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Brain aging in temporal lobe epilepsy: Chronological, structural, and functional. Neuroimage Clin 2020;25:102183



Pubmed ID


Pubmed Central ID




Scopus ID

2-s2.0-85079141146 (requires institutional sign-in at Scopus site)   14 Citations


The association of epilepsy with structural brain changes and cognitive abnormalities in midlife has raised concern regarding the possibility of future accelerated brain and cognitive aging and increased risk of later life neurocognitive disorders. To address this issue we examined age-related processes in both structural and functional neuroimaging among individuals with temporal lobe epilepsy (TLE, N = 104) who were participants in the Epilepsy Connectome Project (ECP). Support vector regression (SVR) models were trained from 151 healthy controls and used to predict TLE patients' brain ages. It was found that TLE patients on average have both older structural (+6.6 years) and functional (+8.3 years) brain ages compared to healthy controls. Accelerated functional brain age (functional - chronological age) was mildly correlated (corrected P = 0.07) with complex partial seizure frequency and the number of anti-epileptic drug intake. Functional brain age was a significant correlate of declining cognition (fluid abilities) and partially mediated chronological age-fluid cognition relationships. Chronological age was the only positive predictor of crystallized cognition. Accelerated aging is evident not only in the structural brains of patients with TLE, but also in their functional brains. Understanding the causes of accelerated brain aging in TLE will be clinically important in order to potentially prevent or mitigate their cognitive deficits.

Author List

Hwang G, Hermann B, Nair VA, Conant LL, Dabbs K, Mathis J, Cook CJ, Rivera-Bonet CN, Mohanty R, Zhao G, Almane DN, Nencka A, Felton E, Struck AF, Birn R, Maganti R, Humphries CJ, Raghavan M, DeYoe EA, Bendlin BB, Prabhakaran V, Binder JR, Meyerand ME


Jeffrey R. Binder MD Professor in the Neurology department at Medical College of Wisconsin
Lisa L. Conant PhD Associate Professor in the Neurology department at Medical College of Wisconsin
Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin
Manoj Raghavan MD, PhD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Age Factors
Aging, Premature
Cerebral Cortex
Cognitive Aging
Cognitive Dysfunction
Epilepsy, Temporal Lobe
Magnetic Resonance Imaging
Middle Aged
Support Vector Machine
Young Adult