Medical College of Wisconsin
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David A. Margolis MD

David A. Margolis MD


Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology/Oncology
Program: Oncology


  • Genomics in clinical practice: lessons from the front lines. (Jacob HJ, Abrams K, Bick DP, Brodie K, Dimmock DP, Farrell M, Geurts J, Harris J, Helbling D, Joers BJ, Kliegman R, Kowalski G, Lazar J, Margolis DA, North P, Northup J, Roquemore-Goins A, Scharer G, Shimoyama M, Strong K, Taylor B, Tsaih SW, Tschannen MR, Veith RL, Wendt-Andrae J, Wilk B, Worthey EA) Sci Transl Med 2013 Jul 17;5(194):194cm5 PMID 23863829
  • Successful autologous cord blood transplantation in a child with acquired severe aplastic anemia. (Buchbinder D, Hsieh L, Puthenveetil G, Soni A, Stites J, Huynh V, Kirov I, Neudorf S, Rubin E, Sender L, Torno L, Margolis D, Childs R, Moore T, Nugent D) Pediatr Transplant 2013 May;17(3):E104-7 PMID 23464883
  • Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes. (Marsh RA, Rao K, Satwani P, Lehmberg K, Müller I, Li D, Kim MO, Fischer A, Latour S, Sedlacek P, Barlogis V, Hamamoto K, Kanegane H, Milanovich S, Margolis DA, Dimmock D, Casper J, Douglas DN, Amrolia PJ, Veys P, Kumar AR, Jordan MB, Bleesing JJ, Filipovich AH) Blood 2013 Feb 7;121(6):877-83 PMID 23131490
  • Endoscopic diagnosis of pediatric acute gastrointestinal graft-versus-host disease. (Sultan M, Ramprasad J, Jensen MK, Margolis D, Werlin S) J Pediatr Gastroenterol Nutr 2012 Oct;55(4):417-20 PMID 22367336
  • Newborn screening for severe combined immunodeficiency; the Wisconsin experience (2008-2011). (Verbsky JW, Baker MW, Grossman WJ, Hintermeyer M, Dasu T, Bonacci B, Reddy S, Margolis D, Casper J, Gries M, Desantes K, Hoffman GL, Brokopp CD, Seroogy CM, Routes JM) J Clin Immunol 2012 Feb;32(1):82-8 PMID 22068910
  • Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis. (Biank VF, Sheth MK, Talano J, Margolis D, Simpson P, Kugathasan S, Stephens M) J Pediatr 2011 Nov;159(5):808-12 PMID 21722918
  • Amelioration of oral mucositis pain by NASA near-infrared light-emitting diodes in bone marrow transplant patients. (Hodgson BD, Margolis DM, Salzman DE, Eastwood D, Tarima S, Williams LD, Sande JE, Vaughan WP, Whelan HT) Support Care Cancer 2012 Jul;20(7):1405-15 PMID 21725826
  • Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. (Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Arca MJ, Casper JT, Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP) Genet Med 2011 Mar;13(3):255-62 PMID 21173700
  • A timely arrival for genomic medicine. (Mayer AN, Dimmock DP, Arca MJ, Bick DP, Verbsky JW, Worthey EA, Jacob HJ, Margolis DA) Genet Med 2011 Mar;13(3):195-6 PMID 21169843
  • Unrelated donor bone marrow transplantation for myelodysplastic syndrome in children. (Woodard P, Carpenter PA, Davies SM, Gross TG, He W, Zhang MJ, Horn BN, Margolis DA, Perentesis JP, Sanders JE, Schultz KR, Seber A, Woods WG, Eapen M) Biol Blood Marrow Transplant 2011 May;17(5):723-8 PMID 20813197
  • Focal nodular hyperplasia in pediatric allogeneic hematopoietic cell transplant: case series. (Anderson L, Gregg D, Margolis D, Casper J, Talano J) Bone Marrow Transplant 2010 Aug;45(8):1357-9 PMID 20140023
  • Generation of cytotoxic T-cell lines using overlapping pentadecapeptides derived from conserved regions of the adenovirus hexon protein. (Zhu F, Xu H, Tsao A, Margolis DA, Keever-Taylor CA) J Gen Virol 2010 Jun;91(Pt 6):1577-89 PMID 20130135
  • Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. (Walters MC, Hardy K, Edwards S, Adamkiewicz T, Barkovich J, Bernaudin F, Buchanan GR, Bunin N, Dickerhoff R, Giller R, Haut PR, Horan J, Hsu LL, Kamani N, Levine JE, Margolis D, Ohene-Frempong K, Patience M, Redding-Lallinger R, Roberts IA, Rogers ZR, Sanders JE, Scott JP, Sullivan KM, Multicenter Study of Bone Marrow Transplantation for Sickle Cell Disease) Biol Blood Marrow Transplant 2010 Feb;16(2):263-72 PMID 19822218
