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Christopher M. Olsen PhD

Christopher M. Olsen PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Neuroscience Research Center


Research Experience

  • Brain Concussion
  • Brain Injuries
  • Brain Injury, Chronic
  • Cocaine-Related Disorders
  • Exploratory Behavior
  • Motivation
  • Opioid-Related Disorders
  • Substance-Related Disorders
  • MCW Program / Core Facilities

  • Neuroscience Research Center
  • Publications

  • Repeated blast model of mild traumatic brain injury alters oxycodone self-administration and drug seeking. (Nawarawong NN, Slaker M, Muelbl M, Shah AS, Chiariello R, Nelson LD, Budde MD, Stemper BD, Olsen CM) Eur J Neurosci 2018 Nov 20 PMID: 30456793 11/21/2018    
  • Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. (Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M) iScience 2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 11/15/2018    
  • Effects of Mild Blast Traumatic Brain Injury on Cognitive- and Addiction-Related Behaviors. (Muelbl MJ, Slaker ML, Shah AS, Nawarawong NN, Gerndt CH, Budde MD, Stemper BD, Olsen CM) Sci Rep 2018 Jul 02;8(1):9941 PMID: 29967344 PMCID: PMC6028456 07/04/2018    
  • Acute Clinical Predictors of Symptom Recovery in Emergency Department Patients with Uncomplicated Mild Traumatic Brain Injury or Non-Traumatic Brain Injuries. (Nelson LD, Furger RE, Ranson J, Tarima S, Hammeke TA, Randolph C, Barr WB, Guskiewicz K, Olsen CM, Lerner EB, McCrea MA) J Neurotrauma 2018 Jan 15;35(2):249-259 PMID: 29017409 PMCID: PMC5784791 10/12/2017       2 Citations
  • Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities. (Olsen CM, Liu QS) Front Biol (Beijing) 2016 Oct;11(5):376-386 PMID: 28974957 PMCID: PMC5617368 10/05/2017    
  • Characterization of differing time-course of cognitive deficits and emotional changes following rotational traumatic brain injury in the rat (Stemper B.D., Shah A.S., Budde M.D., Chiariello R., Wilkins N., Olsen C., Mehta P., Kurpad S.N., McCrea M., Pintar F.A. ) 2015 IRCOBI Conference Proceedings 198-207 09/06/2017    
  • Acute Clinical Predictors of Symptom Recovery from Uncomplicated Mild Traumatic Brain Injury (mTBI) in Emergency Department Patients (LD Nelson, RE Furger, J Ranson, S Tarima, TA Hammeke, C Randolph, WB Barr, K Guskiewicz, CM Olsen, EB Lerner, and MA McCrea) Journal of Neurotrauma (in press) 09/06/2017    
  • Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. (Helfand AI, Olsen CM, Hillard CJ) Int J Mol Sci 2017 Jul 27;18(8) PMID: 28749428 PMCID: PMC5578025 07/28/2017       1 Citations
  • Prediction of Post-Concussive Behavioral Changes in a Rodent Model Based on Head Rotational Acceleration Characteristics. (Stemper BD, Shah AS, Chiariello R, Olsen CM, Budde MD, Glavaski-Joksimovic A, McCrea M, Kurpad SN, Pintar FA) Ann Biomed Eng 2016 Nov;44(11):3252-3265 PMID: 27188340 PMCID: PMC5093216 11/04/2016       1 Citations
  • Responses to drugs of abuse and non-drug rewards in leptin deficient ob/ob mice. (Muelbl MJ, Nawarawong NN, Clancy PT, Nettesheim CE, Lim YW, Olsen CM) Psychopharmacology (Berl) 2016 07;233(14):2799-811 PMID: 27256358 PMCID: PMC5095929 06/04/2016       11 Citations
  • Prediction of post-concussive behavioral changes in a rodent model based on head rotational acceleration characteristics (in press) (Stemper, BD, AS Shah, R Chiariello, CM Olsen, MD Budde, A Glavaski-Joksimovic, M McCrea, SN Kurpad, FA Pintar ) Annals of Biomedical Engineering 05/10/2016    
