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Raul A. Urrutia MD

Raul A. Urrutia MD profile photo picture

Center Director, Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Administration
Program: General

Director of the Mellowes Center for Genomic Sciences and Precision Medicine
Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Center for Disease Prevention Research (CDPR)

Publications (281)

  • Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression. (Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC) J Biol Chem 2024 Apr;300(4):107146 PMID: 38460939 PMCID: PMC11002309 SCOPUS ID: 2-s2.0-85189184192 03/10/2024    
  • Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing. (Li JR, Arsang-Jang S, Cheng Y, Sun F, D'Souza A, Dhakal B, Hari P, Huang Q, Auer P, Li Y, Urrutia R, Zhan F, Shaughnessy JD Jr, Janz S, Dong J, Cheng C) Blood Cancer J 2024 Mar 06;14(1):38 PMID: 38443358 PMCID: PMC10915134 SCOPUS ID: 2-s2.0-85186929795 03/06/2024    
  • Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors. (Santofimia-Castaño P, Fraunhoffer N, Liu X, Bessone IF, di Magliano MP, Audebert S, Camoin L, Estaras M, Brenière M, Modesti M, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J) EMBO Mol Med 2024 Mar;16(3):475-505 PMID: 38360999 PMCID: PMC10940650 SCOPUS ID: 2-s2.0-85185320484 02/16/2024       1 Citation
  • Verteporfin induces lipid peroxidation and ferroptosis in pancreatic cancer cells. (Zhou W, Lim A, Elmadbouh OHM, Edderkaoui M, Osipov A, Mathison AJ, Urrutia R, Liu T, Wang Q, Pandol SJ) Free Radic Biol Med 2024 Feb 20;212:493-504 PMID: 38184120 PMCID: PMC10906657 SCOPUS ID: 2-s2.0-85182384342 01/07/2024       1 Citation
  • Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction. (Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Front Genet 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023    
  • An EMR-Based Approach to Determine Frequency, Prescribing Pattern, and Characteristics of Patients Receiving Drugs with Pharmacogenomic Guidelines. (MacKinnon GE 3rd, Mills M, Stoddard A, Urrutia RA, Broeckel U) Pharmacy (Basel) 2023 Nov 17;11(6) PMID: 37987388 PMCID: PMC10661282 11/21/2023    
  • Identification of novel loci for multiple myeloma when comparing with its precursor condition monoclonal gammopathy of unknown significance. (Buradagunta CS, Arsang-Jang S, Massat B, Thapa B, Patek V, D'Souza A, Auer P, Urrutia R, Janz S, Dhakal B, Hari P, Dong J) Leukemia 2024 Feb;38(2):383-385 PMID: 37919604 SCOPUS ID: 2-s2.0-85175540732 11/03/2023    
  • Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry. (Pollin G, De Assuncao TM, Doria Jorge S, Chi YI, Charlesworth MC, Madden B, Iovanna J, Zimmermann MT, Urrutia R, Lomberk G) Biosci Rep 2023 Oct 31;43(10) PMID: 37782747 PMCID: PMC10611923 SCOPUS ID: 2-s2.0-85175273435 10/02/2023    
  • Advanced computational analysis of CD40LG variants in atypical X-linked hyper-IgM syndrome. (Pazhanisamy A, Jorge SD, Zimmermann MT, Kitcharoensakkul M, Abdalgani M, Khojah A, Victor C, Rueda C, Urrutia R, Abraham RS) Clin Immunol 2023 Aug;253:109692 PMID: 37433422 SCOPUS ID: 2-s2.0-85164736502 07/12/2023    
  • Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells (Fraunhoffer NA, Moreno Vega AI, Abuelafia AM, Morvan M, Lebarbier E, Mary-Huard T, Zimmermann M, Lomberk G, Urrutia R, Dusetti N, Blum Y, Nicolle R, Iovanna J) eBioMedicine June 2023;92 SCOPUS ID: 2-s2.0-85154565512 06/01/2023       2 Citations
  • KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress. (Yang Y, Bhargava D, Chen X, Zhou T, Dursuk G, Jiang W, Wang J, Zong Z, Katz SI, Lomberk GA, Urrutia RA, Katz JP) Cell Death Dis 2023 May 02;14(5):299 PMID: 37130837 PMCID: PMC10154356 SCOPUS ID: 2-s2.0-85157983058 05/03/2023    
  • Prognostic landscape of mitochondrial genome in myelodysplastic syndrome after stem-cell transplantation. (Dong J, Buradagunta CS, Zhang T, Spellman S, Bolon YT, DeZern AE, Gadalla SM, Deeg HJ, Nazha A, Cutler C, Cheng C, Urrutia R, Auer P, Saber W) J Hematol Oncol 2023 Mar 10;16(1):21 PMID: 36899395 PMCID: PMC9999628 SCOPUS ID: 2-s2.0-85149930611 03/11/2023    
  • Impact of integrated translational research on clinical exome sequencing. (Klee EW, Cousin MA, Pinto E Vairo F, Morales-Rosado JA, Macke EL, Jenkinson WG, Ferrer A, Schultz-Rogers LE, Olson RJ, Oliver GR, Sigafoos AN, Schwab TL, Zimmermann MT, Urrutia RA, Kaiwar C, Gupta A, Blackburn PR, Boczek NJ, Prochnow CA, Lowy RJ, Mulvihill LA, McAllister TM, Aoudia SL, Kruisselbrink TM, Gunderson LB, Kemppainen JL, Fisher LJ, Tarnowski JM, Hager MM, Kroc SA, Bertsch NL, Agre KE, Jackson JL, Macklin-Mantia SK, Murphree MI, Rust LM, Summer Bolster JM, Beck SA, Atwal PS, Ellingson MS, Barnett SS, Rasmussen KJ, Lahner CA, Niu Z, Hasadsri L, Ferber MJ, Marcou CA, Clark KJ, Pichurin PN, Deyle DR, Morava-Kozicz E, Gavrilova RH, Dhamija R, Wierenga KJ, Lanpher BC, Babovic-Vuksanovic D, Farrugia G, Schimmenti LA, Stewart AK, Lazaridis KN) Genet Med 2023 Feb;25(2):100359 PMID: 36745126 SCOPUS ID: 2-s2.0-85146870414 02/07/2023    
  • Erratum: Impact of integrated translational research on clinical exome sequencing (Genetics in Medicine (2021) 23(3) (498–507), (S1098360021049455), (10.1038/s41436-020-01005-9)) (Klee EW, Cousin MA, Pinto e Vairo F, Morales-Rosado JA, Macke EL, Jenkinson WG, Ferrer A, Schultz-Rogers LE, Olson RJ, Oliver GR, Sigafoos AN, Schwab TL, Zimmermann MT, Urrutia RA, Kaiwar C, Gupta A, Blackburn PR, Boczek NJ, Prochnow CA, Lowy RJ, Mulvihill LA, McAllister TM, Aoudia SL, Kruisselbrink TM, Gunderson LB, Kemppainen JL, Fisher LJ, Tarnowski JM, Hager MM, Kroc SA, Bertsch NL, Agre KE, Jackson JL, Macklin-Mantia SK, Murphree MI, Rust LM, Summer Bolster JM, Beck SA, Atwal PS, Ellingson MS, Barnett SS, Rasmussen KJ, Lahner CA, Niu Z, Hasadsri L, Ferber MJ, Marcou CA, Clark KJ, Pichurin PN, Deyle DR, Morava-Kozicz E, Gavrilova RH, Dhamija R, Wierenga KJ, Lanpher BC, Babovic-Vuksanovic D, Farrugia G, Schimmenti LA, Stewart AK, Lazaridis KN) Genetics in Medicine February 2023;25(2) SCOPUS ID: 2-s2.0-85146870414 02/01/2023    
  • The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. (Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G) Nat Commun 2023 Jan 03;14(1):1 PMID: 36596776 PMCID: PMC9810714 SCOPUS ID: 2-s2.0-85145429848 01/04/2023       16 Citations
  • Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape (Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT) Computational and Structural Biotechnology Journal January 2023;21:4790-4803 SCOPUS ID: 2-s2.0-85173171942 01/01/2023    
  • A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1 (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Computational and Structural Biotechnology Journal January 2023;21:5249-5258 SCOPUS ID: 2-s2.0-85174744984 01/01/2023    
  • Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction (Fraunhoffer NA, Abuelafia AM, Bigonnet M, Gayet O, Roques J, Nicolle R, Lomberk G, Urrutia R, Dusetti N, Iovanna J) npj Precision Oncology December 2022;6(1) SCOPUS ID: 2-s2.0-85136999952 12/01/2022       7 Citations
  • Precision medicine in trauma: a transformational frontier in patient care, education, and research (Davis CS, Wilkinson KH, Lin E, Carpenter NJ, Georgeades C, Lomberk G, Urrutia R) European Journal of Trauma and Emergency Surgery August 2022;48(4):2607-2612 SCOPUS ID: 2-s2.0-85119154805 08/01/2022       4 Citations
  • NUPR1 protects against hyperPARylation-dependent cell death. (Santofimia-Castaño P, Huang C, Liu X, Xia Y, Audebert S, Camoin L, Peng L, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J) Commun Biol 2022 Jul 22;5(1):732 PMID: 35869257 PMCID: PMC9307593 SCOPUS ID: 2-s2.0-85134559984 07/23/2022       5 Citations
  • "Stripe" transcription factors provide accessibility to co-binding partners in mammalian genomes. (Zhao Y, Vartak SV, Conte A, Wang X, Garcia DA, Stevens E, Kyoung Jung S, Kieffer-Kwon KR, Vian L, Stodola T, Moris F, Chopp L, Preite S, Schwartzberg PL, Kulinski JM, Olivera A, Harly C, Bhandoola A, Heuston EF, Bodine DM, Urrutia R, Upadhyaya A, Weirauch MT, Hager G, Casellas R) Mol Cell 2022 Sep 15;82(18):3398-3411.e11 PMID: 35863348 PMCID: PMC9481673 SCOPUS ID: 2-s2.0-85137823096 07/22/2022       10 Citations
  • Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome. (Cousin MA, Veale EL, Dsouza NR, Tripathi S, Holden RG, Arelin M, Beek G, Bekheirnia MR, Beygo J, Bhambhani V, Bialer M, Bigoni S, Boelman C, Carmichael J, Courtin T, Cogne B, Dabaj I, Doummar D, Fazilleau L, Ferlini A, Gavrilova RH, Graham JM Jr, Haack TB, Juusola J, Kant SG, Kayani S, Keren B, Ketteler P, Klöckner C, Koopmann TT, Kruisselbrink TM, Kuechler A, Lambert L, Latypova X, Lebel RR, Leduc MS, Leonardi E, Lewis AM, Liew W, Machol K, Mardini S, McWalter K, Mignot C, McLaughlin J, Murgia A, Narayanan V, Nava C, Neuser S, Nizon M, Ognibene D, Park J, Platzer K, Poirsier C, Radtke M, Ramsey K, Runke CK, Guillen Sacoto MJ, Scaglia F, Shinawi M, Spranger S, Tan ES, Taylor J, Trentesaux AS, Vairo F, Willaert R, Zadeh N, Urrutia R, Babovic-Vuksanovic D, Zimmermann MT, Mathie A, Klee EW) Genome Med 2022 Jun 13;14(1):62 PMID: 35698242 PMCID: PMC9195326 SCOPUS ID: 2-s2.0-85131795908 06/14/2022       3 Citations
  • Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Comput Struct Biotechnol J 2022;20:2200-2211 PMID: 35615018 PMCID: PMC9111933 SCOPUS ID: 2-s2.0-85130080827 05/27/2022       4 Citations
  • To ChIP, or to CUT, that is the question: Comparative Evaluation of NextGen Methodologies for Studying the genome-wide distribution of Histone H3 Lysine 9 di-methyl mark in pancreatic cells. (Urrutia G, Abrudan JL, Du M, de Assuncao TM, Mathison AJ, Zimmermann MT, Lomberk G, Urrutia R) FASEB J 2022 May;36 Suppl 1 PMID: 35556470 SCOPUS ID: 2-s2.0-85130072518 05/14/2022    
  • Transcriptional Landscape Established by the Euchromatic Histone-lysine N-methyltransferase Pathway During Pancreas Ontogenesis and Pancreatitis. (Urrutia R, Salmonson A, Urrutia G, de Assuncao TM, Zimmermann MT, Mathison AJ, Lomberk G) FASEB J 2022 May;36 Suppl 1 PMID: 35556469 SCOPUS ID: 2-s2.0-85130010001 05/14/2022    
