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Ashraf El-Meanawy MD, PhD

Ashraf El-Meanawy MD, PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Nephrology
Program: Administration

Member of the Cardiovascular Center
Member of the Center for Immunology

View Curriculum Vitae

Research Experience

  • Biology
  • Embryonic Development
  • Embryonic and Fetal Development
  • Genetics
  • Molecular Biology

    • Clinical Expertise

  • Hemodiafiltration
  • Hemodialysis, Home
  • Internal Medicine
  • Peritoneal Dialysis
  • Renal Dialysis
  • Renal Replacement Therapy
  • Sorption Detoxification

  • Publications (39)

  • Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences. (Goorani S, Khan AH, Mishra A, El-Meanawy A, Imig JD) Kidney Blood Press Res 2024;49(1):69-80 PMID: 38185105 PMCID: PMC10877550 SCOPUS ID: 2-s2.0-85184302998 01/08/2024    
  • Impact of Finerenone-Induced Albuminuria Reduction on Chronic Kidney Disease Outcomes in Type 2 Diabetes : A Mediation Analysis. (Agarwal R, Tu W, Farjat AE, Farag YMK, Toto R, Kaul S, Lawatscheck R, Rohwedder K, Ruilope LM, Rossing P, Pitt B, Filippatos G, Anker SD, Bakris GL, FIDELIO-DKD and FIGARO-DKD Investigators) Ann Intern Med 2023 Dec;176(12):1606-1616 PMID: 38048573 SCOPUS ID: 2-s2.0-85180405726 12/04/2023       5 Citations
  • Erratum. Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study. Diabetes Care 2022;45:888-897. (Rossing P, Burgess E, Agarwal R, Anker SD, Filippatos G, Pitt B, Ruilope LM, Gillard P, MacIsaac RJ, Wainstein J, Joseph A, Brinker M, Roessig L, Scott C, Bakris GL, FIDELIO-DKD Investigators ) Diabetes Care 2023 Sep 01;46(9):1721 PMID: 37310695 PMCID: PMC10465986 SCOPUS ID: 2-s2.0-85168809550 06/13/2023    
  • Salt-sensitive hypertension after reversal of unilateral ureteral obstruction. (Imig JD, Khan MAH, Stavniichuk A, Jankiewicz WK, Goorani S, Yeboah MM, El-Meanawy A) Biochem Pharmacol 2023 Apr;210:115438 PMID: 36716827 PMCID: PMC10107073 SCOPUS ID: 2-s2.0-85148360442 01/31/2023       1 Citation
  • Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A) iScience 16 September 2022;25(9) SCOPUS ID: 2-s2.0-85136236916 09/16/2022       5 Citations
  • Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model. (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A) iScience 2022 Sep 16;25(9):104887 PMID: 36039296 PMCID: PMC9418856 SCOPUS ID: 2-s2.0-85136236916 08/31/2022       5 Citations
  • Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Sodium-Glucose Cotransporter 2 Inhibitor Treatment: The FIDELITY Analysis. (Rossing P, Anker SD, Filippatos G, Pitt B, Ruilope LM, Birkenfeld AL, McGill JB, Rosas SE, Joseph A, Gebel M, Roberts L, Scheerer MF, Bakris GL, Agarwal R, FIDELIO-DKD and FIGARO-DKD Investigators) Diabetes Care 2022 Dec 01;45(12):2991-2998 PMID: 35972218 PMCID: PMC9862372 SCOPUS ID: 2-s2.0-85137736615 08/17/2022       60 Citations
  • Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension. (Rinschen MM, Palygin O, El-Meanawy A, Domingo-Almenara X, Palermo A, Dissanayake LV, Golosova D, Schafroth MA, Guijas C, Demir F, Jaegers J, Gliozzi ML, Xue J, Hoehne M, Benzing T, Kok BP, Saez E, Bleich M, Himmerkus N, Weisz OA, Cravatt BF, Krüger M, Benton HP, Siuzdak G, Staruschenko A) Nat Commun 2022 Jul 14;13(1):4099 PMID: 35835746 PMCID: PMC9283537 SCOPUS ID: 2-s2.0-85134142317 07/15/2022       18 Citations
  • Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study. (Rossing P, Burgess E, Agarwal R, Anker SD, Filippatos G, Pitt B, Ruilope LM, Gillard P, MacIsaac RJ, Wainstein J, Joseph A, Brinker M, Roessig L, Scott C, Bakris GL, FIDELIO-DKD Investigators) Diabetes Care 2022 Apr 01;45(4):888-897 PMID: 35061867 PMCID: PMC9271031 SCOPUS ID: 2-s2.0-85128419255 01/22/2022       20 Citations
  • Long-term kidney function and survival in recipients of allografts from living kidney donors with hypertension: a national cohort study. (Al Ammary F, Yu S, Muzaale AD, Segev DL, Liyanage L, Crews DC, Brennan DC, El-Meanawy A, Alqahtani S, Atta MG, Levan ML, Caffo BS, Welling PA, Massie AB) Transpl Int 2021 Aug;34(8):1530-1541 PMID: 34129713 SCOPUS ID: 2-s2.0-85109388213 06/16/2021       4 Citations
  • p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli. (Miller B, Palygin O, El-Meanawy A, Mattson DL, Geurts AM, Staruschenko A, Sorokin A) Life Sci 2021 Aug 15;279:119661 PMID: 34087282 PMCID: PMC8265215 SCOPUS ID: 2-s2.0-85107260373 06/05/2021       6 Citations
  • Role of opioid signaling in kidney damage during the development of salt-induced hypertension. (Golosova D, Palygin O, Bohovyk R, Klemens CA, Levchenko V, Spires DR, Isaeva E, El-Meanawy A, Staruschenko A) Life Sci Alliance 2020 Dec;3(12) PMID: 33046522 PMCID: PMC7556751 SCOPUS ID: 2-s2.0-85092887222 10/14/2020       19 Citations
  • Upregulated proteoglycan-related signaling pathways in fluid flow shear stress-treated podocytes. (Srivastava T, Joshi T, Jiang Y, Heruth DP, Rezaiekhaligh MH, Novak J, Staggs VS, Alon US, Garola RE, El-Meanawy A, McCarthy ET, Zhou J, Boinpelly VC, Sharma R, Savin VJ, Sharma M) Am J Physiol Renal Physiol 2020 Aug 01;319(2):F312-F322 PMID: 32628542 PMCID: PMC7473905 SCOPUS ID: 2-s2.0-85089301199 07/07/2020       8 Citations
  • Urinary prostaglandin E2 is a biomarker of early adaptive hyperfiltration in solitary functioning kidney. (Srivastava T, Ju W, Milne GL, Rezaiekhaligh MH, Staggs VS, Alon US, Sharma R, Zhou J, El-Meanawy A, McCarthy ET, Savin VJ, Sharma M) Prostaglandins Other Lipid Mediat 2020 Feb;146:106403 PMID: 31838197 PMCID: PMC9356765 SCOPUS ID: 2-s2.0-85076524994 12/16/2019       8 Citations
  • Vibrodissociation method for isolation of defined nephron segments from human and rodent kidneys. (Isaeva E, Fedoriuk M, Bohovyk R, Klemens CA, Khedr S, Golosova D, Levchenko V, El-Meanawy A, Palygin O, Staruschenko A) Am J Physiol Renal Physiol 2019 Nov 01;317(5):F1398-F1403 PMID: 31588797 PMCID: PMC6879945 SCOPUS ID: 2-s2.0-85074674820 10/08/2019       8 Citations
  • Improving sensitivity of amyloid detection by Congo red stain by using polarizing microscope and avoiding pitfalls. (El-Meanawy A, Mueller C, Iczkowski KA) Diagn Pathol 2019 Jun 14;14(1):57 PMID: 31200733 PMCID: PMC6567537 SCOPUS ID: 2-s2.0-85067289424 06/16/2019       17 Citations
  • Increased ENaC activity during kidney preservation in Wisconsin solution. (Khedr S, Palygin O, Pavlov TS, Blass G, Levchenko V, Alsheikh A, Brands MW, El-Meanawy A, Staruschenko A) BMC Nephrol 2019 Apr 29;20(1):145 PMID: 31035971 PMCID: PMC6489205 SCOPUS ID: 2-s2.0-85065255744 05/01/2019       7 Citations
  • IgM nephropathy - Successful treatment with rituximab. (Ahmed FA, El-Meanawy A) Saudi J Kidney Dis Transpl 2019;30(1):235-238 PMID: 30804288 SCOPUS ID: 2-s2.0-85062165806 02/26/2019       4 Citations
