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Herve Falet PhD

Herve Falet PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center
Member of the Cardiovascular Center


I am willing to collaborate on research projects.
I am willing to mentor a junior faculty member.

View Curriculum Vitae

Publications (60)

  • MAGT1 mutant platelets unveiled. (Boyd EK, Falet H) J Thromb Haemost 2023 Nov;21(11):3075-3077 PMID: 37858523 SCOPUS ID: 2-s2.0-85174329583 10/20/2023    
  • PACSIN2 regulates platelet integrin β1 hemostatic function. (Biswas R, Boyd EK, Eaton N, Steenackers A, Schulte ML, Reusswig F, Yu H, Drew C, Kahr WHA, Shi Q, Plomann M, Hoffmeister KM, Falet H) J Thromb Haemost 2023 Dec;21(12):3619-3632 PMID: 37678551 PMCID: PMC10841284 SCOPUS ID: 2-s2.0-85172148046 09/08/2023    
  • A novel association between platelet filamin A and soluble N-ethylmaleimide sensitive factor attachment proteins regulates granule secretion. (Golla K, Paul M, Lengyell TC, Simpson EM, Falet H, Kim H) Res Pract Thromb Haemost 2023 May;7(4):100019 PMID: 37538498 PMCID: PMC10394388 SCOPUS ID: 2-s2.0-85159331097 08/04/2023       2 Citations
  • Filamin A in platelets: Bridging the (signaling) gap between the plasma membrane and the actin cytoskeleton. (De Silva E, Hong F, Falet H, Kim H) Front Mol Biosci 2022;9:1060361 PMID: 36605989 PMCID: PMC9808056 SCOPUS ID: 2-s2.0-85145466782 01/07/2023       2 Citations
  • Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice. (Eaton N, Boyd EK, Biswas R, Lee-Sundlov MM, Dlugi TA, Ramsey HE, Zheng S, Burns RT, Sola-Visner MC, Hoffmeister KM, Falet H) Front Oncol 2022;12:959806 PMID: 36110936 PMCID: PMC9468709 SCOPUS ID: 2-s2.0-85138252758 09/17/2022       1 Citation
  • Sialic acid and platelet count regulation: Implications in immune thrombocytopenia. (Lee-Sundlov MM, Rivadeneyra L, Falet H, Hoffmeister KM) Res Pract Thromb Haemost 2022 Mar;6(3):e12691 PMID: 35425875 PMCID: PMC8994053 SCOPUS ID: 2-s2.0-85130646480 04/16/2022       4 Citations
  • Novel GNE Gene Variants Associated with Severe Congenital Thrombocytopenia and Platelet Sialylation Defect. (Zieger B, Boeckelmann D, Anani W, Falet H, Zhu J, Glonnegger H, Full H, Andresen F, Erlacher M, Lausch E, Fels S, Strahm B, Lang P, Hoffmeister KM) Thromb Haemost 2022 Jul;122(7):1139-1146 PMID: 35052006 PMCID: PMC10064489 SCOPUS ID: 2-s2.0-85130195438 01/21/2022       16 Citations
  • Clinical impact of glycans in platelet and megakaryocyte biology. (Falet H, Rivadeneyra L, Hoffmeister KM) Blood 2022 Jun 02;139(22):3255-3263 PMID: 35015813 PMCID: PMC9164739 SCOPUS ID: 2-s2.0-85131270735 01/12/2022       6 Citations
  • Circulating platelet count and glycans. (Rivadeneyra L, Falet H, Hoffmeister KM) Curr Opin Hematol 2021 Nov 01;28(6):431-437 PMID: 34605444 PMCID: PMC8641398 SCOPUS ID: 2-s2.0-85117632516 10/05/2021       2 Citations
  • Bleeding diathesis in mice lacking JAK2 in platelets. (Eaton N, Subramaniam S, Schulte ML, Drew C, Jakab D, Haberichter SL, Weiler H, Falet H) Blood Adv 2021 Aug 10;5(15):2969-2981 PMID: 34342643 PMCID: PMC8361459 08/04/2021    
  • Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling. (Unsworth AJ, Bye AP, Sage T, Gaspar RS, Eaton N, Drew C, Stainer A, Kriek N, Volberding PJ, Hutchinson JL, Riley R, Jones S, Mundell SJ, Cui W, Falet H, Gibbins JM) Haematologica 2021 Jul 01;106(7):1968-1978 PMID: 32467143 PMCID: PMC8252961 SCOPUS ID: 2-s2.0-85111789694 05/30/2020       7 Citations
  • β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis. (Giannini S, Lee-Sundlov MM, Rivadeneyra L, Di Buduo CA, Burns R, Lau JT, Falet H, Balduini A, Hoffmeister KM) Nat Commun 2020 Jan 17;11(1):356 PMID: 31953383 PMCID: PMC6968998 SCOPUS ID: 2-s2.0-85078016291 01/19/2020       33 Citations
  • Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice. (Eaton N, Drew C, Wieser J, Munday AD, Falet H) Haematologica 2020 May;105(5):1414-1423 PMID: 31296575 PMCID: PMC7193499 SCOPUS ID: 2-s2.0-85086048023 07/13/2019       6 Citations