  • Voriconazole-induced blistering in the setting of graft versus host disease: A report of 2 patients. (Conlon JD, Dauenhauer M, Tonkovic-Capin V, Talano J, Margolis D, Drolet BA, Fairley JA) J Am Acad Dermatol 2008 Mar;58(3):484-7 PMID 18280346
  • Stimulation by means of dendritic cells followed by Epstein-Barr virus-transformed B cells as antigen-presenting cells is more efficient than dendritic cells alone in inducing Aspergillus f16-specific cytotoxic T cell responses. (Zhu F, Ramadan G, Davies B, Margolis DA, Keever-Taylor CA) Clin Exp Immunol 2008 Feb;151(2):284-96 PMID 18005260
  • Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. (Eggleston B, Patience M, Edwards S, Adamkiewicz T, Buchanan GR, Davies SC, Dickerhoff R, Donfield S, Feig SA, Giller RH, Haight A, Horan J, Hsu LL, Kamani N, Lane P, Levine JE, Margolis D, Moore TB, Ohene-Frempong K, Redding-Lallinger R, Roberts IA, Rogers ZR, Sanders JE, Scott JP, Sleight B, Thompson AA, Sullivan KM, Walters MC, Multicenter Study of HCT for SCA) Br J Haematol 2007 Feb;136(4):673-6 PMID 17223910
  • Intertriginous eruption associated with chemotherapy in pediatric patients. (Webber KA, Kos L, Holland KE, Margolis DA, Drolet BA) Arch Dermatol 2007 Jan;143(1):67-71 PMID 17224544
  • Recent molecular and cellular advances in pediatric bone marrow transplantation. (Talano JA, Margolis DA) Pediatr Clin North Am 2006 Aug;53(4):685-98 PMID 16872999
  • Clinical and experimental applications of NIR-LED photobiomodulation. (Desmet KD, Paz DA, Corry JJ, Eells JT, Wong-Riley MT, Henry MM, Buchmann EV, Connelly MP, Dovi JV, Liang HL, Henshel DS, Yeager RL, Millsap DS, Lim J, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, Whelan HT) Photomed Laser Surg 2006 Apr;24(2):121-8 PMID 16706690
  • Alternative donor bone marrow transplant for children with Philadelphia chromosome ALL. (Talano JM, Casper JT, Camitta BM, Keever-Taylor CA, Murray KJ, Eapen M, Pierce KL, Margolis DA) Bone Marrow Transplant 2006 Jan;37(2):135-41 PMID 16273115
  • Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. (Eells JT, Wong-Riley MT, VerHoeve J, Henry M, Buchman EV, Kane MP, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, Whelan HT) Mitochondrion 2004 Sep;4(5-6):559-67 PMID 16120414
  • Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization. (Dincer AP, Gottschall J, Margolis DA) J Pediatr Hematol Oncol 2004 Nov;26(11):761-3 PMID 15543014
  • Efficacy of alemtuzumab treatment for refractory T-cell large granular lymphocytic leukemia. (Rosenblum MD, LaBelle JL, Chang CC, Margolis DA, Schauer DW, Vesole DH) Blood 2004 Mar 1;103(5):1969-71 PMID 14976065
  • Malignant infantile osteopetrosis and primary pulmonary hypertension: a new combination? (Kasow KA, Bonfim C, Asch J, Margolis DA, Jenkins J, Tamburro RF, Handgretinger R, Horwitz EM) Pediatr Blood Cancer 2004 Feb;42(2):190-4 PMID 14752886
  • Evaluation of histogenesis of B-lymphocytes in pediatric EBV-related post-transplant lymphoproliferative disorders. (Abed N, Casper JT, Camitta BM, Margolis D, Trost B, Orentas R, Chang CC) Bone Marrow Transplant 2004 Feb;33(3):321-7 PMID 14688820
  • Suppression of EBV release from irradiated B lymphoblastoid cell-lines: superior activity of ganciclovir compared with acyclovir. (Keever-Taylor CA, Behn B, Konings S, Orentas R, Davies B, Margolis D) Cytotherapy 2003;5(4):323-35 PMID 12944239
  • Monitoring and modulation of Epstein-Barr virus loads in pediatric transplant patients. (Orentas RJ, Schauer DW Jr, Ellis FW, Walczak J, Casper JT, Margolis DA) Pediatr Transplant 2003 Aug;7(4):305-14 PMID 12890010
