAW264.7 macrophages infected with Brucella abortus. (Eskra L, Mathison A, Splitter G) Infect Immun 2003 Mar;71(3):1125-33 PMID: 12595423 PMCID: PMC148819 SCOPUS ID: 2-s2.0-0037369742 02/22/2003 94 CitationsIndividual mitochondrion characterization: a comparison of classical assays to capillary electrophoresis with laser-induced fluorescence detection. (Strack A, Duffy CF, Malvey M, Arriaga EA) Anal Biochem PubMed PMID: 11444809 07/15/2001
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