  • Singling out FLI1 in Paris-Trousseau syndrome. (Falet H) Blood 2017 Jun 29;129(26):3399-3401 PMID: 28663223 PMCID: PMC5492094 SCOPUS ID: 2-s2.0-85021764145 07/01/2017       2 Citations
  • Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets. (Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Falet H, Kaminski K, Freedman JE, Liao JK) Cardiovasc Res 2017 Sep 01;113(11):1307-1317 PMID: 28430966 PMCID: PMC5852540 SCOPUS ID: 2-s2.0-85048298808 04/22/2017       19 Citations
  • Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance. (Hoffmeister KM, Falet H) Thromb Res 2016 May;141 Suppl 2(Suppl 2):S68-72 PMID: 27207430 PMCID: PMC5399515 SCOPUS ID: 2-s2.0-84989860946 05/22/2016       57 Citations
  • Glycans and the platelet life cycle. (Li R, Hoffmeister KM, Falet H) Platelets 2016 Sep;27(6):505-11 PMID: 27135356 PMCID: PMC5396182 SCOPUS ID: 2-s2.0-84965011455 05/03/2016       60 Citations
  • Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases. (Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM) Arterioscler Thromb Vasc Biol 2016 Jun;36(6):1164-73 PMID: 27079884 PMCID: PMC5407363 SCOPUS ID: 2-s2.0-84963575819 04/16/2016       48 Citations
  • Regulating billions of blood platelets: glycans and beyond. (Grozovsky R, Giannini S, Falet H, Hoffmeister KM) Blood 2015 Oct 15;126(16):1877-84 PMID: 26330242 PMCID: PMC4608239 SCOPUS ID: 2-s2.0-84944244941 09/04/2015       117 Citations
  • Novel mechanisms of platelet clearance and thrombopoietin regulation. (Grozovsky R, Giannini S, Falet H, Hoffmeister KM) Curr Opin Hematol 2015 Sep;22(5):445-51 PMID: 26154508 PMCID: PMC5326579 SCOPUS ID: 2-s2.0-84942764882 07/15/2015       47 Citations
  • FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. (Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H) Blood 2015 Jul 02;126(1):80-8 PMID: 25838348 PMCID: PMC4492198 SCOPUS ID: 2-s2.0-84937810454 04/04/2015       49 Citations
  • Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. (Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B) Nat Commun 2015 Mar 06;6:6507 PMID: 25744693 PMCID: PMC4400601 SCOPUS ID: 2-s2.0-84924337546 03/07/2015    
  • The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. (Grozovsky R, Begonja AJ, Liu K, Visner G, Hartwig JH, Falet H, Hoffmeister KM) Nat Med 2015 Jan;21(1):47-54 PMID: 25485912 PMCID: PMC4303234 SCOPUS ID: 2-s2.0-84961292027 12/09/2014       252 Citations
  • Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. (Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WH, Hoffmeister KM, Falet H) Blood 2015 Feb 05;125(6):1014-24 PMID: 25468568 PMCID: PMC4319232 SCOPUS ID: 2-s2.0-84922341743 12/04/2014       42 Citations
  • Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. (Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B) Nat Commun 2014 Sep 04;5:4746 PMID: 25187265 SCOPUS ID: 2-s2.0-84920935863 09/05/2014       81 Citations
  • Post-translational arginylation as a novel regulator of platelet function. (Bender M, Falet H) Haematologica 2014 Mar;99(3):402-4 PMID: 24598850 PMCID: PMC3943301 SCOPUS ID: 2-s2.0-84895767463 03/07/2014    
  • Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1. (Kim H, Falet H, Hoffmeister KM, Hartwig JH) J Biol Chem 2013 Nov 29;288(48):34352-63 PMID: 24133214 PMCID: PMC3843050 10/18/2013    
  • Sitosterolemia: platelets on high-sterol diet. (Falet H) Blood 2013 Oct 10;122(15):2534-5 PMID: 24113795 PMCID: PMC3795455 SCOPUS ID: 2-s2.0-84888241052 10/12/2013       3 Citations
  • Platelet size: finding the right balance. (Falet H) Blood 2012 Mar 22;119(12):2702-3 PMID: 22442332 SCOPUS ID: 2-s2.0-84858838312 03/24/2012       2 Citations
  • New insights into the versatile roles of platelet FlnA. (Falet H) Platelets 2013;24(1):1-5 PMID: 22372530 PMCID: PMC6781629 SCOPUS ID: 2-s2.0-84871764376 03/01/2012       26 Citations