  • Defining the Mutational Landscape That Affects the Histone Demethylase KDM6A/UTX in Human Cancer. (Chi YI, Stodola TJ, de Assuncao TM, Volkman B, Smith B, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) FASEB J 2022 May;36 Suppl 1 PMID: 35555661 SCOPUS ID: 2-s2.0-85130046941 05/14/2022    
  • Epigenomic mechanisms used by KrasG12D to regulate inflammatory gene clusters in epithelial pancreatic cancer cells, which are critical for reprogramming the tumor microenvironment. (Du M, Abrudan JL, Urrutia G, de Assuncao TM, Mathison AJ, Zimmermann MT, Lomberk G, Urrutia R) FASEB J 2022 May;36 Suppl 1 PMID: 35552230 SCOPUS ID: 2-s2.0-85130057842 05/14/2022    
  • Functional Inferences Derived from Defining the Interactome of H3K9me2 Writers and Readers (Pollin G, de Assuncao TM, Lomberk G, Urrutia R) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 May 2022;36 PMID: 35552325 SCOPUS ID: 2-s2.0-85130026676 05/01/2022    
  • RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerization. (Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD Jr, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD) JCI Insight 2022 May 09;7(9) PMID: 35358093 PMCID: PMC9090250 SCOPUS ID: 2-s2.0-85129954550 04/01/2022       8 Citations
  • Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons. (Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD) Genes (Basel) 2022 Jan 27;13(2) PMID: 35205286 PMCID: PMC8871895 SCOPUS ID: 2-s2.0-85124092767 02/26/2022       6 Citations
  • Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons (Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD) Genes February 2022;13(2) SCOPUS ID: 2-s2.0-85124092767 02/01/2022       6 Citations
  • Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics (Tripathi S, Dsouza NR, Mathison AJ, Leverence E, Urrutia R, Zimmermann MT) Computational and Structural Biotechnology Journal January 2022;20:117-127 SCOPUS ID: 2-s2.0-85121238740 01/01/2022       3 Citations
  • The current and future role of artificial intelligence in optimizing donor organ utilization and recipient outcomes in heart transplantation (Carlson SF, Kamalia MA, Zimmerman MT, Urrutia RA, Joyce DL) Heart, Vessels and Transplantation 2022;6(4) SCOPUS ID: 2-s2.0-85144581655 01/01/2022    
  • KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells. (Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R) Genome Biol 2021 Oct 14;22(1):289 PMID: 34649604 PMCID: PMC8518179 SCOPUS ID: 2-s2.0-85117299300 10/16/2021       5 Citations
  • Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis. (Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Proteins 2022 Jan;90(1):282-298 PMID: 34414607 PMCID: PMC8671179 SCOPUS ID: 2-s2.0-85114677469 08/21/2021       2 Citations
  • Effects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model. (Kim J, Zimmerman MA, Shin WY, Boettcher BT, Lee JS, Park JI, Ali M, Yang M, Mishra J, Hagen CE, McGraw JE, Mathison A, Woehlck HJ, Lomberk G, Camara AKS, Urrutia RA, Stowe DF, Hong JC) Ann Surg 2023 Feb 01;277(2):e366-e375 PMID: 34387201 PMCID: PMC8840998 SCOPUS ID: 2-s2.0-85146161896 08/14/2021       7 Citations
  • P2T2: Protein Panoramic annoTation Tool for the interpretation of protein coding genetic variants. (DeVoe E, Oliver GR, Zenka R, Blackburn PR, Cousin MA, Boczek NJ, Kocher JA, Urrutia R, Klee EW, Zimmermann MT) JAMIA Open 2021 Jul;4(3):ooab065 PMID: 34377961 PMCID: PMC8346652 SCOPUS ID: 2-s2.0-85118188543 08/12/2021       1 Citation
  • Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks. (Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G) Front Cell Dev Biol 2021;9:681153 PMID: 34249932 PMCID: PMC8261250 SCOPUS ID: 2-s2.0-85116952280 07/13/2021       4 Citations
  • BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease. (Gonzalez MM, Bamidele AO, Svingen PA, Sagstetter MR, Smyrk TC, Gaballa JM, Hamdan FH, Kosinsky RL, Gibbons HR, Sun Z, Ye Z, Nair A, Ramos GP, Braga Neto MB, Wixom AQ, Mathison AJ, Johnsen SA, Urrutia R, Faubion WA Jr) J Clin Invest 2021 Jun 15;131(12) PMID: 34128475 PMCID: PMC8203461 SCOPUS ID: 2-s2.0-85108220626 06/16/2021       13 Citations
  • Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Orphanet J Rare Dis 2021 Jun 01;16(1):247 PMID: 34074320 PMCID: PMC8170813 SCOPUS ID: 2-s2.0-85107273180 06/03/2021    
  • LPCAT1-TERT fusions are uniquely recurrent in epithelioid trophoblastic tumors and positively regulate cell growth. (Oliver GR, Marcano-Bonilla S, Quist J, Tolosa EJ, Iguchi E, Swanson AA, Hoppman NL, Schwab T, Sigafoos A, Prodduturi N, Voss JS, Knight SM, Zhang J, Fadra N, Urrutia R, Zimmerman M, Egan JB, Bilyeu AG, Jen J, Veras E, Al-Safi R, Block M, Kerr S, Fernandez-Zapico ME, Schoolmeester JK, Klee EW) PLoS One 2021;16(5):e0250518 PMID: 34033669 PMCID: PMC8148365 SCOPUS ID: 2-s2.0-85106573389 05/26/2021       5 Citations
  • Corrigendum to: Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer (EMBO Molecular Medicine, (2012), 4, 9, (964-979), 10.1002/emmm.201201255) (Cano CE, José Sandí M, Hamidi T, Calvo EL, Turrini O, Bartholin L, Loncle C, Secq V, Garcia S, Lomberk G, Kroemer G, Urrutia R, Iovanna JL) EMBO Molecular Medicine 7 May 2021;13(5) SCOPUS ID: 2-s2.0-85105133639 05/07/2021       1 Citation
  • SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation. (Delmonte OM, Bergerson JRE, Kawai T, Kuehn HS, McDermott DH, Cortese I, Zimmermann MT, Dobbs AK, Bosticardo M, Fink D, Majumdar S, Palterer B, Pala F, Dsouza NR, Pouzolles M, Taylor N, Calvo KR, Daley SR, Velez D, Agharahimi A, Myint-Hpu K, Dropulic LK, Lyons JJ, Holland SM, Freeman AF, Ghosh R, Similuk MB, Niemela JE, Stoddard J, Kuhns DB, Urrutia R, Rosenzweig SD, Walkiewicz MA, Murphy PM, Notarangelo LD) Blood 2021 Sep 23;138(12):1019-1033 PMID: 33876203 PMCID: PMC8462359 SCOPUS ID: 2-s2.0-85114709336 04/21/2021       29 Citations
  • Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance. (Kaoutari AE, Fraunhoffer NA, Hoare O, Teyssedou C, Soubeyran P, Gayet O, Roques J, Lomberk G, Urrutia R, Dusetti N, Iovanna J) EBioMedicine 2021 Apr;66:103332 PMID: 33862584 PMCID: PMC8054161 SCOPUS ID: 2-s2.0-85104049834 04/17/2021       23 Citations
  • A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer. (Kloesch B, Ionasz V, Paliwal S, Hruschka N, Martinez de Villarreal J, Öllinger R, Mueller S, Dienes HP, Schindl M, Gruber ES, Stift J, Herndler-Brandstetter D, Lomberk GA, Seidler B, Saur D, Rad R, Urrutia RA, Real FX, Martinelli P) Gut 2022 Apr;71(4):766-777 PMID: 33846140 PMCID: PMC9733634 SCOPUS ID: 2-s2.0-85104197617 04/14/2021       37 Citations
  • Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level. (Zimmermann MT, Mathison AJ, Stodola T, Evans DB, Abrudan JL, Demos W, Tschannen M, Aldakkak M, Geurts J, Lomberk G, Tsai S, Urrutia R) Front Oncol 2021;11:606820 PMID: 33747920 PMCID: PMC7973372 SCOPUS ID: 2-s2.0-85102941394 03/23/2021       4 Citations
  • Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Orphanet J Rare Dis 2021 Feb 05;16(1):66 PMID: 33546721 PMCID: PMC7866879 SCOPUS ID: 2-s2.0-85100579633 02/07/2021       11 Citations
  • POLD1 Deficiency Reveals a Role for POLD1 in DNA Repair and T and B Cell Development (Nichols-Vinueza DX, Delmonte OM, Bundy V, Bosticardo M, Zimmermann MT, Dsouza NR, Pala F, Dobbs K, Stoddard J, Niemela JE, Kuehn HS, Keller MD, Rueda CM, Abraham RS, Urrutia R, Rosenzweig SD, Notarangelo LD) Journal of Clinical Immunology January 2021;41(1):270-273 SCOPUS ID: 2-s2.0-85094912585 01/01/2021       11 Citations
  • Structural bioinformatics enhances mechanistic interpretation of genomic variation, demonstrated through the analyses of 935 distinct RAS family mutations. (Tripathi S, Dsouza NR, Urrutia R, Zimmermann MT) Bioinformatics 2021 Jun 16;37(10):1367-1375 PMID: 33226070 PMCID: PMC8208742 SCOPUS ID: 2-s2.0-85108386153 11/24/2020       3 Citations
  • Impact of integrated translational research on clinical exome sequencing. (Klee EW, Cousin MA, Pinto E Vairo F, Morales-Rosado JA, Macke EL, Jenkinson WG, Ferrer A, Schultz-Rogers LE, Olson RJ, Oliver GR, Sigafoos AN, Schwab TL, Zimmermann MT, Urrutia RA, Kaiwar C, Gupta A, Blackburn PR, Boczek NJ, Prochnow CA, Lowy RJ, Mulvihill LA, McAllister TM, Aoudia SL, Kruisselbrink TM, Gunderson LB, Kemppainen JL, Fisher LJ, Tarnowski JM, Hager MM, Kroc SA, Bertsch NL, Agre KE, Jackson JL, Macklin-Mantia SK, Murphree MI, Rust LM, Summer Bolster JM, Beck SA, Atwal PS, Ellingson MS, Barnett SS, Rasmussen KJ, Lahner CA, Niu Z, Hasadsri L, Ferber MJ, Marcou CA, Clark KJ, Pichurin PN, Deyle DR, Morava-Kozicz E, Gavrilova RH, Dhamija R, Wierenga KJ, Lanpher BC, Babovic-Vuksanovic D, Farrugia G, Schimmenti LA, Stewart AK, Lazaridis KN) Genet Med 2021 Mar;23(3):498-507 PMID: 33144682 SCOPUS ID: 2-s2.0-85094871921 11/05/2020       24 Citations
  • Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer. (Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG) FASEB J 2020 Dec;34(12):16034-16048 PMID: 33047385 PMCID: PMC8289339 SCOPUS ID: 2-s2.0-85092336914 10/14/2020       9 Citations
  • The Promise of Circulating Tumor DNA (ctDNA) in the Management of Early-Stage Colon Cancer: A Critical Review. (Chakrabarti S, Xie H, Urrutia R, Mahipal A) Cancers (Basel) 2020 Sep 29;12(10) PMID: 33003583 PMCID: PMC7601010 SCOPUS ID: 2-s2.0-85091766757 10/03/2020       32 Citations
  • ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. (Lan W, Santofimia-Castaño P, Swayden M, Xia Y, Zhou Z, Audebert S, Camoin L, Huang C, Peng L, Jiménez-Alesanco A, Velázquez-Campoy A, Abián O, Lomberk G, Urrutia R, Rizzuti B, Geli V, Soubeyran P, Neira JL, Iovanna J) JCI Insight 2020 Sep 17;5(18) PMID: 32780723 PMCID: PMC7526551 SCOPUS ID: 2-s2.0-85090785767 08/12/2020       26 Citations
  • Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells. (Che M, Kweon SM, Teo JL, Yuan YC, Melstrom LG, Waldron RT, Lugea A, Urrutia RA, Pandol SJ, Lai KKY) Cancers (Basel) 2020 Jun 05;12(6) PMID: 32516943 PMCID: PMC7352534 SCOPUS ID: 2-s2.0-85086132804 06/11/2020       12 Citations
  • Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature. (Yang C, Siebert JR, Burns R, Zheng Y, Mei A, Bonacci B, Wang D, Urrutia RA, Riese MJ, Rao S, Carlson KS, Thakar MS, Malarkannan S) Elife 2020 May 14;9 PMID: 32406817 PMCID: PMC7255804 SCOPUS ID: 2-s2.0-85085630468 05/15/2020       17 Citations
  • Variant anatomy of the biliary system as a cause of pancreatic and peri-ampullary cancers. (Muraki T, Reid MD, Pehlivanoglu B, Gonzalez RS, Sekhar A, Memis B, Xue Y, Cheng J, Jang KT, Mittal P, Cardona K, Kooby DA, Maithel S, Sarmiento JM, El-Rayes B, Lomberk G, Urrutia RA, Christians K, Tsai S, Evans DB, Adsay V) HPB (Oxford) 2020 Dec;22(12):1675-1685 PMID: 32336556 SCOPUS ID: 2-s2.0-85083637358 04/28/2020       10 Citations
  • Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis. (Seminary ER, Santarriaga S, Wheeler L, Mejaki M, Abrudan J, Demos W, Zimmermann MT, Urrutia RA, Fee D, Barkhaus PE, Ebert AD) Cells 2020 Feb 28;9(3) PMID: 32121108 PMCID: PMC7140469 SCOPUS ID: 2-s2.0-85092221701 03/04/2020       10 Citations
  • PAX1 is essential for development and function of the human thymus. (Yamazaki Y, Urrutia R, Franco LM, Giliani S, Zhang K, Alazami AM, Dobbs AK, Masneri S, Joshi A, Otaizo-Carrasquero F, Myers TG, Ganesan S, Bondioni MP, Ho ML, Marks C, Alajlan H, Mohammed RW, Zou F, Valencia CA, Filipovich AH, Facchetti F, Boisson B, Azzari C, Al-Saud BK, Al-Mousa H, Casanova JL, Abraham RS, Notarangelo LD) Sci Immunol 2020 Feb 28;5(44) PMID: 32111619 PMCID: PMC7189207 SCOPUS ID: 2-s2.0-85081071846 03/01/2020       56 Citations
  • Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain. (Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G) PLoS One 2020;15(2):e0217452 PMID: 32027651 PMCID: PMC7004349 SCOPUS ID: 2-s2.0-85079081692 02/07/2020       4 Citations
  • Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse. (Urrutia G, Salmonson A, Toro-Zapata J, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G) Mol Cancer Res 2020 Mar;18(3):448-462 PMID: 31822519 PMCID: PMC7056528 SCOPUS ID: 2-s2.0-85081130002 12/12/2019       10 Citations
  • Genetic variants in DGAT1 cause diverse clinical presentations of malnutrition through a specific molecular mechanism. (Gupta A, Dsouza NR, Zarate YA, Lombardo R, Hopkin R, Linehan AR, Simpson J, McCarrier J, Agre KE, Gavrilova RH, Stephens MC, Grothe RM, Monaghan KG, Xie Y, Basel D, Urrutia RA, Cole CR, Klee EW, Zimmermann MT) Eur J Med Genet 2020 Apr;63(4):103817 PMID: 31778854 SCOPUS ID: 2-s2.0-85076241133 11/30/2019       8 Citations
  • Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. (Santofimia-Castaño P, Xia Y, Peng L, Velázquez-Campoy A, Abián O, Lan W, Lomberk G, Urrutia R, Rizzuti B, Soubeyran P, Neira JL, Iovanna J) Cells 2019 Nov 17;8(11) PMID: 31744261 PMCID: PMC6912534 SCOPUS ID: 2-s2.0-85082729502 11/21/2019       30 Citations
  • SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. (He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG) Proc Natl Acad Sci U S A 2019 Nov 19;116(47):23534-23541 PMID: 31591207 PMCID: PMC6876149 SCOPUS ID: 2-s2.0-85075260452 10/09/2019       51 Citations
  • Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine. (Lomberk G, Dusetti N, Iovanna J, Urrutia R) Nat Commun 2019 Aug 28;10(1):3875 PMID: 31462645 PMCID: PMC6713756 SCOPUS ID: 2-s2.0-85071625821 08/30/2019       57 Citations
  • ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells. (Han EH, Singh P, Lee IK, Urrutia R, Chi YI) J Biol Chem 2019 Sep 20;294(38):13983-13994 PMID: 31362984 PMCID: PMC6755798 SCOPUS ID: 2-s2.0-85072530867 08/01/2019       6 Citations
  • Precision Medicine and Precision Public Health: Academic Education and Community Engagement. (Meurer JR, Whittle JC, Lamb KM, Kosasih MA, Dwinell MR, Urrutia RA) Am J Prev Med 2019 Aug;57(2):286-289 PMID: 31326012 SCOPUS ID: 2-s2.0-85068737878 07/22/2019       4 Citations
  • Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification. (Gupta A, Zimmermann MT, Wang H, Broski SM, Sigafoos AN, Macklin SK, Urrutia RA, Clark KJ, Atwal PS, Pignolo RJ, Klee EW) Am J Med Genet A 2019 Sep;179(9):1764-1777 PMID: 31240838 SCOPUS ID: 2-s2.0-85068139246 06/27/2019       12 Citations
  • Modeling post-translational modifications and cancer-associated mutations that impact the heterochromatin protein 1α-importin α heterodimers. (Zimmermann MT, Williams MM, Klee EW, Lomberk GA, Urrutia R) Proteins 2019 Nov;87(11):904-916 PMID: 31152607 PMCID: PMC6790107 SCOPUS ID: 2-s2.0-85067403924 06/04/2019       4 Citations
  • Aurora kinase B-phosphorylated HP1α functions in chromosomal instability. (Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA) Cell Cycle 2019 Jun;18(12):1407-1421 PMID: 31130069 PMCID: PMC6592258 SCOPUS ID: 2-s2.0-85067316375 05/28/2019       7 Citations
  • CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis. (Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ) JCI Insight 2019 May 16;5(12) PMID: 31095524 PMCID: PMC6629126 SCOPUS ID: 2-s2.0-85070659965 05/17/2019       52 Citations
  • The New Bench for the Academic Surgeon: Precision Medicine (Lomberk G, Urrutia R) Management of Localized Pancreatic Cancer: Current Treatment and Challenges 1 January 2019:187-198 SCOPUS ID: 2-s2.0-85150138867 01/01/2019    
  • Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis. (Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH) Cell Mol Gastroenterol Hepatol 2019;7(1):197-209 PMID: 30539787 PMCID: PMC6282644 SCOPUS ID: 2-s2.0-85057853914 12/13/2018       51 Citations
  • Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation. (Bamidele AO, Svingen PA, Sagstetter MR, Sarmento OF, Gonzalez M, Braga Neto MB, Kugathasan S, Lomberk G, Urrutia RA, Faubion WA Jr) Cell Mol Gastroenterol Hepatol 2019;7(1):55-71 PMID: 30510991 PMCID: PMC6260395 SCOPUS ID: 2-s2.0-85056879256 12/05/2018       23 Citations
  • Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis. (Santofimia-Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, Neira JL, González A, Urrutia R, Soubeyran P, Iovanna J) Sci Rep 2018 Nov 19;8(1):16999 PMID: 30451898 PMCID: PMC6242935 SCOPUS ID: 2-s2.0-85056700597 11/20/2018       43 Citations
  • Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus. (Stoltz KP, Jondle CN, Pulakanti K, Sylvester PA, Urrutia R, Rao S, Tarakanova VL) Virology 2019 Jan 02;526:52-60 PMID: 30342302 PMCID: PMC6875439 SCOPUS ID: 2-s2.0-85054799725 10/21/2018       8 Citations
  • Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway. (Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R) Sci Rep 2018 Oct 10;8(1):15077 PMID: 30305677 PMCID: PMC6180112 SCOPUS ID: 2-s2.0-85054625299 10/12/2018       4 Citations
  • Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells. (Ebine K, Kumar K, Pham TN, Shields MA, Collier KA, Shang M, DeCant BT, Urrutia R, Hwang RF, Grimaldo S, Principe DR, Grippo PJ, Bentrem DJ, Munshi HG) Sci Rep 2018 Sep 05;8(1):13225 PMID: 30185888 PMCID: PMC6125340 SCOPUS ID: 2-s2.0-85052843561 09/07/2018       30 Citations
  • Assessing Human Genetic Variations in Glucose Transporter SLC2A10 and Their Role in Altering Structural and Functional Properties. (Zimmermann MT, Urrutia R, Cousin MA, Oliver GR, Klee EW) Front Genet 2018;9:276 PMID: 30090112 PMCID: PMC6068234 SCOPUS ID: 2-s2.0-85067395217 08/10/2018       10 Citations
  • Epigenetics of gastrointestinal diseases: notes from a workshop. (Marks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME) Epigenetics 2018;13(4):449-457 PMID: 30056798 PMCID: PMC6140811 SCOPUS ID: 2-s2.0-85052053592 07/31/2018       2 Citations
  • Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway. (Xiang X, Wang Y, Zhang H, Piao J, Muthusamy S, Wang L, Deng Y, Zhang W, Kuang R, Billadeau DD, Huang S, Lai J, Urrutia R, Kang N) NPJ Precis Oncol 2018;2(1):2 PMID: 29872721 PMCID: PMC5871906 06/07/2018    
  • Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect? (Polonis K, Blackburn PR, Urrutia RA, Lomberk GA, Kruisselbrink T, Cousin MA, Boczek NJ, Hoppman NL, Babovic-Vuksanovic D, Klee EW, Pichurin PN) Cold Spring Harb Mol Case Stud 2018 Aug;4(4) PMID: 29802153 PMCID: PMC6071565 SCOPUS ID: 2-s2.0-85054778837 05/29/2018       7 Citations
  • Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes. (Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, Armenoult L, Ayadi M, Ordog T, Lee JH, Oliver G, Klee E, Moutardier V, Gayet O, Bian B, Duconseil P, Gilabert M, Bigonnet M, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Secq V, De Reyniès A, Dusetti N, Iovanna J, Urrutia R) Nat Commun 2018 May 17;9(1):1978 PMID: 29773832 PMCID: PMC5958058 SCOPUS ID: 2-s2.0-85047248746 05/19/2018       157 Citations
  • Notch signaling in pancreatic morphogenesis and pancreatic cancer pathogenesis (Lomberk G, Urrutia R) Pancreatic Cancer 11 April 2018:457-479 SCOPUS ID: 2-s2.0-85054047066 04/11/2018    
  • Epigenetics and its applications to the progression model of pancreatic cancer (Lomberk G, Urrutia R) Pancreatic Cancer 11 April 2018:177-208 SCOPUS ID: 2-s2.0-85054045572 04/11/2018    
  • EGFR (ErbB) signaling pathways in pancreatic cancer pathogenesis (Williams M, Lomberk G, Urrutia R) Pancreatic Cancer 11 April 2018:383-408 SCOPUS ID: 2-s2.0-85054048146 04/11/2018       2 Citations
  • Pancreatic Cancer (Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW) Pancreatic Cancer 11 April 2018:1-1661 SCOPUS ID: 2-s2.0-85054043566 04/11/2018       14 Citations
  • Preface (Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW) Pancreatic Cancer 11 April 2018:ix-x SCOPUS ID: 2-s2.0-85054042327 04/11/2018    
  • P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts. (Dou C, Liu Z, Tu K, Zhang H, Chen C, Yaqoob U, Wang Y, Wen J, van Deursen J, Sicard D, Tschumperlin D, Zou H, Huang WC, Urrutia R, Shah VH, Kang N) Gastroenterology 2018 Jun;154(8):2209-2221.e14 PMID: 29454793 PMCID: PMC6039101 SCOPUS ID: 2-s2.0-85047768188 02/20/2018       137 Citations
