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Wei Liu PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Cancer Center
Member of the Center for Immunology

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Publications (82)

Structural Insights into Dopamine Receptor-Ligand Interactions: From Agonists to Antagonists. (Barbosa ED, Ma Y, Clift HE, Olson LJ, Zhu L, Liu W) ACS Chem Neurosci 2024 Nov 20;15(22):4123-4131 PMID: 39485723 SCOPUS ID: 2-s2.0-85208389275 11/01/2024

FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development. (Ji J, Qian Q, Cheng W, Ye X, Jing A, Ma S, Ding Y, Ma X, Wang Y, Sun Q, Wang X, Chen Y, Zhu L, Yuan Q, Xu M, Qin J, Ma L, Yang J, Zhang M, Geng T, Wang S, Wang D, Song Y, Zhang B, Xu Y, Xu L, Liu S, Liu W, Liu B) Cell Death Dis 2024 May 13;15(5):332 PMID: 38740744 PMCID: PMC11091054 SCOPUS ID: 2-s2.0-85192951272 05/14/2024 2 Citations

CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1. (Geng T, Sun Q, He J, Chen Y, Cheng W, Shen J, Liu B, Zhang M, Wang S, Asan K, Song M, Gao Q, Song Y, Liu R, Liu X, Ding Y, Jing A, Ye X, Ren H, Zeng K, Zhou Y, Zhang B, Ma S, Liu W, Liu S, Ji J) Cell Signal 2024 Jul;119:111180 PMID: 38642782 SCOPUS ID: 2-s2.0-85190884720 04/21/2024

FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression. (Ji J, Jing A, Ding Y, Ma X, Qian Q, Geng T, Cheng W, Zhang M, Sun Q, Ma S, Wang X, Yuan Q, Xu M, Qin J, Ma L, Yang J, He J, Du Q, Xia M, Xu Y, Chen Z, Zhu L, Liu W, Liu S, Liu B) Cell Death Dis 2024 Jan 11;15(1):33 PMID: 38212299 PMCID: PMC10784456 SCOPUS ID: 2-s2.0-85182091692 01/12/2024 5 Citations

Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors. (Tan B, Liu C, Li K, Jadhav P, Lambrinidis G, Zhu L, Olson L, Tan H, Wen Y, Kolocouris A, Liu W, Wang J) J Med Chem 2023 Nov 09;66(21):14544-14563 PMID: 37857371 PMCID: PMC11457037 SCOPUS ID: 2-s2.0-85176509223 10/20/2023 3 Citations

Editorial: Protein modifications in epigenetic dysfunctional diseases: mechanisms and potential therapeutic strategies. (Ji J, Jing A, Geng T, Ma X, Liu W, Liu B) Front Cell Dev Biol 2023;11:1216637 PMID: 37255602 PMCID: PMC10225621 SCOPUS ID: 2-s2.0-85161055462 05/31/2023 2 Citations

An Isochroman Analog of CD3254 and Allyl-, Isochroman-Analogs of NEt-TMN Prove to Be More Potent Retinoid-X-Receptor (RXR) Selective Agonists Than Bexarotene. (Jurutka PW, di Martino O, Reshi S, Mallick S, Sausedo MA, Moen GA, Lee IJ, Ivan DJ, Krall TD, Peoples SJ, Perez A, Tromba L, Le A, Khadka I, Petros R, Savage BM, Salama E, Salama J, Ziller JW, Noh Y, Lee MY, Liu W, Welch JS, Marshall PA, Wagner CE) Int J Mol Sci 2022 Dec 19;23(24) PMID: 36555852 PMCID: PMC9782500 SCOPUS ID: 2-s2.0-85144580245 12/24/2022 5 Citations

Cryo-EM structure of the human adenosine A_2B receptor-G_s signaling complex. (Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G) Sci Adv 2022 Dec 23;8(51):eadd3709 PMID: 36563137 PMCID: PMC9788782 SCOPUS ID: 2-s2.0-85144637416 12/24/2022 18 Citations