  • B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. (Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD) Blood 2012 Mar 22;119(12):2819-28 PMID: 22302739 PMCID: PMC3327460 SCOPUS ID: 2-s2.0-84858836089 02/04/2012       90 Citations
  • Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. (Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM) Blood 2012 Feb 02;119(5):1263-73 PMID: 22101895 PMCID: PMC3277358 SCOPUS ID: 2-s2.0-84863012533 11/22/2011       159 Citations
  • Gelsolin-independent podosome formation in dendritic cells. (Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP) PLoS One 2011;6(7):e21615 PMID: 21779330 PMCID: PMC3136926 SCOPUS ID: 2-s2.0-79960140039 07/23/2011       10 Citations
  • FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. (Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H) Blood 2011 Aug 25;118(8):2285-95 PMID: 21652675 PMCID: PMC3162356 SCOPUS ID: 2-s2.0-80052144121 06/10/2011       93 Citations
  • Novel clearance mechanisms of platelets. (Grozovsky R, Hoffmeister KM, Falet H) Curr Opin Hematol 2010 Nov;17(6):585-9 PMID: 20729731 PMCID: PMC4303238 SCOPUS ID: 2-s2.0-78049276308 08/24/2010       89 Citations
  • A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. (Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH) J Exp Med 2010 Aug 30;207(9):1967-79 PMID: 20713593 PMCID: PMC2931168 SCOPUS ID: 2-s2.0-77956246333 08/18/2010       99 Citations
  • Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. (Falet H, Marchetti MP, Hoffmeister KM, Massaad MJ, Geha RS, Hartwig JH) Blood 2009 Nov 19;114(21):4729-37 PMID: 19692704 PMCID: PMC2780308 SCOPUS ID: 2-s2.0-73949146436 08/21/2009       17 Citations
  • Differential stimulation of monocytic cells results in distinct populations of microparticles. (Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD) J Thromb Haemost 2009 Jun;7(6):1019-28 PMID: 19548909 PMCID: PMC3242443 SCOPUS ID: 2-s2.0-65849445995 06/25/2009       125 Citations
  • Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function. (Di Nardo A, Cicchetti G, Falet H, Hartwig JH, Stossel TP, Kwiatkowski DJ) Proc Natl Acad Sci U S A 2005 Nov 08;102(45):16263-8 PMID: 16254049 PMCID: PMC1283463 SCOPUS ID: 2-s2.0-28044449941 10/29/2005       50 Citations
  • Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics. (Falet H, Chang G, Brohard-Bohn B, Rendu F, Hartwig JH) Am J Physiol Cell Physiol 2005 Oct;289(4):C819-25 PMID: 15901596 SCOPUS ID: 2-s2.0-25444437244 05/20/2005       31 Citations
  • WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. (Kettner A, Kumar L, Antón IM, Sasahara Y, de la Fuente M, Pivniouk VI, Falet H, Hartwig JH, Geha RS) J Exp Med 2004 Feb 02;199(3):357-68 PMID: 14757742 PMCID: PMC2211794 SCOPUS ID: 2-s2.0-1342321664 02/06/2004       42 Citations
  • Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. (Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS) Int Immunol 2003 Dec;15(12):1431-40 PMID: 14645152 SCOPUS ID: 2-s2.0-0347407821 12/03/2003       39 Citations
  • Platelet moesin interacts with PECAM-1 (CD31). (Gamulescu MA, Seifert K, Tingart M, Falet H, Hoffmeister KM) Platelets 2003 Jun;14(4):211-7 PMID: 12850829 SCOPUS ID: 2-s2.0-0037711542 07/10/2003       19 Citations
  • Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change. (Barkalow KL, Falet H, Italiano JE Jr, van Vugt A, Carpenter CL, Schreiber AD, Hartwig JH) Am J Physiol Cell Physiol 2003 Oct;285(4):C797-805 PMID: 12788695 SCOPUS ID: 2-s2.0-0141456600 06/06/2003       14 Citations
  • Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. (Kettner A, Pivniouk V, Kumar L, Falet H, Lee JS, Mulligan R, Geha RS) Mol Cell Biol 2003 Apr;23(7):2395-406 PMID: 12640123 PMCID: PMC150723 SCOPUS ID: 2-s2.0-0037379217 03/18/2003       35 Citations