  • Effects of histone methyltransferase inhibition in endometriosis. (Colón-Caraballo M, Torres-Reverón A, Soto-Vargas JL, Young SL, Lessey B, Mendoza A, Urrutia R, Flores I) Biol Reprod 2018 Aug 01;99(2):293-307 PMID: 29408993 PMCID: PMC6373837 SCOPUS ID: 2-s2.0-85055202476 02/07/2018       20 Citations
  • Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway (Xiang X, Wang Y, Zhang H, Piao J, Muthusamy S, Wang L, Deng Y, Zhang W, Kuang R, Billadeau DD, Huang S, Lai J, Urrutia R, Kang N) npj Precision Oncology 2018;2(1) SCOPUS ID: 2-s2.0-85071938232 01/01/2018       19 Citations
  • Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. (Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH) JCI Insight 2017 Dec 21;2(24) PMID: 29263300 PMCID: PMC5752303 SCOPUS ID: 2-s2.0-85050938173 12/22/2017       17 Citations
  • Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts. (Nicolle R, Blum Y, Marisa L, Loncle C, Gayet O, Moutardier V, Turrini O, Giovannini M, Bian B, Bigonnet M, Rubis M, Elarouci N, Armenoult L, Ayadi M, Duconseil P, Gasmi M, Ouaissi M, Maignan A, Lomberk G, Boher JM, Ewald J, Bories E, Garnier J, Goncalves A, Poizat F, Raoul JL, Secq V, Garcia S, Grandval P, Barraud-Blanc M, Norguet E, Gilabert M, Delpero JR, Roques J, Calvo E, Guillaumond F, Vasseur S, Urrutia R, de Reyniès A, Dusetti N, Iovanna J) Cell Rep 2017 Nov 28;21(9):2458-2470 PMID: 29186684 PMCID: PMC6082139 SCOPUS ID: 2-s2.0-85035748327 12/01/2017       135 Citations
  • Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome. (Kaiwar C, Zimmermann MT, Ferber MJ, Niu Z, Urrutia RA, Klee EW, Babovic-Vuksanovic D) Cold Spring Harb Mol Case Stud 2017 Nov;3(6) PMID: 28963436 PMCID: PMC5701304 SCOPUS ID: 2-s2.0-85039764135 10/01/2017       35 Citations
  • Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B. (Santofimia-Castaño P, Rizzuti B, Pey ÁL, Soubeyran P, Vidal M, Urrutia R, Iovanna JL, Neira JL) Proc Natl Acad Sci U S A 2017 Aug 01;114(31):E6332-E6341 PMID: 28720707 PMCID: PMC5547589 SCOPUS ID: 2-s2.0-85026780128 07/20/2017       38 Citations
  • Novel de novo variant in EBF3 is likely to impact DNA binding in a patient with a neurodevelopmental disorder and expanded phenotypes: patient report, in silico functional assessment, and review of published cases. (Blackburn PR, Barnett SS, Zimmermann MT, Cousin MA, Kaiwar C, Pinto E Vairo F, Niu Z, Ferber MJ, Urrutia RA, Selcen D, Klee EW, Pichurin PN) Cold Spring Harb Mol Case Stud 2017 May;3(3):a001743 PMID: 28487885 PMCID: PMC5411688 05/11/2017    
  • A novel de novo frameshift deletion in EHMT1 in a patient with Kleefstra Syndrome results in decreased H3K9 dimethylation. (Blackburn PR, Williams M, Cousin MA, Boczek NJ, Beek GJ, Lomberk GA, Urrutia RA, Babovic-Vuksanovic D, Klee EW) Mol Genet Genomic Med 2017 Mar;5(2):141-146 PMID: 28361100 PMCID: PMC5370226 SCOPUS ID: 2-s2.0-85041429164 04/01/2017       7 Citations
  • Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. (Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ) JCI Insight 2017 Mar 09;2(5):e91225 PMID: 28289718 PMCID: PMC5333962 SCOPUS ID: 2-s2.0-85063284454 03/16/2017       62 Citations
  • Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts. (Bian B, Bigonnet M, Gayet O, Loncle C, Maignan A, Gilabert M, Moutardier V, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Ouaissi M, Secq V, Poizat F, Nicolle R, Blum Y, Marisa L, Rubis M, Raoul JL, Bradner JE, Qi J, Lomberk G, Urrutia R, Saul A, Dusetti N, Iovanna J) EMBO Mol Med 2017 Apr;9(4):482-497 PMID: 28275007 PMCID: PMC5376755 SCOPUS ID: 2-s2.0-85014779112 03/10/2017       58 Citations
  • Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing. (Zimmermann MT, Urrutia R, Oliver GR, Blackburn PR, Cousin MA, Bozeck NJ, Klee EW) PLoS One 2017;12(2):e0170822 PMID: 28182693 PMCID: PMC5300139 SCOPUS ID: 2-s2.0-85012093055 02/10/2017       14 Citations
  • Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome. (Zimmermann MT, Urrutia RA, Blackburn PR, Cousin MA, Boczek NJ, Klee EW, Macmurdo C, Atwal PS) Case Rep Genet 2017;2017:7263780 PMID: 28163941 PMCID: PMC5253504 02/07/2017    
  • The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD). (Sarmento OF, Svingen PA, Xiong Y, Sun Z, Bamidele AO, Mathison AJ, Smyrk TC, Nair AA, Gonzalez MM, Sagstetter MR, Baheti S, McGovern DP, Friton JJ, Papadakis KA, Gautam G, Xavier RJ, Urrutia RA, Faubion WA) J Biol Chem 2017 Jan 13;292(2):706-722 PMID: 27909059 PMCID: PMC5241744 SCOPUS ID: 2-s2.0-85009804809 12/03/2016       54 Citations
  • Novel roles and mechanism for Krüppel-like factor 16 (KLF16) regulation of neurite outgrowth and ephrin receptor A5 (EphA5) expression in retinal ganglion cells. (Wang J, Galvao J, Beach KM, Luo W, Urrutia RA, Goldberg JL, Otteson DC) J Biol Chem 2016 Oct 07;291(41):21422 PMID: 27825077 PMCID: PMC5076813 11/09/2016    
  • Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth. (Saha S, Xiong X, Chakraborty PK, Shameer K, Arvizo RR, Kudgus RA, Dwivedi SK, Hossen MN, Gillies EM, Robertson JD, Dudley JT, Urrutia RA, Postier RG, Bhattacharya R, Mukherjee P) ACS Nano 2016 Dec 27;10(12):10636-10651 PMID: 27758098 PMCID: PMC6939886 SCOPUS ID: 2-s2.0-85007559438 10/21/2016       128 Citations
  • Pharmacological and Therapeutic Targeting of Epigenetic Regulators (Urrutia R, Lomberk GA) Chromatin Signaling and Diseases 24 August 2016:387-401 SCOPUS ID: 2-s2.0-85018796379 08/24/2016    
  • Signaling and Chromatin Networks in Cancer Biology (Hessmann E, Urrutia R, Koenig A) Chromatin Signaling and Diseases 24 August 2016:241-253 SCOPUS ID: 2-s2.0-85018796381 08/24/2016    
  • The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation. (Loncle C, Molejon MI, Lac S, Tellechea JI, Lomberk G, Gramatica L, Fernandez Zapico MF, Dusetti N, Urrutia R, Iovanna JL) Cell Death Dis 2016 Jul 14;7(7):e2295 PMID: 27415425 PMCID: PMC4973346 SCOPUS ID: 2-s2.0-85016946884 07/16/2016       26 Citations
  • "The molecule's the thing:" the promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results. (Oliver GR, Zimmermann MT, Klee EW, Urrutia RA) F1000Res 2016;5:766 PMID: 27408685 PMCID: PMC4920209 07/14/2016    
  • Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells. (Wang J, Galvao J, Beach KM, Luo W, Urrutia RA, Goldberg JL, Otteson DC) J Biol Chem 2016 Aug 26;291(35):18084-95 PMID: 27402841 PMCID: PMC5000058 SCOPUS ID: 2-s2.0-84984669529 07/13/2016       16 Citations
  • Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body. (Campoy EM, Laurito SR, Branham MT, Urrutia G, Mathison A, Gago F, Orozco J, Urrutia R, Mayorga LS, Roqué M) PLoS One 2016;11(7):e0157416 PMID: 27383829 PMCID: PMC4934783 SCOPUS ID: 2-s2.0-84978159641 07/08/2016       7 Citations
  • The promise of epigenomic therapeutics in pancreatic cancer. (Lomberk GA, Iovanna J, Urrutia R) Epigenomics 2016 Jun;8(6):831-42 PMID: 27337224 PMCID: PMC5066125 SCOPUS ID: 2-s2.0-84978187321 06/24/2016       38 Citations
  • REG3β Plays a Key Role in IL17RA Protumoral Effect-Response. (Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL) Cancer Res 2016 Apr 01;76(7):2051 PMID: 26992425 SCOPUS ID: 2-s2.0-84963755978 03/20/2016       5 Citations
  • "The molecule's the thing": The promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results [version 2; referees: 2 approved, 1 approved with reservations] (Oliver GR, Zimmermann MT, Klee EW, Urrutia RA) F1000Research 2016;5 SCOPUS ID: 2-s2.0-85026335697 01/01/2016    
  • The molecule's the thing"": The promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results (Oliver GR, Zimmermann MT, Klee EW, Urrutia RA) F1000Research 2016;5 SCOPUS ID: 2-s2.0-85010943959 01/01/2016       5 Citations
  • "The molecule's the thing": The promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results [version 1; referees: 3 approved with reservations] (Oliver GR, Zimmermann MT, Klee EW, Urrutia RA) F1000Research 2016;5 SCOPUS ID: 2-s2.0-85010934610 01/01/2016    
  • Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ. (Velez G, Lin M, Christensen T, Faubion WA, Lomberk G, Urrutia R) J Mol Model 2016 Jan;22(1):12 PMID: 26680990 PMCID: PMC4683166 SCOPUS ID: 2-s2.0-84950318764 12/19/2015       13 Citations
  • Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation. (Grasso D, Bintz J, Lomberk G, Molejon MI, Loncle C, Garcia MN, Lopez MB, Urrutia R, Iovanna JL) Sci Rep 2015 Nov 30;5:17549 PMID: 26617245 PMCID: PMC4663475 SCOPUS ID: 2-s2.0-84948695230 12/01/2015       25 Citations
  • Epigenetic regulation of ID4 in the determination of the BRCAness phenotype in breast cancer. (Branham MT, Campoy E, Laurito S, Branham R, Urrutia G, Orozco J, Gago F, Urrutia R, Roqué M) Breast Cancer Res Treat 2016 Jan;155(1):13-23 PMID: 26610810 PMCID: PMC6036618 SCOPUS ID: 2-s2.0-84953357119 11/28/2015       12 Citations
  • IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer. (Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL) Cancer Res 2015 Nov 15;75(22):4852-62 PMID: 26404002 PMCID: PMC4651828 SCOPUS ID: 2-s2.0-84955115797 09/26/2015       88 Citations
  • The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure. (Lomberk GA, Urrutia R) Surg Clin North Am 2015 Oct;95(5):935-52 PMID: 26315515 PMCID: PMC4556141 SCOPUS ID: 2-s2.0-84940614230 09/01/2015       18 Citations
  • Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. (Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R) Endocrinology 2015 Oct;156(10):3581-95 PMID: 26248217 PMCID: PMC4588811 SCOPUS ID: 2-s2.0-84943616432 08/08/2015       10 Citations
  • The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. (Leonard PH, Grzenda A, Mathison A, Morbeck DE, Fredrickson JR, de Assuncao TM, Christensen T, Salisbury J, Calvo E, Iovanna J, Coddington CC, Urrutia R, Lomberk G) BMC Dev Biol 2015 May 29;15:23 PMID: 26021315 PMCID: PMC4448908 SCOPUS ID: 2-s2.0-84930204241 05/30/2015       6 Citations
  • Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1. (Lopez MB, Garcia MN, Grasso D, Bintz J, Molejon MI, Velez G, Lomberk G, Neira JL, Urrutia R, Iovanna J) J Cell Physiol 2015 Dec;230(12):2936-50 PMID: 25899918 PMCID: PMC4778741 SCOPUS ID: 2-s2.0-84939839118 04/23/2015       13 Citations
