Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project. Epilepsy Behav 2019 Sep;98(Pt A):220-227
Date
08/07/2019Pubmed ID
31387000Pubmed Central ID
PMC6732015DOI
10.1016/j.yebeh.2019.07.025Scopus ID
2-s2.0-85071832268 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Behavioral and personality disorders in temporal lobe epilepsy (TLE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological correlates in TLE were explored using the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and structural magnetic resonance imaging (MRI) through the Epilepsy Connectome Project (ECP). NEO-FFI scores from 67 individuals with TLE (34.6 ± 9.5 years; 67% women) were compared to 31 healthy controls (32.8 ± 8.9 years; 41% women) to assess differences in the Big 5 traits (agreeableness, openness, conscientiousness, neuroticism, and extraversion). Individuals with TLE showed significantly higher neuroticism, with no significant differences on the other traits. Neural correlates of neuroticism were then determined in participants with TLE including cortical and subcortical volumes. Distributed reductions in cortical gray matter volumes were associated with increased neuroticism. Subcortically, hippocampal and amygdala volumes were negatively associated with neuroticism. These results offer insight into alterations in the Big 5 personality traits in TLE and their brain-related correlates.
Author List
Rivera Bonet CN, Hermann B, Cook CJ, Hwang G, Dabbs K, Nair V, Forseth C, Mathis J, Allen L, Almane DN, Arkush K, Birn R, Conant LL, DeYoe EA, Felton E, Humphries CJ, Kraegel P, Maganti R, Nencka A, Nwoke O, Raghavan M, Rozman M, Shah U, Sosa VN, Struck AF, Tellapragada N, Ustine C, Ward BD, Prabhakaran V, Binder JR, Meyerand MEAuthors
Jeffrey R. Binder MD Professor in the Neurology department at Medical College of WisconsinGyujoon Hwang PhD Assistant Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin
Manoj Raghavan MD, PhD Professor in the Neurology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdultAmygdala
Brain
Connectome
Epilepsy, Temporal Lobe
Female
Gray Matter
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuroticism
Personality
Personality Inventory
