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Christopher M. Olsen PhD

Christopher M. Olsen PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Neuroscience Research Center


Research Experience

  • Cocaine-Related Disorders
  • Exploratory Behavior
  • Motivation
  • Substance-Related Disorders
  • MCW Program / Core Facilities

  • Neuroscience Research Center
  • Publications

  • Increased prefrontal cortex neurogranin enhances plasticity and extinction learning. (Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ) J Neurosci 2015 May 13;35(19):7503-8 PMID: 25972176 PMCID: PMC4429154
  • Voluntary Alcohol Intake following Blast Exposure in a Rat Model of Mild Traumatic Brain Injury. (Lim YW, Meyer NP, Shah AS, Budde MD, Stemper BD, Olsen CM) PLoS One 2015;10(4):e0125130 PMID: 25910266 PMCID: PMC4409117
  • S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. (Zhang N, Zhong P, Shin SM, Metallo J, Danielson E, Olsen CM, Liu QS, Lee SH) J Neurosci 2015 Feb 4;35(5):1892-904 PMID: 25653350 PMCID: PMC4315826
  • Head rotational acceleration characteristics influence behavioral and diffusion tensor imaging outcomes following concussion. (Stemper BD, Shah AS, Pintar FA, McCrea M, Kurpad SN, Glavaski-Joksimovic A, Olsen C, Budde MD) Ann Biomed Eng 2015 May;43(5):1071-88 PMID: 25344352
  • CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. (Liu X, Liu Y, Zhong P, Wilkinson B, Qi J, Olsen CM, Bayer KU, Liu QS) Neuropsychopharmacology 2014 Mar;39(4):989-99 PMID: 24154664 PMCID: PMC3924533
  • Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound. (Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, Olsen CM, Winder DG, Emmitte KA, Lindsley CW) ChemMedChem 2012 Mar 5;7(3):406-14 PMID: 22267125 PMCID: PMC3517057
  • Stimulus dynamics increase the self-administration of compound visual and auditory stimuli. (Olsen CM, Winder DG) Neurosci Lett 2012 Mar 5;511(1):8-11 PMID: 22249116 PMCID: PMC3299404
  • (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction. (Lindsley CW, Bates BS, Menon UN, Jadhav SB, Kane AS, Jones CK, Rodriguez AL, Conn PJ, Olsen CM, Winder DG, Emmitte KA) ACS Chem Neurosci 2011 Aug 17;2(8):471-482 PMID: 21927650 PMCID: PMC3172161
  • Natural rewards, neuroplasticity, and non-drug addictions. (Olsen CM) Neuropharmacology 2011 Dec;61(7):1109-22 PMID: 21459101 PMCID: PMC3139704
  • Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). (Olsen CM, Childs DS, Stanwood GD, Winder DG) PLoS One 2010;5(11):e15085 PMID: 21152045 PMCID: PMC2994905
  • Operant sensation seeking in the mouse. (Olsen CM, Winder DG) J Vis Exp 2010(45): PMID: 21113110 PMCID: PMC3159589
  • Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice. (Olsen CM, Winder DG) Neuropsychopharmacology 2009 Jun;34(7):1685-94 PMID: 19145223 PMCID: PMC2720253
  • Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum. (Olsen CM, Huang Y, Goodwin S, Ciobanu DC, Lu L, Sutter TR, Winder DG) Physiol Genomics 2008 Feb 19;32(3):283-98 PMID: 17911379
  • Experience-dependent effects of cocaine self-administration/conditioning on prefrontal and accumbens dopamine responses. (Ikegami A, Olsen CM, D'Souza MS, Duvauchelle CL) Behav Neurosci 2007 Apr;121(2):389-400 PMID: 17469929 PMCID: PMC2565684
  • A method for single-session cocaine self-administration in the mouse. (Olsen CM, Winder DG) Psychopharmacology (Berl) 2006 Jul;187(1):13-21 PMID: 16767412
  • Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. (Grueter BA, Gosnell HB, Olsen CM, Schramm-Sapyta NL, Nekrasova T, Landreth GE, Winder DG) J Neurosci 2006 Mar 22;26(12):3210-9 PMID: 16554472
  • Prefrontal cortex D1 modulation of the reinforcing properties of cocaine. (Olsen CM, Duvauchelle CL) Brain Res 2006 Feb 23;1075(1):229-35 PMID: 16460710
  • Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. (Schramm-Sapyta NL, Olsen CM, Winder DG) Neuropsychopharmacology 2006 Jul;31(7):1444-51 PMID: 16205778
  • Serotonergic neurotoxic metabolites of ecstasy identified in rat brain. (Jones DC, Duvauchelle C, Ikegami A, Olsen CM, Lau SS, de la Torre R, Monks TJ) J Pharmacol Exp Ther 2005 Apr;313(1):422-31 PMID: 15634943
  • Chronic D1 agonist and ethanol coadministration facilitate ethanol-mediated behaviors. (D'Souza MS, Ikegami A, Olsen CM, Duvauchelle CL) Pharmacol Biochem Behav 2003 Sep;76(2):335-42 PMID: 14592686
  • Cholinergic interneurons of the nucleus accumbens and dorsal striatum are activated by the self-administration of cocaine. (Berlanga ML, Olsen CM, Chen V, Ikegami A, Herring BE, Duvauchelle CL, Alcantara AA) Neuroscience 2003;120(4):1149-56 PMID: 12927219
  • Intravenous ethanol/cocaine self-administration initiates high intake of intravenous ethanol alone. (Ikegami A, Olsen CM, Fleming SM, Guerra EE, Bittner MA, Wagner J, Duvauchelle CL) Pharmacol Biochem Behav 2002 Jul;72(4):787-94 PMID: 12062567
  • Intra-prefrontal cortex injections of SCH 23390 influence nucleus accumbens dopamine levels 24 h post-infusion. (Olsen CM, Duvauchelle CL) Brain Res 2001 Dec 13;922(1):80-6 PMID: 11730704
  • alpha-melanocyte-stimulating hormone and habituation of prey-catching behavior in the Texas toad, Bufo speciosus. (Olsen CM, Lovering AT, Carr JA) Horm Behav 1999 Aug;36(1):62-9 PMID: 10433887
  • Last update: 07/27/2015