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Carol L. Williams PhD

Carol L. Williams PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Cancer Center
Member of the Cardiovascular Research Center

View Curriculum Vitae

Publications (79)

  • An Alkyne-Containing Isoprenoid Analogue Based on a Farnesyl Diphosphate Scaffold Is a Biologically Functional Universal Probe for Proteomic Analysis. (Auger SA, Pedersen JS, Maity S, Sprague-Getsy AM, Lorimer EL, Koehn OJ, Krauklis SA, Berns B, Murphy KM, Hussain J, Thao P, Bernhagen K, Justyna K, Sundaresan AP, McKim DB, Williams CL, Hougland JL, Li L, Distefano MD) Biochemistry 2025 Jan 07;64(1):138-155 PMID: 39652878 PMCID: PMC11706708 SCOPUS ID: 2-s2.0-85211597943 12/09/2024    
  • Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells (Gleason N, Williams CL, Kowluru A) Molecular and Cellular Endocrinology 15 January 2024;580 SCOPUS ID: 2-s2.0-85175808786 01/15/2024       2 Citations
  • Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells. (Gleason N, Williams CL, Kowluru A) Mol Cell Endocrinol 2024 Jan 15;580:112104 PMID: 38013223 PMCID: PMC10842139 SCOPUS ID: 2-s2.0-85175808786 11/28/2023       2 Citations
  • Synthesis, Enzymatic Peptide Incorporation, and Applications of Diazirine-Containing Isoprenoid Diphosphate Analogues. (Justyna K, Das R, Lorimer EL, Hu J, Pedersen JS, Sprague-Getsy AM, Schey GL, Sieburg MA, Koehn OJ, Wang YC, Chen YX, Hougland JL, Williams CL, Distefano MD) Org Lett 2023 Sep 15;25(36):6767-6772 PMID: 37669435 PMCID: PMC10755972 SCOPUS ID: 2-s2.0-85171393145 09/05/2023       6 Citations
  • GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS. (Koehn OJ, Lorimer E, Unger B, Harris R, Das AS, Suazo KF, Auger SA, Distefano MD, Prokop JW, Williams CL) J Biol Chem 2023 Jun;299(6):104698 PMID: 37059183 PMCID: PMC10206184 SCOPUS ID: 2-s2.0-85159174369 04/15/2023       9 Citations
  • The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing. (Das AS, Sherry EC, Vaughan RM, Henderson ML, Zieba J, Uhl KL, Koehn O, Bupp CP, Rajasekaran S, Li X, Chhetri SB, Nissim S, Williams CL, Prokop JW) Front Cell Dev Biol 2022;10:1033695 PMID: 36467401 PMCID: PMC9714508 SCOPUS ID: 2-s2.0-85143361098 12/06/2022       5 Citations
  • Structural and biophysical properties of farnesylated KRas interacting with the chaperone SmgGDS-558. (Michalak DJ, Unger B, Lorimer E, Grishaev A, Williams CL, Heinrich F, Lösche M) Biophys J 2022 Oct 04;121(19):3684-3697 PMID: 35614853 PMCID: PMC9617131 SCOPUS ID: 2-s2.0-85131506379 05/27/2022       2 Citations
  • Rap1A, Rap1B, and β-Adrenergic Signaling in Autologous HCT: A Randomized Controlled Trial of Propranolol. (Johnson AK, Lorimer EL, Szabo A, Wu R, Shah NN, D'Souza A, Chhabra S, Hamadani M, Dhakal B, Hari P, Rao S, Carlson K, Williams CL, Knight JM) Yale J Biol Med 2022 Mar;95(1):45-56 PMID: 35370486 PMCID: PMC8961707 SCOPUS ID: 2-s2.0-85127524780 04/05/2022       5 Citations
  • SmgGDS: An Emerging Master Regulator of Prenylation and Trafficking by Small GTPases in the Ras and Rho Families. (Brandt AC, Koehn OJ, Williams CL) Front Mol Biosci 2021;8:685135 PMID: 34222337 PMCID: PMC8242357 SCOPUS ID: 2-s2.0-85109027231 07/06/2021       17 Citations
  • Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy. (Brandt AC, McNally L, Lorimer EL, Unger B, Koehn OJ, Suazo KF, Rein L, Szabo A, Tsaih SW, Distefano MD, Flister MJ, Rigo F, McNally MT, Williams CL) Proc Natl Acad Sci U S A 2020 Feb 18;117(7):3627-3636 PMID: 32019878 PMCID: PMC7035473 SCOPUS ID: 2-s2.0-85079538992 02/06/2020       24 Citations
  • Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer. (Nissim S, Leshchiner I, Mancias JD, Greenblatt MB, Maertens O, Cassa CA, Rosenfeld JA, Cox AG, Hedgepeth J, Wucherpfennig JI, Kim AJ, Henderson JE, Gonyo P, Brandt A, Lorimer E, Unger B, Prokop JW, Heidel JR, Wang XX, Ukaegbu CI, Jennings BC, Paulo JA, Gableske S, Fierke CA, Getz G, Sunyaev SR, Wade Harper J, Cichowski K, Kimmelman AC, Houvras Y, Syngal S, Williams C, Goessling W) Nat Genet 2019 Sep;51(9):1308-1314 PMID: 31406347 PMCID: PMC7159804 SCOPUS ID: 2-s2.0-85070822684 08/14/2019       46 Citations
  • SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. (Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL) Oncogene 2017 Dec 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 SCOPUS ID: 2-s2.0-85038242723 08/15/2017       12 Citations
  • The Nogo-B receptor promotes Ras plasma membrane localization and activation. (Zhao B, Hu W, Kumar S, Gonyo P, Rana U, Liu Z, Wang B, Duong WQ, Yang Z, Williams CL, Miao QR) Oncogene 2017 Jun 15;36(24):3406-3416 PMID: 28068323 PMCID: PMC5472485 SCOPUS ID: 2-s2.0-85008618992 01/10/2017       29 Citations
  • Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B. (Wilson JM, Prokop JW, Lorimer E, Ntantie E, Williams CL) J Mol Biol 2016 Dec 04;428(24 Pt B):4929-4945 PMID: 27760305 PMCID: PMC5153279 SCOPUS ID: 2-s2.0-85000398931 10/21/2016       25 Citations
  • The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases. (Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL) J Biol Chem 2016 May 13;291(20):10948 PMID: 27197236 PMCID: PMC4865938 05/20/2016    
  • The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. (Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL) J Biol Chem 2016 Mar 18;291(12):6534-45 PMID: 26814130 PMCID: PMC4813585 SCOPUS ID: 2-s2.0-84964859354 01/28/2016       26 Citations
  • β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells. (Wilson JM, Lorimer E, Tyburski MD, Williams CL) Cancer Biol Ther 2015;16(9):1364-74 PMID: 26209110 PMCID: PMC4622671 SCOPUS ID: 2-s2.0-84941806664 07/26/2015       46 Citations
  • SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers. (Schuld NJ, Hauser AD, Gastonguay AJ, Wilson JM, Lorimer EL, Williams CL) Cell Cycle 2014;13(6):941-52 PMID: 24552806 PMCID: PMC3984317 SCOPUS ID: 2-s2.0-84897979722 02/21/2014       18 Citations
  • The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. (Schuld NJ, Vervacke JS, Lorimer EL, Simon NC, Hauser AD, Barbieri JT, Distefano MD, Williams CL) J Biol Chem 2014 Mar 07;289(10):6862-6876 PMID: 24415755 PMCID: PMC3945348 SCOPUS ID: 2-s2.0-84896783691 01/15/2014       37 Citations
  • The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer. (Hauser AD, Bergom C, Schuld NJ, Chen X, Lorimer EL, Huang J, Mackinnon AC, Williams CL) Mol Cancer Res 2014 Jan;12(1):130-42 PMID: 24197117 PMCID: PMC4285378 SCOPUS ID: 2-s2.0-84893101773 11/08/2013       25 Citations
  • Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. (Zimmerman NP, Roy I, Hauser AD, Wilson JM, Williams CL, Dwinell MB) Mol Carcinog 2015 Mar;54(3):203-15 PMID: 24115212 PMCID: PMC4087083 SCOPUS ID: 2-s2.0-84926109550 10/12/2013       48 Citations
  • A new signaling paradigm to control the prenylation and trafficking of small GTPases. (Williams CL) Cell Cycle 2013;12(18):2933-4 PMID: 23974087 PMCID: PMC3875666 SCOPUS ID: 2-s2.0-84884932567 08/27/2013       15 Citations
  • An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. (Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL) Sci Signal 2013 May 28;6(277):ra39 PMID: 23716716 PMCID: PMC4278376 SCOPUS ID: 2-s2.0-84878725519 05/30/2013       83 Citations
  • Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation. (Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H) Arterioscler Thromb Vasc Biol 2013 Jul;33(7):1591-600 PMID: 23640485 PMCID: PMC3863549 SCOPUS ID: 2-s2.0-84879105232 05/04/2013       78 Citations
  • The role of Rac1 in the regulation of NF-κB activity, cell proliferation, and cell migration in non-small cell lung carcinoma. (Gastonguay A, Berg T, Hauser AD, Schuld N, Lorimer E, Williams CL) Cancer Biol Ther 2012 Jun;13(8):647-56 PMID: 22549160 PMCID: PMC3408971 SCOPUS ID: 2-s2.0-84862155618 05/03/2012       90 Citations
  • Erratum: Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells (Endocrinology (2012) 153 (29-41)) (Nithipatikom K, Gomez-Granados AD, Tang AT, Pfeiffer AW, Williams CL, Campbell WB) Endocrinology May 2012;153(5):2531 SCOPUS ID: 2-s2.0-84860346302 05/01/2012    
  • Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells. (Nithipatikom K, Gomez-Granados AD, Tang AT, Pfeiffer AW, Williams CL, Campbell WB) Endocrinology 2012 Jan;153(1):29-41 PMID: 22087025 PMCID: PMC3249681 SCOPUS ID: 2-s2.0-84455160818 11/17/2011       34 Citations
  • SmgGDS splice variants: Potential novel targets for breast cancer therapeutics. (Bergom C, Hauser A, Lorimer EL, Li R, Mackinnon AC, Williams CL) J Clin Oncol 2011 Sep 20;29(27_suppl):225 PMID: 27958111 09/20/2011    
  • Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. (Cheng G, Lopez M, Zielonka J, Hauser AD, Joseph J, McAllister D, Rowe JJ, Sugg SL, Williams CL, Kalyanaraman B) Cancer Biol Ther 2011 Oct 15;12(8):707-17 PMID: 21799303 PMCID: PMC3218525 SCOPUS ID: 2-s2.0-80054116454 07/30/2011       26 Citations
  • Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells. (Bongard RD, Krenz GS, Gastonguay AJ, Williams CL, Lindemer BJ, Merker MP) Free Radic Biol Med 2011 Apr 15;50(8):953-62 PMID: 21238579 PMCID: PMC3851029 SCOPUS ID: 2-s2.0-79952443629 01/18/2011       10 Citations
  • Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists. (Nithipatikom K, Brody DM, Tang AT, Manthati VL, Falck JR, Williams CL, Campbell WB) Cancer Sci 2010 Dec;101(12):2629-36 PMID: 20804500 PMCID: PMC3398840 SCOPUS ID: 2-s2.0-78449289923 09/02/2010       42 Citations
