Faculty Collaboration Database

Using Low-Frequency Oscillations to Detect Temporal Lobe Epilepsy with Machine Learning. Brain Connect 2019 Mar;9(2):184-193

Date

02/26/2019

Pubmed ID

30803273

Pubmed Central ID

PMC6484357

DOI

10.1089/brain.2018.0601

Scopus ID

2-s2.0-85063084464 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

The National Institutes of Health-sponsored Epilepsy Connectome Project aims to characterize connectivity changes in temporal lobe epilepsy (TLE) patients. The magnetic resonance imaging protocol follows that used in the Human Connectome Project, and includes 20 min of resting-state functional magnetic resonance imaging acquired at 3T using 8-band multiband imaging. Glasser parcellation atlas was combined with the FreeSurfer subcortical regions to generate resting-state functional connectivity (RSFC), amplitude of low-frequency fluctuations (ALFFs), and fractional ALFF measures. Seven different frequency ranges such as Slow-5 (0.01-0.027 Hz) and Slow-4 (0.027-0.073 Hz) were selected to compute these measures. The goal was to train machine learning classification models to discriminate TLE patients from healthy controls, and to determine which combination of the resting state measure and frequency range produced the best classification model. The samples included age- and gender-matched groups of 60 TLE patients and 59 healthy controls. Three traditional machine learning models were trained: support vector machine, linear discriminant analysis, and naive Bayes classifier. The highest classification accuracy was obtained using RSFC measures in the Slow-4 + 5 band (0.01-0.073 Hz) as features. Leave-one-out cross-validation accuracies were ∼83%, with receiver operating characteristic area-under-the-curve reaching close to 90%. Increased connectivity from right area posterior 9-46v in TLE patients contributed to the high accuracies. With increased sample sizes in the near future, better machine learning models will be trained not only to aid the diagnosis of TLE, but also as a tool to understand this brain disorder.

Author List

Hwang G, Nair VA, Mathis J, Cook CJ, Mohanty R, Zhao G, Tellapragada N, Ustine C, Nwoke OO, Rivera-Bonet C, Rozman M, Allen L, Forseth C, Almane DN, Kraegel P, Nencka A, Felton E, Struck AF, Birn R, Maganti R, Conant LL, Humphries CJ, Hermann B, Raghavan M, DeYoe EA, Binder JR, Meyerand E, Prabhakaran V

Authors

Jeffrey R. Binder MD Professor in the Neurology department at Medical College of Wisconsin
Gyujoon Hwang PhD Assistant Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin
Manoj Raghavan MD, PhD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Bayes Theorem
Brain
Connectome
Epilepsy, Temporal Lobe
Female
Functional Laterality
Hippocampus
Humans
Machine Learning
Magnetic Resonance Imaging
Male
Middle Aged
Support Vector Machine
Temporal Lobe