  • Hyperfiltration-mediated Injury in the Remaining Kidney of a Transplant Donor. (Srivastava T, Hariharan S, Alon US, McCarthy ET, Sharma R, El-Meanawy A, Savin VJ, Sharma M) Transplantation 2018 Oct;102(10):1624-1635 PMID: 29847501 PMCID: PMC6153061 SCOPUS ID: 2-s2.0-85054327271 05/31/2018       35 Citations
  • Mechanotransduction signaling in podocytes from fluid flow shear stress. (Srivastava T, Dai H, Heruth DP, Alon US, Garola RE, Zhou J, Duncan RS, El-Meanawy A, McCarthy ET, Sharma R, Johnson ML, Savin VJ, Sharma M) Am J Physiol Renal Physiol 2018 Jan 01;314(1):F22-F34 PMID: 28877882 PMCID: PMC5866353 SCOPUS ID: 2-s2.0-85043506758 09/08/2017       27 Citations
  • Role of biomechanical forces in hyperfiltration-mediated glomerular injury in congenital anomalies of the kidney and urinary tract. (Srivastava T, Thiagarajan G, Alon US, Sharma R, El-Meanawy A, McCarthy ET, Savin VJ, Sharma M) Nephrol Dial Transplant 2017 May 01;32(5):759-765 PMID: 28339567 PMCID: PMC6075083 SCOPUS ID: 2-s2.0-85020217027 03/25/2017       20 Citations
  • Mechanisms of BK virus infection of renal cells and therapeutic implications. (Mbianda C, El-Meanawy A, Sorokin A) J Clin Virol 2015 Oct;71:59-62 PMID: 26295751 PMCID: PMC4572911 SCOPUS ID: 2-s2.0-84941554328 08/22/2015       27 Citations
  • Cyclooxygenase-2, prostaglandin E2, and prostanoid receptor EP2 in fluid flow shear stress-mediated injury in the solitary kidney. (Srivastava T, Alon US, Cudmore PA, Tarakji B, Kats A, Garola RE, Duncan RS, McCarthy ET, Sharma R, Johnson ML, Bonewald LF, El-Meanawy A, Savin VJ, Sharma M) Am J Physiol Renal Physiol 2014 Dec 15;307(12):F1323-33 PMID: 25234310 SCOPUS ID: 2-s2.0-84918802845 09/23/2014       27 Citations
  • Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis. (Khan S, Abu Jawdeh BG, Goel M, Schilling WP, Parker MD, Puchowicz MA, Yadav SP, Harris RC, El-Meanawy A, Hoshi M, Shinlapawittayatorn K, Deschênes I, Ficker E, Schelling JR) J Clin Invest 2014 Mar;124(3):1057-68 PMID: 24531551 PMCID: PMC3934167 SCOPUS ID: 2-s2.0-84896766836 02/18/2014       45 Citations
  • Fluid flow shear stress upregulates prostanoid receptor EP2 but not EP4 in murine podocytes. (Srivastava T, McCarthy ET, Sharma R, Kats A, Carlton CG, Alon US, Cudmore PA, El-Meanawy A, Sharma M) Prostaglandins Other Lipid Mediat 2013;104-105:49-57 PMID: 23262148 SCOPUS ID: 2-s2.0-84879689638 12/25/2012       23 Citations
  • Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes. (El-Meanawy A, Schelling JR, Iyengar SK, Hayden P, Barathan S, Goddard K, Pozuelo F, Elashi E, Nair V, Kretzler M, Sedor JR) BMC Nephrol 2012 Jul 19;13:61 PMID: 22813067 PMCID: PMC3502501 SCOPUS ID: 2-s2.0-84869763097 07/21/2012       6 Citations
  • Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria. (Stelloh C, Allen KP, Mattson DL, Lerch-Gaggl A, Reddy S, El-Meanawy A) Transl Res 2012 Feb;159(2):80-9 PMID: 22243792 PMCID: PMC3896045 SCOPUS ID: 2-s2.0-84855827231 01/17/2012       67 Citations
  • Short-term exposure to tobacco toxins alters expression of multiple proliferation gene markers in primary human bronchial epithelial cell cultures. (Chaudhry IS, El-Meanawy A, Khiyami A, Tomashefski JF Jr, Machekano RN, Kass L) J Oncol 2011;2011:208563 PMID: 21776270 PMCID: PMC3137990 SCOPUS ID: 2-s2.0-79959196589 07/22/2011       2 Citations