Structural basis for receptor selectivity and inverse agonism in S1P₅ receptors. (Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, Vakhrameev D, Ergasheva M, Kovaleva M, Khusainov G, Khorn P, Shevtsov M, Kovalev K, Bukhdruker S, Okhrimenko I, Popov P, Hu H, Weierstall U, Liu W, Cho Y, Gushchin I, Rogachev A, Bourenkov G, Park S, Park G, Hyun HJ, Park J, Gordeliy V, Borshchevskiy V, Mishin A, Cherezov V) Nat Commun 2022 Aug 12;13(1):4736 PMID: 35961984 PMCID: PMC9374744 SCOPUS ID: 2-s2.0-85135832975 08/13/2022 8 Citations

Structures of β₁-adrenergic receptor in complex with Gs and ligands of different efficacies. (Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY) Nat Commun 2022 Jul 14;13(1):4095 PMID: 35835792 PMCID: PMC9283524 SCOPUS ID: 2-s2.0-85134147752 07/15/2022 15 Citations

Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. (Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY) Nat Commun 2022 Feb 08;13(1):731 PMID: 35136060 PMCID: PMC8826421 SCOPUS ID: 2-s2.0-85124279039 02/10/2022 47 Citations

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB). (Jurutka PW, di Martino O, Reshi S, Mallick S, Sabir ZL, Staniszewski LJP, Warda A, Maiorella EL, Minasian A, Davidson J, Ibrahim SJ, Raban S, Haddad D, Khamisi M, Suban SL, Dawson BJ, Candia R, Ziller JW, Lee MY, Liu C, Liu W, Marshall PA, Welch JS, Wagner CE) Int J Mol Sci 2021 Nov 16;22(22) PMID: 34830251 PMCID: PMC8624485 SCOPUS ID: 2-s2.0-85119007925 11/28/2021 6 Citations

Molecular basis for lipid recognition by the prostaglandin D₂ receptor CRTH2. (Liu H, Deepak RNVK, Shiriaeva A, Gati C, Batyuk A, Hu H, Weierstall U, Liu W, Wang L, Cherezov V, Fan H, Zhang C) Proc Natl Acad Sci U S A 2021 Aug 10;118(32) PMID: 34341104 PMCID: PMC8364189 SCOPUS ID: 2-s2.0-85111810793 08/04/2021 12 Citations

Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma. (Olson TL, Zhang S, Labban D, Kaschner E, Aceves M, Iyer S, Meza-Aguilar JD, Zook JD, Chun E, Craciunescu FM, Liu W, Shi CX, Stewart AK, Hansen DT, Meurice N, Fromme P) Protein Expr Purif 2021 Sep;185:105890 PMID: 33971243 SCOPUS ID: 2-s2.0-85106932337 05/11/2021 4 Citations

Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors. (Geiger J, Sexton R, Al-Sahouri Z, Lee MY, Chun E, Harikumar KG, Miller LJ, Beckstein O, Liu W) Biochim Biophys Acta Biomembr 2021 Sep 01;1863(9):183557 PMID: 33444621 PMCID: PMC8656464 SCOPUS ID: 2-s2.0-85099613775 01/15/2021 9 Citations

Harnessing the power of an X-ray laser for serial crystallography of membrane proteins crystallized in lipidic cubic phase. (Lee MY, Geiger J, Ishchenko A, Han GW, Barty A, White TA, Gati C, Batyuk A, Hunter MS, Aquila A, Boutet S, Weierstall U, Cherezov V, Liu W) IUCrJ 2020 Nov 01;7(Pt 6):976-984 PMID: 33209312 PMCID: PMC7642783 SCOPUS ID: 2-s2.0-85095813668 11/20/2020 14 Citations

Serial Crystallography for Structure-Based Drug Discovery. (Zhu L, Chen X, Abola EE, Jing L, Liu W) Trends Pharmacol Sci 2020 Nov;41(11):830-839 PMID: 32950259 PMCID: PMC7572805 SCOPUS ID: 2-s2.0-85091103704 09/21/2020 12 Citations

Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β₁-Adrenergic Receptor. (Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY) Mol Cell 2020 Oct 01;80(1):59-71.e4 PMID: 32818430 PMCID: PMC7541785 SCOPUS ID: 2-s2.0-85090205426 08/21/2020 59 Citations

Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED. (Zhu L, Bu G, Jing L, Shi D, Lee MY, Gonen T, Liu W, Nannenga BL) Structure 2020 Oct 06;28(10):1149-1159.e4 PMID: 32735770 PMCID: PMC7544639 SCOPUS ID: 2-s2.0-85089367384 08/01/2020 20 Citations

XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia. (Zook J, Shekhar M, Hansen D, Conrad C, Grant T, Gupta C, White T, Barty A, Basu S, Zhao Y, Zatsepin N, Ishchenko A, Batyuk A, Gati C, Li C, Galli L, Coe J, Hunter M, Liang M, Weierstall U, Nelson G, James D, Stauch B, Craciunescu F, Thifault D, Liu W, Cherezov V, Singharoy A, Fromme P) Structure 2020 May 05;28(5):540-547.e3 PMID: 32142641 PMCID: PMC9014820 SCOPUS ID: 2-s2.0-85083862415 03/07/2020 7 Citations

Toward G protein-coupled receptor structure-based drug design using X-ray lasers. (Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V) IUCrJ 2019 Nov 01;6(Pt 6):1106-1119 PMID: 31709066 PMCID: PMC6830214 SCOPUS ID: 2-s2.0-85074594917 11/12/2019 56 Citations

Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. (Luginina A, Gusach A, Marin E, Mishin A, Brouillette R, Popov P, Shiriaeva A, Besserer-Offroy É, Longpré JM, Lyapina E, Ishchenko A, Patel N, Polovinkin V, Safronova N, Bogorodskiy A, Edelweiss E, Hu H, Weierstall U, Liu W, Batyuk A, Gordeliy V, Han GW, Sarret P, Katritch V, Borshchevskiy V, Cherezov V) Sci Adv 2019 Oct;5(10):eaax2518 PMID: 31633023 PMCID: PMC6785256 SCOPUS ID: 2-s2.0-85073622965 10/22/2019 66 Citations

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. (Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, Zhang C, Tian XL, Wang J, Clapham DE, Zeng B, Li Z, Zhang J) Sci Adv 2019 Jul;5(7):eaaw7935 PMID: 31355338 PMCID: PMC6656536 SCOPUS ID: 2-s2.0-85069936406 07/30/2019 75 Citations

High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source. (Martin-Garcia JM, Zhu L, Mendez D, Lee MY, Chun E, Li C, Hu H, Subramanian G, Kissick D, Ogata C, Henning R, Ishchenko A, Dobson Z, Zhang S, Weierstall U, Spence JCH, Fromme P, Zatsepin NA, Fischetti RF, Cherezov V, Liu W) IUCrJ 2019 May 01;6(Pt 3):412-425 PMID: 31098022 PMCID: PMC6503920 SCOPUS ID: 2-s2.0-85065335933 05/18/2019 42 Citations

Publisher Correction: Structural basis of ligand recognition at the human MT₁ melatonin receptor. (Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V) Nature 2019 May;569(7756):E6 PMID: 31048811 SCOPUS ID: 2-s2.0-85065291548 05/03/2019 2 Citations

Structural basis of ligand recognition at the human MT₁ melatonin receptor. (Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V) Nature 2019 May;569(7755):284-288 PMID: 31019306 PMCID: PMC6696938 SCOPUS ID: 2-s2.0-85064887125 04/26/2019 157 Citations

XFEL structures of the human MT₂ melatonin receptor reveal the basis of subtype selectivity. (Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, Zhu L, Zatsepin NA, Weierstall U, Yous S, Stevens RC, Liu W, Roth BL, Katritch V, Cherezov V) Nature 2019 May;569(7755):289-292 PMID: 31019305 PMCID: PMC6589158 SCOPUS ID: 2-s2.0-85064930899 04/26/2019 115 Citations

SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response. (Du SC, Zhu L, Wang YX, Liu J, Zhang D, Chen YL, Peng Q, Liu W, Liu B) Cancer Cell Int 2019;19:4 PMID: 30622440 PMCID: PMC6317191 SCOPUS ID: 2-s2.0-85059387641 01/10/2019 27 Citations

Publisher Correction: Crystal structure of misoprostol bound to the labor inducer prostaglandin E₂ receptor. (Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC) Nat Chem Biol 2019 Feb;15(2):206 PMID: 30573766 SCOPUS ID: 2-s2.0-85060117538 12/24/2018

Crystal structure of misoprostol bound to the labor inducer prostaglandin E₂ receptor. (Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC) Nat Chem Biol 2019 Jan;15(1):11-17 PMID: 30510194 PMCID: PMC6289721 SCOPUS ID: 2-s2.0-85058043420 12/05/2018 37 Citations

Overview of Biochemical Assays in Lipidic Cubic Phase. (Lan Z, Lee MY, Chun E, Liu B, Liu W) Trends Biochem Sci 2019 Apr;44(4):295-299 PMID: 30243833 SCOPUS ID: 2-s2.0-85053657482 09/24/2018 2 Citations

Solving protein structure from sparse serial microcrystal diffraction data at a storage-ring synchrotron source. (Lan TY, Wierman JL, Tate MW, Philipp HT, Martin-Garcia JM, Zhu L, Kissick D, Fromme P, Fischetti RF, Liu W, Elser V, Gruner SM) IUCrJ 2018 Sep 01;5(Pt 5):548-558 PMID: 30224958 PMCID: PMC6126656 SCOPUS ID: 2-s2.0-85053159147 09/19/2018 10 Citations

The Lipid Cubic Phase as a Medium for the Growth of Membrane Protein Microcrystals (Al-Sahouri Z, Lee MY, Li D, Liu W, Caffrey M) X-ray Free Electron Lasers: A Revolution in Structural Biology 1 January 2018:87-107 SCOPUS ID: 2-s2.0-85089364221 01/01/2018 2 Citations

FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death. (Li DZ, Liu SF, Zhu L, Wang YX, Chen YX, Liu J, Hu G, Yu X, Li J, Zhang J, Wu ZX, Lu H, Liu W, Liu B) Oncotarget 2017 Nov 14;8(57):97178-97186 PMID: 29228602 PMCID: PMC5722554 SCOPUS ID: 2-s2.0-85033786438 12/13/2017 9 Citations

Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation. (Martin-Garcia JM, Conrad CE, Nelson G, Stander N, Zatsepin NA, Zook J, Zhu L, Geiger J, Chun E, Kissick D, Hilgart MC, Ogata C, Ishchenko A, Nagaratnam N, Roy-Chowdhury S, Coe J, Subramanian G, Schaffer A, James D, Ketwala G, Venugopalan N, Xu S, Corcoran S, Ferguson D, Weierstall U, Spence JCH, Cherezov V, Fromme P, Fischetti RF, Liu W) IUCrJ 2017 Jul 01;4(Pt 4):439-454 PMID: 28875031 PMCID: PMC5571807 SCOPUS ID: 2-s2.0-85021805557 09/07/2017 118 Citations

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody. (Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Patel N, Messerschmidt M, Weierstall U, Liu W, Katritch V, Roth BL, Stevens RC, Cherezov V) Proc Natl Acad Sci U S A 2017 Aug 01;114(31):8223-8228 PMID: 28716900 PMCID: PMC5547598 SCOPUS ID: 2-s2.0-85026770347 07/19/2017 56 Citations

Structure of the full-length glucagon class B G-protein-coupled receptor. (Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B) Nature 2017 Jun 08;546(7657):259-264 PMID: 28514451 PMCID: PMC5492955 SCOPUS ID: 2-s2.0-85020450107 05/18/2017 171 Citations

