Von Willebrand disease in the United States: a perspective from Wisconsin. Semin Thromb Hemost 2011 Jul;37(5):528-34
Date
11/22/2011Pubmed ID
22102196Pubmed Central ID
PMC3807766DOI
10.1055/s-0031-1281039Scopus ID
2-s2.0-81755171917 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Von Willebrand disease (VWD) is a common bleeding disorder with prevalence in the United States of 0.01 to 1% and a prevalence in the region around Milwaukee, Wisconsin, of at least 0.025%. Care of local patients with VWD primarily occurs through our comprehensive treatment centers, although some patients are managed solely by their primary care physician or community hematologist. Type 1 VWD is the most common subtype, with more females carrying this diagnosis than males. Diagnosis and treatment in general follows guidelines outlined by the National Institutes of Health. An ongoing study, the Zimmerman Program for the Molecular and Clinical Biology of VWD, is currently enrolling patients with all VWD subtypes across the United States to better delineate the extent of VWD and correlate bleeding symptoms with laboratory findings and VWF ( Von Willebrand factor) sequence variations. Results so far have shown that VWF gene polymorphisms are common, particularly in African Americans, and may affect laboratory assays of VWF function.
Author List
Flood VH, Gill JC, Friedman KD, Bellissimo DB, Haberichter SL, Montgomery RRAuthors
Veronica H. Flood MD Chief, Professor in the Pediatrics department at Medical College of WisconsinKenneth D. Friedman MD Professor in the Medicine department at Medical College of Wisconsin
Robert R. Montgomery MD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
FemaleHumans
Male
Mutation
National Institutes of Health (U.S.)
Practice Guidelines as Topic
United States
Wisconsin
von Willebrand Diseases
von Willebrand Factor