  • Splice variants of SmgGDS control small GTPase prenylation and membrane localization. (Berg TJ, Gastonguay AJ, Lorimer EL, Kuhnmuench JR, Li R, Fields AP, Williams CL) J Biol Chem 2010 Nov 12;285(46):35255-66 PMID: 20709748 PMCID: PMC2975149 SCOPUS ID: 2-s2.0-78149231569 08/17/2010       67 Citations
  • SmgGDS is up-regulated in prostate carcinoma and promotes tumour phenotypes in prostate cancer cells. (Zhi H, Yang XJ, Kuhnmuench J, Berg T, Thill R, Yang H, See WA, Becker CG, Williams CL, Li R) J Pathol 2009 Feb;217(3):389-97 PMID: 18973191 SCOPUS ID: 2-s2.0-60549096862 11/01/2008       22 Citations
  • Expression and function of fatty acid amide hydrolase in prostate cancer. (Endsley MP, Thill R, Choudhry I, Williams CL, Kajdacsy-Balla A, Campbell WB, Nithipatikom K) Int J Cancer 2008 Sep 15;123(6):1318-26 PMID: 18566995 PMCID: PMC2548421 SCOPUS ID: 2-s2.0-49749120682 06/21/2008       85 Citations
  • Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells. (Thill R, Campbell WB, Williams CL) J Cell Biochem 2008 Aug 01;104(5):1760-70 PMID: 18348285 SCOPUS ID: 2-s2.0-50249171006 03/19/2008       6 Citations
  • SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma. (Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL) J Biol Chem 2008 Jan 11;283(2):963-76 PMID: 17951244 SCOPUS ID: 2-s2.0-38149140259 10/24/2007       59 Citations
  • Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. (Kotamraju S, Williams CL, Kalyanaraman B) Cancer Res 2007 Aug 01;67(15):7386-94 PMID: 17671209 SCOPUS ID: 2-s2.0-34547641739 08/03/2007       139 Citations
  • Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS. (Zhang Y, Deng Q, Porath JA, Williams CL, Pederson-Gulrud KJ, Barbieri JT) Cell Microbiol 2007 Sep;9(9):2192-201 PMID: 17490406 SCOPUS ID: 2-s2.0-34547913066 05/11/2007       19 Citations
  • The Rac1 C-terminal polybasic region regulates the nuclear localization and protein degradation of Rac1. (Lanning CC, Daddona JL, Ruiz-Velasco R, Shafer SH, Williams CL) J Biol Chem 2004 Oct 15;279(42):44197-210 PMID: 15304504 SCOPUS ID: 2-s2.0-6344231828 08/12/2004       94 Citations
  • Elevated Rac1 activity changes the M3 muscarinic acetylcholine receptor-mediated inhibition of proliferation to induction of cell death. (Shafer SH, Williams CL) Mol Pharmacol 2004 May;65(5):1080-91 PMID: 15102936 SCOPUS ID: 2-s2.0-2142806835 04/23/2004       11 Citations
  • Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment. (Shafer SH, Williams CL) Int J Oncol 2003 Aug;23(2):389-400 PMID: 12851688 SCOPUS ID: 2-s2.0-1542707232 07/10/2003       20 Citations
  • Muscarinic signaling in carcinoma cells. (Williams CL) Life Sci 2003 Mar 28;72(18-19):2173-82 PMID: 12628476 SCOPUS ID: 2-s2.0-0037470683 03/12/2003       29 Citations
  • The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies. (Varker KA, Phelps SH, King MM, Williams CL) Int J Oncol 2003 Mar;22(3):671-81 PMID: 12579323 SCOPUS ID: 2-s2.0-0642348940 02/13/2003       18 Citations
  • Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1. (Lanning CC, Ruiz-Velasco R, Williams CL) J Biol Chem 2003 Apr 04;278(14):12495-506 PMID: 12551911 SCOPUS ID: 2-s2.0-0038485593 01/29/2003       84 Citations