  • Mechanisms and implications of platelet discoid shape. (Italiano JE Jr, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA) Blood 2003 Jun 15;101(12):4789-96 PMID: 12586623 SCOPUS ID: 2-s2.0-0038792174 02/15/2003       137 Citations
  • The clearance mechanism of chilled blood platelets. (Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH) Cell 2003 Jan 10;112(1):87-97 PMID: 12526796 SCOPUS ID: 2-s2.0-0037428090 01/16/2003       373 Citations
  • Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealants. (Michaud SE, Wang LZ, Korde N, Bucki R, Randhawa PK, Pastore JJ, Falet H, Hoffmeister K, Kuuse R, Uibo R, Herod J, Sawyer E, Janmey PA) Thromb Res 2002 Sep 01;107(5):245-54 PMID: 12479886 SCOPUS ID: 2-s2.0-0036762638 12/14/2002       33 Citations
  • Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. (Falet H, Hoffmeister KM, Neujahr R, Italiano JE Jr, Stossel TP, Southwick FS, Hartwig JH) Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16782-7 PMID: 12464680 PMCID: PMC139221 SCOPUS ID: 2-s2.0-0037168604 12/05/2002       73 Citations
  • Normal Arp2/3 complex activation in platelets lacking WASp. (Falet H, Hoffmeister KM, Neujahr R, Hartwig JH) Blood 2002 Sep 15;100(6):2113-22 PMID: 12200375 SCOPUS ID: 2-s2.0-0037105573 08/30/2002       62 Citations
  • Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. (Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH, Stossel TP) J Cell Biol 2001 Nov 12;155(4):511-7 PMID: 11706047 PMCID: PMC2198874 SCOPUS ID: 2-s2.0-84924195703 11/14/2001       16 Citations
  • Mechanisms of cold-induced platelet actin assembly. (Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH) J Biol Chem 2001 Jul 06;276(27):24751-9 PMID: 11328807 SCOPUS ID: 2-s2.0-0035816637 05/01/2001       85 Citations
  • Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. (Falet H, Barkalow KL, Pivniouk VI, Barnes MJ, Geha RS, Hartwig JH) Blood 2000 Dec 01;96(12):3786-92 PMID: 11090061 SCOPUS ID: 2-s2.0-0034554857 11/23/2000       49 Citations
  • Tyrosine phosphorylation and association of FcgammaRII and p72(Syk) are not limited to the FcgammaRII signalling pathway. (Pain S, Falet H, Saci A, Bachelot-Loza C, Rendu F) Cell Signal 2000 Mar;12(3):165-71 PMID: 10704823 SCOPUS ID: 2-s2.0-0033995237 03/08/2000       15 Citations
  • Calpain controls the balance between protein tyrosine kinase and tyrosine phosphatase activities during platelet activation. (Pain S, Monstero-Lastres A, Falet H, Brohard-Bohn B, Fraiz N, Bachelot-Loza C, Cano E, Rendu F) FEBS Lett 1999 Jun 18;453(1-2):119-23 PMID: 10403387 SCOPUS ID: 2-s2.0-0032767712 07/14/1999       5 Citations
  • Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain. (Falet H, Pain S, Rendu F) Biochem Biophys Res Commun 1998 Nov 09;252(1):51-5 PMID: 9813145 SCOPUS ID: 2-s2.0-0032501155 11/14/1998       23 Citations
  • Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c-Src in human platelets. (Falet H, Ramos-Morales F, Bachelot C, Fischer S, Rendu F) FEBS Lett 1996 Apr 01;383(3):165-9 PMID: 8925889 SCOPUS ID: 2-s2.0-0029914934 04/01/1996       36 Citations
  • The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: comparison with thrombin. (Si-Tahar M, Renesto P, Falet H, Rendu F, Chignard M) Biochem J 1996 Jan 15;313 ( Pt 2)(Pt 2):401-8 PMID: 8573071 PMCID: PMC1216922 SCOPUS ID: 2-s2.0-0030048270 01/15/1996       34 Citations
  • Different abilities of thrombin receptor activating peptide and thrombin to induce platelet calcium rise and full release reaction. (Lasne D, Donato J, Falet H, Rendu F) Thromb Haemost 1995 Nov;74(5):1323-8 PMID: 8607117 SCOPUS ID: 2-s2.0-0028840277 11/01/1995       23 Citations
  • Calcium mobilisation controls tyrosine protein phosphorylation independently of the activation of protein kinase C in human platelets. (Falet H, Rendu F) FEBS Lett 1994 May 23;345(1):87-91 PMID: 7515012 SCOPUS ID: 2-s2.0-0028359043 05/23/1994       20 Citations
    • Last update: 05/08/2024