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Michael B. Dwinell PhD

Michael B. Dwinell PhD profile photo picture

Director, Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Director of the Center for Immunology
Member of the Cancer Center
Member of the Mellowes Center for Genomic Sciences and Precision Medicine

View Curriculum Vitae

Research Experience

  • Adjuvants, Immunologic
  • Carcinoma, Pancreatic Ductal
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Chemokines
  • Cytokines
  • Energy Metabolism
  • Immunity, Mucosal
  • Inflammation
  • Mice
  • Mice, Knockout
  • Mitochondria
  • Neoplasm Metastasis
  • Receptors, Chemokine
  • Receptors, G-Protein-Coupled
  • Signal Transduction
  • Tumor Microenvironment
  • Wound Healing
  • Xenograft Model Antitumor Assays
  • Immuno-Oncology

    • Publications (93)

  • Gait speed is a biomarker of cancer-associated cachexia decline and recovery. (Roy I, Binder-Markey B, Sychowski D, Willbanks A, Phipps T, McAllister D, Bhakta A, Marquez E, D'Andrea D, Franz C, Pichika R, Dwinell MB, Jayabalan P, Lieber RL) bioRxiv 2023 Nov 15 PMID: 38014165 PMCID: PMC10680669 11/28/2023    
  • Synthesis of fluorinated triphenylphosphonium analogs that improve cancer cell selectivity and in vivo detection. (Keyes RF, McAllister D, Dwinell MB, Smith BC) STAR Protoc 2023 Sep 15;4(3):102437 PMID: 37552599 PMCID: PMC10424135 SCOPUS ID: 2-s2.0-85175638505 08/08/2023    
  • Targeted immune activation in pediatric solid tumors: opportunities to complement local control approaches. (Vonderhaar EP, Dwinell MB, Craig BT) Front Immunol 2023;14:1202169 PMID: 37426669 PMCID: PMC10325564 SCOPUS ID: 2-s2.0-85164152167 07/10/2023    
  • Increased CXCL10 is seen at 1-year after autologous hematopoietic cell transplantation in multiple myeloma patients on maintenance lenalidomide therapy. (Mohan M, Janz S, Brazauskas R, Dwinell MB, Teng BQ, Yun G, Dong J, Pasquini MC, Giralt S, Landau H, Stadtmauer E, Krishnan A, D'Souza A) Bone Marrow Transplant 2023 Aug;58(8):953-955 PMID: 37149674 PMCID: PMC10555486 SCOPUS ID: 2-s2.0-85158126520 05/07/2023    
  • A modified ELISA assay differentiates CCL20 locked dimers from wild-type monomers. (Wu X, Clarke WR, Koplinski CA, Peterson FC, Dwinell MB, Wei G, Chao E, Huynh M, Yamada D, Volkman BF, Hwang ST) J Immunol Methods 2023 Apr;515:113453 PMID: 36863695 PMCID: PMC10715733 SCOPUS ID: 2-s2.0-85150034077 03/03/2023    
  • Fragment-based drug discovery of small molecule ligands for the human chemokine CCL28. (Zhou AL, Jensen DR, Peterson FC, Thomas MA, Schlimgen RR, Dwinell MB, Smith BC, Volkman BF) SLAS Discov 2023 Jun;28(4):163-169 PMID: 36841432 PMCID: PMC10339762 SCOPUS ID: 2-s2.0-85149845436 02/26/2023       1 Citation
  • DPP4-Truncated CXCL12 Alters CXCR4/ACKR3 Signaling, Osteogenic Cell Differentiation, Migration, and Senescence. (Elmansi AM, Eisa NH, Periyasamy-Thandavan S, Kondrikova G, Kondrikov D, Calkins MM, Aguilar-Pérez A, Chen J, Johnson M, Shi XM, Reitman C, McGee-Lawrence ME, Crawford KS, Dwinell MB, Volkman BF, Blumer JB, Luttrell LM, McCorvy JD, Hill WD) ACS Pharmacol Transl Sci 2023 Jan 13;6(1):22-39 PMID: 36659961 PMCID: PMC9844133 SCOPUS ID: 2-s2.0-85143982229 01/21/2023       1 Citation
