Medical College of Wisconsin
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Daochun Sun PhD

Daochun Sun PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center


I am willing to collaborate on research projects.

View Curriculum Vitae

Research Areas of Interest

  • Computational Biology
  • Developmental Biology
  • Glioblastoma
  • Glioma
  • Neoplastic Stem Cells
  • Neural Crest
  • Neural Stem Cells
  • Neurofibroma
  • Neurofibroma, Plexiform
  • Neurofibromatosis 1
  • Stem Cell Niche

    • Research Experience

  • Glioblastoma
  • Nerve Sheath Neoplasms
  • Neurofibroma, Plexiform
  • Neurofibromatosis 1
  • Peripheral Nervous System Neoplasms

    • Publications (25)

  • Natural history of SPP1 signaling in NF1 tumors. (Njoya K, Zayed H, Sun L, Alson D, Aina O, Khan S, Veneklasen X, Lytle N, Chaluvally-Raghavan P, Sun D) NPJ Precis Oncol 2025 Oct 06;9(1):320 PMID: 41053414 PMCID: PMC12501028 SCOPUS ID: 2-s2.0-105018220877 10/07/2025    
  • The Combination of HSP90 Inhibitors and Selumetinib Reinforces the Inhibitory Effects on Plexiform Neurofibromas. (Khan S, Aina O, Veneklasen X, Edens H, Alson D, Sun L, Zayed H, Njoya K, Sun D) Cancers (Basel) 2025 Jul 16;17(14) PMID: 40723243 PMCID: PMC12293785 SCOPUS ID: 2-s2.0-105011769892 07/29/2025    
  • Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors. (Sait SF, Tang KH, Angus SP, Brown R, Sun D, Xie X, Iltis C, Lien M, D Socci N, Bale TA, Davis C, Dixon SAH, Zhang C, Wade Clapp D, Neel BG, Parada LF) Proc Natl Acad Sci U S A 2025 Jan 07;122(1):e2407745121 PMID: 39793045 PMCID: PMC11725864 SCOPUS ID: 2-s2.0-85214365299 01/10/2025       2 Citations
  • Glioblastoma functional heterogeneity and enrichment of cancer stem cells with tumor recurrence (Xie XP, Ganbold M, Li J, Lien M, Chipman ME, Wang T, Jayewickreme CD, Pedraza AM, Bale T, Tabar V, Brennan C, Sun D, Sharma R, Parada LF) Neuron 18 December 2024;112(24):4017-4032.e6 SCOPUS ID: 2-s2.0-85208408102 12/18/2024       10 Citations
  • Leveraging Neural Crest-Derived Tumors to Identify NF1 Cancer Stem Cell Signatures. (Khan S, Alson D, Sun L, Maloney C, Sun D) Cancers (Basel) 2024 Oct 29;16(21) PMID: 39518076 PMCID: PMC11545784 SCOPUS ID: 2-s2.0-85208430439 11/13/2024       1 Citation
  • Glioblastoma functional heterogeneity and enrichment of cancer stem cells with tumor recurrence. (Xie XP, Ganbold M, Li J, Lien M, Chipman ME, Wang T, Jayewickreme CD, Pedraza AM, Bale T, Tabar V, Brennan C, Sun D, Sharma R, Parada LF) Neuron 2024 Dec 18;112(24):4017-4032.e6 PMID: 39510072 PMCID: PMC11659040 SCOPUS ID: 2-s2.0-85208408102 11/13/2024       10 Citations
  • The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy. (Pierpont EI, Bennett AM, Schoyer L, Stronach B, Anschutz A, Borrie SC, Briggs B, Burkitt-Wright E, Castel P, Cirstea IC, Draaisma F, Ellis M, Fear VS, Frone MN, Flex E, Gelb BD, Green T, Gripp KW, Khoshkhoo S, Kieran MW, Kleemann K, Klein-Tasman BP, Kontaridis MI, Kruszka P, Leoni C, Liu CZ, Merchant N, Magoulas PL, Moertel C, Prada CE, Rauen KA, Roelofs R, Rossignol R, Sevilla C, Sevilla G, Sheedy R, Stieglitz E, Sun D, Tiemens D, White F, Wingbermühle E, Wolf C, Zenker M, Andelfinger G) Am J Med Genet A 2024 Apr;194(4):e63477 PMID: 37969032 PMCID: PMC10939912 SCOPUS ID: 2-s2.0-85176918944 11/16/2023       5 Citations
  • Tumor progression is independent of tumor-associated macrophages in cell lineage-based mouse models of glioblastoma. (Chipman ME, Wang Z, Sun D, Pedraza AM, Bale TA, Parada LF) Proc Natl Acad Sci U S A 2023 Apr 18;120(16):e2222084120 PMID: 37040416 PMCID: PMC10120014 SCOPUS ID: 2-s2.0-85152244270 04/12/2023       8 Citations
  • Integrated Drug Mining Reveals Actionable Strategies Inhibiting Plexiform Neurofibromas. (Brown RM, Farouk Sait S, Dunn G, Sullivan A, Bruckert B, Sun D) Brain Sci 2022 May 31;12(6) PMID: 35741605 PMCID: PMC9221468 SCOPUS ID: 2-s2.0-85134032406 06/25/2022       3 Citations
  • Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy. (Xie XP, Laks DR, Sun D, Ganbold M, Wang Z, Pedraza AM, Bale T, Tabar V, Brennan C, Zhou X, Parada LF) Dev Cell 2022 Jan 10;57(1):32-46.e8 PMID: 35016005 PMCID: PMC8820651 SCOPUS ID: 2-s2.0-85123256377 01/12/2022       125 Citations
  • Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression. (Sun D, Xie XP, Zhang X, Wang Z, Sait SF, Iyer SV, Chen YJ, Brown R, Laks DR, Chipman ME, Shern JF, Parada LF) Cell Stem Cell 2021 Aug 05;28(8):1397-1410.e4 PMID: 34010628 PMCID: PMC8349880 SCOPUS ID: 2-s2.0-85107299241 05/20/2021       35 Citations
  • High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging. (Xie XP, Laks DR, Sun D, Poran A, Laughney AM, Wang Z, Sam J, Belenguer G, Fariñas I, Elemento O, Zhou X, Parada LF) Proc Natl Acad Sci U S A 2020 Dec 08;117(49):31448-31458 PMID: 33229571 PMCID: PMC7733854 SCOPUS ID: 2-s2.0-85097581685 11/25/2020       41 Citations
  • Cell Lineage-Based Stratification for Glioblastoma. (Wang Z, Sun D, Chen YJ, Xie X, Shi Y, Tabar V, Brennan CW, Bale TA, Jayewickreme CD, Laks DR, Alcantara Llaguno S, Parada LF) Cancer Cell 2020 Sep 14;38(3):366-379.e8 PMID: 32649888 PMCID: PMC7494533 SCOPUS ID: 2-s2.0-85088376925 07/11/2020       83 Citations
  • Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. (Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF) Nature 2019 Mar;567(7748):341-346 PMID: 30842654 PMCID: PMC6655586 SCOPUS ID: 2-s2.0-85063281637 03/08/2019       257 Citations
  • Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction. (Alcantara Llaguno S, Sun D, Pedraza AM, Vera E, Wang Z, Burns DK, Parada LF) Nat Neurosci 2019 Apr;22(4):545-555 PMID: 30778149 PMCID: PMC6594191 SCOPUS ID: 2-s2.0-85061730449 02/20/2019       110 Citations
  • Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes. (Alcantara Llaguno SR, Wang Z, Sun D, Chen J, Xu J, Kim E, Hatanpaa KJ, Raisanen JM, Burns DK, Johnson JE, Parada LF) Cancer Cell 2015 Oct 12;28(4):429-440 PMID: 26461091 PMCID: PMC4607935 SCOPUS ID: 2-s2.0-84944041780 10/16/2015       176 Citations
  • Brief biography of Daochun sun (Sun D) Current Bioinformatics 1 March 2015;10(1):1 SCOPUS ID: 2-s2.0-84928797117 03/01/2015    
  • RAS/MEK-independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST. (Sun D, Haddad R, Kraniak JM, Horne SD, Tainsky MA) Mol Cancer Res 2013 Jun;11(6):616-27 PMID: 23423222 SCOPUS ID: 2-s2.0-84879300153 02/21/2013       12 Citations
  • Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy. (Sun D, Tainsky MA, Haddad R) Transl Oncogenomics 2012;5:1-7 PMID: 22346343 PMCID: PMC3273949 SCOPUS ID: 2-s2.0-84856994155 02/22/2012       12 Citations
  • The role of neurofibromin in N-Ras mediated AP-1 regulation in malignant peripheral nerve sheath tumors. (Kraniak JM, Sun D, Mattingly RR, Reiners JJ Jr, Tainsky MA) Mol Cell Biochem 2010 Nov;344(1-2):267-76 PMID: 20680410 PMCID: PMC3809002 SCOPUS ID: 2-s2.0-78449304547 08/04/2010       12 Citations
  • Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. (Sun Y, Sun D, Li F, Tian L, Li C, Li L, Lin R, Wang S) Lung Cancer 2007 Oct;58(1):21-9 PMID: 17624472 SCOPUS ID: 2-s2.0-34548598664 07/13/2007       69 Citations
  • Identification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis. (Huang M, Wang Y, Sun D, Zhu H, Yin Y, Zhang W, Yang S, Quan L, Bai J, Wang S, Chen Q, Li S, Xu N) BMC Cancer 2006 Sep 07;6:221 PMID: 16959035 PMCID: PMC1574340 SCOPUS ID: 2-s2.0-33749034704 09/09/2006       47 Citations
  • Microarray analysis of differentially expressed genes in mouse bone marrow tissues after ionizing radiation. (Dai JM, Sun DC, Lin RX, Yang J, Lou S, Wang SQ) Int J Radiat Biol 2006 Jul;82(7):511-21 PMID: 16882623 SCOPUS ID: 2-s2.0-33746819082 08/03/2006       19 Citations
  • Selection of antisense oligonucleotides based on multiple predicted target mRNA structures. (Bo X, Lou S, Sun D, Shu W, Yang J, Wang S) BMC Bioinformatics 2006 Mar 09;7:122 PMID: 16526963 PMCID: PMC1421440 SCOPUS ID: 2-s2.0-33645469194 03/11/2006       11 Citations
  • AOBase: a database for antisense oligonucleotides selection and design. (Bo X, Lou S, Sun D, Yang J, Wang S) Nucleic Acids Res 2006 Jan 01;34(Database issue):D664-7 PMID: 16381954 PMCID: PMC1347428 SCOPUS ID: 2-s2.0-33644877165 12/31/2005       8 Citations
    • Last update: 01/19/2026