Medical College of Wisconsin
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Raul A. Urrutia MD

Raul A. Urrutia MD

Center Director, Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Administration
Program: General

Member of the Cancer Center


Publications

  • Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B. (Santofimia-Castaño P, Rizzuti B, Pey ÁL, Soubeyran P, Vidal M, Urrutia R, Iovanna JL, Neira JL) Proc Natl Acad Sci U S A 2017 Jul 18 PMID: 28720707 PMCID: PMC5547589 07/20/2017
  • Novel de novo variant in EBF3 is likely to impact DNA binding in a patient with a neurodevelopmental disorder and expanded phenotypes: patient report, in silico functional assessment, and review of published cases. (Blackburn PR, Barnett SS, Zimmermann MT, Cousin MA, Kaiwar C, Pinto E Vairo F, Niu Z, Ferber MJ, Urrutia RA, Selcen D, Klee EW, Pichurin PN) Cold Spring Harb Mol Case Stud 2017 May;3(3):a001743 PMID: 28487885 PMCID: PMC5411688 05/11/2017
  • A novel de novo frameshift deletion in EHMT1 in a patient with Kleefstra Syndrome results in decreased H3K9 dimethylation. (Blackburn PR, Williams M, Cousin MA, Boczek NJ, Beek GJ, Lomberk GA, Urrutia RA, Babovic-Vuksanovic D, Klee EW) Mol Genet Genomic Med 2017 Mar;5(2):141-146 PMID: 28361100 PMCID: PMC5370226 04/01/2017
  • Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. (Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ) JCI Insight 2017 Mar 09;2(5):e91225 PMID: 28289718 PMCID: PMC5333962 03/16/2017
  • Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts. (Bian B, Bigonnet M, Gayet O, Loncle C, Maignan A, Gilabert M, Moutardier V, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Ouaissi M, Secq V, Poizat F, Nicolle R, Blum Y, Marisa L, Rubis M, Raoul JL, Bradner JE, Qi J, Lomberk G, Urrutia R, Saul A, Dusetti N, Iovanna J) EMBO Mol Med 2017 Apr;9(4):482-497 PMID: 28275007 PMCID: PMC5376755 03/10/2017
  • Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing. (Zimmermann MT, Urrutia R, Oliver GR, Blackburn PR, Cousin MA, Bozeck NJ, Klee EW) PLoS One 2017;12(2):e0170822 PMID: 28182693 PMCID: PMC5300139 02/10/2017
  • Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome. (Zimmermann MT, Urrutia RA, Blackburn PR, Cousin MA, Boczek NJ, Klee EW, Macmurdo C, Atwal PS) Case Rep Genet 2017;2017:7263780 PMID: 28163941 PMCID: PMC5253504 02/07/2017
  • The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD). (Sarmento OF, Svingen PA, Xiong Y, Sun Z, Bamidele AO, Mathison AJ, Smyrk TC, Nair AA, Gonzalez MM, Sagstetter MR, Baheti S, McGovern DP, Friton JJ, Papadakis KA, Gautam G, Xavier RJ, Urrutia RA, Faubion WA) J Biol Chem 2017 Jan 13;292(2):706-722 PMID: 27909059 PMCID: PMC5241744 12/03/2016
  • Novel roles and mechanism for Krüppel-like factor 16 (KLF16) regulation of neurite outgrowth and ephrin receptor A5 (EphA5) expression in retinal ganglion cells. (Wang J, Galvao J, Beach KM, Luo W, Urrutia RA, Goldberg JL, Otteson DC) J Biol Chem 2016 Oct 07;291(41):21422 PMID: 27825077 PMCID: PMC5076813 11/09/2016
  • Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth. (Saha S, Xiong X, Chakraborty PK, Shameer K, Arvizo RR, Kudgus RA, Dwivedi SK, Hossen MN, Gillies EM, Robertson JD, Dudley JT, Urrutia RA, Postier RG, Bhattacharya R, Mukherjee P) ACS Nano 2016 Dec 27;10(12):10636-10651 PMID: 27758098 10/21/2016
  • The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation. (Loncle C, Molejon MI, Lac S, Tellechea JI, Lomberk G, Gramatica L, Fernandez Zapico MF, Dusetti N, Urrutia R, Iovanna JL) Cell Death Dis 2016 Jul 14;7:e2295 PMID: 27415425 PMCID: PMC4973346 07/16/2016