  • The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1, IQGAP1, and actin. (Ruiz-Velasco R, Lanning CC, Williams CL) J Biol Chem 2002 Sep 06;277(36):33081-91 PMID: 12070151 SCOPUS ID: 2-s2.0-0037031481 06/19/2002       21 Citations
  • Involvement of the muscarinic acetylcholine receptor in inhibition of cell migration. (Varker KA, Williams CL) Biochem Pharmacol 2002 Feb 15;63(4):597-605 PMID: 11992627 SCOPUS ID: 2-s2.0-0037085006 05/07/2002       8 Citations
  • Reduced expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. (Williams CL, Noti JD) Int J Oncol 2001 Dec;19(6):1227-33 PMID: 11713593 SCOPUS ID: 2-s2.0-0035653457 11/20/2001       7 Citations
  • P2Y2 purinergic and M3 muscarinic acetylcholine receptors activate different phospholipase C-beta isoforms that are uniquely susceptible to protein kinase C-dependent phosphorylation and inactivation. (Strassheim D, Williams CL) J Biol Chem 2000 Dec 15;275(50):39767-72 PMID: 10995776 SCOPUS ID: 2-s2.0-0034670378 09/21/2000       53 Citations
  • Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma. (Strassheim D, Shafer SH, Phelps SH, Williams CL) Cancer Res 2000 May 15;60(10):2730-6 PMID: 10825148 SCOPUS ID: 2-s2.0-0034658432 05/29/2000       48 Citations
  • Unique in vivo associations with SmgGDS and RhoGDI and different guanine nucleotide exchange activities exhibited by RhoA, dominant negative RhoA(Asn-19), and activated RhoA(Val-14). (Strassheim D, Porter RA, Phelps SH, Williams CL) J Biol Chem 2000 Mar 10;275(10):6699-702 PMID: 10702222 SCOPUS ID: 2-s2.0-0034629117 03/04/2000       24 Citations
  • Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5. (Carey I, Williams CL, Ways DK, Noti JD) Int J Oncol 1999 Jul;15(1):127-36 PMID: 10375605 SCOPUS ID: 2-s2.0-0033160367 06/22/1999       22 Citations
  • M3 muscarinic acetylcholine receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein kinase C isoforms. (Strassheim D, May LG, Varker KA, Puhl HL, Phelps SH, Porter RA, Aronstam RS, Noti JD, Williams CL) J Biol Chem 1999 Jun 25;274(26):18675-85 PMID: 10373480 SCOPUS ID: 2-s2.0-0033603052 06/22/1999       43 Citations
  • Activation of transfected M1 or M3 muscarinic acetylcholine receptors induces cell-cell adhesion of Chinese hamster ovary cells expressing endogenous cadherins. (Shafer SH, Puhl HL, Phelps SH, Williams CL) Exp Cell Res 1999 Apr 10;248(1):148-59 PMID: 10094822 SCOPUS ID: 2-s2.0-0033541164 03/30/1999       19 Citations
  • Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. (Shafer SH, Phelps SH, Williams CL) Biochem Pharmacol 1998 Nov 01;56(9):1229-36 PMID: 9802335 SCOPUS ID: 2-s2.0-0031740825 11/05/1998       45 Citations
  • Regulation of integrin-mediated adhesion by muscarinic acetylcholine receptors and protein kinase C in small cell lung carcinoma. (Quigley RL, Shafer SH, Williams CL) Chest 1998 Sep;114(3):839-46 PMID: 9743176 SCOPUS ID: 2-s2.0-0031695391 09/22/1998       27 Citations
  • Ethanol disrupts carbamylcholine-stimulated release of arachidonic acid from Chinese hamster ovary cells expressing different subtypes of human muscarinic receptor. (Stair SM, May LG, Puhl HL, Phelps SH, Williams CL, Aronstam RS) Alcohol Clin Exp Res 1998 Apr;22(2):409-15 PMID: 9581647 SCOPUS ID: 2-s2.0-0031981772 05/15/1998    
