Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Herve Falet PhD

Herve Falet PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration


I am willing to mentor a junior faculty member.
I am willing to collaborate on research projects.


Publications (50)

  • Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. (Unsworth AJ, Bye AP, Sage T, Gaspar RS, Eaton N, Drew C, Stainer A, Kriek N, Volberding PJ, Hutchinson JL, Riley R, Jones S, Mundell SJ, Cui W, Falet H, Gibbins JM) Haematologica 2020 May 28 PMID: 32467143 05/30/2020    
  • β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis. (Giannini S, Lee-Sundlov MM, Rivadeneyra L, Di Buduo CA, Burns R, Lau JT, Falet H, Balduini A, Hoffmeister KM) Nat Commun 2020 01 17;11(1):356 PMID: 31953383 PMCID: PMC6968998 01/19/2020       3 Citations
  • Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice. (Eaton N, Drew C, Wieser J, Munday AD, Falet H) Haematologica 2020 May;105(5):1414-1423 PMID: 31296575 PMCID: PMC7193499 07/13/2019    
  • Singling out FLI1 in Paris-Trousseau syndrome. (Falet H) Blood 2017 06 29;129(26):3399-3401 PMID: 28663223 PMCID: PMC5492094 07/01/2017    
  • Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets. (Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Falet H, Kaminski K, Freedman JE, Liao JK) Cardiovasc Res 2017 Sep 01;113(11):1307-1317 PMID: 28430966 PMCID: PMC5852540 04/22/2017       8 Citations
  • Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance. (Hoffmeister KM, Falet H) Thromb Res 2016 May;141 Suppl 2:S68-72 PMID: 27207430 PMCID: PMC5399515 05/22/2016       22 Citations
  • Glycans and the platelet life cycle. (Li R, Hoffmeister KM, Falet H) Platelets 2016 Sep;27(6):505-11 PMID: 27135356 PMCID: PMC5396182 05/03/2016       24 Citations
  • Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases. (Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM) Arterioscler Thromb Vasc Biol 2016 06;36(6):1164-73 PMID: 27079884 PMCID: PMC5407363 04/16/2016       29 Citations
  • Regulating billions of blood platelets: glycans and beyond. (Grozovsky R, Giannini S, Falet H, Hoffmeister KM) Blood 2015 Oct 15;126(16):1877-84 PMID: 26330242 PMCID: PMC4608239 09/04/2015       61 Citations
  • Novel mechanisms of platelet clearance and thrombopoietin regulation. (Grozovsky R, Giannini S, Falet H, Hoffmeister KM) Curr Opin Hematol 2015 Sep;22(5):445-51 PMID: 26154508 PMCID: PMC5326579 07/15/2015       16 Citations
  • FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. (Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H) Blood 2015 Jul 02;126(1):80-8 PMID: 25838348 PMCID: PMC4492198 04/04/2015       29 Citations
  • Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. (Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B) Nat Commun 2015 Mar 06;6:6507 PMID: 25744693 PMCID: PMC4400601 03/07/2015    
  • The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. (Grozovsky R, Begonja AJ, Liu K, Visner G, Hartwig JH, Falet H, Hoffmeister KM) Nat Med 2015 Jan;21(1):47-54 PMID: 25485912 PMCID: PMC4303234 12/09/2014       140 Citations
  • Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. (Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WH, Hoffmeister KM, Falet H) Blood 2015 Feb 05;125(6):1014-24 PMID: 25468568 PMCID: PMC4319232 12/04/2014       25 Citations
  • Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. (Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B) Nat Commun 2014 Sep 04;5:4746 PMID: 25187265 09/05/2014       58 Citations
  • Post-translational arginylation as a novel regulator of platelet function. (Bender M, Falet H) Haematologica 2014 Mar;99(3):402-4 PMID: 24598850 PMCID: PMC3943301 03/07/2014    
  • Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1. (Kim H, Falet H, Hoffmeister KM, Hartwig JH) J Biol Chem 2013 Nov 29;288(48):34352-63 PMID: 24133214 PMCID: PMC3843050 10/18/2013    
  • Sitosterolemia: platelets on high-sterol diet. (Falet H) Blood 2013 Oct 10;122(15):2534-5 PMID: 24113795 PMCID: PMC3795455 10/12/2013       2 Citations
  • Platelet size: finding the right balance. (Falet H) Blood 2012 Mar 22;119(12):2702-3 PMID: 22442332 03/24/2012    
  • New insights into the versatile roles of platelet FlnA. (Falet H) Platelets 2013;24(1):1-5 PMID: 22372530 PMCID: PMC6781629 03/01/2012       15 Citations
  • B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. (Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD) Blood 2012 Mar 22;119(12):2819-28 PMID: 22302739 PMCID: PMC3327460 02/04/2012       68 Citations
  • Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. (Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM) Blood 2012 Feb 02;119(5):1263-73 PMID: 22101895 PMCID: PMC3277358 11/22/2011       101 Citations
  • Gelsolin-independent podosome formation in dendritic cells. (Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP) PLoS One 2011;6(7):e21615 PMID: 21779330 PMCID: PMC3136926 07/23/2011       9 Citations
  • FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. (Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H) Blood 2011 Aug 25;118(8):2285-95 PMID: 21652675 PMCID: PMC3162356 06/10/2011       68 Citations
  • Novel clearance mechanisms of platelets. (Grozovsky R, Hoffmeister KM, Falet H) Curr Opin Hematol 2010 Nov;17(6):585-9 PMID: 20729731 PMCID: PMC4303238 08/24/2010       64 Citations
  • A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. (Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH) J Exp Med 2010 Aug 30;207(9):1967-79 PMID: 20713593 PMCID: PMC2931168 08/18/2010       80 Citations
  • Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. (Falet H, Marchetti MP, Hoffmeister KM, Massaad MJ, Geha RS, Hartwig JH) Blood 2009 Nov 19;114(21):4729-37 PMID: 19692704 PMCID: PMC2780308 08/21/2009       16 Citations
  • Differential stimulation of monocytic cells results in distinct populations of microparticles. (Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD) J Thromb Haemost 2009 Jun;7(6):1019-28 PMID: 19548909 PMCID: PMC3242443 06/25/2009       97 Citations
  • Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function. (Di Nardo A, Cicchetti G, Falet H, Hartwig JH, Stossel TP, Kwiatkowski DJ) Proc Natl Acad Sci U S A 2005 Nov 08;102(45):16263-8 PMID: 16254049 PMCID: PMC1283463 10/29/2005       47 Citations
  • Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics. (Falet H, Chang G, Brohard-Bohn B, Rendu F, Hartwig JH) Am J Physiol Cell Physiol 2005 Oct;289(4):C819-25 PMID: 15901596 05/20/2005       26 Citations
  • WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. (Kettner A, Kumar L, Antón IM, Sasahara Y, de la Fuente M, Pivniouk VI, Falet H, Hartwig JH, Geha RS) J Exp Med 2004 Feb 02;199(3):357-68 PMID: 14757742 PMCID: PMC2211794 02/06/2004       40 Citations
  • Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. (Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS) Int Immunol 2003 Dec;15(12):1431-40 PMID: 14645152 12/03/2003       34 Citations
  • Platelet moesin interacts with PECAM-1 (CD31). (Gamulescu MA, Seifert K, Tingart M, Falet H, Hoffmeister KM) Platelets 2003 Jun;14(4):211-7 PMID: 12850829 07/10/2003       16 Citations
  • Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change. (Barkalow KL, Falet H, Italiano JE Jr, van Vugt A, Carpenter CL, Schreiber AD, Hartwig JH) Am J Physiol Cell Physiol 2003 Oct;285(4):C797-805 PMID: 12788695 06/06/2003       12 Citations
  • Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. (Kettner A, Pivniouk V, Kumar L, Falet H, Lee JS, Mulligan R, Geha RS) Mol Cell Biol 2003 Apr;23(7):2395-406 PMID: 12640123 PMCID: PMC150723 03/18/2003       34 Citations
  • Mechanisms and implications of platelet discoid shape. (Italiano JE Jr, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA) Blood 2003 Jun 15;101(12):4789-96 PMID: 12586623 02/15/2003       116 Citations
  • The clearance mechanism of chilled blood platelets. (Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH) Cell 2003 Jan 10;112(1):87-97 PMID: 12526796 01/16/2003       289 Citations
  • Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealants. (Michaud SE, Wang LZ, Korde N, Bucki R, Randhawa PK, Pastore JJ, Falet H, Hoffmeister K, Kuuse R, Uibo R, Herod J, Sawyer E, Janmey PA) Thromb Res 2002 Sep 01;107(5):245-54 PMID: 12479886 12/14/2002       29 Citations
  • Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. (Falet H, Hoffmeister KM, Neujahr R, Italiano JE Jr, Stossel TP, Southwick FS, Hartwig JH) Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16782-7 PMID: 12464680 PMCID: PMC139221 12/05/2002       63 Citations
  • Normal Arp2/3 complex activation in platelets lacking WASp. (Falet H, Hoffmeister KM, Neujahr R, Hartwig JH) Blood 2002 Sep 15;100(6):2113-22 PMID: 12200375 08/30/2002       56 Citations
  • Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. (Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH, Stossel TP) J Cell Biol 2001 Nov 12;155(4):511-7 PMID: 11706047 PMCID: PMC2198874 11/14/2001       11 Citations
  • Mechanisms of cold-induced platelet actin assembly. (Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH) J Biol Chem 2001 Jul 06;276(27):24751-9 PMID: 11328807 05/01/2001       64 Citations
  • Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. (Falet H, Barkalow KL, Pivniouk VI, Barnes MJ, Geha RS, Hartwig JH) Blood 2000 Dec 01;96(12):3786-92 PMID: 11090061 11/23/2000       46 Citations
  • Tyrosine phosphorylation and association of FcgammaRII and p72(Syk) are not limited to the FcgammaRII signalling pathway. (Pain S, Falet H, Saci A, Bachelot-Loza C, Rendu F) Cell Signal 2000 Mar;12(3):165-71 PMID: 10704823 03/08/2000       14 Citations
  • Calpain controls the balance between protein tyrosine kinase and tyrosine phosphatase activities during platelet activation. (Pain S, Monstero-Lastres A, Falet H, Brohard-Bohn B, Fraiz N, Bachelot-Loza C, Cano E, Rendu F) FEBS Lett 1999 Jun 18;453(1-2):119-23 PMID: 10403387 07/14/1999       5 Citations
  • Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain. (Falet H, Pain S, Rendu F) Biochem Biophys Res Commun 1998 Nov 09;252(1):51-5 PMID: 9813145 11/14/1998       22 Citations
  • Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c-Src in human platelets. (Falet H, Ramos-Morales F, Bachelot C, Fischer S, Rendu F) FEBS Lett 1996 Apr 01;383(3):165-9 PMID: 8925889 04/01/1996       36 Citations
  • The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: comparison with thrombin. (Si-Tahar M, Renesto P, Falet H, Rendu F, Chignard M) Biochem J 1996 Jan 15;313 ( Pt 2):401-8 PMID: 8573071 PMCID: PMC1216922 01/15/1996       32 Citations
  • Different abilities of thrombin receptor activating peptide and thrombin to induce platelet calcium rise and full release reaction. (Lasne D, Donato J, Falet H, Rendu F) Thromb Haemost 1995 Nov;74(5):1323-8 PMID: 8607117 11/01/1995       23 Citations
  • Calcium mobilisation controls tyrosine protein phosphorylation independently of the activation of protein kinase C in human platelets. (Falet H, Rendu F) FEBS Lett 1994 May 23;345(1):87-91 PMID: 7515012 05/23/1994       20 Citations
  • Last update: 07/07/2020
    jenkins-FCD Prod-469 c3fc8ab87196149f9b23743c01b947d47e7319e5