Faculty Collaboration Database

Follicular lymphoma transformation to dual translocated Burkitt-like lymphoma: improved disease control associated with radiation therapy. Int J Hematol 2009 Dec;90(5):616-622

Date

11/26/2009

Pubmed ID

19937165

DOI

10.1007/s12185-009-0444-9

Scopus ID

2-s2.0-73449127535 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

Dual translocated (or "dual hit") lymphomas are highly aggressive B cell neoplasms associated with an extremely poor prognosis. The optimal treatment for these lymphomas remains undefined. We present two cases of follicular lymphoma with transformation to Burkitt-like lymphoma. In both cases dual translocations involving both the bcl-2 and c-myc loci were present. Each patient underwent intensive induction immunochemotherapy followed by autologous stem cell transplantation and radiation therapy. The first patient received post-transplant mediastinal radiation and developed recurrence in multiple areas outside of the radiation field. The second patient received total body irradiation as part of the conditioning regimen, and is without recurrence 18 months after transplant, and 24 months after diagnosis of the dual translocated lymphoma. We review dual translocation B cell lymphoma in the setting of transformation from follicular lymphoma, and suggest a potential role for total body irradiation in the management of this highly aggressive non-Hodgkin lymphoma.

Author List

Parker SM, Olteanu H, VanTuinen P, Lawton CA, Schultz CJ, Christians KK, Fenske TS

Authors

Kathleen K. Christians MD Professor in the Surgery department at Medical College of Wisconsin
Timothy Fenske MD Professor in the Medicine department at Medical College of Wisconsin
Christopher J. Schultz MD Chair, Professor in the Radiation Oncology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Burkitt Lymphoma
Cell Transformation, Neoplastic
Humans
Lymphoma, Follicular
Male
Middle Aged
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-myc
Whole-Body Irradiation