  • Acute kidney injury requiring dialysis secondary to adenovirus nephritis in renal transplant recipient. (Sujeet K, Vasudev B, Desai P, Bellizzi J, Novoa-Takara L, He C, El-Meanawy A) Transpl Infect Dis 2011 Apr;13(2):174-7 PMID: 20946204 SCOPUS ID: 2-s2.0-79953322013 10/16/2010       29 Citations
  • Recombinant Schistosoma mansoni 3-hydroxymethylglutaryl-coenzyme-A reductase has different inhibitor kinetics compared to the mammalian host enzyme. (El-Meanawy A, Hammd H, Chen GZ, Rottman F, Bennett JL) Trop Gastroenterol 2005;26(3):132-5 PMID: 16512462 SCOPUS ID: 2-s2.0-33645646588 03/04/2006    
  • The African American Study of Kidney Disease: do these results indicate that 140/90 mm hg is good enough? (Rahman M, El-Meanawy A, Romanello J) Curr Hypertens Rep 2005 Oct;7(5):363-6 PMID: 16157080 SCOPUS ID: 2-s2.0-27544502885 09/15/2005       2 Citations
  • Renal phenotype is exacerbated in Os and lpr double mutant mice. (Jarad G, Lakhe-Reddy S, Blatnik J, Koepke M, Khan S, El-Meanawy MA, O'Connor AS, Sedor JR, Schelling JR) Kidney Int 2004 Sep;66(3):1029-35 PMID: 15327396 SCOPUS ID: 2-s2.0-4344589589 08/26/2004       4 Citations
  • A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. (Srichai MB, Konieczkowski M, Padiyar A, Konieczkowski DJ, Mukherjee A, Hayden PS, Kamat S, El-Meanawy MA, Khan S, Mundel P, Lee SB, Bruggeman LA, Schelling JR, Sedor JR) J Biol Chem 2004 Apr 02;279(14):14398-408 PMID: 14736876 SCOPUS ID: 2-s2.0-11144355698 01/23/2004       76 Citations
  • Serial analysis of gene expression. (el-Meanawy MA, Barathan S, Hayden PS, Iyengar SK, Schelling JR, Sedor JR) Methods Mol Med 2003;86:257-74 PMID: 12886774 SCOPUS ID: 2-s2.0-0043234942 07/31/2003       3 Citations
  • DNA expression analysis: serial analysis of gene expression, microarrays and kidney disease. (Hayden PS, El-Meanawy A, Schelling JR, Sedor JR) Curr Opin Nephrol Hypertens 2003 Jul;12(4):407-14 PMID: 12815337 SCOPUS ID: 2-s2.0-0037765263 06/20/2003       15 Citations
  • Generation of kidney transcriptomes using serial analysis of gene expression. (Schelling JR, El-Meanawy MA, Barathan S, Dodig T, Iyengar SK, Sedor JR) Exp Nephrol 2002;10(2):82-92 PMID: 11937755 SCOPUS ID: 2-s2.0-0036217255 04/09/2002       11 Citations
  • Use of serial analysis of gene expression to generate kidney expression libraries. (El-Meanawy MA, Schelling JR, Pozuelo F, Churpek MM, Ficker EK, Iyengar S, Sedor JR) Am J Physiol Renal Physiol 2000 Aug;279(2):F383-92 PMID: 10919859 SCOPUS ID: 2-s2.0-0033844165 08/05/2000       32 Citations
  • Identification and molecular cloning of a 67-kilodalton protein in Schistosoma japonicum homologous to a family of actin-binding proteins. (Kurtis JD, Ramirez BL, Wiest PM, Dong KL, El-Meanawy A, Petzke MM, Johnson JH, Edmison J, Maier RA Jr, Olds GR) Infect Immun 1997 Jan;65(1):344-7 PMID: 8975937 PMCID: PMC174601 SCOPUS ID: 2-s2.0-0031031012 01/01/1997       14 Citations
  • Definition of the complete Schistosoma mansoni hemoglobinase mRNA sequence and gene expression in developing parasites. (el Meanawy MA, Aji T, Phillips NF, Davis RE, Salata RA, Malhotra I, McClain D, Aikawa M, Davis AH) Am J Trop Med Hyg 1990 Jul;43(1):67-78 PMID: 2382765 SCOPUS ID: 2-s2.0-0025126767 07/01/1990       37 Citations
    • Last update: 04/22/2024