  • DPP4-Truncated CXCL12 Alters CXCR4/ACKR3 Signaling, Osteogenic Cell Differentiation, Migration, and Senescence (Elmansi AM, Eisa NH, Periyasamy-Thandavan S, Kondrikova G, Kondrikov D, Calkins MM, Aguilar-Pérez A, Chen J, Johnson M, Shi XM, Reitman C, McGee-Lawrence ME, Crawford KS, Dwinell MB, Volkman BF, Blumer JB, Luttrell LM, McCorvy JD, Hill WD) ACS Pharmacology and Translational Science 13 January 2023;6(1):22-39 SCOPUS ID: 2-s2.0-85143982229 01/13/2023       1 Citation
  • Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin. (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB) iScience 2022 Dec 22;25(12):105670 PMID: 36567718 PMCID: PMC9768319 SCOPUS ID: 2-s2.0-85143723525 12/27/2022       5 Citations
  • Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB) iScience 22 December 2022;25(12) SCOPUS ID: 2-s2.0-85143723525 12/22/2022       5 Citations
  • DNA methylation in circulating leukocytes is a novel biomarker in multiple myeloma. (D'Souza A, Brazauskas R, Teng BQ, Yun G, Uttley H, Dong J, Dwinell MB, Pasquini MC, Giralt S, Landau H, Stadtmauer E, Krishnan A, Janz S) Bone Marrow Transplant 2023 Mar;58(3):334-336 PMID: 36460820 SCOPUS ID: 2-s2.0-85143207078 12/03/2022    
  • Physiology of chemokines in the cancer microenvironment. (Drouillard D, Craig BT, Dwinell MB) Am J Physiol Cell Physiol 2023 Jan 01;324(1):C167-C182 PMID: 36317799 PMCID: PMC9829481 SCOPUS ID: 2-s2.0-85145954846 11/02/2022       9 Citations
  • The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus. (Jørgensen AS, Brandum EP, Mikkelsen JM, Orfin KA, Boilesen DR, Egerod KL, Moussouras NA, Vilhardt F, Kalinski P, Basse P, Chen YH, Yang Z, Dwinell MB, Volkman BF, Veldkamp CT, Holst PJ, Lahl K, Goth CK, Rosenkilde MM, Hjortø GM) Cell Mol Life Sci 2021 Nov;78(21-22):6963-6978 PMID: 34586443 PMCID: PMC8558179 SCOPUS ID: 2-s2.0-85116031161 09/30/2021       11 Citations
  • Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth. (Geethadevi A, Nair A, Parashar D, Ku Z, Xiong W, Deng H, Li Y, George J, McAllister DM, Sun Y, Kadamberi IP, Gupta P, Dwinell MB, Bradley WH, Rader JS, Rui H, Schwabe RF, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P) Cancer Res 2021 Oct 15;81(20):5336-5352 PMID: 34380633 PMCID: PMC8530981 SCOPUS ID: 2-s2.0-85116424540 08/13/2021       28 Citations
  • Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks. (Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G) Front Cell Dev Biol 2021;9:681153 PMID: 34249932 PMCID: PMC8261250 SCOPUS ID: 2-s2.0-85116952280 07/13/2021       4 Citations
  • Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression. (AbuEid M, McAllister DM, McOlash L, Harwig MC, Cheng G, Drouillard D, Boyle KA, Hardy M, Zielonka J, Johnson BD, Hill RB, Kalyanaraman B, Dwinell MB) iScience 2021 Jun 25;24(6):102653 PMID: 34189432 PMCID: PMC8220235 SCOPUS ID: 2-s2.0-85107963806 07/01/2021       18 Citations
  • Targeted biologic inhibition of both tumor cell-intrinsic and intercellular CLPTM1L/CRR9-mediated chemotherapeutic drug resistance. (Parashar D, Geethadevi A, McAllister D, Ebben J, Peterson FC, Jensen DR, Bishop E, Pradeep S, Volkman BF, Dwinell MB, Chaluvally-Raghavan P, James MA) NPJ Precis Oncol 2021 Mar 02;5(1):16 PMID: 33654182 PMCID: PMC7925570 SCOPUS ID: 2-s2.0-85109651282 03/04/2021       13 Citations
  • Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer. (Xin G, Chen Y, Topchyan P, Kasmani MY, Burns R, Volberding PJ, Wu X, Cohn A, Chen Y, Lin CW, Ho PC, Silverstein R, Dwinell MB, Cui W) Cancer Immunol Res 2021 Apr;9(4):454-469 PMID: 33579728 PMCID: PMC8137571 SCOPUS ID: 2-s2.0-85104420312 02/14/2021       20 Citations
  • STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. (Vonderhaar EP, Barnekow NS, McAllister D, McOlash L, Eid MA, Riese MJ, Tarakanova VL, Johnson BD, Dwinell MB) Cell Mol Gastroenterol Hepatol 2021;12(1):41-58 PMID: 33548597 PMCID: PMC8081932 SCOPUS ID: 2-s2.0-85104314508 02/07/2021       32 Citations
  • Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells. (Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, Abu Eid M, McAllister D, Bennett B, Kresty LA, Dwinell MB, Kalyanaraman B) Cancer Treat Res Commun 2020;25:100210 PMID: 32987287 PMCID: PMC7883397 SCOPUS ID: 2-s2.0-85091576205 09/29/2020       19 Citations
  • p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. (Wang F, Qi XM, Wertz R, Mortensen M, Hagen C, Evans J, Sheinin Y, James M, Liu P, Tsai S, Thomas J, Mackinnon A, Dwinell M, Myers CR, Bartrons Bach R, Fu L, Chen G) Cancer Res 2020 Aug 15;80(16):3251-3264 PMID: 32580961 PMCID: PMC9358694 SCOPUS ID: 2-s2.0-85089787021 06/26/2020       41 Citations
  • Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21. (Moussouras NA, Hjortø GM, Peterson FC, Szpakowska M, Chevigné A, Rosenkilde MM, Volkman BF, Dwinell MB) Biochemistry 2020 Apr 07;59(13):1338-1350 PMID: 32182428 PMCID: PMC7307649 SCOPUS ID: 2-s2.0-85083041593 03/18/2020       11 Citations
  • Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses. (Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B) Free Radic Biol Med 2020 Feb 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019       16 Citations
  • Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators. (Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B) Oncotarget 2019 May 28;10(37):3518-3532 PMID: 31191823 PMCID: PMC6544408 SCOPUS ID: 2-s2.0-85089087803 06/14/2019       14 Citations
  • STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models. (Jing W, McAllister D, Vonderhaar EP, Palen K, Riese MJ, Gershan J, Johnson BD, Dwinell MB) J Immunother Cancer 2019 Apr 29;7(1):115 PMID: 31036082 PMCID: PMC6489306 SCOPUS ID: 2-s2.0-85065258266 05/01/2019       105 Citations
  • A Serum-Induced Transcriptome and Serum Cytokine Signature Obtained at Diagnosis Correlates with the Development of Early Pancreatic Ductal Adenocarcinoma Metastasis. (Tsai S, McOlash L, Jia S, Zhang J, Simpson P, Kaldunski ML, Aldakkak M, Grewal J, Palen K, Dwinell MB, Johnson BD, Mackinnon A, Hessner MJ, Gershan JA) Cancer Epidemiol Biomarkers Prev 2019 Apr;28(4):680-689 PMID: 30530849 PMCID: PMC6545232 SCOPUS ID: 2-s2.0-85063867816 12/12/2018       2 Citations
  • Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation. (Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB) J Biol Chem 2018 Sep 21;293(38):14891-14904 PMID: 30087121 PMCID: PMC6153299 SCOPUS ID: 2-s2.0-85054023214 08/09/2018       97 Citations
  • Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance. (Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ) Immunohorizons 2018 Apr 01;2(4):107-118 PMID: 30027154 PMCID: PMC6048965 SCOPUS ID: 2-s2.0-85075290149 07/22/2018       12 Citations
  • GEMMs Are a Gem When it Comes to Defining the Role of HIF2α in Mucinous Cystic Neoplasms. (Boyle KA, Dwinell MB) Cell Mol Gastroenterol Hepatol 2018;5(2):165-166 PMID: 29693045 PMCID: PMC5904046 SCOPUS ID: 2-s2.0-85039848766 04/26/2018    