  • NASA light-emitting diodes for the prevention of oral mucositis in pediatric bone marrow transplant patients. (Whelan HT, Connelly JF, Hodgson BD, Barbeau L, Post AC, Bullard G, Buchmann EV, Kane M, Whelan NT, Warwick A, Margolis D) J Clin Laser Med Surg 2002 Dec;20(6):319-24 PMID 12513918
  • Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly human leukocyte antigen-disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishing a treatment algorithm for recipients of alternative donor grafts. (Drobyski WR, Klein J, Flomenberg N, Pietryga D, Vesole DH, Margolis DA, Keever-Taylor CA) Blood 2002 Feb 1;99(3):806-14 PMID 11806980
  • Analysis of risk factors for the development of GVHD after T cell-depleted allogeneic BMT: effect of HLA disparity, ABO incompatibility, and method of T-cell depletion. (Keever-Taylor CA, Bredeson C, Loberiza FR, Casper JT, Lawton C, Rizzo D, Burns WH, Margolis DA, Vesole DH, Horowitz M, Zhang MJ, Juckett M, Drobyski WR) Biol Blood Marrow Transplant 2001;7(11):620-30 PMID 11760150
  • Effect of NASA light-emitting diode irradiation on wound healing. (Whelan HT, Smits RL Jr, Buchman EV, Whelan NT, Turner SG, Margolis DA, Cevenini V, Stinson H, Ignatius R, Martin T, Cwiklinski J, Philippi AF, Graf WR, Hodgson B, Gould L, Kane M, Chen G, Caviness J) J Clin Laser Med Surg 2001 Dec;19(6):305-14 PMID 11776448
  • Factors affecting neutrophil and platelet reconstitution following T cell-depleted bone marrow transplantation: differential effects of growth factor type and role of CD34(+) cell dose. (Keever-Taylor CA, Klein JP, Eastwood D, Bredeson C, Margolis DA, Burns WH, Vesole DH) Bone Marrow Transplant 2001 Apr;27(8):791-800 PMID 11477435
  • In vitro T-cell receptor V beta repertoire analysis may identify which T-cell V beta families mediate graft-versus-leukaemia and graft-versus-host responses after human leucocyte antigen-matched sibling stem cell transplantation. (Epperson DE, Margolis DA, McOlash L, Janczak T, Barrett AJ) Br J Haematol 2001 Jul;114(1):57-62 PMID 11472345
  • Cytomegalovirus-specific cytolytic T-cell lines and clones generated against adenovirus-pp65-infected dendritic cells. (Keever-Taylor CA, Margolis D, Konings S, Sandford GR, Nicolette CA, Lawendowski C, Burns WH) Biol Blood Marrow Transplant 2001;7(5):247-56 PMID 11400946
  • Chronic graft-versus-host disease of the liver: presentation as an acute hepatitis. (Strasser SI, Shulman HM, Flowers ME, Reddy R, Margolis DA, Prumbaum M, Seropian SE, McDonald GB) Hepatology 2000 Dec;32(6):1265-71 PMID 11093733
  • Infiltrating T cells during liver graft-versus-host disease show a restricted T-cell repertoire. (Margolis DA, Casper JT, Segura AD, Janczak T, McOlash L, Fisher B, Miller K, Gorski J) Biol Blood Marrow Transplant 2000;6(4):408-15 PMID 10917576
  • Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease. (Walters MC, Storb R, Patience M, Leisenring W, Taylor T, Sanders JE, Buchanan GE, Rogers ZR, Dinndorf P, Davies SC, Roberts IA, Dickerhoff R, Yeager AM, Hsu L, Kurtzberg J, Ohene-Frempong K, Bunin N, Bernaudin F, Wong WY, Scott JP, Margolis D, Vichinsky E, Wall DA, Wayne AS, Pegelow C, Redding-Lallinger R, Wiley J, Klemperer M, Mentzer WC, Smith FO, Sullivan KM) Blood 2000 Mar 15;95(6):1918-24 PMID 10706855
  • Alternative-donor hematopoietic stem-cell transplantation for severe aplastic anemia. (Margolis DA, Casper JT) Semin Hematol 2000 Jan;37(1):43-55 PMID 10676910
  • T-cell depletion plus salvage immunotherapy with donor leukocyte infusions as a strategy to treat chronic-phase chronic myelogenous leukemia patients undergoing HLA-identical sibling marrow transplantation. (Drobyski WR, Hessner MJ, Klein JP, Kabler-Babbitt C, Vesole DH, Margolis DA, Keever-Taylor CA) Blood 1999 Jul 15;94(2):434-41 PMID 10397710
  • Hematopoietic stem cell transplantation for severe aplastic anemia. (Margolis DA, Cammita BM) Curr Opin Hematol 1998 Nov;5(6):441-4 PMID 9814653
