Medical College of Wisconsin
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Carol L. Williams PhD

Carol L. Williams PhD


Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Cancer Center


  • SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. (Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL) Oncogene 2017 12 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 08/15/2017       2 Citations
  • The Nogo-B receptor promotes Ras plasma membrane localization and activation. (Zhao B, Hu W, Kumar S, Gonyo P, Rana U, Liu Z, Wang B, Duong WQ, Yang Z, Williams CL, Miao QR) Oncogene 2017 06 15;36(24):3406-3416 PMID: 28068323 PMCID: PMC5472485 01/10/2017       5 Citations
  • Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B. (Wilson JM, Prokop JW, Lorimer E, Ntantie E, Williams CL) J Mol Biol 2016 12 04;428(24 Pt B):4929-4945 PMID: 27760305 PMCID: PMC5153279 10/21/2016       7 Citations
  • The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases. (Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL) J Biol Chem 2016 May 13;291(20):10948 PMID: 27197236 PMCID: PMC4865938 05/20/2016    
  • The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. (Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL) J Biol Chem 2016 Mar 18;291(12):6534-45 PMID: 26814130 PMCID: PMC4813585 01/28/2016       9 Citations
  • β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells. (Wilson JM, Lorimer E, Tyburski MD, Williams CL) Cancer Biol Ther 2015;16(9):1364-74 PMID: 26209110 PMCID: PMC4622671 07/26/2015       15 Citations
  • SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers. (Schuld NJ, Hauser AD, Gastonguay AJ, Wilson JM, Lorimer EL, Williams CL) Cell Cycle 2014;13(6):941-52 PMID: 24552806 PMCID: PMC3984317 02/21/2014       7 Citations
  • The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. (Schuld NJ, Vervacke JS, Lorimer EL, Simon NC, Hauser AD, Barbieri JT, Distefano MD, Williams CL) J Biol Chem 2014 Mar 07;289(10):6862-76 PMID: 24415755 PMCID: PMC3945348 01/15/2014       18 Citations
  • The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer. (Hauser AD, Bergom C, Schuld NJ, Chen X, Lorimer EL, Huang J, Mackinnon AC, Williams CL) Mol Cancer Res 2014 Jan;12(1):130-42 PMID: 24197117 PMCID: PMC4285378 11/08/2013       14 Citations
  • Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. (Zimmerman NP, Roy I, Hauser AD, Wilson JM, Williams CL, Dwinell MB) Mol Carcinog 2015 Mar;54(3):203-15 PMID: 24115212 PMCID: PMC4087083 10/12/2013       19 Citations
  • A new signaling paradigm to control the prenylation and trafficking of small GTPases. (Williams CL) Cell Cycle 2013;12(18):2933-4 PMID: 23974087 PMCID: PMC3875666 08/27/2013       6 Citations
  • An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. (Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL) Sci Signal 2013 May 28;6(277):ra39 PMID: 23716716 PMCID: PMC4278376 05/30/2013       46 Citations
  • Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation. (Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H) Arterioscler Thromb Vasc Biol 2013 Jul;33(7):1591-600 PMID: 23640485 PMCID: PMC3863549 05/04/2013       38 Citations
  • The role of Rac1 in the regulation of NF-κB activity, cell proliferation, and cell migration in non-small cell lung carcinoma. (Gastonguay A, Berg T, Hauser AD, Schuld N, Lorimer E, Williams CL) Cancer Biol Ther 2012 Jun;13(8):647-56 PMID: 22549160 PMCID: PMC3408971 05/03/2012       32 Citations
  • Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells. (Nithipatikom K, Gomez-Granados AD, Tang AT, Pfeiffer AW, Williams CL, Campbell WB) Endocrinology 2012 Jan;153(1):29-41 PMID: 22087025 PMCID: PMC3249681 11/17/2011       20 Citations
  • SmgGDS splice variants: Potential novel targets for breast cancer therapeutics. (Bergom C, Hauser A, Lorimer EL, Li R, Mackinnon AC, Williams CL) J Clin Oncol 2011 Sep 20;29(27_suppl):225 PMID: 27958111 09/20/2011    
  • Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. (Cheng G, Lopez M, Zielonka J, Hauser AD, Joseph J, McAllister D, Rowe JJ, Sugg SL, Williams CL, Kalyanaraman B) Cancer Biol Ther 2011 Oct 15;12(8):707-17 PMID: 21799303 PMCID: PMC3218525 07/30/2011       19 Citations
  • Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells. (Bongard RD, Krenz GS, Gastonguay AJ, Williams CL, Lindemer BJ, Merker MP) Free Radic Biol Med 2011 Apr 15;50(8):953-62 PMID: 21238579 PMCID: PMC3851029 01/18/2011       6 Citations
  • Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists. (Nithipatikom K, Brody DM, Tang AT, Manthati VL, Falck JR, Williams CL, Campbell WB) Cancer Sci 2010 Dec;101(12):2629-36 PMID: 20804500 PMCID: PMC3398840 09/02/2010       28 Citations
  • Splice variants of SmgGDS control small GTPase prenylation and membrane localization. (Berg TJ, Gastonguay AJ, Lorimer EL, Kuhnmuench JR, Li R, Fields AP, Williams CL) J Biol Chem 2010 Nov 12;285(46):35255-66 PMID: 20709748 PMCID: PMC2975149 08/17/2010       37 Citations
  • SmgGDS is up-regulated in prostate carcinoma and promotes tumour phenotypes in prostate cancer cells. (Zhi H, Yang XJ, Kuhnmuench J, Berg T, Thill R, Yang H, See WA, Becker CG, Williams CL, Li R) J Pathol 2009 Feb;217(3):389-97 PMID: 18973191 11/01/2008       16 Citations
  • Expression and function of fatty acid amide hydrolase in prostate cancer. (Endsley MP, Thill R, Choudhry I, Williams CL, Kajdacsy-Balla A, Campbell WB, Nithipatikom K) Int J Cancer 2008 Sep 15;123(6):1318-26 PMID: 18566995 PMCID: PMC2548421 06/21/2008       59 Citations
  • Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells. (Thill R, Campbell WB, Williams CL) J Cell Biochem 2008 Aug 01;104(5):1760-70 PMID: 18348285 03/19/2008       5 Citations
  • SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma. (Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL) J Biol Chem 2008 Jan 11;283(2):963-76 PMID: 17951244 10/24/2007       40 Citations
  • Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. (Kotamraju S, Williams CL, Kalyanaraman B) Cancer Res 2007 Aug 01;67(15):7386-94 PMID: 17671209 08/03/2007       98 Citations
  • Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS. (Zhang Y, Deng Q, Porath JA, Williams CL, Pederson-Gulrud KJ, Barbieri JT) Cell Microbiol 2007 Sep;9(9):2192-201 PMID: 17490406 05/11/2007       17 Citations
  • The Rac1 C-terminal polybasic region regulates the nuclear localization and protein degradation of Rac1. (Lanning CC, Daddona JL, Ruiz-Velasco R, Shafer SH, Williams CL) J Biol Chem 2004 Oct 15;279(42):44197-210 PMID: 15304504 08/12/2004       73 Citations
  • Elevated Rac1 activity changes the M3 muscarinic acetylcholine receptor-mediated inhibition of proliferation to induction of cell death. (Shafer SH, Williams CL) Mol Pharmacol 2004 May;65(5):1080-91 PMID: 15102936 04/23/2004       6 Citations
  • Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment. (Shafer SH, Williams CL) Int J Oncol 2003 Aug;23(2):389-400 PMID: 12851688 07/10/2003       17 Citations
  • Muscarinic signaling in carcinoma cells. (Williams CL) Life Sci 2003 Mar 28;72(18-19):2173-82 PMID: 12628476 03/12/2003       29 Citations
  • The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies. (Varker KA, Phelps SH, King MM, Williams CL) Int J Oncol 2003 Mar;22(3):671-81 PMID: 12579323 02/13/2003       16 Citations
  • Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1. (Lanning CC, Ruiz-Velasco R, Williams CL) J Biol Chem 2003 Apr 04;278(14):12495-506 PMID: 12551911 01/29/2003       63 Citations
  • The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1, IQGAP1, and actin. (Ruiz-Velasco R, Lanning CC, Williams CL) J Biol Chem 2002 Sep 06;277(36):33081-91 PMID: 12070151 06/19/2002       18 Citations
  • Involvement of the muscarinic acetylcholine receptor in inhibition of cell migration. (Varker KA, Williams CL) Biochem Pharmacol 2002 Feb 15;63(4):597-605 PMID: 11992627 05/07/2002       8 Citations
  • Reduced expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. (Williams CL, Noti JD) Int J Oncol 2001 Dec;19(6):1227-33 PMID: 11713593 11/20/2001       7 Citations
  • P2Y2 purinergic and M3 muscarinic acetylcholine receptors activate different phospholipase C-beta isoforms that are uniquely susceptible to protein kinase C-dependent phosphorylation and inactivation. (Strassheim D, Williams CL) J Biol Chem 2000 Dec 15;275(50):39767-72 PMID: 10995776 09/21/2000       46 Citations
  • Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma. (Strassheim D, Shafer SH, Phelps SH, Williams CL) Cancer Res 2000 May 15;60(10):2730-6 PMID: 10825148 05/29/2000       36 Citations
  • Unique in vivo associations with SmgGDS and RhoGDI and different guanine nucleotide exchange activities exhibited by RhoA, dominant negative RhoA(Asn-19), and activated RhoA(Val-14). (Strassheim D, Porter RA, Phelps SH, Williams CL) J Biol Chem 2000 Mar 10;275(10):6699-702 PMID: 10702222 03/04/2000       19 Citations
  • Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5. (Carey I, Williams CL, Ways DK, Noti JD) Int J Oncol 1999 Jul;15(1):127-36 PMID: 10375605 06/22/1999       18 Citations
  • M3 muscarinic acetylcholine receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein kinase C isoforms. (Strassheim D, May LG, Varker KA, Puhl HL, Phelps SH, Porter RA, Aronstam RS, Noti JD, Williams CL) J Biol Chem 1999 Jun 25;274(26):18675-85 PMID: 10373480 06/22/1999       40 Citations
  • Activation of transfected M1 or M3 muscarinic acetylcholine receptors induces cell-cell adhesion of Chinese hamster ovary cells expressing endogenous cadherins. (Shafer SH, Puhl HL, Phelps SH, Williams CL) Exp Cell Res 1999 Apr 10;248(1):148-59 PMID: 10094822 03/30/1999       17 Citations
  • Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. (Shafer SH, Phelps SH, Williams CL) Biochem Pharmacol 1998 Nov 01;56(9):1229-36 PMID: 9802335 11/05/1998       45 Citations
  • Regulation of integrin-mediated adhesion by muscarinic acetylcholine receptors and protein kinase C in small cell lung carcinoma. (Quigley RL, Shafer SH, Williams CL) Chest 1998 Sep;114(3):839-46 PMID: 9743176 09/22/1998       25 Citations
  • Ethanol disrupts carbamylcholine-stimulated release of arachidonic acid from Chinese hamster ovary cells expressing different subtypes of human muscarinic receptor. (Stair SM, May LG, Puhl HL, Phelps SH, Williams CL, Aronstam RS) Alcohol Clin Exp Res 1998 Apr;22(2):409-15 PMID: 9581647 05/15/1998    
  • Nicotinic acetylcholine receptors of muscle and neuronal (alpha7) types coexpressed in a small cell lung carcinoma. (Sciamanna MA, Griesmann GE, Williams CL, Lennon VA) J Neurochem 1997 Dec;69(6):2302-11 PMID: 9375661 12/31/1997       41 Citations
  • Influence of acute and chronic ethanol treatment on muscarinic responses and receptor expression in Chinese hamster ovary cells. (Chang ZL, Puhl HL, May LG, Williams CL, Aronstam RS) Biochem Pharmacol 1997 Oct 01;54(7):833-9 PMID: 9353138 11/14/1997       6 Citations
  • Regulation of cadherin-mediated adhesion by the small GTP-binding protein Rho in small cell lung carcinoma cells. (Tokman MG, Porter RA, Williams CL) Cancer Res 1997 May 01;57(9):1785-93 PMID: 9135023 05/01/1997       35 Citations
  • Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpiperazin e (KN-62). (Puhl HL, Raman PS, Williams CL, Aronstam RS) Biochem Pharmacol 1997 Apr 25;53(8):1107-14 PMID: 9175715 04/25/1997       9 Citations
  • Basic science of small cell lung cancer. (Williams CL) Chest Surg Clin N Am 1997 Feb;7(1):1-19 PMID: 9001753 02/01/1997       23 Citations
  • Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma. (Williams CL, Phelps SH, Porter RA) Biochem Pharmacol 1996 Mar 08;51(5):707-15 PMID: 8615909 03/08/1996       33 Citations
  • Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) . (Williams CL, Porter RA, Phelps SH) Biochem Pharmacol 1995 Dec 22;50(12):1979-85 PMID: 8849323 12/22/1995       12 Citations
  • Enteric GABA-containing nerves projecting to the guinea-pig inferior mesenteric ganglion modulate acetylcholine release. (Parkman HP, Stapelfeldt WH, Williams CL, Lennon VA, Szurszewski JH) J Physiol 1993 Nov;471:191-207 PMID: 8120803 PMCID: PMC1143958 11/01/1993       17 Citations
  • Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma. (Williams CL, Hayes VY, Hummel AM, Tarara JE, Halsey TJ) J Cell Biol 1993 May;121(3):643-54 PMID: 8387530 PMCID: PMC2119556 05/01/1993       88 Citations
  • Human monoclonal striational autoantibodies isolated from thymic B lymphocytes of patients with myasthenia gravis use VH and VL gene segments associated with the autoimmune repertoire. (Victor KD, Pascual V, Williams CL, Lennon VA, Capra JD) Eur J Immunol 1992 Sep;22(9):2231-6 PMID: 1516616 09/01/1992       21 Citations
  • Paraneoplastic cerebellar autoantibodies associated with gynecological cancer bind to myenteric plexus neurons. (Altermatt HJ, Williams CL, Lennon VA) Ann Neurol 1991 Jun;29(6):687-8 PMID: 1892373 06/01/1991       11 Citations
  • Activation of muscarinic acetylcholine receptors inhibits cell cycle progression of small cell lung carcinoma. (Williams CL, Lennon VA) Cell Regul 1991 May;2(5):373-81 PMID: 1654127 PMCID: PMC361805 05/01/1991       34 Citations
  • Activation of M3 muscarinic acetylcholine receptors inhibits voltage-dependent calcium influx in small cell lung carcinoma. (Williams CL, Lennon VA) J Biol Chem 1990 Jan 25;265(3):1443-7 PMID: 2153134 01/25/1990       31 Citations
  • Last update: 02/14/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796