  • Stromal inflammation in pancreatic cancer: Mechanisms and translational applications (Boyle KA, James MA, Tsai S, Evans DB, Dwinell MB) Pancreatic Cancer 11 April 2018:481-508 SCOPUS ID: 2-s2.0-85054043119 04/11/2018    
  • Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models. (Tsai S, McOlash L, Palen K, Johnson B, Duris C, Yang Q, Dwinell MB, Hunt B, Evans DB, Gershan J, James MA) BMC Cancer 2018 Mar 27;18(1):335 PMID: 29587663 PMCID: PMC5870823 SCOPUS ID: 2-s2.0-85044523365 03/29/2018       255 Citations
  • Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316-327]. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 Jun;16:426-427 PMID: 29548725 PMCID: PMC5952812 SCOPUS ID: 2-s2.0-85043469209 03/20/2018       6 Citations
  • A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 Apr;14:316-327 PMID: 29017115 PMCID: PMC5633086 SCOPUS ID: 2-s2.0-85030681499 10/11/2017       165 Citations
  • Differences in Sulfotyrosine Binding amongst CXCR1 and CXCR2 Chemokine Ligands. (Moussouras NA, Getschman AE, Lackner ER, Veldkamp CT, Dwinell MB, Volkman BF) Int J Mol Sci 2017 Sep 03;18(9) PMID: 28869519 PMCID: PMC5618543 SCOPUS ID: 2-s2.0-85028764300 09/05/2017       12 Citations
  • CCR7 Sulfotyrosine Enhances CCL21 Binding. (Phillips AJ, Taleski D, Koplinski CA, Getschman AE, Moussouras NA, Richard AM, Peterson FC, Dwinell MB, Volkman BF, Payne RJ, Veldkamp CT) Int J Mol Sci 2017 Aug 25;18(9) PMID: 28841151 PMCID: PMC5618506 SCOPUS ID: 2-s2.0-85028343200 08/26/2017       20 Citations
  • Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell MB) Cell Biochem Biophys 2017 Dec;75(3-4):311-317 PMID: 28429253 PMCID: PMC5680142 SCOPUS ID: 2-s2.0-85018513016 04/22/2017       20 Citations
  • Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell M) Interface Focus 2017 Apr 06;7(2):20160109 PMID: 28382202 PMCID: PMC5311906 SCOPUS ID: 2-s2.0-85013194895 04/07/2017       23 Citations
  • Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation. (Ziarek JJ, Kleist AB, London N, Raveh B, Montpas N, Bonneterre J, St-Onge G, DiCosmo-Ponticello CJ, Koplinski CA, Roy I, Stephens B, Thelen S, Veldkamp CT, Coffman FD, Cohen MC, Dwinell MB, Thelen M, Peterson FC, Heveker N, Volkman BF) Sci Signal 2017 Mar 21;10(471) PMID: 28325822 PMCID: PMC5648539 SCOPUS ID: 2-s2.0-85016334108 03/23/2017       71 Citations
  • Cancer cell chemokines direct chemotaxis of activated stellate cells in pancreatic ductal adenocarcinoma. (Roy I, Boyle KA, Vonderhaar EP, Zimmerman NP, Gorse E, Mackinnon AC, Hwang RF, Franco-Barraza J, Cukierman E, Tsai S, Evans DB, Dwinell MB) Lab Invest 2017 Mar;97(3):302-317 PMID: 28092365 PMCID: PMC5334280 SCOPUS ID: 2-s2.0-85014533549 01/17/2017       27 Citations
  • Exploiting agonist biased signaling of chemokines to target cancer. (Roy I, Getschman AE, Volkman BF, Dwinell MB) Mol Carcinog 2017 Mar;56(3):804-813 PMID: 27648825 PMCID: PMC5479419 SCOPUS ID: 2-s2.0-84994851814 09/21/2016       13 Citations
  • E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells. (Palen K, Weber J, Dwinell MB, Johnson BD, Ramchandran R, Gershan JA) Oncotarget 2016 Jul 12;7(28):43363-43375 PMID: 27270319 PMCID: PMC5190029 SCOPUS ID: 2-s2.0-84978710944 06/09/2016       19 Citations
  • Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells. (Cheng G, Zielonka J, Ouari O, Lopez M, McAllister D, Boyle K, Barrios CS, Weber JJ, Johnson BD, Hardy M, Dwinell MB, Kalyanaraman B) Cancer Res 2016 Jul 01;76(13):3904-15 PMID: 27216187 PMCID: PMC4930686 SCOPUS ID: 2-s2.0-84977588183 05/25/2016       153 Citations
  • Generation and characterization of mice harboring a conditional CXCL12 allele. (Hillmer RE, Boisvert JP, Cucciare MJ, Dwinell MB, Joksimovic M) Int J Dev Biol 2015;59(4-6):205-9 PMID: 26505253 SCOPUS ID: 2-s2.0-84944199867 10/28/2015       5 Citations
  • Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. (Roy I, McAllister DM, Gorse E, Dixon K, Piper CT, Zimmerman NP, Getschman AE, Tsai S, Engle DD, Evans DB, Volkman BF, Kalyanaraman B, Dwinell MB) Cancer Res 2015 Sep 01;75(17):3529-42 PMID: 26330165 PMCID: PMC4560104 SCOPUS ID: 2-s2.0-84942898695 09/04/2015       52 Citations
  • Correction: Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2015;10(8):e0137369 PMID: 26322640 PMCID: PMC4554722 SCOPUS ID: 2-s2.0-84943279669 09/01/2015       2 Citations
  • p38γ MAPK Is a Therapeutic Target for Triple-Negative Breast Cancer by Stimulation of Cancer Stem-Like Cell Expansion. (Qi X, Yin N, Ma S, Lepp A, Tang J, Jing W, Johnson B, Dwinell MB, Chitambar CR, Chen G) Stem Cells 2015 Sep;33(9):2738-47 PMID: 26077647 PMCID: PMC4792188 SCOPUS ID: 2-s2.0-84940467357 06/17/2015       30 Citations
  • Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism. (Cheng G, Zielonka J, McAllister D, Hardy M, Ouari O, Joseph J, Dwinell MB, Kalyanaraman B) Cancer Lett 2015 Aug 28;365(1):96-106 PMID: 26004344 PMCID: PMC4476640 SCOPUS ID: 2-s2.0-84930823628 05/26/2015       61 Citations
  • CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. (Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ) Cancer Res 2014 Nov 15;74(22):6419-29 PMID: 25172839 PMCID: PMC4247541 SCOPUS ID: 2-s2.0-84918497707 08/31/2014       25 Citations
  • Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation. (Cheng G, Zielonka J, McAllister D, Tsai S, Dwinell MB, Kalyanaraman B) Br J Cancer 2014 Jul 08;111(1):85-93 PMID: 24867695 PMCID: PMC4090735 SCOPUS ID: 2-s2.0-84904114424 05/29/2014       68 Citations
  • Chemokines and chemokine receptors: update on utility and challenges for the clinician. (Roy I, Evans DB, Dwinell MB) Surgery 2014 Jun;155(6):961-73 PMID: 24856117 PMCID: PMC4390364 SCOPUS ID: 2-s2.0-84901387582 05/27/2014       52 Citations
  • CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. (Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB, Dwinell MB) PLoS One 2014;9(3):e90400 PMID: 24594697 PMCID: PMC3942415 SCOPUS ID: 2-s2.0-84897093538 03/07/2014       73 Citations
  • Astrocytes directly influence tumor cell invasion and metastasis in vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2013;8(12):e80933 PMID: 24324647 PMCID: PMC3851470 SCOPUS ID: 2-s2.0-84891893696 12/11/2013       76 Citations
  • Chemokines in colitis: microRNA control. (Roy I, Veldkamp CT, Volkman BF, Dwinell MB) Gut 2014 Aug;63(8):1202-4 PMID: 24142964 PMCID: PMC4608425 SCOPUS ID: 2-s2.0-84904047100 10/22/2013       5 Citations
  • Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. (Zimmerman NP, Roy I, Hauser AD, Wilson JM, Williams CL, Dwinell MB) Mol Carcinog 2015 Mar;54(3):203-15 PMID: 24115212 PMCID: PMC4087083 SCOPUS ID: 2-s2.0-84926109550 10/12/2013       45 Citations
  • Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. (Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B) BMC Cancer 2013 Jun 13;13:285 PMID: 23764021 PMCID: PMC3686663 SCOPUS ID: 2-s2.0-84878817212 06/15/2013       106 Citations
  • An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. (Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL) Sci Signal 2013 May 28;6(277):ra39 PMID: 23716716 PMCID: PMC4278376 SCOPUS ID: 2-s2.0-84878725519 05/30/2013       76 Citations
  • CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis. (Takekoshi T, Wu X, Mitsui H, Tada Y, Kao MC, Sato S, Dwinell MB, Hwang ST) J Invest Dermatol 2013 Nov;133(11):2530-2537 PMID: 23528817 PMCID: PMC3972890 SCOPUS ID: 2-s2.0-84885960571 03/27/2013       21 Citations
  • E-cadherin is critical for collective sheet migration and is regulated by the chemokine CXCL12 protein during restitution. (Hwang S, Zimmerman NP, Agle KA, Turner JR, Kumar SN, Dwinell MB) J Biol Chem 2012 Jun 22;287(26):22227-40 PMID: 22549778 PMCID: PMC3381184 SCOPUS ID: 2-s2.0-84862705745 05/03/2012       36 Citations
  • Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA. (Zimmerman NP, Kumar SN, Turner JR, Dwinell MB) Inflamm Bowel Dis 2012 Jun;18(6):1081-91 PMID: 21993975 PMCID: PMC3258471 SCOPUS ID: 2-s2.0-84861333263 10/14/2011       30 Citations
  • Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. (Drury LJ, Ziarek JJ, Gravel S, Veldkamp CT, Takekoshi T, Hwang ST, Heveker N, Volkman BF, Dwinell MB) Proc Natl Acad Sci U S A 2011 Oct 25;108(43):17655-60 PMID: 21990345 PMCID: PMC3203819 SCOPUS ID: 2-s2.0-80055081893 10/13/2011       169 Citations
  • Chemokine stimulation promotes enterocyte migration through laminin-specific integrins. (Agle KA, Vongsa RA, Dwinell MB) Am J Physiol Gastrointest Liver Physiol 2011 Dec;301(6):G968-80 PMID: 21921288 PMCID: PMC3233784 SCOPUS ID: 2-s2.0-82455219469 09/17/2011       10 Citations
  • Targeted intestinal epithelial deletion of the chemokine receptor CXCR4 reveals important roles for extracellular-regulated kinase-1/2 in restitution. (Zimmerman NP, Vongsa RA, Faherty SL, Salzman NH, Dwinell MB) Lab Invest 2011 Jul;91(7):1040-55 PMID: 21537329 PMCID: PMC3167207 SCOPUS ID: 2-s2.0-79959760786 05/04/2011       26 Citations
  • CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis. (Drury LJ, Wendt MK, Dwinell MB) PLoS One 2010 Sep 22;5(9):e12895 PMID: 20877573 PMCID: PMC2943927 SCOPUS ID: 2-s2.0-77958506768 09/30/2010       40 Citations
  • Calcium mobilization triggered by the chemokine CXCL12 regulates migration in wounded intestinal epithelial monolayers. (Agle KA, Vongsa RA, Dwinell MB) J Biol Chem 2010 May 21;285(21):16066-75 PMID: 20348095 PMCID: PMC2871475 SCOPUS ID: 2-s2.0-77952334175 03/30/2010       47 Citations
  • CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells. (Vongsa RA, Zimmerman NP, Dwinell MB) J Biol Chem 2009 Apr 10;284(15):10034-45 PMID: 19233848 PMCID: PMC2665058 SCOPUS ID: 2-s2.0-65649118172 02/24/2009       73 Citations
  • Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells. (Wendt MK, Drury LJ, Vongsa RA, Dwinell MB) Gastroenterology 2008 Aug;135(2):508-17 PMID: 18558091 PMCID: PMC2583344 SCOPUS ID: 2-s2.0-48549091884 06/19/2008       43 Citations
  • Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease. (Zimmerman NP, Vongsa RA, Wendt MK, Dwinell MB) Inflamm Bowel Dis 2008 Jul;14(7):1000-11 PMID: 18452220 PMCID: PMC4114077 SCOPUS ID: 2-s2.0-47949116890 05/03/2008       127 Citations
  • Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells. (Wendt MK, Cooper AN, Dwinell MB) Oncogene 2008 Feb 28;27(10):1461-71 PMID: 17724466 SCOPUS ID: 2-s2.0-39849096261 08/29/2007       105 Citations
  • Rho activation regulates CXCL12 chemokine stimulated actin rearrangement and restitution in model intestinal epithelia. (Moyer RA, Wendt MK, Johanesen PA, Turner JR, Dwinell MB) Lab Invest 2007 Aug;87(8):807-17 PMID: 17572689 PMCID: PMC2693067 SCOPUS ID: 2-s2.0-34447534323 06/19/2007       67 Citations
  • Mucosal immunity. (Dwinell MB, Kagnoff MF) Curr Opin Gastroenterol 1999 Jan;15(1):33-8 PMID: 17023915 SCOPUS ID: 2-s2.0-0033060325 10/07/2006       3 Citations
  • Flagellin-independent regulation of chemokine host defense in Campylobacter jejuni-infected intestinal epithelium. (Johanesen PA, Dwinell MB) Infect Immun 2006 Jun;74(6):3437-47 PMID: 16714574 PMCID: PMC1479283 SCOPUS ID: 2-s2.0-33744921358 05/23/2006       45 Citations
  • Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis. (Wendt MK, Johanesen PA, Kang-Decker N, Binion DG, Shah V, Dwinell MB) Oncogene 2006 Aug 17;25(36):4986-97 PMID: 16568088 PMCID: PMC4610155 SCOPUS ID: 2-s2.0-33747371948 03/29/2006       129 Citations
  • Molecular stratification of Crohn's disease by chemokine receptors: fractalkine receptor polymorphisms define a fibrostenosing ileal subgroup. (Binion DG, Kugathasan S, Dwinell MB) Am J Gastroenterol 2006 Jan;101(1):107-9 PMID: 16405541 SCOPUS ID: 2-s2.0-33644850652 01/13/2006       2 Citations
  • Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells. (Yang CC, Ogawa H, Dwinell MB, McCole DF, Eckmann L, Kagnoff MF) Am J Physiol Cell Physiol 2005 Feb;288(2):C321-8 PMID: 15483227 SCOPUS ID: 2-s2.0-12144262859 10/16/2004       37 Citations
  • CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity. (Smith JM, Johanesen PA, Wendt MK, Binion DG, Dwinell MB) Am J Physiol Gastrointest Liver Physiol 2005 Feb;288(2):G316-26 PMID: 15358596 SCOPUS ID: 2-s2.0-12344262717 09/11/2004       80 Citations
  • Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells. (Heidemann J, Ogawa H, Rafiee P, Lügering N, Maaser C, Domschke W, Binion DG, Dwinell MB) Am J Physiol Gastrointest Liver Physiol 2004 Jun;286(6):G1059-68 PMID: 14764445 SCOPUS ID: 2-s2.0-2642545685 02/07/2004       65 Citations
  • SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4. (Dwinell MB, Ogawa H, Barrett KE, Kagnoff MF) Am J Physiol Gastrointest Liver Physiol 2004 May;286(5):G844-50 PMID: 14684377 SCOPUS ID: 2-s2.0-1942519774 12/20/2003       40 Citations
  • Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation. (Rafiee P, Ogawa H, Heidemann J, Li MS, Aslam M, Lamirand TH, Fisher PJ, Graewin SJ, Dwinell MB, Johnson CP, Shaker R, Binion DG) Am J Physiol Gastrointest Liver Physiol 2003 Dec;285(6):G1277-92 PMID: 12919942 SCOPUS ID: 2-s2.0-17544404890 08/16/2003       35 Citations
  • Immunobiology of epithelial chemokines in the intestinal mucosa. (Dwinell MB, Johanesen PA, Smith JM) Surgery 2003 Jun;133(6):601-7 PMID: 12796725 SCOPUS ID: 2-s2.0-0037782141 06/11/2003       44 Citations
  • Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. (Heidemann J, Ogawa H, Dwinell MB, Rafiee P, Maaser C, Gockel HR, Otterson MF, Ota DM, Lugering N, Domschke W, Binion DG) J Biol Chem 2003 Mar 07;278(10):8508-15 PMID: 12496258 SCOPUS ID: 2-s2.0-0037424253 12/24/2002       404 Citations
