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Cynthia A. Lien MD

Cynthia A. Lien MD

Chair, Professor

Institution: Medical College of Wisconsin
Department: Anesthesiology
Division: Administration
Program: Froedtert Hospital East

Member of the Comprehensive Injury Center


Research Experience

  • Dose-Response Relationship, Drug
  • Education
  • Neuromuscular Blocking Agents
  • Neuromuscular Depolarizing Agents
  • Neuromuscular Nondepolarizing Agents
  • Pharmacokinetics
  • Clinical Expertise

  • Anesthesiology
  • Leadership Positions

  • John P. Kampine Professor and Chair
  • Publications

  • In Reply. (Warner DO, Zhou Y, Keegan MT, Lien CA, Sun H) Anesthesiology 2018 Dec;129(6):1191-1192 PMID: 30422859 11/14/2018    
  • Optimizing Patient Access During an Emergency While Using Intraoperative Computed Tomography. (Bustillo MA, Lien CA, Mack PF, Kopman DJ, Safavynia SA, Rubin L, Stein D, Hartl R, Stieg PE, Hernandez RN, Goldstein PA) World Neurosurg 2019 Jan;121:274-278.e1 PMID: 30266700 09/30/2018    
  • If Only the Practice of Evidence-Based Medicine Was as Simple as Creating Guidelines…. (Lien CA) Anesth Analg 2018 Jul;127(1):9-11 PMID: 29912053 06/19/2018    
  • Gender Distribution of the American Board of Anesthesiology Diplomates, Examiners, and Directors (1985-2015). (Fahy BG, Culley DJ, Sun H, Dainer R, Lutkoski BP, Lien CA) Anesth Analg 2018 Aug;127(2):564-568 PMID: 29683833 04/24/2018    
  • Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers. (Kaullen JD, Owen JS, Brouwer KLR, Heerdt PM, Lien CA, Savarese JJ, Schmith VD) Anesthesiology 2018 Jun;128(6):1107-1116 PMID: 29494403 PMCID: PMC5953789 03/02/2018    
  • Effect of the BASIC Examination on Knowledge Acquisition during Anesthesiology Residency. (Zhou Y, Sun H, Lien CA, Keegan MT, Wang T, Harman AE, Warner DO) Anesthesiology 2018 Apr;128(4):813-820 PMID: 29251641 12/19/2017    
  • Simulation for Assessment of the Practice of Board-certified Anesthesiologists. (Lien CA, Warner MA, Rathmell JP) Anesthesiology 2017 09;127(3):410-412 PMID: 28671902 07/04/2017       1 Citations
  • The ABMS MOC Part III Examination: Value, Concerns, and Alternative Formats. (Hawkins RE, Irons MB, Welcher CM, Pouwels MV, Holmboe ES, Reisdorff EJ, Cohen JM, Dentzer S, Nichols DG, Lien CA, Horn TD, Noone RB, Lipner RS, Eva KW, Norcini JJ, Nora LM, Gold JP) Acad Med 2016 11;91(11):1509-1515 PMID: 27355778 10/26/2016       4 Citations
  • Association between Participation in an Intensive Longitudinal Assessment Program and Performance on a Cognitive Examination in the Maintenance of Certification in Anesthesiology Program®. (Sun H, Zhou Y, Culley DJ, Lien CA, Harman AE, Warner DO) Anesthesiology 2016 11;125(5):1046-1055 PMID: 27560464 10/19/2016       6 Citations
  • Dose-response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man. (Heerdt PM, Sunaga H, Owen JS, Murrell MT, Malhotra JK, Godfrey D, Steinkamp M, Savard P, Savarese JJ, Lien CA) Anesthesiology 2016 12;125(6):1136-1143 PMID: 27749289 10/18/2016       5 Citations
  • Education in Anesthesiology: Is It Time to Expand the Focus? (McEvoy MD, Lien CA) A A Case Rep 2016 Jun 15;6(12):380-2 PMID: 27301051 06/15/2016       3 Citations