Structural basis for selectivity and diversity in angiotensin II receptors. (Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V) Nature 2017 Apr 20;544(7650):327-332 PMID: 28379944 PMCID: PMC5525545 SCOPUS ID: 2-s2.0-85017413904 04/06/2017 177 Citations

Successful Strategies to Determine High-Resolution Structures of GPCRs. (Xiang J, Chun E, Liu C, Jing L, Al-Sahouri Z, Zhu L, Liu W) Trends Pharmacol Sci 2016 Dec;37(12):1055-1069 PMID: 27726881 SCOPUS ID: 2-s2.0-84992170625 10/12/2016 56 Citations

Native phasing of x-ray free-electron laser data for a G protein-coupled receptor. (Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V) Sci Adv 2016 Sep;2(9):e1600292 PMID: 27679816 PMCID: PMC5035125 SCOPUS ID: 2-s2.0-85042167986 09/30/2016 96 Citations

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography. (Ishchenko A, Cherezov V, Liu W) J Vis Exp 2016 Sep 20(115) PMID: 27683972 PMCID: PMC5092055 SCOPUS ID: 2-s2.0-84989291120 09/30/2016 21 Citations

Serial Femtosecond Crystallography of Membrane Proteins. (Zhu L, Weierstall U, Cherezov V, Liu W) Adv Exp Med Biol 2016;922:151-160 PMID: 27553241 PMCID: PMC5110035 SCOPUS ID: 2-s2.0-84983781462 08/25/2016 10 Citations

Serial femtosecond crystallography datasets from G protein-coupled receptors. (White TA, Barty A, Liu W, Ishchenko A, Zhang H, Gati C, Zatsepin NA, Basu S, Oberthür D, Metz M, Beyerlein KR, Yoon CH, Yefanov OM, James D, Wang D, Messerschmidt M, Koglin JE, Boutet S, Weierstall U, Cherezov V) Sci Data 2016 Aug 01;3:160057 PMID: 27479354 PMCID: PMC4968193 SCOPUS ID: 2-s2.0-84982730384 08/02/2016 11 Citations

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex. (Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Suino-Powell KM, Boutet S, Williams GJ, Wang M, Li D, Caffrey M, Chapman HN, Spence JC, Fromme P, Weierstall U, Stevens RC, Cherezov V, Melcher K, Xu HE) Sci Data 2016 Apr 12;3:160021 PMID: 27070998 PMCID: PMC4828943 SCOPUS ID: 2-s2.0-84963812810 04/14/2016 46 Citations

Serial femtosecond X-ray diffraction of enveloped virus microcrystals. (Lawrence RM, Conrad CE, Zatsepin NA, Grant TD, Liu H, James D, Nelson G, Subramanian G, Aquila A, Hunter MS, Liang M, Boutet S, Coe J, Spence JC, Weierstall U, Liu W, Fromme P, Cherezov V, Hogue BG) Struct Dyn 2015 Jul;2(4):041720 PMID: 26798819 PMCID: PMC4711640 SCOPUS ID: 2-s2.0-84939833420 01/23/2016 11 Citations

Ternary structure reveals mechanism of a membrane diacylglycerol kinase. (Li D, Stansfeld PJ, Sansom MSP, Keogh A, Vogeley L, Howe N, Lyons JA, Aragao D, Fromme P, Fromme R, Basu S, Grotjohann I, Kupitz C, Rendek K, Weierstall U, Zatsepin NA, Cherezov V, Liu W, Bandaru S, English NJ, Gati C, Barty A, Yefanov O, Chapman HN, Diederichs K, Messerschmidt M, Boutet S, Williams GJ, Marvin Seibert M, Caffrey M) Nat Commun 2015 Dec 17;6:10140 PMID: 26673816 PMCID: PMC4703834 SCOPUS ID: 2-s2.0-84950268487 12/18/2015 31 Citations