  • "The molecule's the thing:" the promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results. (Oliver GR, Zimmermann MT, Klee EW, Urrutia RA) F1000Res 2016;5:766 PMID: 27408685 PMCID: PMC4920209 07/14/2016
  • Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells. (Wang J, Galvao J, Beach KM, Luo W, Urrutia RA, Goldberg JL, Otteson DC) J Biol Chem 2016 Aug 26;291(35):18084-95 PMID: 27402841 PMCID: PMC5000058 07/13/2016
  • Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body. (Campoy EM, Laurito SR, Branham MT, Urrutia G, Mathison A, Gago F, Orozco J, Urrutia R, Mayorga LS, Roqué M) PLoS One 2016;11(7):e0157416 PMID: 27383829 PMCID: PMC4934783 07/08/2016
  • The promise of epigenomic therapeutics in pancreatic cancer. (Lomberk GA, Iovanna J, Urrutia R) Epigenomics 2016 Jun;8(6):831-42 PMID: 27337224 PMCID: PMC5066125 06/24/2016
  • REG3β Plays a Key Role in IL17RA Protumoral Effect-Response. (Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL) Cancer Res 2016 04 01;76(7):2051 PMID: 26992425 03/20/2016
  • Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ. (Velez G, Lin M, Christensen T, Faubion WA, Lomberk G, Urrutia R) J Mol Model 2016 Jan;22(1):12 PMID: 26680990 PMCID: PMC4683166 12/19/2015
  • Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation. (Grasso D, Bintz J, Lomberk G, Molejon MI, Loncle C, Garcia MN, Lopez MB, Urrutia R, Iovanna JL) Sci Rep 2015 Nov 30;5:17549 PMID: 26617245 PMCID: PMC4663475 12/01/2015
  • Epigenetic regulation of ID4 in the determination of the BRCAness phenotype in breast cancer. (Branham MT, Campoy E, Laurito S, Branham R, Urrutia G, Orozco J, Gago F, Urrutia R, Roqué M) Breast Cancer Res Treat 2016 Jan;155(1):13-23 PMID: 26610810 11/28/2015
  • IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer. (Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL) Cancer Res 2015 Nov 15;75(22):4852-62 PMID: 26404002 PMCID: PMC4651828 09/26/2015
  • The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure. (Lomberk GA, Urrutia R) Surg Clin North Am 2015 Oct;95(5):935-52 PMID: 26315515 PMCID: PMC4556141 09/01/2015
  • Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. (Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R) Endocrinology 2015 Oct;156(10):3581-95 PMID: 26248217 PMCID: PMC4588811 08/08/2015
  • The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. (Leonard PH, Grzenda A, Mathison A, Morbeck DE, Fredrickson JR, de Assuncao TM, Christensen T, Salisbury J, Calvo E, Iovanna J, Coddington CC, Urrutia R, Lomberk G) BMC Dev Biol 2015 May 29;15:23 PMID: 26021315 PMCID: PMC4448908 05/30/2015
  • Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1. (Lopez MB, Garcia MN, Grasso D, Bintz J, Molejon MI, Velez G, Lomberk G, Neira JL, Urrutia R, Iovanna J) J Cell Physiol 2015 Dec;230(12):2936-50 PMID: 25899918 PMCID: PMC4778741 04/23/2015
  • Membrane-to-Nucleus Signals and Epigenetic Mechanisms for Myofibroblastic Activation and Desmoplastic Stroma: Potential Therapeutic Targets for Liver Metastasis? (Kang N, Shah VH, Urrutia R) Mol Cancer Res 2015 Apr;13(4):604-12 PMID: 25548101 PMCID: PMC4398610 12/31/2014
  • IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation. (Garcia MN, Grasso D, Lopez-Millan MB, Hamidi T, Loncle C, Tomasini R, Lomberk G, Porteu F, Urrutia R, Iovanna JL) J Clin Invest 2014 Nov;124(11):4709-22 PMID: 25250570 PMCID: PMC4347237 09/25/2014
  • Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice. (Koh KH, Pan X, Zhang W, McLachlan A, Urrutia R, Jeong H) Mol Pharmacol 2014 Dec;86(6):727-35 PMID: 25217496 PMCID: PMC4244597 09/14/2014
  • Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins. (Urrutia R, Velez G, Lin M, Lomberk G, Neira JL, Iovanna J) J Mol Model 2014 Aug;20(8):2357 PMID: 25056123 PMCID: PMC4139591 07/25/2014
  • Deleted in Breast Cancer 1 regulates cellular senescence during obesity. (Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN) Aging Cell 2014 Oct;13(5):951-3 PMID: 24992635 PMCID: PMC4172532 07/06/2014
  • Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene. (Xiong Y, Svingen PA, Sarmento OO, Smyrk TC, Dave M, Khanna S, Lomberk GA, Urrutia RA, Faubion WA Jr) Am J Physiol Regul Integr Comp Physiol 2014 Sep 15;307(6):R608-20 PMID: 24944246 PMCID: PMC4166759 06/20/2014
  • Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence. (Grasso D, Garcia MN, Hamidi T, Cano C, Calvo E, Lomberk G, Urrutia R, Iovanna JL) Cell Death Differ 2014 Oct;21(10):1633-41 PMID: 24902898 PMCID: PMC4158688 06/07/2014
  • Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks. (Calvo E, Grzenda A, Lomberk G, Mathison A, Iovanna J, Urrutia R) BMC Mol Biol 2014 May 25;15:10 PMID: 24885560 PMCID: PMC4049485 06/03/2014
  • New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. (de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH) J Biol Chem 2014 May 30;289(22):15798-809 PMID: 24759103 PMCID: PMC4140934 04/25/2014
  • Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. (Baumgart S, Chen NM, Siveke JT, König A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson D, Urrutia R, Ellenrieder V) Cancer Discov 2014 Jun;4(6):688-701 PMID: 24694735 PMCID: PMC4069603 04/04/2014
  • Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1. (Grasso D, Garcia MN, Hamidi T, Cano C, Calvo E, Lomberk G, Urrutia R, Iovanna JL) Mol Cell Oncol 2014;1(1):e29913 PMID: 27308320 PMCID: PMC4905183 01/01/2014
  • Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. (Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ, Kendrick ML, Shen KR, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Farrugia G, Urrutia RA, Ordog T) PLoS One 2013;8(10):e76822 PMID: 24116170 PMCID: PMC3792098 10/12/2013
  • Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis. (Cano CE, Hamidi T, Garcia MN, Grasso D, Loncle C, Garcia S, Calvo E, Lomberk G, Dusetti N, Bartholin L, Urrutia R, Iovanna JL) Gut 2014 Jun;63(6):984-95 PMID: 24026351 09/13/2013
  • Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression. (Grzenda A, Leonard P, Seo S, Mathison AJ, Urrutia G, Calvo E, Iovanna J, Urrutia R, Lomberk G) Epigenetics Chromatin 2013 Jul 05;6(1):21 PMID: 23829974 PMCID: PMC3707784 07/09/2013
  • Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. (Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R) J Biol Chem 2013 Jun 14;288(24):17745-58 PMID: 23589285 PMCID: PMC3682574 04/17/2013
  • Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. (Goicoechea SM, García-Mata R, Staub J, Valdivia A, Sharek L, McCulloch CG, Hwang RF, Urrutia R, Yeh JJ, Kim HJ, Otey CA) Oncogene 2014 Mar 06;33(10):1265-73 PMID: 23524582 PMCID: PMC3912215 03/26/2013
  • Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs. (Gilabert M, Vaccaro MI, Fernandez-Zapico ME, Calvo EL, Turrini O, Secq V, Garcia S, Moutardier V, Lomberk G, Dusetti N, Urrutia R, Iovanna JL) J Cell Physiol 2013 Sep;228(9):1834-43 PMID: 23460482 PMCID: PMC4048029 03/06/2013
  • Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression. (Grzenda A, Lomberk G, Svingen P, Mathison A, Calvo E, Iovanna J, Xiong Y, Faubion W, Urrutia R) Epigenetics Chromatin 2013 Feb 28;6(1):3 PMID: 23448518 PMCID: PMC3606351 03/02/2013
  • Mechanistic insights into self-reinforcing processes driving abnormal histogenesis during the development of pancreatic cancer. (Iovanna JL, Marks DL, Fernandez-Zapico ME, Urrutia R) Am J Pathol 2013 Apr;182(4):1078-86 PMID: 23375449 PMCID: PMC3969507 02/05/2013
  • Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. (McCleary-Wheeler AL, Lomberk GA, Weiss FU, Schneider G, Fabbri M, Poshusta TL, Dusetti NJ, Baumgart S, Iovanna JL, Ellenrieder V, Urrutia R, Fernandez-Zapico ME) Cancer Lett 2013 Jan 28;328(2):212-21 PMID: 23073473 PMCID: PMC3513548 10/18/2012
  • NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells. (Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Goruppi S, Urrutia R, Carracedo A, Velasco G, Iovanna JL) Autophagy 2013 Jan;9(1):95-7 PMID: 23047430 PMCID: PMC3542222 10/11/2012
  • Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death. (Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Urrutia R, Goruppi S, Carracedo A, Velasco G, Iovanna JL) Clin Cancer Res 2012 Oct 01;18(19):5234-46 PMID: 22899799 08/18/2012
  • Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. (Xiong Y, Khanna S, Grzenda AL, Sarmento OF, Svingen PA, Lomberk GA, Urrutia RA, Faubion WA Jr) J Biol Chem 2012 Oct 05;287(41):34372-85 PMID: 22896699 PMCID: PMC3464543 08/17/2012
  • Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer. (Cano CE, Sandí MJ, Hamidi T, Calvo EL, Turrini O, Bartholin L, Loncle C, Secq V, Garcia S, Lomberk G, Kroemer G, Urrutia R, Iovanna JL) EMBO Mol Med 2012 Sep;4(9):964-79 PMID: 22821859 PMCID: PMC3491828 07/24/2012
  • Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts. (Kitange GJ, Mladek AC, Carlson BL, Schroeder MA, Pokorny JL, Cen L, Decker PA, Wu W, Lomberk GA, Gupta SK, Urrutia RA, Sarkaria JN) Clin Cancer Res 2012 Aug 01;18(15):4070-9 PMID: 22675172 PMCID: PMC3716364 06/08/2012
  • Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. (Hamidi T, Algül H, Cano CE, Sandi MJ, Molejon MI, Riemann M, Calvo EL, Lomberk G, Dagorn JC, Weih F, Urrutia R, Schmid RM, Iovanna JL) J Clin Invest 2012 Jun;122(6):2092-103 PMID: 22565310 PMCID: PMC3366404 05/09/2012
  • Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells. (Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R) J Biol Chem 2012 Apr 13;287(16):12723-35 PMID: 22375010 PMCID: PMC3339994 03/01/2012
  • Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. (Lomberk G, Mathison AJ, Grzenda A, Seo S, DeMars CJ, Rizvi S, Bonilla-Velez J, Calvo E, Fernandez-Zapico ME, Iovanna J, Buttar NS, Urrutia R) J Biol Chem 2012 Apr 13;287(16):13026-39 PMID: 22318730 PMCID: PMC3339955 02/10/2012
  • Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. (Singh SK, Baumgart S, Singh G, König AO, Reutlinger K, Hofbauer LC, Barth P, Gress TM, Lomberk G, Urrutia R, Fernandez-Zapico ME, Ellenrieder V) J Biol Chem 2011 Aug 19;286(33):28761-71 PMID: 21628454 PMCID: PMC3190684 06/02/2011
  • Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype. (Cao Y, Szabolcs A, Dutta SK, Yaqoob U, Jagavelu K, Wang L, Leof EB, Urrutia RA, Shah VH, Mukhopadhyay D) J Biol Chem 2010 Oct 08;285(41):31840-8 PMID: 20675371 PMCID: PMC2951255 08/03/2010
  • 2007 American Pancreatic Association Presidential Address: a proud member of the APA. (Urrutia RA) Pancreas 2008 Nov;37(4):456-8 PMID: 18953263 10/28/2008
  • A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome. (Nickander KK, Carlson PJ, Urrutia RA, Camilleri M, Low PA) Auton Neurosci 2005 Jun 15;120(1-2):97-103 PMID: 15946904 06/11/2005
  • Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. (Ougolkov AV, Fernandez-Zapico ME, Savoy DN, Urrutia RA, Billadeau DD) Cancer Res 2005 Mar 15;65(6):2076-81 PMID: 15781615 03/23/2005
  • Last update: 08/23/2017
    jenkins-FCD Prod-130 96200611f8481f0aa4f84230b11dd74d063847a3