  • Provider Board Certification Status and Practice Patterns in Total Knee Arthroplasty. (Fleischut PM, Eskreis-Winkler JM, Gaber-Baylis LK, Giambrone GP, Wu X, Sun X, Lien CA, Faggiani SL, Dutton RP, Memtsoudis SG) Acad Med 2016 Jan;91(1):79-86 PMID: 26200572 PMCID: PMC4826752 07/23/2015       5 Citations
  • Predictors of performance on the Maintenance of Certification in Anesthesiology Program® (MOCA®) examination. (Sun H, Culley DJ, Lien CA, Kitchener DL, Harman AE, Warner DO) J Clin Anesth 2015 Feb;27(1):1-6 PMID: 25468588 12/04/2014       5 Citations
  • Current recommendations for monitoring depth of neuromuscular blockade. (Lien CA, Kopman AF) Curr Opin Anaesthesiol 2014 Dec;27(6):616-22 PMID: 25251919 09/25/2014       17 Citations
  • In reply. (Rathmell JP, Lien CA, Harman A) Anesthesiology 2014 Aug;121(2):432 PMID: 25050507 07/23/2014    
  • A need to establish programs to detect and prevent drug diversion. (Lien CA) Mayo Clin Proc 2012 Jul;87(7):607-9 PMID: 22766079 PMCID: PMC3498429 07/07/2012    
  • Development and potential clinical impairment of ultra-short-acting neuromuscular blocking agents. (Lien CA) Br J Anaesth 2011 Dec;107 Suppl 1:i60-71 PMID: 22156271 12/22/2011       21 Citations
  • Neuromuscular dose-response studies: determining sample size. (Kopman AF, Lien CA, Naguib M) Br J Anaesth 2011 Feb;106(2):194-8 PMID: 21068050 11/12/2010       9 Citations
  • Determining the potency of neuromuscular blockers: are traditional methods flawed? (Kopman AF, Lien CA, Naguib M) Br J Anaesth 2010 Jun;104(6):705-10 PMID: 20430764 05/01/2010       8 Citations
  • Neostigmine: how much is necessary for patients who receive a nondepolarizing neuromuscular blocking agent? (Lien CA) Anesthesiology 2010 Jan;112(1):16-8 PMID: 19952723 12/03/2009       10 Citations
  • A survey of current management of neuromuscular block in the United States and Europe. (Naguib M, Kopman AF, Lien CA, Hunter JM, Lopez A, Brull SJ) Anesth Analg 2010 Jul;111(1):110-9 PMID: 19910616 11/17/2009       142 Citations
  • Fumarates: unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine. (Lien CA, Savard P, Belmont M, Sunaga H, Savarese JJ) J Crit Care 2009 Mar;24(1):50-7 PMID: 19272539 03/11/2009       18 Citations
  • Combining non-depolarizing neuromuscular blocking agents: synergism, addition or antagonism? (Lien CA) Curr Opin Anaesthesiol 1999 Jul;12(4):467-71 PMID: 17013353 10/03/2006    
  • Supplemental oxygen and risk of surgical wound infection. (Pryor KO, Lien CA, Fahey TJ 3rd, Goldstein PA) JAMA 2006 Apr 12;295(14):1642; author reply 1642-3 PMID: 16609081 04/13/2006       8 Citations
  • GW280430A: pharmacodynamics and potential adverse effects. (Lien CA, Belmont MR, Heerdt PM) Anesthesiology 2005 Apr;102(4):861-2; author reply 862-3 PMID: 15791118 03/26/2005       7 Citations
  • Posttetanic potentiation and fade in the response to tetanic and train-of-four stimulation during succinylcholine-induced block. (Naguib M, Lien CA, Aker J, Eliazo R) Anesth Analg 2004 Jun;98(6):1686-91, table of contents PMID: 15155329 05/25/2004       10 Citations