Serial femtosecond crystallography of soluble proteins in lipidic cubic phase. (Fromme R, Ishchenko A, Metz M, Chowdhury SR, Basu S, Boutet S, Fromme P, White TA, Barty A, Spence JC, Weierstall U, Liu W, Cherezov V) IUCrJ 2015 Sep 01;2(Pt 5):545-51 PMID: 26306196 PMCID: PMC4547822 SCOPUS ID: 2-s2.0-84940932911 08/26/2015 63 Citations

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. (Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE) Nature 2015 Jul 30;523(7562):561-7 PMID: 26200343 PMCID: PMC4521999 SCOPUS ID: 2-s2.0-84938359988 07/23/2015 658 Citations

Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. (Zhang H, Unal H, Gati C, Han GW, Liu W, Zatsepin NA, James D, Wang D, Nelson G, Weierstall U, Sawaya MR, Xu Q, Messerschmidt M, Williams GJ, Boutet S, Yefanov OM, White TA, Wang C, Ishchenko A, Tirupula KC, Desnoyer R, Coe J, Conrad CE, Fromme P, Stevens RC, Katritch V, Karnik SS, Cherezov V) Cell 2015 May 07;161(4):833-44 PMID: 25913193 PMCID: PMC4427029 SCOPUS ID: 2-s2.0-84937761091 04/29/2015 313 Citations

Structural basis for bifunctional peptide recognition at human δ-opioid receptor. (Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwé D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V) Nat Struct Mol Biol 2015 Mar;22(3):265-8 PMID: 25686086 PMCID: PMC4351130 SCOPUS ID: 2-s2.0-84924231852 02/17/2015 155 Citations

Two classes of cholesterol binding sites for the β2AR revealed by thermostability and NMR. (Gater DL, Saurel O, Iordanov I, Liu W, Cherezov V, Milon A) Biophys J 2014 Nov 18;107(10):2305-12 PMID: 25418299 PMCID: PMC4241438 SCOPUS ID: 2-s2.0-84912119192 11/25/2014 47 Citations

GPCR crystallization using lipidic cubic phase technique. (Yin X, Xu H, Hanson M, Liu W) Curr Pharm Biotechnol 2014;15(10):971-9 PMID: 25248558 SCOPUS ID: 2-s2.0-84926654801 09/25/2014 8 Citations

Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography. (Liu W, Ishchenko A, Cherezov V) Nat Protoc 2014 Sep;9(9):2123-34 PMID: 25122522 PMCID: PMC4209290 SCOPUS ID: 2-s2.0-84907020020 08/15/2014 100 Citations

Femtosecond crystallography of membrane proteins in the lipidic cubic phase. (Liu W, Wacker D, Wang C, Abola E, Cherezov V) Philos Trans R Soc Lond B Biol Sci 2014 Jul 17;369(1647):20130314 PMID: 24914147 PMCID: PMC4052856 SCOPUS ID: 2-s2.0-84902668640 06/11/2014 44 Citations

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. (Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Marvin Seibert M, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M, Cherezov V) Nat Commun 2014;5:3309 PMID: 24525480 PMCID: PMC4061911 SCOPUS ID: 2-s2.0-84894037590 02/15/2014 469 Citations

Serial femtosecond crystallography of G protein-coupled receptors. (Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah ST, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JC, Stevens RC, Cherezov V) Science 2013 Dec 20;342(6165):1521-4 PMID: 24357322 PMCID: PMC3902108 SCOPUS ID: 2-s2.0-84890840505 12/21/2013 395 Citations

The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. (Gutiérrez-de-Terán H, Massink A, Rodríguez D, Liu W, Han GW, Joseph JS, Katritch I, Heitman LH, Xia L, Ijzerman AP, Cherezov V, Katritch V, Stevens RC) Structure 2013 Dec 03;21(12):2175-85 PMID: 24210756 PMCID: PMC3858454 SCOPUS ID: 2-s2.0-84889573352 11/12/2013 111 Citations

