Tyce J. Kearl MD, PhD
Research Experience
ImmunotherapyClinical Expertise
OncologistsMethodologies and Techniques
Cell Culture TechniquesImmune SystemSequence Analysis, RNASingle-Cell AnalysisLeadership Positions
Research Director, BMT and Cell Therapy LaboratoryCo-Director, Cell Therapy and Immune Monitoring shared resource laboratoryMCW Program / Core Facilities
Pediatric OncologyPublications (9)
CAR T-cell therapy for B-cell lymphomas: outcomes and resistance mechanisms. (Kearl TJ, Furqan F, Shah NN) Cancer Metastasis Rev 2024 Dec 01;44(1):12 PMID: 39617795 12/02/2024 In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations (Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ) Oral Oncology September 2024;156 SCOPUS ID: 2-s2.0-85198374252 09/01/2024 TIM-3 blockade enhances ex vivo stimulated allogeneic NK cell therapy for relapsed murine neuroblastoma after hematopoietic cell transplant. (Quamine A, Mohrdieck NR, King CA, Griggs AA, Kline JM, Cho MM, Rinella SP, Tippins KE, Bates PD, Shi L, Song L, Hess NJ, Kearl TJ, Johnson BD, Capitini CM) bioRxiv 2024 Jul 12 PMID: 39026718 PMCID: PMC11257576 07/19/2024 Corrigendum to Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture (Translational Oncology (2024) 42, (S1936523324000251), (10.1016/j.tranon.2024.101899)) (Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA) Translational Oncology June 2024;44 SCOPUS ID: 2-s2.0-85187349354 06/01/2024 Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture. (Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA) Transl Oncol 2024 Apr;42:101899 PMID: 38320395 PMCID: PMC10851216 SCOPUS ID: 2-s2.0-85184507548 02/07/2024 1 CitationControlling Cytokine Release Syndrome to Harness the Full Potential of CAR-Based Cellular Therapy. (Thakar MS, Kearl TJ, Malarkannan S) Front Oncol 2019;9:1529 PMID: 32076597 PMCID: PMC7006459 SCOPUS ID: 2-s2.0-85079671509 02/23/2020 23 CitationsProgrammed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma. (Kearl TJ, Jing W, Gershan JA, Johnson BD) J Immunol 2013 Jun 01;190(11):5620-8 PMID: 23616570 PMCID: PMC3891840 SCOPUS ID: 2-s2.0-84878099006 04/26/2013 85 CitationsPhosphatidylethanolamine is externalized at the surface of microparticles. (Larson MC, Woodliff JE, Hillery CA, Kearl TJ, Zhao M) Biochim Biophys Acta 2012 Dec;1821(12):1501-7 PMID: 22960380 PMCID: PMC3809829 SCOPUS ID: 2-s2.0-84866500244 09/11/2012 53 CitationsMethods for studying voltage-gated sodium channels in heterologous expression systems. (Dice MS, Kearl T, Ruben PC) Methods Mol Med 2006;129:163-85 PMID: 17085811 SCOPUS ID: 2-s2.0-35548949165 11/07/2006 3 Citations Last update: 12/02/2024