  • Responses to drugs of abuse and non-drug rewards in leptin deficient ob/ob mice (in press) (Muelbl, MJ, NN Nawarawong, PT Clancy, CE Nettesheim, YW Lim, CM Olsen ) Psychopharmacology 05/09/2016    
  • Behavioral Outcomes Differ between Rotational Acceleration and Blast Mechanisms of Mild Traumatic Brain Injury. (Stemper BD, Shah AS, Budde MD, Olsen CM, Glavaski-Joksimovic A, Kurpad SN, McCrea M, Pintar FA) Front Neurol 2016;7:31 PMID: 27014184 PMCID: PMC4789366 03/26/2016    
  • Increased prefrontal cortex neurogranin enhances plasticity and extinction learning. (Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ) J Neurosci 2015 May 13;35(19):7503-8 PMID: 25972176 PMCID: PMC4429154 05/15/2015       10 Citations
  • Voluntary Alcohol Intake following Blast Exposure in a Rat Model of Mild Traumatic Brain Injury. (Lim YW, Meyer NP, Shah AS, Budde MD, Stemper BD, Olsen CM) PLoS One 2015;10(4):e0125130 PMID: 25910266 PMCID: PMC4409117 04/25/2015       14 Citations
  • S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. (Zhang N, Zhong P, Shin SM, Metallo J, Danielson E, Olsen CM, Liu QS, Lee SH) J Neurosci 2015 Feb 04;35(5):1892-904 PMID: 25653350 PMCID: PMC4315826 02/06/2015       4 Citations
  • Head rotational acceleration characteristics influence behavioral and diffusion tensor imaging outcomes following concussion. (Stemper BD, Shah AS, Pintar FA, McCrea M, Kurpad SN, Glavaski-Joksimovic A, Olsen C, Budde MD) Ann Biomed Eng 2015 May;43(5):1071-88 PMID: 25344352 PMCID: PMC4654450 10/26/2014       22 Citations
  • CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. (Liu X, Liu Y, Zhong P, Wilkinson B, Qi J, Olsen CM, Bayer KU, Liu QS) Neuropsychopharmacology 2014 Mar;39(4):989-99 PMID: 24154664 PMCID: PMC3924533 10/25/2013       13 Citations
  • Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound. (Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, Olsen CM, Winder DG, Emmitte KA, Lindsley CW) ChemMedChem 2012 Mar 05;7(3):406-14 PMID: 22267125 PMCID: PMC3517057 01/24/2012       25 Citations
  • Stimulus dynamics increase the self-administration of compound visual and auditory stimuli. (Olsen CM, Winder DG) Neurosci Lett 2012 Mar 05;511(1):8-11 PMID: 22249116 PMCID: PMC3299404 01/18/2012       10 Citations
  • (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction. (Lindsley CW, Bates BS, Menon UN, Jadhav SB, Kane AS, Jones CK, Rodriguez AL, Conn PJ, Olsen CM, Winder DG, Emmitte KA) ACS Chem Neurosci 2011 Aug 17;2(8):471-482 PMID: 21927650 PMCID: PMC3172161 09/20/2011    
  • Natural rewards, neuroplasticity, and non-drug addictions. (Olsen CM) Neuropharmacology 2011 Dec;61(7):1109-22 PMID: 21459101 PMCID: PMC3139704 04/05/2011       104 Citations
  • Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). (Olsen CM, Childs DS, Stanwood GD, Winder DG) PLoS One 2010 Nov 30;5(11):e15085 PMID: 21152045 PMCID: PMC2994905 12/15/2010       25 Citations
  • Operant sensation seeking in the mouse. (Olsen CM, Winder DG) J Vis Exp 2010 Nov 10(45) PMID: 21113110 PMCID: PMC3159589 11/30/2010       11 Citations
  • Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice. (Olsen CM, Winder DG) Neuropsychopharmacology 2009 Jun;34(7):1685-94 PMID: 19145223 PMCID: PMC2720253 01/16/2009       62 Citations
  • Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum. (Olsen CM, Huang Y, Goodwin S, Ciobanu DC, Lu L, Sutter TR, