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Christina Runge PhD

Christina Runge PhD profile photo picture

Associate Provost, Chief, Professor

Institution: Medical College of Wisconsin
Department: Otolaryngology
Program: Clinical

Member of the Cancer Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)
Member of the Neuroscience Research Center


Research Experience

  • Allied Health Occupations
  • Anatomy Category
  • Audiology
  • Biological Science Disciplines
  • Biomedical Engineering
  • Biophysics
  • Cardiovascular Diseases
  • Cochlear Microphonic Potentials
  • Congenital Abnormalities
  • Congenital, Hereditary, and Neonatal Diseases and Abnormalities
  • Disciplines and Occupations Category
  • Diseases Category
  • Ear
  • Ear Diseases
  • Electrophysiology
  • Engineering
  • Event-Related Potentials, P300
  • Evoked Potentials
  • Evoked Potentials, Auditory
  • Evoked Potentials, Auditory, Brain Stem
  • Genetic Diseases, Inborn
  • Genetic Predisposition to Disease
  • Genotype
  • Health Care Category
  • Health Occupations
  • Health Services Administration
  • Heterozygote
  • Homozygote
  • Infant, Newborn, Diseases
  • Nervous System Diseases
  • Neurophysiology
  • Neurosciences
  • Organization and Administration
  • Otorhinolaryngologic Diseases
  • Phenomena and Processes Category
  • Phenotype
  • Physics
  • Physiological Phenomena
  • Physiology
  • Program Development
  • Quality of Health Care
  • Sense Organs
  • Clinical Expertise

  • Biological Science Disciplines
  • Biophysics
  • Cochlear Microphonic Potentials
  • Deafness
  • Disciplines and Occupations Category
  • Diseases Category
  • Ear Diseases
  • Electrophysiology
  • Event-Related Potentials, P300
  • Evoked Potentials
  • Evoked Potentials, Auditory
  • Evoked Potentials, Auditory, Brain Stem
  • Hearing Disorders
  • Hearing Loss
  • Hearing Loss, Bilateral
  • Hearing Loss, Conductive
  • Hearing Loss, Functional
  • Hearing Loss, High-Frequency
  • Hearing Loss, Mixed Conductive-Sensorineural
  • Hearing Loss, Sensorineural
  • Hearing Loss, Unilateral
  • Natural Science Disciplines
  • Neurophysiology
  • Neurosciences
  • Otorhinolaryngologic Diseases
  • Phenomena and Processes Category
  • Physics
  • Physiological Phenomena
  • Physiology
  • Leadership Positions

  • Associate Professor, Department of Otolaryngology and Communication Sciences
  • Director, Koss Cochlear Implant Program
  • Chief, Division of Communication Sciences
  • Director of Faculty Development
  • Community Partnerships

  • Board of Directors, Center for Communication, Hearing, and Deafness
  • Publications (62)

  • Development of in-house genetic screening for pediatric hearing loss. (Doerfer KW, Sander T, Konduri GG, Friedland DR, Kerschner JE, Runge CL) Laryngoscope Investig Otolaryngol 2020 Jun;5(3):497-505 PMID: 32596493 PMCID: PMC7314470 07/01/2020    
  • Results of a 2-Year Prospective Multicenter Study Evaluating Long-term Audiological and Clinical Outcomes of a Transcutaneous Implant for Bone Conduction Hearing. (Kruyt IJ, Monksfield P, Skarzynski PH, Green K, Runge C, Bosman A, Blechert JI, Wigren S, Mylanus EAM, Hol MKS) Otol Neurotol 2020 Aug;41(7):901-911 PMID: 32310837 PMCID: PMC7373438 SCOPUS ID: 2-s2.0-85088486999 04/21/2020    
  • Audiological and clinical outcomes of a transcutaneous bone conduction hearing implant: Six-month results from a multicentre study. (den Besten CA, Monksfield P, Bosman A, Skarzynski PH, Green K, Runge C, Wigren S, Blechert JI, Flynn MC, Mylanus EAM, Hol MKS) Clin Otolaryngol 2019 03;44(2):144-157 PMID: 30358920 SCOPUS ID: 2-s2.0-85056761069 10/26/2018       6 Citations
  • TMTC2 variant associated with sensorineural hearing loss and auditory neuropathy spectrum disorder in a family dyad. (Guillen-Ahlers H, Erbe CB, Chevalier FD, Montoya MJ, Zimmerman KD, Langefeld CD, Olivier M, Runge CL) Mol Genet Genomic Med 2018 Apr 19 PMID: 29671961 PMCID: PMC6081214 04/20/2018    
  • TMTC2 variant associated with sensorineural hearing loss and auditory neuropathy spectrum disorder in a family dyad (Guillen-Ahlers H, Erbe CB, Chevalier FD, Montoya MJ, Zimmerman KD, Langefeld CD, Olivier M, Runge CL) Molecular Genetics and Genomic Medicine (in press) 04/19/2018    
  • Improved Speech Perception in Cochlear Implant Users With Interleaved High-Rate Pulse Trains. (Runge CL, Du F, Hu Y) Otol Neurotol 2018 06;39(5):e319-e324 PMID: 29649048 SCOPUS ID: 2-s2.0-85048081634 04/13/2018       1 Citation
  • Tablet-based Screening for Hearing Loss: Feasibility of Testing in Nonspecialty Locations. (Kelly EA, Stadler ME, Nelson S, Runge CL, Friedland DR) Otol Neurotol 2018 04;39(4):410-416 PMID: 29494473 SCOPUS ID: 2-s2.0-85044158582 03/02/2018       5 Citations
  • Multicenter US Clinical Trial With an Electric-Acoustic Stimulation (EAS) System in Adults: Final Outcomes. (Pillsbury HC 3rd, Dillon MT, Buchman CA, Staecker H, Prentiss SM, Ruckenstein MJ, Bigelow DC, Telischi FF, Martinez DM, Runge CL, Friedland DR, Blevins NH, Larky JB, Alexiades G, Kaylie DM, Roland PS, Miyamoto RT, Backous DD, Warren FM, El-Kashlan HK, Slager HK, Reyes C, Racey AI, Adunka OF) Otol Neurotol 2018 03;39(3):299-305 PMID: 29342054 PMCID: PMC5821485 SCOPUS ID: 2-s2.0-85042489455 01/18/2018       21 Citations
  • Temporal and spectral contributions to musical instrument identification and discrimination among cochlear implant users. (Prentiss SM, Friedland DR, Fullmer T, Crane A, Stoddard T, Runge CL) World J Otorhinolaryngol Head Neck Surg 2016 Sep;2(3):148-156 PMID: 29204560 PMCID: PMC5698532 12/06/2017    
  • Temporal and Spectral Contributions to Musical Instrument Identification and Discrimination Among Cochlear Implant Users (Prentiss SM, Friedland DR, Fullmer T, Crane A, Stoddard T, Runge CL) World Journal of Otorhinolaryngology-Head and Neck Surgery September 2016 Vol2(3) pp. 148-156 12/16/2016    
  • Association of TMTC2 With Human Nonsyndromic Sensorineural Hearing Loss. (Runge CL, Indap A, Zhou Y, Kent JW Jr, King E, Erbe CB, Cole R, Littrell J, Merath K, James R, Rüschendorf F, Kerschner JE, Marth G, Hübner N, Göring HH, Friedland DR, Kwok WM, Olivier M) JAMA Otolaryngol Head Neck Surg 2016 09 01;142(9):866-72 PMID: 27311106 PMCID: PMC5025373 SCOPUS ID: 2-s2.0-84997646398 06/17/2016       10 Citations
  • Clinical Outcomes of the Cochlear™ Nucleus(®) 5 Cochlear Implant System and SmartSound™ 2 Signal Processing. (Runge CL, Henion K, Tarima S, Beiter A, Zwolan TA) J Am Acad Audiol 2016 06;27(6):425-440 PMID: 27310402 SCOPUS ID: 2-s2.0-84974691605 06/17/2016       5 Citations
  • Evaluation of a spectral subtraction strategy to suppress reverberant energy in cochlear implant devices. (Kokkinakis K, Runge C, Tahmina Q, Hu Y) J Acoust Soc Am 2015 Jul;138(1):115-24 PMID: 26233012 PMCID: PMC5392068 SCOPUS ID: 2-s2.0-84935488613 08/04/2015       4 Citations
  • Differences in Perception of Musical Stimuli among Acoustic, Electric, and Combined Modality Listeners. (Prentiss SM, Friedland DR, Nash JJ, Runge CL) J Am Acad Audiol 2015 May;26(5):494-501 PMID: 26055838 SCOPUS ID: 2-s2.0-84930802590 06/10/2015       4 Citations
  • The role of age on cochlear implant performance, use, and health utility: a multicenter clinical trial. (Zwolan TA, Henion K, Segel P, Runge C) Otol Neurotol 2014 Oct;35(9):1560-8 PMID: 25203562 SCOPUS ID: 2-s2.0-84914106442 09/10/2014       11 Citations
  • Patient Outcomes in Magnet-Based Implantable Auditory Assist Devices. (O'Niel MB, Runge CL, Friedland DR, Kerschner JE) JAMA Otolaryngol Head Neck Surg 2014 Jun;140(6):513-20 PMID: 24763485 SCOPUS ID: 2-s2.0-84903537445 04/26/2014       26 Citations
  • Surgical implantation of the Sophono transcutaneous bone conduction system (Friedland DR, Runge CL, Kerschner JA) Operative Techniques in Otolaryngology - Head and Neck Surgery 1 December 2014;25(4):344-347 SCOPUS ID: 2-s2.0-84916236161 01/01/2014    
  • The perception of telephone-processed speech by combined electric and acoustic stimulation. (Hu Y, Tahmina Q, Runge C, Friedland DR) Trends Amplif 2013 Sep-Dec;17(3):189-96 PMID: 24265213 PMCID: PMC4070615 SCOPUS ID: 2-s2.0-84890475508 11/23/2013       2 Citations
  • A novel otoferlin splice-site mutation in siblings with auditory neuropathy spectrum disorder. (Runge CL, Erbe CB, McNally MT, Van Dusen C, Friedland DR, Kwitek AE, Kerschner JE) Audiol Neurootol 2013;18(6):374-82 PMID: 24135434 PMCID: PMC3877672 SCOPUS ID: 2-s2.0-84885522606 10/19/2013       9 Citations
  • Variant discovery in targeted resequencing using whole genome amplified DNA. (Indap AR, Cole R, Runge CL, Marth GT, Olivier M) BMC Genomics 2013 Jul 10;14:468 PMID: 23837845 PMCID: PMC3716764 SCOPUS ID: 2-s2.0-84880024289 07/11/2013       4 Citations
  • Statistical model for prediction of hearing loss in patients receiving cisplatin chemotherapy. (Johnson A, Tarima S, Wong S, Friedland DR, Runge CL) JAMA Otolaryngol Head Neck Surg 2013 Mar;139(3):256-64 PMID: 23429908 SCOPUS ID: 2-s2.0-84875829521 02/23/2013       6 Citations
  • Bimodal Hearing on Music and Speech with FSP and HDCIS. (Atwood K, Runge C, Friedland DR) Otolaryngol Head Neck Surg 2012 Aug;147(2 suppl):P81 PMID: 25719115 08/01/2012    
  • Effects of Stimulation Rate on Musical Instrument Identification. (Zhang H, Runge C, Friedland DR) Otolaryngol Head Neck Surg 2012 Aug;147(2 suppl):P207 PMID: 25718735 08/01/2012    
  • Recovery from forward masking in elderly cochlear implant users. (Lee ER, Friedland DR, Runge CL) Otol Neurotol 2012 Apr;33(3):355-63 PMID: 22410729 SCOPUS ID: 2-s2.0-84861066808 03/14/2012       15 Citations
  • Electrode failure and device failure in adult cochlear implantation. (Schow B, Friedland DR, Jensen J, Burg L, Runge CL) Cochlear Implants Int 2012 Feb;13(1):35-40 PMID: 22340750 SCOPUS ID: 2-s2.0-84856822085 02/22/2012       6 Citations
  • Aiding and occluding the contralateral ear in implanted children with auditory neuropathy spectrum disorder. (Runge CL, Jensen J, Friedland DR, Litovsky RY, Tarima S) J Am Acad Audiol 2011 Oct;22(9):567-577 PMID: 22192602 PMCID: PMC3404494 SCOPUS ID: 2-s2.0-84855217693 12/24/2011       9 Citations