  • T cell-depleted allogeneic bone marrow transplantation for high-risk non-Hodgkin's lymphoma: clinical and molecular follow-up. (Juckett M, Rowlings P, Hessner M, Keever-Taylor C, Burns W, Camitta B, Casper J, Drobyski WR, Hanson G, Horowitz M, Lawton C, Margolis J, Peitryga D, Vesole D) Bone Marrow Transplant 1998 May;21(9):893-9 PMID 9613781
  • Reversible parkinsonism in a child after bone marrow transplantation and lipid-based amphotericin B therapy. (Manley TJ, Chusid MJ, Rand SD, Wells D, Margolis DA) Pediatr Infect Dis J 1998 May;17(5):433-4 PMID 9613664
  • Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction. HGTRI 0103. (Link CJ Jr, Burt RK, Traynor AE, Drobyski WR, Seregina T, Levy JP, Gordon L, Rosen ST, Burns WH, Camitta B, Casper J, Horowitz M, Juckett M, Lawton C, Margolis D, Pietryga D, Rowlings P, Taylor C, Furtado M, Stefka J, Gupta-Burt S, Kaiser H, Vesole DH) Hum Gene Ther 1998 Jan 1;9(1):115-34 PMID 9458247
  • Concurrent or sequential delta and beta TCR gene rearrangement during thymocyte development: individual thymi follow distinct pathways. (Margolis D, Yassai M, Hletko A, McOlash L, Gorski J) J Immunol 1997 Jul 15;159(2):529-33 PMID 9218565
  • Effect of T cell subset dose on outcome of T cell-depleted bone marrow transplantation. (Kawanishi Y, Passweg J, Drobyski WR, Rowlings P, Cook-Craig A, Casper J, Pietryga D, Garbrecht F, Camitta B, Horowitz M, Juckett M, Margolis D, Flomenberg N, Keever-Taylor CA) Bone Marrow Transplant 1997 Jun;19(11):1069-77 PMID 9193748
  • Unrelated donor bone marrow transplantation to treat severe aplastic anaemia in children and young adults. (Margolis D, Camitta B, Pietryga D, Keever-Taylor C, Baxter-Lowe LA, Pierce K, Kupst MJ, French J 3rd, Truitt R, Lawton C, Murray K, Garbrecht F, Flomenberg N, Casper J) Br J Haematol 1996 Jul;94(1):65-72 PMID 8757510
  • Three new exon 10 glucose-6-phosphate dehydrogenase mutations. (Beutler E, Westwood B, Melemed A, Dal Borgo P, Margolis D) Blood Cells Mol Dis 1995;21(1):64-72 PMID 7655862
  • Pancreatitis associated with brain tumor therapy. (Margolis DA, Werlin SL, Murray KJ, Strother DR) Am J Pediatr Hematol Oncol 1994 Nov;16(4):301-4 PMID 7978045
  • Unsuspected brucellosis diagnosed in a child as a result of an outbreak of laboratory-acquired brucellosis. (Chusid MJ, Russler SK, Mohr BA, Margolis DA, Hillery CA, Kehl KC) Pediatr Infect Dis J 1993 Dec;12(12):1031-3 PMID 8108214
  • Do monoamine oxidase inhibitors alter carbamazepine blood levels? (Barklage NE, Jefferson JW, Margolis D) J Clin Psychiatry 1992 Jul;53(7):258 PMID 1639748
  • Enterobacter cloacae bacteremia in children: a review of 30 cases in 12 years. (Bonadio WA, Margolis D, Tovar M) Clin Pediatr (Phila) 1991 May;30(5):310-3 PMID 2044341
  • Grants and Awards

  • A Multicenter Phase II Trial of Hemotopoetic Stem Cell Transplantation of the Treatment of Patients with Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction with Busulfan, Cyclophospasmide and Flu (#9305934 05/01/2010 - 04/30/2013) Sponsor: Fanconi Anemia Research Fund
  • Multi-Center, Open Label, Randomized Trial Comparing Single Versus Double Umbilical Cord Blood (UCB) Transplatation in Pediatric Patients with High Risk Leukemia and Myelodysplasia #501 (#9205578 12/12/2008 - 11/20/2013) Sponsor: National Childhood Cancer Foundation
  • NMDP BMT-CTN Clinical Protocol #601 (#9208258 02/12/2013 - 03/31/2014) Sponsor: Children's Hospital of Philadelphia
  • NMDP BMT-CTN Clinical Protocol #0501 (#9208252 01/22/2013 - 03/31/2014) Sponsor: Children's Hospital of Philadelphia
  • NMDP BMT-CTN Clinical Protocol #801 (#9208257 02/12/2013 - 03/31/2014) Sponsor: Children's Hospital of Philadelphia
  • Unrelated Donor Hematopoietic Cell Transplatation for Children with Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen #601 (#9205579 12/12/2008 - 04/02/2014) Sponsor: National Childhood Cancer Foundation