  • Nicotinic acetylcholine receptors of muscle and neuronal (alpha7) types coexpressed in a small cell lung carcinoma. (Sciamanna MA, Griesmann GE, Williams CL, Lennon VA) J Neurochem 1997 Dec;69(6):2302-11 PMID: 9375661 SCOPUS ID: 2-s2.0-0030692732 12/31/1997       47 Citations
  • Influence of acute and chronic ethanol treatment on muscarinic responses and receptor expression in Chinese hamster ovary cells. (Chang ZL, Puhl HL, May LG, Williams CL, Aronstam RS) Biochem Pharmacol 1997 Oct 01;54(7):833-9 PMID: 9353138 SCOPUS ID: 2-s2.0-0030846775 11/14/1997       6 Citations
  • Regulation of cadherin-mediated adhesion by the small GTP-binding protein Rho in small cell lung carcinoma cells. (Tokman MG, Porter RA, Williams CL) Cancer Res 1997 May 01;57(9):1785-93 PMID: 9135023 SCOPUS ID: 2-s2.0-0030904698 05/01/1997       36 Citations
  • Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpiperazin e (KN-62). (Puhl HL, Raman PS, Williams CL, Aronstam RS) Biochem Pharmacol 1997 Apr 25;53(8):1107-14 PMID: 9175715 SCOPUS ID: 2-s2.0-0030612777 04/25/1997       10 Citations
  • Basic science of small cell lung cancer. (Williams CL) Chest Surg Clin N Am 1997 Feb;7(1):1-19 PMID: 9001753 SCOPUS ID: 2-s2.0-0031036319 02/01/1997       26 Citations
  • Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma. (Williams CL, Phelps SH, Porter RA) Biochem Pharmacol 1996 Mar 08;51(5):707-15 PMID: 8615909 SCOPUS ID: 2-s2.0-0029670380 03/08/1996       44 Citations
  • Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) . (Williams CL, Porter RA, Phelps SH) Biochem Pharmacol 1995 Dec 22;50(12):1979-85 PMID: 8849323 SCOPUS ID: 2-s2.0-0029416847 12/22/1995       14 Citations
  • Enteric GABA-containing nerves projecting to the guinea-pig inferior mesenteric ganglion modulate acetylcholine release. (Parkman HP, Stapelfeldt WH, Williams CL, Lennon VA, Szurszewski JH) J Physiol 1993 Nov;471:191-207 PMID: 8120803 PMCID: PMC1143958 SCOPUS ID: 2-s2.0-0027436451 11/01/1993       19 Citations
  • Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma. (Williams CL, Hayes VY, Hummel AM, Tarara JE, Halsey TJ) J Cell Biol 1993 May;121(3):643-54 PMID: 8387530 PMCID: PMC2119556 SCOPUS ID: 2-s2.0-0027289308 05/01/1993       96 Citations
  • Human monoclonal striational autoantibodies isolated from thymic B lymphocytes of patients with myasthenia gravis use VH and VL gene segments associated with the autoimmune repertoire. (Victor KD, Pascual V, Williams CL, Lennon VA, Capra JD) Eur J Immunol 1992 Sep;22(9):2231-6 PMID: 1516616 SCOPUS ID: 2-s2.0-0026775966 09/01/1992       23 Citations
  • Paraneoplastic cerebellar autoantibodies associated with gynecological cancer bind to myenteric plexus neurons. (Altermatt HJ, Williams CL, Lennon VA) Ann Neurol 1991 Jun;29(6):687-8 PMID: 1892373 SCOPUS ID: 2-s2.0-0025752282 06/01/1991       10 Citations
  • Activation of muscarinic acetylcholine receptors inhibits cell cycle progression of small cell lung carcinoma. (Williams CL, Lennon VA) Cell Regul 1991 May;2(5):373-81 PMID: 1654127 PMCID: PMC361805 SCOPUS ID: 2-s2.0-0026164317 05/01/1991       44 Citations