  • Production of MDC/CCL22 by human intestinal epithelial cells. (Berin MC, Dwinell MB, Eckmann L, Kagnoff MF) Am J Physiol Gastrointest Liver Physiol 2001 Jun;280(6):G1217-26 PMID: 11352815 SCOPUS ID: 2-s2.0-0034972989 05/16/2001       63 Citations
  • Regulated MIP-3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. (Izadpanah A, Dwinell MB, Eckmann L, Varki NM, Kagnoff MF) Am J Physiol Gastrointest Liver Physiol 2001 Apr;280(4):G710-9 PMID: 11254498 SCOPUS ID: 2-s2.0-0035013827 03/20/2001       207 Citations
  • Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells. (Dwinell MB, Lügering N, Eckmann L, Kagnoff MF) Gastroenterology 2001 Jan;120(1):49-59 PMID: 11208713 SCOPUS ID: 2-s2.0-0035165138 02/24/2001       178 Citations
  • Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella. (Eckmann L, Smith JR, Housley MP, Dwinell MB, Kagnoff MF) J Biol Chem 2000 May 12;275(19):14084-94 PMID: 10799483 SCOPUS ID: 2-s2.0-0034640417 05/09/2000       167 Citations
  • Human intestinal epithelial cells express receptors for platelet-activating factor. (Merendino N, Dwinell MB, Varki N, Eckmann L, Kagnoff MF) Am J Physiol 1999 Oct;277(4):G810-8 PMID: 10516147 SCOPUS ID: 2-s2.0-0032699565 10/12/1999       22 Citations
  • Chemokine receptor expression by human intestinal epithelial cells. (Dwinell MB, Eckmann L, Leopard JD, Varki NM, Kagnoff MF) Gastroenterology 1999 Aug;117(2):359-67 PMID: 10419917 SCOPUS ID: 2-s2.0-0032801427 07/27/1999       184 Citations
  • Hymenolepis diminuta fractions but not previous tapeworm infection stimulate intestinal myoelectric alterations in vivo in the rat. (Dwinell MB, Bass P, Oaks JA) J Parasitol 1998 Aug;84(4):673-80 PMID: 9714192 SCOPUS ID: 2-s2.0-0031818277 08/26/1998       13 Citations
  • Hymenolepsis diminuta: mucosal mastocytosis and intestinal smooth muscle hypertrophy occur in tapeworm-infected rats. (Dwinell MB, Wise RM, Bass P, Oaks JA) Exp Parasitol 1998 May;89(1):92-102 PMID: 9603494 SCOPUS ID: 2-s2.0-0032056393 05/29/1998       25 Citations
  • Tapeworm infection decreases intestinal transit and enteric aerobic bacterial populations. (Dwinell MB, Bass P, Schaefer DM, Oaks JA) Am J Physiol 1997 Aug;273(2 Pt 1):G480-5 PMID: 9277428 SCOPUS ID: 2-s2.0-0030826981 08/01/1997       36 Citations
  • Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. (Rowell DL, Eckmann L, Dwinell MB, Carpenter SP, Raucy JL, Yang SK, Kagnoff MF) Am J Physiol 1997 Aug;273(2 Pt 1):G322-32 PMID: 9277410 SCOPUS ID: 2-s2.0-0030882523 08/01/1997       100 Citations
  • Mast cell hyperplasia and smooth muscle hypertrophy during intestinal motility alterations in tapeworm infected rats (Dwinell MB, Bass P, Oaks JA) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-33745363064 12/01/1996       1 Citation
  • Praziquantel treatment normalizes intestinal myoelectric alterations associated with Hymenolepis diminuta-infected rats. (Dwinell MB, Bass P, Oaks JA) J Parasitol 1995 Dec;81(6):979-84 PMID: 8544075 SCOPUS ID: 2-s2.0-0029594154 12/01/1995       13 Citations
  • Intestinal myoelectric alterations in rats chronically infected with the tapeworm Hymenolepis diminuta. (Dwinell MB, Bass P, Oaks JA) Am J Physiol 1994 Nov;267(5 Pt 1):G851-8 PMID: 7977747 SCOPUS ID: 2-s2.0-0028116998 11/01/1994       30 Citations
    • Last update: 02/23/2024