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Michael B. Dwinell PhD

Michael B. Dwinell PhD

Director, Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)


Research Experience

  • Carcinoma
  • Chemokines
  • Defensins
  • Immunity, Mucosal
  • Neoplasm Metastasis
  • Receptors, CXCR4
  • Receptors, Chemokine
  • Wound Healing
  • Publications

  • A serum-induced transcriptome and serum cytokine signature obtained at diagnosis correlates with the development of early pancreatic ductal adenocarcinoma metastasis. (Tsai S, McOlash L, Jia S, Zhang J, Simpson P, Kaldunski ML, Aldakkak M, Grewal J, Palen K, Dwinell MB, Johnson BD, Mackinnon A, Hessner MJ, Gershan JA) Cancer Epidemiol Biomarkers Prev 2018 Dec 07 PMID: 30530849 12/12/2018    
  • Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation. (Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB) J Biol Chem 2018 Sep 21;293(38):14891-14904 PMID: 30087121 PMCID: PMC6153299 08/09/2018    
  • Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance. (Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ) Immunohorizons 2018 Apr 01;2(4):107-118 PMID: 30027154 PMCID: PMC6048965 07/22/2018    
  • GEMMs Are a Gem When it Comes to Defining the Role of HIF2α in Mucinous Cystic Neoplasms. (Boyle KA, Dwinell MB) Cell Mol Gastroenterol Hepatol 2018;5(2):165-166 PMID: 29693045 PMCID: PMC5904046 04/26/2018    
  • Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models. (Tsai S, McOlash L, Palen K, Johnson B, Duris C, Yang Q, Dwinell MB, Hunt B, Evans DB, Gershan J, James MA) BMC Cancer 2018 03 27;18(1):335 PMID: 29587663 PMCID: PMC5870823 03/29/2018       3 Citations
  • Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316-327]. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 06;16:426-427 PMID: 29548725 PMCID: PMC5952812 03/20/2018    
  • A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 04;14:316-327 PMID: 29017115 PMCID: PMC5633086 10/11/2017       18 Citations
  • Differences in Sulfotyrosine Binding amongst CXCR1 and CXCR2 Chemokine Ligands. (Moussouras NA, Getschman AE, Lackner ER, Veldkamp CT, Dwinell MB, Volkman BF) Int J Mol Sci 2017 Sep 03;18(9) PMID: 28869519 PMCID: PMC5618543 09/05/2017       1 Citations
  • CCR7 Sulfotyrosine Enhances CCL21 Binding. (Phillips AJ, Taleski D, Koplinski CA, Getschman AE, Moussouras NA, Richard AM, Peterson FC, Dwinell MB, Volkman BF, Payne RJ, Veldkamp CT) Int J Mol Sci 2017 Aug 25;18(9) PMID: 28841151 PMCID: PMC5618506 08/26/2017       2 Citations
  • Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell MB) Cell Biochem Biophys 2017 Dec;75(3-4):311-317 PMID: 28429253 PMCID: PMC5680142 04/22/2017       6 Citations
  • Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell M) Interface Focus 2017 Apr 06;7(2):20160109 PMID: 28382202 PMCID: PMC5311906 04/07/2017    
  • Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation. (Ziarek JJ, Kleist AB, London N, Raveh B, Montpas N, Bonneterre J, St-Onge G, DiCosmo-Ponticello CJ, Koplinski CA, Roy I, Stephens B, Thelen S, Veldkamp CT, Coffman FD, Cohen MC, Dwinell MB, Thelen M, Peterson FC, Heveker N, Volkman BF) Sci Signal 2017 Mar 21;10(471) PMID: 28325822 PMCID: PMC5648539 03/23/2017       23 Citations
  • Cancer cell chemokines direct chemotaxis of activated stellate cells in pancreatic ductal adenocarcinoma. (Roy I, Boyle KA, Vonderhaar EP, Zimmerman NP, Gorse E, Mackinnon AC, Hwang RF, Franco-Barraza J, Cukierman E, Tsai S, Evans DB, Dwinell MB) Lab Invest 2017 03;97(3):302-317 PMID: 28092365 PMCID: PMC5334280 01/17/2017       4 Citations
  • Exploiting agonist biased signaling of chemokines to target cancer. (Roy I, Getschman AE, Volkman BF, Dwinell MB) Mol Carcinog 2017 03;56(3):804-813 PMID: 27648825 PMCID: PMC5479419 09/21/2016       2 Citations
  • E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells. (Palen K, Weber J, Dwinell MB, Johnson BD, Ramchandran R, Gershan JA) Oncotarget 2016 Jul 12;7(28):43363-43375 PMID: 27270319 PMCID: PMC5190029 06/09/2016       7 Citations
  • Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells. (Cheng G, Zielonka J, Ouari O, Lopez M, McAllister D, Boyle K, Barrios CS, Weber JJ, Johnson BD, Hardy M, Dwinell MB, Kalyanaraman B) Cancer Res 2016 07 01;76(13):3904-15 PMID: 27216187 PMCID: PMC4930686 05/25/2016       40 Citations
  • Generation and characterization of mice harboring a conditional CXCL12 allele. (Hillmer RE, Boisvert JP, Cucciare MJ, Dwinell MB, Joksimovic M) Int J Dev Biol 2015;59(4-6):205-9 PMID: 26505253 10/28/2015       2 Citations
  • Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. (Roy I, McAllister DM, Gorse E, Dixon K, Piper CT, Zimmerman NP, Getschman AE, Tsai S, Engle DD, Evans DB, Volkman BF, Kalyanaraman B, Dwinell MB) Cancer Res 2015 Sep 01;75(17):3529-42 PMID: 26330165 PMCID: PMC4560104 09/04/2015       15 Citations
  • Correction: Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2015;10(8):e0137369 PMID: 26322640 PMCID: PMC4554722 09/01/2015    
  • p38γ MAPK Is a Therapeutic Target for Triple-Negative Breast Cancer by Stimulation of Cancer Stem-Like Cell Expansion. (Qi X, Yin N, Ma S, Lepp A, Tang J, Jing W, Johnson B, Dwinell MB, Chitambar CR, Chen G) Stem Cells 2015 Sep;33(9):2738-47 PMID: 26077647 PMCID: PMC4792188 06/17/2015       11 Citations
  • Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism. (Cheng G, Zielonka J, McAllister D, Hardy M, Ouari O, Joseph J, Dwinell MB, Kalyanaraman B) Cancer Lett 2015 Aug 28;365(1):96-106 PMID: 26004344 PMCID: PMC4476640 05/26/2015       22 Citations
  • CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. (Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ) Cancer Res 2014 Nov 15;74(22):6419-29 PMID: 25172839 PMCID: PMC4247541 08/31/2014       8 Citations
  • Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation. (Cheng G, Zielonka J, McAllister D, Tsai S, Dwinell MB, Kalyanaraman B) Br J Cancer 2014 Jul 08;111(1):85-93 PMID: 24867695 PMCID: PMC4090735 05/29/2014       35 Citations
  • Chemokines and chemokine receptors: update on utility and challenges for the clinician. (Roy I, Evans DB, Dwinell MB) Surgery 2014 Jun;155(6):961-73 PMID: 24856117 PMCID: PMC4390364 05/27/2014       28 Citations
  • CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. (Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB, Dwinell MB) PLoS One 2014;9(3):e90400 PMID: 24594697 PMCID: PMC3942415 03/07/2014       36 Citations
  • Astrocytes directly influence tumor cell invasion and metastasis in vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2013;8(12):e80933 PMID: 24324647 PMCID: PMC3851470 12/11/2013       36 Citations
  • Chemokines in colitis: microRNA control. (Roy I, Veldkamp CT, Volkman BF, Dwinell MB) Gut 2014 Aug;63(8):1202-4 PMID: 24142964 PMCID: PMC4608425 10/22/2013       3 Citations
  • Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. (Zimmerman NP, Roy I, Hauser AD, Wilson JM, Williams CL, Dwinell MB) Mol Carcinog 2015 Mar;54(3):203-15 PMID: 24115212 PMCID: PMC4087083 10/12/2013       19 Citations
  • Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. (Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B) BMC Cancer 2013 Jun 13;13:285 PMID: 23764021 PMCID: PMC3686663 06/15/2013       50 Citations
  • An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. (Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL) Sci Signal 2013 May 28;6(277):ra39 PMID: 23716716 PMCID: PMC4278376 05/30/2013       46 Citations
  • CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis. (Takekoshi T, Wu X, Mitsui H, Tada Y, Kao MC, Sato S, Dwinell MB, Hwang ST) J Invest Dermatol 2013 Nov;133(11):2530-2537 PMID: 23528817 PMCID: PMC3972890 03/27/2013       11 Citations
  • E-cadherin is critical for collective sheet migration and is regulated by the chemokine CXCL12 protein during restitution. (Hwang S, Zimmerman NP, Agle KA, Turner JR, Kumar SN, Dwinell MB) J Biol Chem 2012 Jun 22;287(26):22227-40 PMID: 22549778 PMCID: PMC3381184 05/03/2012       20 Citations
  • Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA. (Zimmerman NP, Kumar SN, Turner JR, Dwinell MB) Inflamm Bowel Dis 2012 Jun;18(6):1081-91 PMID: 21993975 PMCID: PMC3258471 10/14/2011       17 Citations
  • Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. (Drury LJ, Ziarek JJ, Gravel S, Veldkamp CT, Takekoshi T, Hwang ST, Heveker N, Volkman BF, Dwinell MB) Proc Natl Acad Sci U S A 2011 Oct 25;108(43):17655-60 PMID: 21990345 PMCID: PMC3203819 10/13/2011       119 Citations
  • Chemokine stimulation promotes enterocyte migration through laminin-specific integrins. (Agle KA, Vongsa RA, Dwinell MB) Am J Physiol Gastrointest Liver Physiol 2011 Dec;301(6):G968-80 PMID: 21921288 PMCID: PMC3233784 09/17/2011       8 Citations
  • Targeted intestinal epithelial deletion of the chemokine receptor CXCR4 reveals important roles for extracellular-regulated kinase-1/2 in restitution. (Zimmerman NP, Vongsa RA, Faherty SL, Salzman NH, Dwinell MB) Lab Invest 2011 Jul;91(7):1040-55 PMID: 21537329 PMCID: PMC3167207 05/04/2011       18 Citations
  • CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis. (Drury LJ, Wendt MK, Dwinell MB) PLoS One 2010 Sep 22;5(9):e12895 PMID: 20877573 PMCID: PMC2943927 09/30/2010       25 Citations
  • Calcium mobilization triggered by the chemokine CXCL12 regulates migration in wounded intestinal epithelial monolayers. (Agle KA, Vongsa RA, Dwinell MB) J Biol Chem 2010 May 21;285(21):16066-75 PMID: 20348095 PMCID: PMC2871475 03/30/2010       33 Citations
  • CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells. (Vongsa RA, Zimmerman NP, Dwinell MB) J Biol Chem 2009 Apr 10;284(15):10034-45 PMID: 19233848 PMCID: PMC2665058 02/24/2009       51 Citations
  • Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells. (Wendt MK, Drury LJ, Vongsa RA, Dwinell MB) Gastroenterology 2008 Aug;135(2):508-17 PMID: 18558091 PMCID: PMC2583344 06/19/2008       35 Citations
  • Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease. (Zimmerman NP, Vongsa RA, Wendt MK, Dwinell MB) Inflamm Bowel Dis 2008 Jul;14(7):1000-11 PMID: 18452220 PMCID: PMC4114077 05/03/2008       87 Citations
  • Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells. (Wendt MK, Cooper AN, Dwinell MB) Oncogene 2008 Feb 28;27(10):1461-71 PMID: 17724466 08/29/2007       91 Citations
  • Rho activation regulates CXCL12 chemokine stimulated actin rearrangement and restitution in model intestinal epithelia. (Moyer RA, Wendt MK, Johanesen PA, Turner JR, Dwinell MB) Lab Invest 2007 Aug;87(8):807-17 PMID: 17572689 PMCID: PMC2693067 06/19/2007       53 Citations
  • Mucosal immunity. (Dwinell MB, Kagnoff MF) Curr Opin Gastroenterol 1999 Jan;15(1):33-8 PMID: 17023915 10/07/2006    
  • Flagellin-independent regulation of chemokine host defense in Campylobacter jejuni-infected intestinal epithelium. (Johanesen PA, Dwinell MB) Infect Immun 2006 Jun;74(6):3437-47 PMID: 16714574 PMCID: PMC1479283 05/23/2006       39 Citations
  • Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis. (Wendt MK, Johanesen PA, Kang-Decker N, Binion DG, Shah V, Dwinell MB) Oncogene 2006 Aug 17;25(36):4986-97 PMID: 16568088 PMCID: PMC4610155 03/29/2006       99 Citations
  • Molecular stratification of Crohn's disease by chemokine receptors: fractalkine receptor polymorphisms define a fibrostenosing ileal subgroup. (Binion DG, Kugathasan S, Dwinell MB) Am J Gastroenterol 2006 Jan;101(1):107-9 PMID: 16405541 01/13/2006       2 Citations
  • Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells. (Yang CC, Ogawa H, Dwinell MB, McCole DF, Eckmann L, Kagnoff MF) Am J Physiol Cell Physiol 2005 Feb;288(2):C321-8 PMID: 15483227 10/16/2004       33 Citations
  • CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity. (Smith JM, Johanesen PA, Wendt MK, Binion DG, Dwinell MB) Am J Physiol Gastrointest Liver Physiol 2005 Feb;288(2):G316-26 PMID: 15358596 09/11/2004       61 Citations
  • Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells. (Heidemann J, Ogawa H, Rafiee P, Lügering N, Maaser C, Domschke W, Binion DG, Dwinell MB) Am J Physiol Gastrointest Liver Physiol 2004 Jun;286(6):G1059-68 PMID: 14764445 02/07/2004    
  • SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4. (Dwinell MB, Ogawa H, Barrett KE, Kagnoff MF) Am J Physiol Gastrointest Liver Physiol 2004 May;286(5):G844-50 PMID: 14684377 12/20/2003       36 Citations
  • Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation. (Rafiee P, Ogawa H, Heidemann J, Li MS, Aslam M, Lamirand TH, Fisher PJ, Graewin SJ, Dwinell MB, Johnson CP, Shaker R, Binion DG) Am J Physiol Gastrointest Liver Physiol 2003 Dec;285(6):G1277-92 PMID: 12919942 08/16/2003       29 Citations
  • Immunobiology of epithelial chemokines in the intestinal mucosa. (Dwinell MB, Johanesen PA, Smith JM) Surgery 2003 Jun;133(6):601-7 PMID: 12796725 06/11/2003       40 Citations
  • Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. (Heidemann J, Ogawa H, Dwinell MB, Rafiee P, Maaser C, Gockel HR, Otterson MF, Ota DM, Lugering N, Domschke W, Binion DG) J Biol Chem 2003 Mar 07;278(10):8508-15 PMID: 12496258 12/24/2002       290 Citations
  • Production of MDC/CCL22 by human intestinal epithelial cells. (Berin MC, Dwinell MB, Eckmann L, Kagnoff MF) Am J Physiol Gastrointest Liver Physiol 2001 Jun;280(6):G1217-26 PMID: 11352815 05/16/2001       54 Citations
  • Regulated MIP-3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. (Izadpanah A, Dwinell MB, Eckmann L, Varki NM, Kagnoff MF) Am J Physiol Gastrointest Liver Physiol 2001 Apr;280(4):G710-9 PMID: 11254498 03/20/2001       196 Citations
  • Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells. (Dwinell MB, Lügering N, Eckmann L, Kagnoff MF) Gastroenterology 2001 Jan;120(1):49-59 PMID: 11208713 02/24/2001    
  • Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella. (Eckmann L, Smith JR, Housley MP, Dwinell MB, Kagnoff MF) J Biol Chem 2000 May 12;275(19):14084-94 PMID: 10799483 05/09/2000       156 Citations
  • Human intestinal epithelial cells express receptors for platelet-activating factor. (Merendino N, Dwinell MB, Varki N, Eckmann L, Kagnoff MF) Am J Physiol 1999 10;277(4):G810-8 PMID: 10516147 10/12/1999       20 Citations
  • Chemokine receptor expression by human intestinal epithelial cells. (Dwinell MB, Eckmann L, Leopard JD, Varki NM, Kagnoff MF) Gastroenterology 1999 Aug;117(2):359-67 PMID: 10419917 07/27/1999       172 Citations
  • Hymenolepis diminuta fractions but not previous tapeworm infection stimulate intestinal myoelectric alterations in vivo in the rat. (Dwinell MB, Bass P, Oaks JA) J Parasitol 1998 Aug;84(4):673-80 PMID: 9714192 08/26/1998       12 Citations
  • Hymenolepsis diminuta: mucosal mastocytosis and intestinal smooth muscle hypertrophy occur in tapeworm-infected rats. (Dwinell MB, Wise RM, Bass P, Oaks JA) Exp Parasitol 1998 May;89(1):92-102 PMID: 9603494 05/29/1998       25 Citations
  • Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. (Rowell DL, Eckmann L, Dwinell MB, Carpenter SP, Raucy JL, Yang SK, Kagnoff MF) Am J Physiol 1997 Aug;273(2 Pt 1):G322-32 PMID: 9277410 08/01/1997       85 Citations
  • Tapeworm infection decreases intestinal transit and enteric aerobic bacterial populations. (Dwinell MB, Bass P, Schaefer DM, Oaks JA) Am J Physiol 1997 Aug;273(2 Pt 1):G480-5 PMID: 9277428 08/01/1997       36 Citations
  • Praziquantel treatment normalizes intestinal myoelectric alterations associated with Hymenolepis diminuta-infected rats. (Dwinell MB, Bass P, Oaks JA) J Parasitol 1995 Dec;81(6):979-84 PMID: 8544075 12/01/1995       13 Citations
  • Intestinal myoelectric alterations in rats chronically infected with the tapeworm Hymenolepis diminuta. (Dwinell MB, Bass P, Oaks JA) Am J Physiol 1994 Nov;267(5 Pt 1):G851-8 PMID: 7977747 11/01/1994       30 Citations
  • Last update: 07/20/2018
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