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors. (Lane JR, Chubukov P, Liu W, Canals M, Cherezov V, Abagyan R, Stevens RC, Katritch V) Mol Pharmacol 2013 Dec;84(6):794-807 PMID: 24021214 PMCID: PMC3834142 SCOPUS ID: 2-s2.0-84888883269 09/12/2013 82 Citations

Structure of the human glucagon class B G-protein-coupled receptor. (Siu FY, He M, de Graaf C, Han GW, Yang D, Zhang Z, Zhou C, Xu Q, Wacker D, Joseph JS, Liu W, Lau J, Cherezov V, Katritch V, Wang MW, Stevens RC) Nature 2013 Jul 25;499(7459):444-9 PMID: 23863937 PMCID: PMC3820480 SCOPUS ID: 2-s2.0-84881193006 07/19/2013 335 Citations

Structure of the human smoothened receptor bound to an antitumour agent. (Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC) Nature 2013 May 16;497(7449):338-43 PMID: 23636324 PMCID: PMC3657389 SCOPUS ID: 2-s2.0-84878112106 05/03/2013 415 Citations

Structural features for functional selectivity at serotonin receptors. (Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC) Science 2013 May 03;340(6132):615-9 PMID: 23519215 PMCID: PMC3644390 SCOPUS ID: 2-s2.0-84877631485 03/23/2013 583 Citations

Structural basis for molecular recognition at serotonin receptors. (Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, Stevens RC, Xu HE) Science 2013 May 03;340(6132):610-4 PMID: 23519210 PMCID: PMC3644373 SCOPUS ID: 2-s2.0-84877607189 03/23/2013 440 Citations

Erratum: Crystal structure of a voltage-gated K⁺ channel pore module in a closed state in lipid membranes (Journal Of Biological Chemistry (2012) 287 (43063-43070)) (Santos JS, Asmar-Rovira GA, Han GW, Liu W, Syeda R, Cherezov V, Baker KA, Stevens RC, Montal M) Journal of Biological Chemistry 1 February 2013;288(5):3476 SCOPUS ID: 2-s2.0-84873295177 02/01/2013

Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes. (Santos JS, Asmar-Rovira GA, Han GW, Liu W, Syeda R, Cherezov V, Baker KA, Stevens RC, Montal M) J Biol Chem 2012 Dec 14;287(51):43063-70 PMID: 23095758 PMCID: PMC3522301 SCOPUS ID: 2-s2.0-84871124956 10/26/2012 23 Citations

Structural basis for allosteric regulation of GPCRs by sodium ions. (Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC) Science 2012 Jul 13;337(6091):232-6 PMID: 22798613 PMCID: PMC3399762 SCOPUS ID: 2-s2.0-84861961427 07/17/2012 789 Citations

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. (Chun E, Thompson AA, Liu W, Roth CB, Griffith MT, Katritch V, Kunken J, Xu F, Cherezov V, Hanson MA, Stevens RC) Structure 2012 Jun 06;20(6):967-76 PMID: 22681902 PMCID: PMC3375611 SCOPUS ID: 2-s2.0-84861984672 06/12/2012 349 Citations

Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis. (Fairman JW, Dautin N, Wojtowicz D, Liu W, Noinaj N, Barnard TJ, Udho E, Przytycka TM, Cherezov V, Buchanan SK) Structure 2012 Jul 03;20(7):1233-43 PMID: 22658748 PMCID: PMC3392549 SCOPUS ID: 2-s2.0-84863527277 06/05/2012 80 Citations

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. (Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC) Nature 2012 May 16;485(7398):395-9 PMID: 22596163 PMCID: PMC3356928 SCOPUS ID: 2-s2.0-84861019261 05/19/2012 418 Citations

Structure of the human κ-opioid receptor in complex with JDTic. (Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC) Nature 2012 Mar 21;485(7398):327-32 PMID: 22437504 PMCID: PMC3356457 SCOPUS ID: 2-s2.0-84862777742 03/23/2012 775 Citations