  • Membrane-to-Nucleus Signals and Epigenetic Mechanisms for Myofibroblastic Activation and Desmoplastic Stroma: Potential Therapeutic Targets for Liver Metastasis? (Kang N, Shah VH, Urrutia R) Mol Cancer Res 2015 Apr;13(4):604-12 PMID: 25548101 PMCID: PMC4398610 SCOPUS ID: 2-s2.0-84928039023 12/31/2014       42 Citations
  • IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation. (Garcia MN, Grasso D, Lopez-Millan MB, Hamidi T, Loncle C, Tomasini R, Lomberk G, Porteu F, Urrutia R, Iovanna JL) J Clin Invest 2014 Nov;124(11):4709-22 PMID: 25250570 PMCID: PMC4347237 SCOPUS ID: 2-s2.0-84908609029 09/25/2014       32 Citations
  • Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice. (Koh KH, Pan X, Zhang W, McLachlan A, Urrutia R, Jeong H) Mol Pharmacol 2014 Dec;86(6):727-35 PMID: 25217496 PMCID: PMC4244597 SCOPUS ID: 2-s2.0-84964698054 09/14/2014       31 Citations
  • Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins. (Urrutia R, Velez G, Lin M, Lomberk G, Neira JL, Iovanna J) J Mol Model 2014 Aug;20(8):2357 PMID: 25056123 PMCID: PMC4139591 SCOPUS ID: 2-s2.0-84904525832 07/25/2014       17 Citations
  • Deleted in Breast Cancer 1 regulates cellular senescence during obesity. (Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN) Aging Cell 2014 Oct;13(5):951-3 PMID: 24992635 PMCID: PMC4172532 SCOPUS ID: 2-s2.0-84940363648 07/06/2014       23 Citations
  • Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene. (Xiong Y, Svingen PA, Sarmento OO, Smyrk TC, Dave M, Khanna S, Lomberk GA, Urrutia RA, Faubion WA Jr) Am J Physiol Regul Integr Comp Physiol 2014 Sep 15;307(6):R608-20 PMID: 24944246 PMCID: PMC4166759 SCOPUS ID: 2-s2.0-84907147778 06/20/2014       24 Citations
  • Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence. (Grasso D, Garcia MN, Hamidi T, Cano C, Calvo E, Lomberk G, Urrutia R, Iovanna JL) Cell Death Differ 2014 Oct;21(10):1633-41 PMID: 24902898 PMCID: PMC4158688 SCOPUS ID: 2-s2.0-84939779108 06/07/2014       40 Citations
  • Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks. (Calvo E, Grzenda A, Lomberk G, Mathison A, Iovanna J, Urrutia R) BMC Mol Biol 2014 May 25;15:10 PMID: 24885560 PMCID: PMC4049485 SCOPUS ID: 2-s2.0-84902078010 06/03/2014       6 Citations
  • New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. (de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH) J Biol Chem 2014 May 30;289(22):15798-809 PMID: 24759103 PMCID: PMC4140934 SCOPUS ID: 2-s2.0-84901702509 04/25/2014       42 Citations
  • Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. (Baumgart S, Chen NM, Siveke JT, König A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson D, Urrutia R, Ellenrieder V) Cancer Discov 2014 Jun;4(6):688-701 PMID: 24694735 PMCID: PMC4069603 SCOPUS ID: 2-s2.0-84904046340 04/04/2014       96 Citations
  • Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1. (Grasso D, Garcia MN, Hamidi T, Cano C, Calvo E, Lomberk G, Urrutia R, Iovanna JL) Mol Cell Oncol 2014;1(1):e29913 PMID: 27308320 PMCID: PMC4905183 SCOPUS ID: 2-s2.0-85051828809 01/01/2014       4 Citations
  • Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. (Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ, Kendrick ML, Shen KR, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Farrugia G, Urrutia RA, Ordog T) PLoS One 2013;8(10):e76822 PMID: 24116170 PMCID: PMC3792098 SCOPUS ID: 2-s2.0-84885041041 10/12/2013       13 Citations
  • Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis. (Cano CE, Hamidi T, Garcia MN, Grasso D, Loncle C, Garcia S, Calvo E, Lomberk G, Dusetti N, Bartholin L, Urrutia R, Iovanna JL) Gut 2014 Jun;63(6):984-95 PMID: 24026351 SCOPUS ID: 2-s2.0-84899917831 09/13/2013       34 Citations
  • Corrigendum to "Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis" [Cancer Lett. 328 (2) (2012) 212-221] (McCleary-Wheeler AL, Lomberk GA, Weiss FU, Schneider G, Fabbri M, Poshusta TL, Dusetti NJ, Baumgart S, Iovanna JL, Ellenrieder V, Urrutia R, Fernandez-Zapico ME) Cancer Letters 28 August 2013;337(1):143-144 SCOPUS ID: 2-s2.0-84880046000 08/28/2013    
  • Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression. (Grzenda A, Leonard P, Seo S, Mathison AJ, Urrutia G, Calvo E, Iovanna J, Urrutia R, Lomberk G) Epigenetics Chromatin 2013 Jul 05;6(1):21 PMID: 23829974 PMCID: PMC3707784 SCOPUS ID: 2-s2.0-84879835428 07/09/2013       18 Citations
  • Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. (Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R) J Biol Chem 2013 Jun 14;288(24):17745-58 PMID: 23589285 PMCID: PMC3682574 SCOPUS ID: 2-s2.0-84879068306 04/17/2013       24 Citations
  • Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. (Goicoechea SM, García-Mata R, Staub J, Valdivia A, Sharek L, McCulloch CG, Hwang RF, Urrutia R, Yeh JJ, Kim HJ, Otey CA) Oncogene 2014 Mar 06;33(10):1265-73 PMID: 23524582 PMCID: PMC3912215 SCOPUS ID: 2-s2.0-84895922145 03/26/2013       96 Citations
  • Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs. (Gilabert M, Vaccaro MI, Fernandez-Zapico ME, Calvo EL, Turrini O, Secq V, Garcia S, Moutardier V, Lomberk G, Dusetti N, Urrutia R, Iovanna JL) J Cell Physiol 2013 Sep;228(9):1834-43 PMID: 23460482 PMCID: PMC4048029 SCOPUS ID: 2-s2.0-84878217099 03/06/2013       12 Citations
  • Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression. (Grzenda A, Lomberk G, Svingen P, Mathison A, Calvo E, Iovanna J, Xiong Y, Faubion W, Urrutia R) Epigenetics Chromatin 2013 Feb 28;6(1):3 PMID: 23448518 PMCID: PMC3606351 SCOPUS ID: 2-s2.0-84874345376 03/02/2013       27 Citations
  • Mechanistic insights into self-reinforcing processes driving abnormal histogenesis during the development of pancreatic cancer. (Iovanna JL, Marks DL, Fernandez-Zapico ME, Urrutia R) Am J Pathol 2013 Apr;182(4):1078-86 PMID: 23375449 PMCID: PMC3969507 SCOPUS ID: 2-s2.0-84875199836 02/05/2013       15 Citations
  • Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. (McCleary-Wheeler AL, Lomberk GA, Weiss FU, Schneider G, Fabbri M, Poshusta TL, Dusetti NJ, Baumgart S, Iovanna JL, Ellenrieder V, Urrutia R, Fernandez-Zapico ME) Cancer Lett 2013 Jan 28;328(2):212-21 PMID: 23073473 PMCID: PMC3513548 SCOPUS ID: 2-s2.0-84870342265 10/18/2012       64 Citations
  • NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells. (Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Goruppi S, Urrutia R, Carracedo A, Velasco G, Iovanna JL) Autophagy 2013 Jan;9(1):95-7 PMID: 23047430 PMCID: PMC3542222 SCOPUS ID: 2-s2.0-84872203457 10/11/2012       22 Citations
  • Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death. (Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Urrutia R, Goruppi S, Carracedo A, Velasco G, Iovanna JL) Clin Cancer Res 2012 Oct 01;18(19):5234-46 PMID: 22899799 SCOPUS ID: 2-s2.0-84866931110 08/18/2012       61 Citations
  • Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. (Xiong Y, Khanna S, Grzenda AL, Sarmento OF, Svingen PA, Lomberk GA, Urrutia RA, Faubion WA Jr) J Biol Chem 2012 Oct 05;287(41):34372-85 PMID: 22896699 PMCID: PMC3464543 SCOPUS ID: 2-s2.0-84867266681 08/17/2012       53 Citations
  • Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer. (Cano CE, Sandí MJ, Hamidi T, Calvo EL, Turrini O, Bartholin L, Loncle C, Secq V, Garcia S, Lomberk G, Kroemer G, Urrutia R, Iovanna JL) EMBO Mol Med 2012 Sep;4(9):964-79 PMID: 22821859 PMCID: PMC3491828 SCOPUS ID: 2-s2.0-84863201071 07/24/2012       63 Citations
  • Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts. (Kitange GJ, Mladek AC, Carlson BL, Schroeder MA, Pokorny JL, Cen L, Decker PA, Wu W, Lomberk GA, Gupta SK, Urrutia RA, Sarkaria JN) Clin Cancer Res 2012 Aug 01;18(15):4070-9 PMID: 22675172 PMCID: PMC3716364 SCOPUS ID: 2-s2.0-84864495476 06/08/2012       116 Citations
  • Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. (Hamidi T, Algül H, Cano CE, Sandi MJ, Molejon MI, Riemann M, Calvo EL, Lomberk G, Dagorn JC, Weih F, Urrutia R, Schmid RM, Iovanna JL) J Clin Invest 2012 Jun;122(6):2092-103 PMID: 22565310 PMCID: PMC3366404 SCOPUS ID: 2-s2.0-84861821128 05/09/2012       102 Citations
  • Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells. (Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R) J Biol Chem 2012 Apr 13;287(16):12723-35 PMID: 22375010 PMCID: PMC3339994 SCOPUS ID: 2-s2.0-84859776104 03/01/2012       33 Citations
  • Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. (Lomberk G, Mathison AJ, Grzenda A, Seo S, DeMars CJ, Ilyas SI, Bonilla-Velez J, Calvo E, Fernandez-Zapico ME, Iovanna J, Buttar NS, Urrutia R) J Biol Chem 2012 Apr 13;287(16):13026-39 PMID: 22318730 PMCID: PMC3339955 SCOPUS ID: 2-s2.0-84859753082 02/10/2012       45 Citations
  • Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. (Singh SK, Baumgart S, Singh G, König AO, Reutlinger K, Hofbauer LC, Barth P, Gress TM, Lomberk G, Urrutia R, Fernandez-Zapico ME, Ellenrieder V) J Biol Chem 2011 Aug 19;286(33):28761-28771 PMID: 21628454 PMCID: PMC3190684 SCOPUS ID: 2-s2.0-80051694778 06/02/2011       22 Citations
  • Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. (Bonnefond A, Lomberk G, Buttar N, Busiah K, Vaillant E, Lobbens S, Yengo L, Dechaume A, Mignot B, Simon A, Scharfmann R, Neve B, Tanyolaç S, Hodoglugil U, Pattou F, Cavé H, Iovanna J, Stein R, Polak M, Vaxillaire M, Froguel P, Urrutia R) J Biol Chem 2011 Aug 12;286(32):28414-24 PMID: 21592955 PMCID: PMC3151084 SCOPUS ID: 2-s2.0-80051527724 05/20/2011       68 Citations
  • Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis. (Thabut D, Routray C, Lomberk G, Shergill U, Glaser K, Huebert R, Patel L, Masyuk T, Blechacz B, Vercnocke A, Ritman E, Ehman R, Urrutia R, Shah V) Hepatology 2011 Aug;54(2):573-85 PMID: 21567441 PMCID: PMC3145033 SCOPUS ID: 2-s2.0-79960714053 05/14/2011       91 Citations
  • Polycomb and the emerging epigenetics of pancreatic cancer. (Grzenda A, Ordog T, Urrutia R) J Gastrointest Cancer 2011 Jun;42(2):100-11 PMID: 21336826 PMCID: PMC3678558 SCOPUS ID: 2-s2.0-79956226771 02/22/2011       14 Citations