  • Striational autoantibodies: Paraneoplastic antibodies associated with thymoma and myasthenia gravis (Williams CL, Lennon VA) Clinical Immunology Newsletter November 1991;11(11):161 SCOPUS ID: 2-s2.0-44949273583 01/01/1991       1 Citation
  • Activation of M3 muscarinic acetylcholine receptors inhibits voltage-dependent calcium influx in small cell lung carcinoma. (Williams CL, Lennon VA) J Biol Chem 1990 Jan 25;265(3):1443-7 PMID: 2153134 SCOPUS ID: 2-s2.0-0025192955 01/25/1990       33 Citations
  • Novel redistribution of myosin-containing filaments in cultured keratinocytes identified by a human monoclonal autoantibody. (Williams CL, Lennon VA, Pittelkow MR) In Vitro Cell Dev Biol 1989 May;25(5):397-401 PMID: 2471703 SCOPUS ID: 2-s2.0-0024353210 05/01/1989       3 Citations
  • Striational autoantibodies: quantitative detection by enzyme immunoassay in myasthenia gravis, thymoma, and recipients of D-penicillamine or allogeneic bone marrow. (Cikes N, Momoi MY, Williams CL, Howard FM Jr, Hoagland HC, Whittingham S, Lennon VA) Mayo Clin Proc 1988 May;63(5):474-81 PMID: 3283472 SCOPUS ID: 2-s2.0-0023923563 05/01/1988       56 Citations
  • Serum antibodies and monoclonal antibodies secreted by thymic B-cell clones from patients with myasthenia gravis define striational antigens. (Williams CL, Lennon VA, Momoi MY, Howard FM Jr) Ann N Y Acad Sci 1987;505:168-79 PMID: 3500666 SCOPUS ID: 2-s2.0-0023632438 01/01/1987       8 Citations
  • Thymic B lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, alpha actinin, or actin. (Williams CL, Lennon VA) J Exp Med 1986 Oct 01;164(4):1043-59 PMID: 3020150 PMCID: PMC2188418 SCOPUS ID: 2-s2.0-0022517678 10/01/1986       110 Citations
  • Trypanosoma lewisi: stage-specific surface antigens and exoantigens recognized by monoclonal antibodies. (Williams CL, Prasertsiriroj V, Dusanic DG) Exp Parasitol 1986 Apr;61(2):252-60 PMID: 3514258 SCOPUS ID: 2-s2.0-0022515725 04/01/1986       1 Citation
  • Comparison of the rhythmic emergence of Schistosoma mansoni cercariae from Biomphalaria glabrata in different lighting regimens. (Williams CL, Wessels WS, Gilbertson DE) J Parasitol 1984 Jun;70(3):450-2 PMID: 6541689 SCOPUS ID: 2-s2.0-0021680912 06/01/1984       9 Citations
  • Stage specific agglutination of Trypanosoma lewisi by monoclonal antibodies (Williams CL, Dusanic DG) Federation Proceedings 1984;43(6) SCOPUS ID: 2-s2.0-0021203183 01/01/1984    
  • Effects of alterations in the heartbeat rate and locomotor activity of Schistosoma mansoni-infected Biomphalaria glabrata on cercarial emergence. (Williams CL, Gilbertson DE) J Parasitol 1983 Aug;69(4):677-81 PMID: 6631637 SCOPUS ID: 2-s2.0-0020974908 08/01/1983       15 Citations
  • Altered feeding response as a cause for the altered heartbeat rate and locomotor activity of Schistosoma mansoni-infected biomphalaria glabrata. (Williams CL, Gilbertson DE) J Parasitol 1983 Aug;69(4):671-6 PMID: 6631636 SCOPUS ID: 2-s2.0-0021029408 08/01/1983       27 Citations
    • Last update: 05/13/2025