  • Hearing preservation surgery: proposal for an evidence-based grading scale. (Friedland DR, Runge C) Cochlear Implants Int 2011 May;12 Suppl 1:S76-7 PMID: 21756480 SCOPUS ID: 2-s2.0-84855165114 08/04/2011       1 Citation
  • The effect of acute introduction of fine structure processing on music and speech perception in adult cochlear implant users (Johnson A, Runge C, Friedland D) Laryngoscope 2011;121(SUPPL. 4) SCOPUS ID: 2-s2.0-79959948218 07/11/2011    
  • Effects of stimulation rate on speech perception in elderly cochlear implant users (Zhang H, Runge-Samuelson C, Friedland DR) Laryngoscope 2011;121(SUPPL. 4) SCOPUS ID: 2-s2.0-79959941678 07/11/2011    
  • Rate of neural recovery in implanted children with auditory neuropathy spectrum disorder. (Fulmer SL, Runge CL, Jensen JW, Friedland DR) Otolaryngol Head Neck Surg 2011 Feb;144(2):274-9 PMID: 21493430 SCOPUS ID: 2-s2.0-79959603771 04/16/2011       17 Citations
  • Stereotactic Radiosurgery of Skull Base Tumors (Ashley Wackym P, Runge-Samuelson CL, Friedland DR) Otologic Surgery 2010:785-798 SCOPUS ID: 2-s2.0-84882722810 12/01/2010    
  • Longitudinal aspect of case-control analysis: Reply (Friedland DR, Runge-Samuelson C) Archives of Otolaryngology - Head and Neck Surgery November 2010;136(11):1150 SCOPUS ID: 2-s2.0-78449252439 11/01/2010    
  • Gamma knife surgery of vestibular schwannomas: volumetric dosimetry correlations to hearing loss suggest stria vascularis devascularization as the mechanism of early hearing loss. (Wackym PA, Runge-Samuelson CL, Nash JJ, Poetker DM, Albano K, Bovi J, Michel MA, Friedland DR, Zhu YR, Hannley MT) Otol Neurotol 2010 Dec;31(9):1480-7 PMID: 20930653 SCOPUS ID: 2-s2.0-78649520552 10/12/2010       25 Citations
  • Association of hearing loss with PHACE syndrome. (Duffy KJ, Runge-Samuelson C, Bayer ML, Friedland D, Sulman C, Chun R, Kerschner JE, Metry D, Adams D, Drolet BA) Arch Dermatol 2010 Dec;146(12):1391-6 PMID: 20713775 SCOPUS ID: 2-s2.0-78650493680 08/18/2010       17 Citations
  • Case-control analysis of cochlear implant performance in elderly patients. (Friedland DR, Runge-Samuelson C, Baig H, Jensen J) Arch Otolaryngol Head Neck Surg 2010 May;136(5):432-8 PMID: 20479370 SCOPUS ID: 2-s2.0-77952467174 05/19/2010       58 Citations
  • The rocky road toward clinical genetic testing: insights into the physio-genetic basis of hearing loss. (Runge-Samuelson C, Olivier M) Physiol Genomics 2009 Oct 07;39(2):83-4 PMID: 19706690 PMCID: PMC2765068 SCOPUS ID: 2-s2.0-70350339789 08/27/2009       2 Citations
  • Case-control analysis of cochlear implant performance in the elderly case-control analysis of cochlear implant performance in the elderly (Runge-Samuelson C, Baig H, Jensen J, Wackym PA, Friedland D) Laryngoscope 2009;119(SUPPL. 1):126 SCOPUS ID: 2-s2.0-68449084680 08/17/2009    
  • Soft cochlear implantation: rationale for the surgical approach. (Friedland DR, Runge-Samuelson C) Trends Amplif 2009 Jun;13(2):124-38 PMID: 19447766 PMCID: PMC4111526 SCOPUS ID: 2-s2.0-65649097622 05/19/2009       65 Citations
  • Effects of high-rate pulse trains on electrode discrimination in cochlear implant users. (Runge-Samuelson CL) Trends Amplif 2009 Jun;13(2):76-86 PMID: 19447763 PMCID: PMC2763511 SCOPUS ID: 2-s2.0-65649148257 05/19/2009       2 Citations