Erratum: The monoolein-cholesterol cubic phase: Characterization by NMR spectroscopy (Biophysical Journal (2012) (390a)) (Gater D, Saurel O, Réat V, Jolibois F, Liu W, Cherezov V, Milon A) Biophysical Journal 21 March 2012;102(6):1469 SCOPUS ID: 2-s2.0-84863352740 03/21/2012

Characterization of lipid matrices for membrane protein crystallization by high-throughput small angle X-ray scattering. (Joseph JS, Liu W, Kunken J, Weiss TM, Tsuruta H, Cherezov V) Methods 2011 Dec;55(4):342-9 PMID: 21903166 PMCID: PMC3243793 SCOPUS ID: 2-s2.0-84862908785 09/10/2011 32 Citations

High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment. (Tiefenbrunn T, Liu W, Chen Y, Katritch V, Stout CD, Fee JA, Cherezov V) PLoS One 2011;6(7):e22348 PMID: 21814577 PMCID: PMC3141039 SCOPUS ID: 2-s2.0-79960650299 08/05/2011 102 Citations

Structure of the human histamine H1 receptor complex with doxepin. (Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S) Nature 2011 Jun 22;475(7354):65-70 PMID: 21697825 PMCID: PMC3131495 SCOPUS ID: 2-s2.0-79960070651 06/24/2011 708 Citations

Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases. (Xu F, Liu W, Hanson MA, Stevens RC, Cherezov V) Cryst Growth Des 2011 Apr 06;11(4):1193-1201 PMID: 21660116 PMCID: PMC3108193 SCOPUS ID: 2-s2.0-79953901342 06/11/2011 47 Citations

Crystallization of membrane proteins in lipidic mesophases. (Liu W, Cherezov V) J Vis Exp 2011 Mar 28(49) PMID: 21490572 PMCID: PMC3197299 SCOPUS ID: 2-s2.0-80055115291 04/15/2011 26 Citations

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. (Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC) Science 2010 Nov 19;330(6007):1091-5 PMID: 21097933 PMCID: PMC3058422 SCOPUS ID: 2-s2.0-78449305788 11/26/2010 1015 Citations

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. (Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC) Science 2010 Nov 19;330(6007):1066-71 PMID: 20929726 PMCID: PMC3074590 SCOPUS ID: 2-s2.0-85027927015 10/12/2010 1555 Citations

LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment. (Liu W, Hanson MA, Stevens RC, Cherezov V) Biophys J 2010 Apr 21;98(8):1539-48 PMID: 20409473 PMCID: PMC2856142 SCOPUS ID: 2-s2.0-77951645706 04/23/2010 52 Citations

In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin. (Cherezov V, Liu W, Derrick JP, Luan B, Aksimentiev A, Katritch V, Caffrey M) Proteins 2008 Apr;71(1):24-34 PMID: 18076035 SCOPUS ID: 2-s2.0-40549083360 12/14/2007 35 Citations

In meso structure of the cobalamin transporter, BtuB, at 1.95 A resolution. (Cherezov V, Yamashita E, Liu W, Zhalnina M, Cramer WA, Caffrey M) J Mol Biol 2006 Dec 08;364(4):716-34 PMID: 17028020 PMCID: PMC1808586 SCOPUS ID: 2-s2.0-33750965918 10/10/2006 89 Citations

Interactions of tryptophan, tryptophan peptides, and tryptophan alkyl esters at curved membrane interfaces. (Liu W, Caffrey M) Biochemistry 2006 Oct 03;45(39):11713-26 PMID: 17002272 PMCID: PMC2568979 SCOPUS ID: 2-s2.0-33749347076 09/28/2006 42 Citations

Gramicidin structure and disposition in highly curved membranes. (Liu W, Caffrey M) J Struct Biol 2005 Apr;150(1):23-40 PMID: 15797727 SCOPUS ID: 2-s2.0-15444380710 03/31/2005 50 Citations

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Wei Liu PhD

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Publications (82)