  • A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth. (Fernandez-Zapico ME, Lomberk GA, Tsuji S, DeMars CJ, Bardsley MR, Lin YH, Almada LL, Han JJ, Mukhopadhyay D, Ordog T, Buttar NS, Urrutia R) Biochem J 2011 Apr 15;435(2):529-37 PMID: 21171965 PMCID: PMC3130109 SCOPUS ID: 2-s2.0-79953172903 12/22/2010       83 Citations
  • Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. (Grasso D, Ropolo A, Lo Ré A, Boggio V, Molejón MI, Iovanna JL, Gonzalez CD, Urrutia R, Vaccaro MI) J Biol Chem 2011 Mar 11;286(10):8308-8324 PMID: 21173155 PMCID: PMC3048716 SCOPUS ID: 2-s2.0-79953144994 12/22/2010       168 Citations
  • Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype. (Cao Y, Szabolcs A, Dutta SK, Yaqoob U, Jagavelu K, Wang L, Leof EB, Urrutia RA, Shah VH, Mukhopadhyay D) J Biol Chem 2010 Oct 08;285(41):31840-8 PMID: 20675371 PMCID: PMC2951255 SCOPUS ID: 2-s2.0-77957787219 08/03/2010       74 Citations
  • Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis. (Huebert RC, Jagavelu K, Liebl AF, Huang BQ, Splinter PL, LaRusso NF, Urrutia RA, Shah VH) Lab Invest 2010 Dec;90(12):1770-81 PMID: 20644520 PMCID: PMC2992582 SCOPUS ID: 2-s2.0-78649680847 07/21/2010       49 Citations
  • Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. (Bardsley MR, Horváth VJ, Asuzu DT, Lorincz A, Redelman D, Hayashi Y, Popko LN, Young DL, Lomberk GA, Urrutia RA, Farrugia G, Rubin BP, Ordog T) Gastroenterology 2010 Sep;139(3):942-52 PMID: 20621681 PMCID: PMC2933938 SCOPUS ID: 2-s2.0-77956146147 07/14/2010       98 Citations
  • The Aroma and Flavor of Science (Urrutia R) Pancreatology April 2010;10(1):III SCOPUS ID: 2-s2.0-85097909839 04/01/2010    
  • Conservation of the TGFbeta/Labial homeobox signaling loop in endoderm-derived cells between Drosophila and mammals. (Lomberk GA, Imoto I, Gebelein B, Urrutia R, Cook TA) Pancreatology 2010;10(1):74-84 PMID: 20339309 PMCID: PMC2865486 SCOPUS ID: 2-s2.0-77949871512 03/27/2010       3 Citations
  • Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment. (Das A, Shergill U, Thakur L, Sinha S, Urrutia R, Mukhopadhyay D, Shah VH) Am J Physiol Gastrointest Liver Physiol 2010 Jun;298(6):G908-15 PMID: 20338920 PMCID: PMC3695393 SCOPUS ID: 2-s2.0-77952730719 03/27/2010       52 Citations
  • Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis. (Buttar NS, DeMars CJ, Lomberk G, Ilyas SI, Bonilla-Velez J, Achra S, Rashtak S, Wang KK, Fernandez-Zapico ME, Urrutia R) J Biol Chem 2010 Apr 09;285(15):11433-44 PMID: 20154088 PMCID: PMC2857022 SCOPUS ID: 2-s2.0-77951214442 02/16/2010       36 Citations
  • A team of champions. (Urrutia R) Pancreatology 2010;10(6):III-IV PMID: 21422770 SCOPUS ID: 2-s2.0-79952951028 01/01/2010    
  • Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes (Mathison A, Liebl A, Bharucha J, Mukhopadhyay D, Lomberk G, Shah V, Urrutia R) Pancreatology October 2010;10(4):505-516 SCOPUS ID: 2-s2.0-77956593984 01/01/2010       41 Citations
  • MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. (Fernandez-Zapico ME, van Velkinburgh JC, Gutiérrez-Aguilar R, Neve B, Froguel P, Urrutia R, Stein R) J Biol Chem 2009 Dec 25;284(52):36482-36490 PMID: 19843526 PMCID: PMC2794764 SCOPUS ID: 2-s2.0-73649098806 10/22/2009       88 Citations
  • Voluntarism and pancreatic societies: fuelling a new trend for which the time has come? (Urrutia R) Pancreatology 2009;9(4):III-IV PMID: 19526653 SCOPUS ID: 2-s2.0-70349576899 06/17/2009    
  • Interplay of tumor microenvironment cell types with parenchymal cells in pancreatic cancer development and therapeutic implications. (Guturu P, Shah V, Urrutia R) J Gastrointest Cancer 2009;40(1-2):1-9 PMID: 19513861 SCOPUS ID: 2-s2.0-66449129565 06/11/2009       16 Citations
  • Sin3: master scaffold and transcriptional corepressor. (Grzenda A, Lomberk G, Zhang JS, Urrutia R) Biochim Biophys Acta 2009;1789(6-8):443-50 PMID: 19505602 PMCID: PMC3686104 SCOPUS ID: 2-s2.0-69449089064 06/10/2009       196 Citations
  • Role of ischemic preconditioning in liver surgery and hepatic transplantation. (Montalvo-Jave EE, Piña E, Montalvo-Arenas C, Urrutia R, Benavente-Chenhalls L, Peña-Sanchez J, Geller DA) J Gastrointest Surg 2009 Nov;13(11):2074-83 PMID: 19404711 SCOPUS ID: 2-s2.0-77952997344 05/01/2009       29 Citations
  • Globalization: exporting the risk of pancreatic cancer to the West? (Urrutia R) Pancreatology 2009;9(1-2):III-IV PMID: 19353825 SCOPUS ID: 2-s2.0-67650458293 04/10/2009       1 Citation
  • Primers on molecular pathways--the insulin pathway. (Lomberk G, Urrutia R) Pancreatology 2009;9(3):203-5 PMID: 19299910 SCOPUS ID: 2-s2.0-62449129275 03/21/2009       5 Citations
  • The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research. (Lomberk G, Mathison AJ, Grzenda A, Urrutia R) Curr Opin Gastroenterol 2008 Sep;24(5):597-602 PMID: 19122501 PMCID: PMC2941574 SCOPUS ID: 2-s2.0-55549090720 01/06/2009       18 Citations
  • The IAP: more international than ever. (Urrutia R) Pancreatology 2009;9(6):III-IV PMID: 20397310 SCOPUS ID: 2-s2.0-77951267395 01/01/2009       2 Citations
  • Krüppel-like factor proteins and chromatin dynamics (Buttar NS, Lomberk GA, Daftary GS, Urrutia RA) The Biology of Krüppel-like Factors 2009:33-49 SCOPUS ID: 2-s2.0-84900216308 01/01/2009       1 Citation
  • The pancreatic section at DDW: A threat for extinction and what we can all do to save it (Urrutia R) Pancreatology May 2009;9(3) SCOPUS ID: 2-s2.0-67649855171 01/01/2009    
  • Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. (Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R) J Biol Chem 2009 Mar 06;284(10):6291-300 PMID: 19088080 PMCID: PMC2649086 SCOPUS ID: 2-s2.0-65249180911 12/18/2008       54 Citations
  • Primers on molecular pathways--caspase pathway. (Lomberk G, Urrutia R) Pancreatology 2009;9(1-2):6-8 PMID: 19077449 SCOPUS ID: 2-s2.0-57449121665 12/17/2008       6 Citations
  • 2007 American Pancreatic Association Presidential Address: a proud member of the APA. (Urrutia RA) Pancreas 2008 Nov;37(4):456-8 PMID: 18953263 SCOPUS ID: 2-s2.0-58149148180 10/28/2008    
  • Outreach work by Pancreatology: serving the IAP to support the birth of forward-looking IAP-sponsored societies. (Urrutia R) Pancreatology 2008;8(4-5):III-IV PMID: 18832864 SCOPUS ID: 2-s2.0-53549103869 10/04/2008    
  • Primers on molecular pathways--pain and opioid receptors, I. (Lomberk G, Cruciani R, Urrutia R) Pancreatology 2008;8(6):544-5 PMID: 18818506 SCOPUS ID: 2-s2.0-52349119874 09/27/2008       2 Citations
  • Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver. (Decker NK, Abdelmoneim SS, Yaqoob U, Hendrickson H, Hormes J, Bentley M, Pitot H, Urrutia R, Gores GJ, Shah VH) Am J Pathol 2008 Oct;173(4):1002-12 PMID: 18755846 PMCID: PMC2543069 SCOPUS ID: 2-s2.0-53149135036 08/30/2008       41 Citations
  • Pivotal role of the international pancreatologist in shaping the American landscape in our field. (Urrutia R) Pancreatology 2008;8(3):221-2 PMID: 18509250 SCOPUS ID: 2-s2.0-45149084434 05/30/2008    
  • The anthropological role of the doctor: do our patients feel better? (Urrutia R) Pancreatology 2008;8(1):III-IV PMID: 18391507 SCOPUS ID: 2-s2.0-42549165446 04/09/2008    
  • Primers on molecular pathways--notch. (Lomberk G, Urrutia R) Pancreatology 2008;8(2):103-4 PMID: 18382095 SCOPUS ID: 2-s2.0-43449100656 04/03/2008       6 Citations
  • Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome. (Aerssens J, Camilleri M, Talloen W, Thielemans L, Göhlmann HW, Van Den Wyngaert I, Thielemans T, De Hoogt R, Andrews CN, Bharucha AE, Carlson PJ, Busciglio I, Burton DD, Smyrk T, Urrutia R, Coulie B) Clin Gastroenterol Hepatol 2008 Feb;6(2):194-205 PMID: 18237869 PMCID: PMC2453689 SCOPUS ID: 2-s2.0-38649131433 02/02/2008       115 Citations
  • Characterization of the CXCR4 signaling in pancreatic cancer cells. (Billadeau DD, Chatterjee S, Bramati P, Sreekumar R, Shah V, Hedin K, Urrutia R) Int J Gastrointest Cancer 2006;37(4):110-9 PMID: 18175225 SCOPUS ID: 2-s2.0-43149117047 01/05/2008       54 Citations
  • The IAP 'Sails' to America for the 2008 APA (Urrutia R) Pancreatology October 2008;8(6):539 SCOPUS ID: 2-s2.0-53449088463 01/01/2008    
  • The enriching experience of reading Pancreatology (Urrutia R) Pancreatology May 2008;8(2) SCOPUS ID: 2-s2.0-43449104214 01/01/2008    
  • The future of pancreatology: how to go where we have never been before. (Urrutia R) Am J Surg 2007 Oct;194(4 Suppl):S153-7 PMID: 17903433 PMCID: PMC3762983 SCOPUS ID: 2-s2.0-34548817027 12/06/2007       1 Citation
  • Basics of TGF-beta and pancreatic cancer. (Truty MJ, Urrutia R) Pancreatology 2007;7(5-6):423-35 PMID: 17898532 SCOPUS ID: 2-s2.0-35348901453 09/28/2007       133 Citations
  • Academic skills: a concise guide to grant writing. (Urrutia R) Pancreatology 2007;7(4):307-10 PMID: 17684423 SCOPUS ID: 2-s2.0-34748832858 08/09/2007       8 Citations
  • Academic skills: focusing. (Urrutia R) Pancreatology 2006;6(6):III-IV PMID: 17287609 SCOPUS ID: 2-s2.0-33847644553 02/09/2007    
  • Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. (Camilleri M, Andrews CN, Bharucha AE, Carlson PJ, Ferber I, Stephens D, Smyrk TC, Urrutia R, Aerssens J, Thielemans L, Göhlmann H, van den Wyngaert I, Coulie B) Gastroenterology 2007 Jan;132(1):17-25 PMID: 17241856 PMCID: PMC2474784 SCOPUS ID: 2-s2.0-33846256685 01/24/2007       120 Citations
  • The Heterochromatin Protein 1 family. (Lomberk G, Wallrath L, Urrutia R) Genome Biol 2006;7(7):228 PMID: 17224041 PMCID: PMC1779566 SCOPUS ID: 2-s2.0-33845192953 01/17/2007       206 Citations
  • A great year for our journal (Urrutia R) Pancreatology October 2007;7(5-6):391-392 SCOPUS ID: 2-s2.0-35348906818 01/01/2007    
  • Transforming growth factor-beta: what every pancreatic surgeon should know. (Truty MJ, Urrutia R) Surgery 2007 Jan;141(1):1-6 PMID: 17188161 SCOPUS ID: 2-s2.0-33845502537 12/26/2006       11 Citations
  • Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration. (Das A, Fernandez-Zapico ME, Cao S, Yao J, Fiorucci S, Hebbel RP, Urrutia R, Shah VH) J Biol Chem 2006 Dec 22;281(51):39105-13 PMID: 17071613 SCOPUS ID: 2-s2.0-33846032701 10/31/2006       66 Citations