  • Electrically evoked auditory brainstem responses in adults and children: effects of lateral to medial placement of the nucleus 24 contour electrode array. (Runge-Samuelson C, Firszt JB, Gaggl W, Wackym PA) Otol Neurotol 2009 Jun;30(4):464-70 PMID: 19300297 SCOPUS ID: 2-s2.0-68249132073 03/21/2009       7 Citations
  • Gamma Knife surgery of vestibular schwannomas: longitudinal changes in vestibular function and measurement of the Dizziness Handicap Inventory. (Wackym PA, Hannley MT, Runge-Samuelson CL, Jensen J, Zhu YR) J Neurosurg 2008 Dec;109 Suppl:137-43 PMID: 19123900 SCOPUS ID: 2-s2.0-58949085426 01/10/2009       18 Citations
  • Feasibility of auditory cortical stimulation for the treatment of tinnitus. (Friedland DR, Gaggl W, Runge-Samuelson C, Ulmer JL, Kopell BH) Otol Neurotol 2007 Dec;28(8):1005-12 PMID: 18043428 SCOPUS ID: 2-s2.0-36549027472 11/29/2007       60 Citations
  • Quantitative analysis of electrically evoked auditory brainstem responses in implanted children with auditory neuropathy/dyssynchrony. (Runge-Samuelson CL, Drake S, Wackym PA) Otol Neurotol 2008 Feb;29(2):174-8 PMID: 18025997 SCOPUS ID: 2-s2.0-38649108545 11/21/2007       16 Citations
  • More challenging speech-perception tasks demonstrate binaural benefit in bilateral cochlear implant users. (Wackym PA, Runge-Samuelson CL, Firszt JB, Alkaf FM, Burg LS) Ear Hear 2007 Apr;28(2 Suppl):80S-85S PMID: 17496654 SCOPUS ID: 2-s2.0-34247581296 05/15/2007       45 Citations
  • Biomechanical strength of reconstruction plates when used for medial support of MED-El cochlear implants: implications for diagnostic MRI. (Poetker DM, Wackym PA, Yoganandan N, Runge-Samuelson CL, Firszt JB, Pintar FA) ORL J Otorhinolaryngol Relat Spec 2006;68(2):77-82 PMID: 16432305 SCOPUS ID: 2-s2.0-33644928452 01/25/2006       5 Citations
  • Gamma Knife Radiosurgery and Other Forms of Radiosurgery for Management of Skull Base Tumors (Wackym AP, Runge-Samuelson CL) Neurotology 2005:1164-1186 SCOPUS ID: 2-s2.0-32744454862 12/01/2005    
  • Distortion of magnetic resonance images used in gamma knife radiosurgery treatment planning: implications for acoustic neuroma outcomes. (Poetker DM, Jursinic PA, Runge-Samuelson CL, Wackym PA) Otol Neurotol 2005 Nov;26(6):1220-8 PMID: 16272946 SCOPUS ID: 2-s2.0-22244456142 11/08/2005       16 Citations
  • Intraoperative assessment of cochlear implant and auditory brainstem implant device function (Firszt JB, Runge-Samuelson CL, Wackym PA) Operative Techniques in Otolaryngology - Head and Neck Surgery June 2005;16(2):131-139 SCOPUS ID: 2-s2.0-23344444807 06/01/2005    
  • Auditory brainstem implantation (Wackym PA, Runge-Samuelson CL, Firszt JB) Operative Techniques in Otolaryngology - Head and Neck Surgery June 2005;16(2):159-163 SCOPUS ID: 2-s2.0-23344438826 06/01/2005    
  • Cochlear implantation in children younger than 12 months of age (Wackym PA, Firszt JB, Runge-Samuelson CL) Operative Techniques in Otolaryngology - Head and Neck Surgery June 2005;16(2):101-106 SCOPUS ID: 2-s2.0-23344439266 01/01/2005    
  • Electrosurgery after cochlear implantation: eighth nerve electrophysiology. (Poetker DM, Runge-Samuelson CL, Firszt JB, Wackym PA) Laryngoscope 2004 Dec;114(12):2252-4 PMID: 15564856 SCOPUS ID: 2-s2.0-10044243977 11/27/2004       12 Citations