  • Clinical pharmacology of GW280430A in humans. (Belmont MR, Lien CA, Tjan J, Bradley E, Stein B, Patel SS, Savarese JJ) Anesthesiology 2004 Apr;100(4):768-73 PMID: 15087609 04/17/2004       53 Citations
  • Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial. (Pryor KO, Fahey TJ 3rd, Lien CA, Goldstein PA) JAMA 2004 Jan 07;291(1):79-87 PMID: 14709579 01/08/2004       257 Citations
  • Dexmedetomidine and neurocognitive testing in awake craniotomy. (Mack PF, Perrine K, Kobylarz E, Schwartz TH, Lien CA) J Neurosurg Anesthesiol 2004 Jan;16(1):20-5 PMID: 14676565 12/17/2003       108 Citations
  • Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium. (Suzuki T, Lien CA, Belmont MR, Tjan J, Savarese JJ) Can J Anaesth 2003 Nov;50(9):879-85 PMID: 14617582 11/18/2003       3 Citations
  • Regional versus general anesthesia for hip surgery in older patients: does the choice affect patient outcome? (Lien CA) J Am Geriatr Soc 2002 Jan;50(1):191-4 PMID: 12028267 05/25/2002       13 Citations
  • Postoperative narcotic requirement after microscopic lumbar discectomy is not affected by intraoperative ketorolac or bupivacaine. (Mack PF, Hass D, Lavyne MH, Snow RB, Lien CA) Spine (Phila Pa 1976) 2001 Mar 15;26(6):658-61 PMID: 11246381 03/14/2001       37 Citations
  • Pharmacodynamics and the plasma concentration of mivacurium during spontaneous recovery and neostigmine-facilitated recovery. (Lien CA, Belmont MR, Wray Roth DL, Okamoto M, Abalos A, Savarese JJ) Anesthesiology 1999 Jul;91(1):119-26 PMID: 10422936 07/28/1999       7 Citations
  • The nature of spontaneous recovery from mivacurium-induced neuromuscular block. (Lien CA, Belmont MR, Abalos A, Hass D, Savarese JJ) Anesth Analg 1999 Mar;88(3):648-53 PMID: 10072021 03/11/1999       12 Citations
  • [The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium]. (Savarese JJ, Lien CA, Belmont MR, Wastila WB) Anaesthesist 1997 Oct;46(10):840-9 PMID: 9424966 01/10/1998       14 Citations
  • Emergence and extubation: a systematic approach. (Lien CA, Koff H, Malhotra V, Gadalla F) Anesth Analg 1997 Nov;85(5):1177 PMID: 9356123 11/14/1997       7 Citations
  • A comparison: the efficacy of sevoflurane-nitrous oxide or propofol-nitrous oxide for the induction and maintenance of general anesthesia. (Lien CA, Hemmings HC, Belmont MR, Abalos A, Hollmann C, Kelly RE) J Clin Anesth 1996 Dec;8(8):639-43 PMID: 8982891 12/01/1996       28 Citations
  • Importance of the organ-independent elimination of cisatracurium. (Kisor DF, Schmith VD, Wargin WA, Lien CA, Ornstein E, Cook DR) Anesth Analg 1996 Nov;83(5):1065-71 PMID: 8895287 11/01/1996       100 Citations
  • Efficacy and safety of divided dose administration of mivacurium for a 90-second tracheal intubation. (Ali HH, Lien CA, Witkowski T, Brull SJ, Stout RG, Bartkowski R, Silverman DG, Patel S, Ascher JA, Goudsouzian NG) J Clin Anesth 1996 Jun;8(4):276-81 PMID: 8695129 06/01/1996       18 Citations
  • Antagonism of residual mivacurium blockade: setting the record straight. (Savarese JJ, Lien CA, Belmont MR) Anesthesiology 1996 Jun;84(6):1525-8 PMID: 8669705 06/01/1996       2 Citations