  • Academic skills: I got my own laboratory! And now what? (Urrutia R) Pancreatology 2006;6(5):III-V PMID: 17033156 SCOPUS ID: 2-s2.0-33750293575 10/13/2006    
  • Applications of microarray technology to pancreatic cancer research and drug development. (Truty MJ, Urrutia R) Expert Opin Drug Discov 2006 Oct;1(5):447-58 PMID: 23495945 SCOPUS ID: 2-s2.0-80052478784 10/01/2006    
  • Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias. (Buttar NS, Fernandez-Zapico ME, Urrutia R) Curr Opin Gastroenterol 2006 Sep;22(5):505-11 PMID: 16891881 SCOPUS ID: 2-s2.0-33746913059 08/08/2006       13 Citations
  • Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders? (Andresen V, Camilleri M, Kim HJ, Stephens DA, Carlson PJ, Talley NJ, Saito YA, Urrutia R, Zinsmeister AR) Gastroenterology 2006 Jun;130(7):1985-94 PMID: 16762621 SCOPUS ID: 2-s2.0-33744543509 06/10/2006       53 Citations
  • Evidence for the existence of an HP1-mediated subcode within the histone code. (Lomberk G, Bensi D, Fernandez-Zapico ME, Urrutia R) Nat Cell Biol 2006 Apr;8(4):407-15 PMID: 16531993 SCOPUS ID: 2-s2.0-33645725188 03/15/2006       159 Citations
  • A study of candidate genotypes associated with dyspepsia in a U.S. community. (Camilleri CE, Carlson PJ, Camilleri M, Castillo EJ, Locke GR 3rd, Geno DM, Stephens DA, Zinsmeister AR, Urrutia R) Am J Gastroenterol 2006 Mar;101(3):581-92 PMID: 16464220 SCOPUS ID: 2-s2.0-33644774923 02/09/2006       98 Citations
  • Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1. (Toruner M, Fernandez-Zapico M, Sha JJ, Pham L, Urrutia R, Egan LJ) J Biol Chem 2006 Mar 31;281(13):8686-96 PMID: 16407217 SCOPUS ID: 2-s2.0-33646823629 01/13/2006       47 Citations
  • Highlights from the editor-in-chief (Urrutia R) Pancreatology March 2007;6(6):505-506 SCOPUS ID: 2-s2.0-33847640576 01/01/2006    
  • Highlights from the editor-in-chief (Urrutia R) Pancreatology October 2006;6(5):423-424 SCOPUS ID: 2-s2.0-33750347437 01/01/2006    
  • On mentorship: The gold is there, but no gold rush. Why? (Urrutia R) Pancreatology August 2006;6(4) SCOPUS ID: 2-s2.0-33748313184 01/01/2006       1 Citation
  • Highlights from the editor-in-chief (Urrutia R) Pancreatology August 2006;6(4):261-262 SCOPUS ID: 2-s2.0-33748310653 01/01/2006    
  • Highlights from a mosaic of ideas (Urrutia R) Pancreatology July 2006;6(3):169-170 SCOPUS ID: 2-s2.0-33746366164 01/01/2006    
  • Highlights chosen by the editor (Urrutia R) Pancreatology April 2006;6(1-2):1-2 SCOPUS ID: 2-s2.0-33646146167 01/01/2006    
  • Defining a strong identity: A commitment to excellence in the study of the biology and pathobiology of the exocrine pancreas (Urrutia R) Pancreatology April 2006;6(1-2) SCOPUS ID: 2-s2.0-33646124703 01/01/2006    
  • A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function. (Natesampillai S, Fernandez-Zapico ME, Urrutia R, Veldhuis JD) J Biol Chem 2006 Feb 10;281(6):3040-7 PMID: 16303770 SCOPUS ID: 2-s2.0-33645650286 11/24/2005       26 Citations
  • The family feud: turning off Sp1 by Sp1-like KLF proteins. (Lomberk G, Urrutia R) Biochem J 2005 Nov 15;392(Pt 1):1-11 PMID: 16266294 PMCID: PMC1317658 SCOPUS ID: 2-s2.0-28044461728 11/04/2005       171 Citations
  • Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss. (Kalinec GM, Fernandez-Zapico ME, Urrutia R, Esteban-Cruciani N, Chen S, Kalinec F) Proc Natl Acad Sci U S A 2005 Nov 01;102(44):16019-24 PMID: 16239342 PMCID: PMC1276101 SCOPUS ID: 2-s2.0-27644518168 10/22/2005       63 Citations
  • When developmental signaling pathways go wrong and their impact on pancreatic cancer development. (Lomberk G, Fernandez-Zapico ME, Urrutia R) Curr Opin Gastroenterol 2005 Sep;21(5):555-60 PMID: 16093769 SCOPUS ID: 2-s2.0-23944515739 08/12/2005       7 Citations
  • A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome. (Nickander KK, Carlson PJ, Urrutia RA, Camilleri M, Low PA) Auton Neurosci 2005 Jun 15;120(1-2):97-103 PMID: 15946904 SCOPUS ID: 2-s2.0-21444433818 06/11/2005       16 Citations
  • Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. (Ougolkov AV, Fernandez-Zapico ME, Savoy DN, Urrutia RA, Billadeau DD) Cancer Res 2005 Mar 15;65(6):2076-81 PMID: 15781615 SCOPUS ID: 2-s2.0-16844374033 03/23/2005       300 Citations
  • The first initiative targeted to increase the training of African-American scientists in pancreatic cancer research: the Mayo Clinic College of Medicine-Oakwood College alliance. (Randriamahefa A, Fernandez-Zapico ME, Mladek AC, Evans L, Melbourne L, Osborne S, Cochran RL, Knight M, Beckford D, Gullo S, Paul A, McGee R, Urrutia R) Pancreas 2005 Apr;30(3):288-91 PMID: 15782110 SCOPUS ID: 2-s2.0-20144383239 03/23/2005       1 Citation
  • Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. (Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, Joly E, Vaillant E, Benmezroua Y, Durand E, Bakaher N, Delannoy V, Vaxillaire M, Cook T, Dallinga-Thie GM, Jansen H, Charles MA, Clément K, Galan P, Hercberg S, Helbecque N, Charpentier G, Prentki M, Hansen T, Pedersen O, Urrutia R, Melloul D, Froguel P) Proc Natl Acad Sci U S A 2005 Mar 29;102(13):4807-12 PMID: 15774581 PMCID: PMC554843 SCOPUS ID: 2-s2.0-20144389645 03/19/2005       207 Citations
  • Effect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic study. (Cremonini F, Camilleri M, McKinzie S, Carlson P, Camilleri CE, Burton D, Thomforde G, Urrutia R, Zinsmeister AR) Am J Gastroenterol 2005 Mar;100(3):652-63 PMID: 15743365 SCOPUS ID: 2-s2.0-16844364043 03/04/2005       91 Citations
  • Expression profiling in pancreatic cancer research: the initial steps and the road ahead. (Fernandez-Zapico ME, Callahan G, Delgado S, Urrutia R) Curr Opin Gastroenterol 2003 Sep;19(5):467-72 PMID: 15703590 SCOPUS ID: 2-s2.0-0042887541 02/11/2005    
  • Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. (Fernandez-Zapico ME, Gonzalez-Paz NC, Weiss E, Savoy DN, Molina JR, Fonseca R, Smyrk TC, Chari ST, Urrutia R, Billadeau DD) Cancer Cell 2005 Jan;7(1):39-49 PMID: 15652748 SCOPUS ID: 2-s2.0-19944432938 01/18/2005       179 Citations
  • Keeping the tradition of pursuing innovation (Urrutia R) Pancreatology 2005;5(1):1-4 SCOPUS ID: 2-s2.0-18744414527 01/01/2005    
  • KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling. (Cao S, Fernandez-Zapico ME, Jin D, Puri V, Cook TA, Lerman LO, Zhu XY, Urrutia R, Shah V) J Biol Chem 2005 Jan 21;280(3):1901-10 PMID: 15531587 SCOPUS ID: 2-s2.0-12544252248 11/09/2004       56 Citations
  • KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells. (Ellenrieder V, Buck A, Harth A, Jungert K, Buchholz M, Adler G, Urrutia R, Gress TM) Gastroenterology 2004 Aug;127(2):607-20 PMID: 15300592 SCOPUS ID: 2-s2.0-4143069155 08/10/2004       74 Citations
  • Bioinformatics tools to understand human diseases. (Debes JD, Urrutia R) Surgery 2004 Jun;135(6):579-85 PMID: 15179363 SCOPUS ID: 2-s2.0-3042576234 06/05/2004       5 Citations
  • Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. (Kim HJ, Camilleri M, Carlson PJ, Cremonini F, Ferber I, Stephens D, McKinzie S, Zinsmeister AR, Urrutia R) Gut 2004 Jun;53(6):829-37 PMID: 15138209 PMCID: PMC1774073 SCOPUS ID: 2-s2.0-2442677620 05/13/2004       163 Citations
  • Molecular pathways of pancreatic carcinogenesis (Fernandez-Zapico ME, Urrutia R) Drug Discovery Today: Disease Mechanisms November 2004;1(2):247-252 SCOPUS ID: 2-s2.0-23744433866 01/01/2004       7 Citations
  • KRAB-containing zinc-finger repressor proteins. (Urrutia R) Genome Biol 2003;4(10):231 PMID: 14519192 PMCID: PMC328446 SCOPUS ID: 2-s2.0-0346274978 10/02/2003       421 Citations
  • An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation. (Fernandez-Zapico ME, Mladek A, Ellenrieder V, Folch-Puy E, Miller L, Urrutia R) EMBO J 2003 Sep 15;22(18):4748-58 PMID: 12970187 PMCID: PMC212736 SCOPUS ID: 2-s2.0-0141625268 09/13/2003       91 Citations
  • Fundamentals of transcription factors and their impact on pancreatic development and cancer. (Fernandez-Zapico ME, Bramati PS, Zakaria S, Kaczynski JA, Urrutia R) Pancreatology 2003;3(4):276-83 PMID: 12890989 SCOPUS ID: 2-s2.0-0042674175 08/02/2003       3 Citations
  • Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A. (Pang YP, Kumar GA, Zhang JS, Urrutia R) FEBS Lett 2003 Jul 31;548(1-3):108-12 PMID: 12885416 SCOPUS ID: 2-s2.0-0041736054 07/30/2003       20 Citations
  • ROCK-dependent and ROCK-independent control of cochlear outer hair cell electromotility. (Zhang M, Kalinec GM, Urrutia R, Billadeau DD, Kalinec F) J Biol Chem 2003 Sep 12;278(37):35644-50 PMID: 12837763 SCOPUS ID: 2-s2.0-0041315515 07/03/2003       31 Citations
  • Growth inhibitory signalling by TGFbeta is blocked in Ras-transformed intestinal epithelial cells at a post-receptor locus. (Jiang B, Zhang JS, Du J, Urrutia R, Barnard J) Cell Signal 2003 Jul;15(7):699-708 PMID: 12742230 SCOPUS ID: 2-s2.0-0038737918 05/14/2003       11 Citations
  • Intraductal papillary mucinous neoplasm: did it exist prior to 1980? (Tollefson MK, Libsch KD, Sarr MG, Chari ST, DiMagno EP, Urrutia R, Smyrk TC) Pancreas 2003 Apr;26(3):e55-8 PMID: 12657965 SCOPUS ID: 2-s2.0-0242505996 03/27/2003       47 Citations
  • Emerging cellular and molecular themes in pancreatic cancer research. (Urrutia R) Int J Gastrointest Cancer 2002;31(1-3):1-4 PMID: 12622409 SCOPUS ID: 2-s2.0-0036944329 03/08/2003       2 Citations
  • Sp1- and Krüppel-like transcription factors. (Kaczynski J, Cook T, Urrutia R) Genome Biol 2003;4(2):206 PMID: 12620113 PMCID: PMC151296 SCOPUS ID: 2-s2.0-0037218919 03/07/2003       782 Citations
  • Invasive cancer and survival of intraductal papillary mucinous tumors of the pancreas. (Raimondo M, Tachibana I, Urrutia R, Burgart LJ, DiMagno EP) Am J Gastroenterol 2002 Oct;97(10):2553-8 PMID: 12385438 SCOPUS ID: 2-s2.0-0036790636 10/19/2002       80 Citations
  • Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. (Camilleri M, Atanasova E, Carlson PJ, Ahmad U, Kim HJ, Viramontes BE, McKinzie S, Urrutia R) Gastroenterology 2002 Aug;123(2):425-32 PMID: 12145795 SCOPUS ID: 2-s2.0-0036325415 07/30/2002       251 Citations
  • Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. (Kaczynski JA, Conley AA, Fernandez Zapico M, Delgado SM, Zhang JS, Urrutia R) Biochem J 2002 Sep 15;366(Pt 3):873-82 PMID: 12036432 PMCID: PMC1222816 SCOPUS ID: 2-s2.0-0037106344 05/31/2002       48 Citations
  • Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor. (Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R) EMBO J 2002 May 15;21(10):2451-60 PMID: 12006497 PMCID: PMC126002 SCOPUS ID: 2-s2.0-0037093448 05/15/2002       50 Citations
  • DNA microarrays: revolutionary insight into the living genome. (Fernandez Zapico ME, Ahmad US, Urrutia R) Surgery 2001 Sep;130(3):403-7 PMID: 11562660 SCOPUS ID: 2-s2.0-0034832595 09/20/2001       5 Citations
  • The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1. (Kaczynski J, Zhang JS, Ellenrieder V, Conley A, Duenes T, Kester H, van Der Burg B, Urrutia R) J Biol Chem 2001 Sep 28;276(39):36749-56 PMID: 11477107 SCOPUS ID: 2-s2.0-0035965276 07/31/2001       78 Citations
  • A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. (Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R) Mol Cell Biol 2001 Aug;21(15):5041-9 PMID: 11438660 PMCID: PMC87230 SCOPUS ID: 2-s2.0-0034954161 07/05/2001       163 Citations
  • Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein. (Gebelein B, Urrutia R) Mol Cell Biol 2001 Feb;21(3):928-39 PMID: 11154279 PMCID: PMC86683 SCOPUS ID: 2-s2.0-0035136902 01/12/2001       67 Citations
  • Transcription factors in cell biology, surgery, and transplantation. (Hedin KE, Kaczynski JA, Gibson MR, Urrutia R) Surgery 2000 Jul;128(1):1-5 PMID: 10876177 SCOPUS ID: 2-s2.0-0033938027 07/06/2000       8 Citations
  • Rho GTPases mediate the regulation of cochlear outer hair cell motility by acetylcholine. (Kalinec F, Zhang M, Urrutia R, Kalinec G) J Biol Chem 2000 Sep 08;275(36):28000-5 PMID: 10862776 SCOPUS ID: 2-s2.0-0034623130 06/23/2000       57 Citations
  • TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth. (Cook T, Urrutia R) Am J Physiol Gastrointest Liver Physiol 2000 Apr;278(4):G513-21 PMID: 10762604 SCOPUS ID: 2-s2.0-0034003075 04/14/2000       82 Citations
  • The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stress. (Ribeiro A, Bronk SF, Roberts PJ, Urrutia R, Gores GJ) Hepatology 1999 Dec;30(6):1490-7 PMID: 10573529 SCOPUS ID: 2-s2.0-0032696730 11/26/1999       144 Citations
  • Three conserved transcriptional repressor domains are a defining feature of the TIEG subfamily of Sp1-like zinc finger proteins. (Cook T, Gebelein B, Belal M, Mesa K, Urrutia R) J Biol Chem 1999 Oct 08;274(41):29500-4 PMID: 10506214 SCOPUS ID: 2-s2.0-0032856361 10/03/1999       109 Citations
  • Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors. (Cook T, Gebelein B, Urrutia R) Ann N Y Acad Sci 1999 Jun 30;880:94-102 PMID: 10415854 SCOPUS ID: 2-s2.0-0003049247 07/23/1999       123 Citations
  • KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1. (Gebelein B, Fernandez-Zapico M, Imoto M, Urrutia R) J Clin Invest 1998 Dec 01;102(11):1911-9 PMID: 9835615 PMCID: PMC509142 SCOPUS ID: 2-s2.0-0032423820 12/03/1998       43 Citations
  • Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. (Zhang JS, Nelson M, Wang L, Liu W, Qian CP, Shridhar V, Urrutia R, Smith DI) Genomics 1998 Nov 15;54(1):149-54 PMID: 9806841 SCOPUS ID: 2-s2.0-0032533292 11/10/1998       34 Citations
  • Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. (Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R) J Biol Chem 1998 Oct 02;273(40):25929-36 PMID: 9748269 SCOPUS ID: 2-s2.0-0032475869 09/25/1998       171 Citations
  • Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase Vps1p. (Imoto M, Tachibana I, Urrutia R) J Cell Sci 1998 May;111 ( Pt 10):1341-9 PMID: 9570752 SCOPUS ID: 2-s2.0-0031799717 05/07/1998       90 Citations
  • 1996 Comfort Symposium on Pancreatic Carcinogenesis. (Urrutia R, Miller LJ, DiMagno EP) Pancreas 1998 Jan;16(1):1-5 PMID: 9436855 SCOPUS ID: 2-s2.0-0031973219 01/22/1998       1 Citation
  • Novel membrane-to-nucleus pathways in the regulation of pancreatic acinar cell function (Urrutia R, Miller LJ) Current Opinion in Gastroenterology 1998;14(5):369-375 SCOPUS ID: 2-s2.0-0031665453 01/01/1998       1 Citation
  • Exploring the role of homeobox and zinc finger proteins in pancreatic cell proliferation, differentiation, and apoptosis. (Urrutia R) Int J Pancreatol 1997 Aug;22(1):1-14 PMID: 9387019 SCOPUS ID: 2-s2.0-0030724241 08/01/1997       10 Citations
  • Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. (Tachibana I, Imoto M, Adjei PN, Gores GJ, Subramaniam M, Spelsberg TC, Urrutia R) J Clin Invest 1997 May 15;99(10):2365-74 PMID: 9153278 PMCID: PMC508075 SCOPUS ID: 2-s2.0-0030610532 05/15/1997       203 Citations
  • The dynamins: redundant or distinct functions for an expanding family of related GTPases? (Urrutia R, Henley JR, Cook T, McNiven MA) Proc Natl Acad Sci U S A 1997 Jan 21;94(2):377-84 PMID: 9012790 PMCID: PMC34135 SCOPUS ID: 2-s2.0-0031026631 01/21/1997       256 Citations
  • Upregulation of dynamin II expression during the acquisition of a mature pancreatic acinar cell phenotype. (Cook TA, Mesa KJ, Gebelein BA, Urrutia RA) J Histochem Cytochem 1996 Dec;44(12):1373-8 PMID: 8985129 SCOPUS ID: 2-s2.0-3242844837 12/01/1996       7 Citations
  • Three dynamin-encoding genes are differentially expressed in developing rat brain. (Cook T, Mesa K, Urrutia R) J Neurochem 1996 Sep;67(3):927-31 PMID: 8752097 SCOPUS ID: 2-s2.0-0029799506 09/01/1996       82 Citations
  • A novel profile of expressed sequence tags for zinc finger encoding genes from the poorly differentiated exocrine pancreatic cell line AR4IP. (Gebelein B, Mesa K, Urrutia R) Cancer Lett 1996 Aug 02;105(2):225-31 PMID: 8697448 SCOPUS ID: 2-s2.0-0030565009 08/02/1996       8 Citations
  • Identification and characterization of zinc finger encoding genes from the tumoral exocrine pancreatic cell line AR42J. (Mesa K, Gebelein B, Cook T, Urrutia R) Cancer Lett 1996 Jun 05;103(2):143-9 PMID: 8635150 SCOPUS ID: 2-s2.0-0029979585 06/05/1996       4 Citations
  • Upregulation of molecular motor-encoding genes during hepatocyte growth factor- and epidermal growth factor-induced cell motility. (Török N, Urrutia R, Nakamura T, McNiven MA) J Cell Physiol 1996 Jun;167(3):422-33 PMID: 8655596 SCOPUS ID: 2-s2.0-0029994068 06/01/1996       24 Citations
  • Expression of dynamin immunoreactivity in experimental pancreatic tumors induced in rat by mancozeb-nitrosomethylurea. (Valentich MA, Cook T, Urrutia R) Cancer Lett 1996 Apr 19;102(1-2):23-9 PMID: 8603375 SCOPUS ID: 2-s2.0-0029871063 04/19/1996       7 Citations
  • Genetic markers: the key to early diagnosis and improved survival in pancreatic cancer? (Urrutia R, DiMagno EP) Gastroenterology 1996 Jan;110(1):306-10 PMID: 8536876 SCOPUS ID: 2-s2.0-0030034907 01/01/1996       24 Citations
  • A soluble motor from the alga Nitella supports fast movement of actin filaments in vitro. (Rivolta MN, Urrutia R, Kachar B) Biochim Biophys Acta 1995 Nov 21;1232(1-2):1-4 PMID: 7495833 SCOPUS ID: 2-s2.0-0028786783 11/21/1995       14 Citations
  • Dynamin 1 antisense oligonucleotide treatment prevents neurite formation in cultured hippocampal neurons. (Torre E, McNiven MA, Urrutia R) J Biol Chem 1994 Dec 23;269(51):32411-7 PMID: 7798241 SCOPUS ID: 2-s2.0-0028670775 12/23/1994       78 Citations
  • Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues. (Cook TA, Urrutia R, McNiven MA) Proc Natl Acad Sci U S A 1994 Jan 18;91(2):644-8 PMID: 8290576 PMCID: PMC43005 SCOPUS ID: 2-s2.0-0028137796 01/18/1994       171 Citations
  • The Dictyostelium myosin IE heavy chain gene encodes a truncated isoform that lacks sequences corresponding to the actin binding site in the tail. (Urrutia RA, Jung G, Hammer JA 3rd) Biochim Biophys Acta 1993 May 28;1173(2):225-9 PMID: 8504170 SCOPUS ID: 2-s2.0-0027180914 05/28/1993       30 Citations
  • Synthesis of RNA probes by the direct in vitro transcription of PCR-generated DNA templates. (Urrutia R, McNiven MA, Kachar B) J Biochem Biophys Methods 1993 May;26(2-3):113-20 PMID: 8509599 SCOPUS ID: 2-s2.0-0027461543 05/01/1993       14 Citations
  • Kinesin-mediated vesicular transport in a biochemically defined assay. (Urrutia R, Murphy DB, Kachar B, McNiven MA) Methods Cell Biol 1993;39:253-66 PMID: 8246802 SCOPUS ID: 2-s2.0-0027722733 01/01/1993       4 Citations
  • Myosin-mediated vesicular transport in the extruded cytoplasm of characean algae cells. (Kachar B, Urrutia R, Rivolta MN, McNiven MA) Methods Cell Biol 1993;39:179-90 PMID: 8246797 SCOPUS ID: 2-s2.0-0027768343 01/01/1993       7 Citations
  • An improved method for the purification of kinesin from bovine adrenal medulla. (Urrutia R, Kachar B) J Biochem Biophys Methods 1992 Mar;24(1-2):63-70 PMID: 1560182 SCOPUS ID: 2-s2.0-0026514213 03/01/1992       5 Citations
  • Purified kinesin promotes vesicle motility and induces active sliding between microtubules in vitro. (Urrutia R, McNiven MA, Albanesi JP, Murphy DB, Kachar B) Proc Natl Acad Sci U S A 1991 Aug 01;88(15):6701-5 PMID: 1830666 PMCID: PMC52156 SCOPUS ID: 2-s2.0-0026009462 08/01/1991       117 Citations
  • Multicentric focal acinar cell hyperplasia and hepatocyte-like cell metaplasia are induced by nitrosomethylurea in rat pancreas. (Monis B, Valentich MA, Urrutia R, Rivolta M) Int J Pancreatol 1991 Feb;8(2):119-31 PMID: 2033323 SCOPUS ID: 2-s2.0-0025891949 02/01/1991       10 Citations
  • A Feulgen microspectrophotometric study of the DNA content of essential fatty acid-deficient rat pancreas treated with nitrosomethylurea. (Urrutia RA, Rivolta CM, Valentich MA, Monis B) Cell Mol Biol 1990;36(5):547-55 PMID: 2073679 SCOPUS ID: 2-s2.0-0025668851 01/01/1990       3 Citations
  • Spontaneous polymerization of the antibiotic peptide magainin 2. (Urrutia R, Cruciani RA, Barker JL, Kachar B) FEBS Lett 1989 Apr 10;247(1):17-21 PMID: 2707446 SCOPUS ID: 2-s2.0-0024546947 04/10/1989       40 Citations
    • Last update: 04/24/2024