Medical College of Wisconsin
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Nashaat Gerges PhD

Chair, Associate Professor

Institution: Medical College of Wisconsin
Department: School of Pharmacy
Division: Administration
Program: Program Development

Member of the Neuroscience Research Center


Publications

  • Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression. (Brown JC, Petersen A, Zhong L, Himelright ML, Murphy JA, Walikonis RS, Gerges NZ) Nat Commun 2016 Mar 24;7:11080 PMID: 27009485 PMCID: PMC4820844 03/25/2016       6 Citations
  • PTEN recruitment controls synaptic and cognitive function in Alzheimer's models. (Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA) Nat Neurosci 2016 Mar;19(3):443-53 PMID: 26780512 01/19/2016       41 Citations
  • Neurogranin restores amyloid β-mediated synaptic transmission and long-term potentiation deficits. (Kaleka KS, Gerges NZ) Exp Neurol 2016 Mar;277:115-123 PMID: 26721336 01/02/2016       9 Citations
  • The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation. (Santarriaga S, Petersen A, Ndukwe K, Brandt A, Gerges N, Bruns Scaglione J, Scaglione KM) J Biol Chem 2015 Oct 16;290(42):25571-8 PMID: 26330554 PMCID: PMC4646202 09/04/2015       6 Citations
  • Neurogranin regulates CaM dynamics at dendritic spines. (Petersen A, Gerges NZ) Sci Rep 2015 Jun 18;5:11135 PMID: 26084473 PMCID: PMC4471661 06/19/2015       11 Citations
  • Increased prefrontal cortex neurogranin enhances plasticity and extinction learning. (Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ) J Neurosci 2015 May 13;35(19):7503-8 PMID: 25972176 PMCID: PMC4429154 05/15/2015       10 Citations
  • Post-embedding Immunogold labeling of synaptic proteins in hippocampal slice cultures. (Zhong L, Brown JC, Wells C, Gerges NZ) J Vis Exp 2013 Apr 03(74) PMID: 23609099 PMCID: PMC3643798 04/24/2013       6 Citations
  • Structural basis for the interaction of unstructured neuron specific substrates neuromodulin and neurogranin with Calmodulin. (Kumar V, Chichili VP, Zhong L, Tang X, Velazquez-Campoy A, Sheu FS, Seetharaman J, Gerges NZ, Sivaraman J) Sci Rep 2013;3:1392 PMID: 23462742 PMCID: PMC3589724 03/07/2013       26 Citations
  • GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. (Shin SM, Zhang N, Hansen J, Gerges NZ, Pak DT, Sheng M, Lee SH) Nat Neurosci 2012 Dec;15(12):1655-66 PMID: 23143515 PMCID: PMC3804128 11/13/2012       64 Citations
  • Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors. (Garrison SR, Kramer AA, Gerges NZ, Hillery CA, Stucky CL) Mol Pain 2012 Sep 10;8:62 PMID: 22963123 PMCID: PMC3495672 09/12/2012       24 Citations
  • Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation. (Zhong L, Gerges NZ) PLoS One 2012;7(7):e41275 PMID: 22848456 PMCID: PMC3405117 08/01/2012       16 Citations
  • S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors. (Danielson E, Zhang N, Metallo J, Kaleka K, Shin SM, Gerges N, Lee SH) J Neurosci 2012 May 16;32(20):6967-80 PMID: 22593065 PMCID: PMC3365591 05/18/2012       24 Citations
  • Pull-down of calmodulin-binding proteins. (Kaleka KS, Petersen AN, Florence MA, Gerges NZ) J Vis Exp 2012 Jan 23(59) PMID: 22297704 PMCID: PMC3462570 02/03/2012       5 Citations
  • Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. (Renic M, Kumar SN, Gebremedhin D, Florence MA, Gerges NZ, Falck JR, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2012 Mar 15;302(6):H1285-93 PMID: 22245774 PMCID: PMC3311475 01/17/2012       22 Citations
  • Neurogranin phosphorylation fine-tunes long-term potentiation. (Zhong L, Kaleka KS, Gerges NZ) Eur J Neurosci 2011 Jan;33(2):244-50 PMID: 21198977 PMCID: PMC3058258 01/05/2011       12 Citations
  • Neurogranin and synaptic plasticity balance. (Zhong L, Gerges NZ) Commun Integr Biol 2010 Jul;3(4):340-2 PMID: 20798820 PMCID: PMC2928312 08/28/2010    
  • Neurogranin enhances synaptic strength through its interaction with calmodulin. (Zhong L, Cherry T, Bies CE, Florence MA, Gerges NZ) EMBO J 2009 Oct 07;28(19):3027-39 PMID: 19713936 PMCID: PMC2736013 08/29/2009       60 Citations
  • Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies. (Alzoubi KH, Gerges NZ, Aleisa AM, Alkadhi KA) Hippocampus 2009 Jan;19(1):66-78 PMID: 18680156 08/06/2008       87 Citations
  • Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies. (Alzoubi KH, Aleisa AM, Gerges NZ, Alkadhi KA) J Neurosci Res 2006 Oct;84(5):944-53 PMID: 16902999 08/12/2006       46 Citations
  • Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. (Gerges NZ, Backos DS, Rupasinghe CN, Spaller MR, Esteban JA) EMBO J 2006 Apr 19;25(8):1623-34 PMID: 16601687 PMCID: PMC1440842 04/08/2006       101 Citations
  • Chronic psychosocial stress-induced impairment of hippocampal LTP: possible role of BDNF. (Aleisa AM, Alzoubi KH, Gerges NZ, Alkadhi KA) Neurobiol Dis 2006 Jun;22(3):453-62 PMID: 16530419 03/15/2006       70 Citations
  • Analysis of Rab protein function in neurotransmitter receptor trafficking at hippocampal synapses. (Gerges NZ, Brown TC, Correia SS, Esteban JA) Methods Enzymol 2005;403:153-66 PMID: 16473584 02/14/2006       17 Citations
  • Nicotine blocks stress-induced impairment of spatial memory and long-term potentiation of the hippocampal CA1 region. (Aleisa AM, Alzoubi KH, Gerges NZ, Alkadhi KA) Int J Neuropsychopharmacol 2006 Aug;9(4):417-26 PMID: 16316479 12/01/2005       52 Citations
  • Levothyroxin restores hypothyroidism-induced impairment of LTP of hippocampal CA1: electrophysiological and molecular studies. (Alzoubi KH, Gerges NZ, Alkadhi KA) Exp Neurol 2005 Oct;195(2):330-41 PMID: 16004982 07/12/2005       74 Citations
  • Role of phosphorylated CaMKII and calcineurin in the differential effect of hypothyroidism on LTP of CA1 and dentate gyrus. (Gerges NZ, Alzoubi KH, Alkadhi KA) Hippocampus 2005;15(4):480-90 PMID: 15714506 02/17/2005       49 Citations
  • Adverse effect of the combination of hypothyroidism and chronic psychosocial stress on hippocampus-dependent memory in rats. (Gerges NZ, Alzoubi KH, Park CR, Diamond DM, Alkadhi KA) Behav Brain Res 2004 Nov 05;155(1):77-84 PMID: 15325781 08/25/2004       84 Citations
  • Local control of AMPA receptor trafficking at the postsynaptic terminal by a small GTPase of the Rab family. (Gerges NZ, Backos DS, Esteban JA) J Biol Chem 2004 Oct 15;279(42):43870-8 PMID: 15297461 08/07/2004       88 Citations
  • Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors. (Gerges NZ, Tran IC, Backos DS, Harrell JM, Chinkers M, Pratt WB, Esteban JA) J Neurosci 2004 May 19;24(20):4758-66 PMID: 15152036 05/21/2004       54 Citations
  • Reduced basal CaMKII levels in hippocampal CA1 region: possible cause of stress-induced impairment of LTP in chronically stressed rats. (Gerges NZ, Aleisa AM, Schwarz LA, Alkadhi KA) Hippocampus 2004;14(3):402-10 PMID: 15132438 05/11/2004       72 Citations
  • Hypothyroidism impairs late LTP in CA1 region but not in dentate gyrus of the intact rat hippocampus: MAPK involvement. (Gerges NZ, Alkadhi KA) Hippocampus 2004;14(1):40-5 PMID: 15058481 04/03/2004       85 Citations
  • Impaired long-term potentiation in obese zucker rats: possible involvement of presynaptic mechanism. (Gerges NZ, Aleisa AM, Alkadhi KA) Neuroscience 2003;120(2):535-9 PMID: 12890522 08/02/2003       52 Citations
  • Chronic psychosocial stress decreases calcineurin in the dentate gyrus: a possible mechanism for preservation of early ltp. (Gerges NZ, Aleisa AM, Schwarz LA, Alkadhi KA) Neuroscience 2003;117(4):869-74 PMID: 12654339 03/26/2003       29 Citations
  • Reduction of elevated arterial blood pressure in obese Zucker rats by inhibition of ganglionic long-term potentiation. (Gerges NZ, Aleisa AM, Alhaider AA, Alkadhi KA) Neuropharmacology 2002 Dec;43(7):1070-6 PMID: 12504912 12/31/2002       21 Citations
  • Combination of hypothyroidism and stress abolishes early LTP in the CA1 but not dentate gyrus of hippocampus of adult rats. (Gerges NZ, Stringer JL, Alkadhi KA) Brain Res 2001 Dec 20;922(2):250-60 PMID: 11743957 12/18/2001       131 Citations
  • Last update: 01/31/2017
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6