Faculty Collaboration Database

Effective Connectivity Within the Default Mode Network in Left Temporal Lobe Epilepsy: Findings from the Epilepsy Connectome Project. Brain Connect 2019 Mar;9(2):174-183

Date

11/07/2018

Pubmed ID

30398367

Pubmed Central ID

PMC6444922

DOI

10.1089/brain.2018.0600

Scopus ID

2-s2.0-85063100708 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

The Epilepsy Connectome Project examines the differences in connectomes between temporal lobe epilepsy (TLE) patients and healthy controls. Using these data, the effective connectivity of the default mode network (DMN) in patients with left TLE compared with healthy controls was investigated using spectral dynamic causal modeling (spDCM) of resting-state functional magnetic resonance imaging data. Group comparisons were made using two parametric empirical Bayes (PEB) models. The first level of each PEB model consisted of each participant's spDCM. Two different second-level models were constructed: the first comparing effective connectivity of the groups directly and the second using the Rey Auditory Verbal Learning Test (RAVLT) delayed free recall index as a covariate at the second level to assess effective connectivity controlling for the poor memory performance of left TLE patients. After an automated search over the nested parameter space and thresholding parameters at 95% posterior probability, both models revealed numerous connections in the DMN, which lead to inhibition of the left hippocampal formation. Left hippocampal formation inhibition may be an inherent result of the left temporal epileptogenic focus as memory differences were controlled for in one model and the same connections remained. An excitatory connection from the posterior cingulate cortex to the medial prefrontal cortex was found to be concomitant with left hippocampal formation inhibition in TLE patients when including RAVLT delayed free recall at the second level.

Author List

Cook CJ, Hwang G, Mathis J, Nair VA, Conant LL, Allen L, Almane DN, Birn R, DeYoe EA, Felton E, Forseth C, Humphries CJ, Kraegel P, Nencka A, Nwoke O, Raghavan M, Rivera-Bonet C, Rozman M, Tellapragada N, Ustine C, Ward BD, Struck A, Maganti R, Hermann B, Prabhakaran V, Binder JR, Meyerand ME

Authors

Jeffrey R. Binder MD Professor in the Neurology department at Medical College of Wisconsin
Gyujoon Hwang PhD Assistant Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin
Manoj Raghavan MD, PhD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Bayes Theorem
Brain
Connectome
Epilepsy
Epilepsy, Temporal Lobe
Female
Functional Laterality
Hippocampus
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
Neural Pathways
Prefrontal Cortex
Temporal Lobe