  • The comparative effects of sevoflurane versus propofol in the induction and maintenance of anesthesia in adult patients. (Jellish WS, Lien CA, Fontenot HJ, Hall R) Anesth Analg 1996 Mar;82(3):479-85 PMID: 8623947 03/01/1996       116 Citations
  • Pharmacodynamics and pharmacokinetics of cisatracurium in geriatric surgical patients. (Ornstein E, Lien CA, Matteo RS, Ostapkovich ND, Diaz J, Wolf KB) Anesthesiology 1996 Mar;84(3):520-5 PMID: 8659778 03/01/1996       69 Citations
  • Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia. (Lien CA, Schmith VD, Belmont MR, Abalos A, Kisor DF, Savarese JJ) Anesthesiology 1996 Feb;84(2):300-8 PMID: 8602660 02/01/1996       64 Citations
  • The clinical neuromuscular pharmacology of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. (Belmont MR, Lien CA, Quessy S, Abou-Donia MM, Abalos A, Eppich L, Savarese JJ) Anesthesiology 1995 May;82(5):1139-45 PMID: 7741288 05/01/1995       147 Citations
  • The cardiovascular effects and histamine-releasing properties of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. (Lien CA, Belmont MR, Abalos A, Eppich L, Quessy S, Abou-Donia MM, Savarese JJ) Anesthesiology 1995 May;82(5):1131-8 PMID: 7537945 05/01/1995       117 Citations
  • The accuracy of the 5%-25% (T1-T3) twitch recovery interval in predicting the speed of spontaneous recovery from mivacurium-induced neuromuscular blockade. (Savarese JJ, Lien CA, Belmont MR) Anesth Analg 1995 Jan;80(1):209-10 PMID: 7802290 01/01/1995       4 Citations
  • The clinical and basic pharmacology of mivacurium: a short-acting nondepolarizing benzylisoquinolinium diester neuromuscular blocking drug. (Savarese JJ, Lien CA, Belmont MR, Rubin L) Acta Anaesthesiol Scand Suppl 1995;106:18-22 PMID: 8533538 01/01/1995       11 Citations
  • The pharmacokinetics and pharmacodynamics of the stereoisomers of mivacurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia. (Lien CA, Schmith VD, Embree PB, Belmont MR, Wargin WA, Savarese JJ) Anesthesiology 1994 Jun;80(6):1296-302 PMID: 8010476 06/01/1994       72 Citations
  • The effect of ondansetron on atracurium-induced neuromuscular blockade. (Lien CA, Gadalla F, Kudlak TT, Embree PB, Sharp GJ, Savarese JJ) J Clin Anesth 1993 Sep-Oct;5(5):399-403 PMID: 8217176 09/01/1993       7 Citations
  • Depression of neuromuscular function in a patient during desflurane anesthesia. (Kelly RE, Lien CA, Savarese JJ, Belmont MR, Hartman GS, Russo JR, Hollmann C) Anesth Analg 1993 Apr;76(4):868-71 PMID: 8466031 04/01/1993       13 Citations
  • Unexplained bradycardia during craniotomy closure: the role of intracranial hypotension. (Wasnick JD, Lien CA, Rubin LA, Fraser RA) Anesth Analg 1993 Feb;76(2):432-3 PMID: 7818607 02/01/1993       18 Citations
  • Distribution, elimination, and action of vecuronium in the elderly. (Lien CA, Matteo RS, Ornstein E, Schwartz AE, Diaz J) Anesth Analg 1991 Jul;73(1):39-42 PMID: 1677546 07/01/1991       44 Citations
  • Effect of massive intraoperative thiopental loading on cardiovascular hemodynamics and myocardial performance. (Stone JG, Young WL, Khambatta HJ, Lien CA, Hsu DT, Solomon RA, Smith CR) J Neurosurg Anesthesiol 1991 Jun;3(2):132-5 PMID: 15815392 06/01/1991    
  • Last update: 12/18/2018
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