  • Multidisciplinary approach for ABI recipients: Surgical, electrophysiologic, and behavioral outcomes (Wackym PA, Runge-Samuelson CL, Firszt JB) International Congress Series 1 November 2004;1273(C):433-436 SCOPUS ID: 2-s2.0-33644494628 11/01/2004    
  • Gamma knife radiosurgery for acoustic neuromas performed by a neurotologist: early experiences and outcomes. (Wackym PA, Runge-Samuelson CL, Poetker DM, Michel MA, Alkaf FM, Burg LS, Firszt JB) Otol Neurotol 2004 Sep;25(5):752-61 PMID: 15354007 SCOPUS ID: 2-s2.0-4544252630 09/09/2004       27 Citations
  • Fungal biofilm formation on cochlear implant hardware after antibiotic-induced fungal overgrowth within the middle ear. (Cristobal R, Edmiston CE Jr, Runge-Samuelson CL, Owen HA, Firszt JB, Wackym PA) Pediatr Infect Dis J 2004 Aug;23(8):774-8 PMID: 15295230 SCOPUS ID: 2-s2.0-4043133715 08/06/2004       16 Citations
  • Recognition of speech presented at soft to loud levels by adult cochlear implant recipients of three cochlear implant systems. (Firszt JB, Holden LK, Skinner MW, Tobey EA, Peterson A, Gaggl W, Runge-Samuelson CL, Wackym PA) Ear Hear 2004 Aug;25(4):375-87 PMID: 15292777 SCOPUS ID: 2-s2.0-3543118454 08/05/2004       159 Citations
  • Effect of magnetic resonance imaging on internal magnet strength in Med-El Combi 40+ cochlear implants. (Wackym PA, Michel MA, Prost RW, Banks KL, Runge-Samuelson CL, Firszt JB) Laryngoscope 2004 Aug;114(8):1355-61 PMID: 15280707 SCOPUS ID: 2-s2.0-3843071110 07/29/2004       34 Citations
  • Response of the auditory nerve to sinusoidal electrical stimulation: effects of high-rate pulse trains. (Runge-Samuelson CL, Abbas PJ, Rubinstein JT, Miller CA, Robinson BK) Hear Res 2004 Aug;194(1-2):1-13 PMID: 15276671 SCOPUS ID: 2-s2.0-3342996932 07/28/2004       12 Citations
  • Auditory sensitivity in children using the auditory steady-state response. (Firszt JB, Gaggl W, Runge-Samuelson CL, Burg LS, Wackym PA) Arch Otolaryngol Head Neck Surg 2004 May;130(5):536-40 PMID: 15148173 SCOPUS ID: 2-s2.0-2342552081 05/19/2004       36 Citations
  • Connexin 26 and connexin 30 mutations in children with nonsyndromic hearing loss. (Erbe CB, Harris KC, Runge-Samuelson CL, Flanary VA, Wackym PA) Laryngoscope 2004 Apr;114(4):607-11 PMID: 15064611 SCOPUS ID: 2-s2.0-1842505708 04/06/2004       24 Citations
  • Electrophysiologic effects of placing cochlear implant electrodes in a perimodiolar position in young children. (Wackym PA, Firszt JB, Gaggl W, Runge-Samuelson CL, Reeder RM, Raulie JC) Laryngoscope 2004 Jan;114(1):71-6 PMID: 14709998 SCOPUS ID: 2-s2.0-0942265287 01/08/2004       32 Citations
  • Auditory nerve responses to monophasic and biphasic electric stimuli. (Miller CA, Robinson BK, Rubinstein JT, Abbas PJ, Runge-Samuelson CL) Hear Res 2001 Jan;151(1-2):79-94 PMID: 11124454 SCOPUS ID: 2-s2.0-0035211726 12/22/2000       61 Citations
  • Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13). (McGuirt WT, Prasad SD, Griffith AJ, Kunst HP, Green GE, Shpargel KB, Runge C, Huybrechts C, Mueller RF, Lynch E, King MC, Brunner HG, Cremers CW, Takanosu M, Li SW, Arita M, Mayne R, Prockop DJ, Van Camp G, Smith RJ) Nat Genet 1999 Dec;23(4):413-9 PMID: 10581026 SCOPUS ID: 2-s2.0-0032755733 12/02/1999       181 Citations
  • Last update: 09/17/2020
    jenkins-FCD Prod-480 9a4deaf152b0b06dd18151814fff2e18f6c05280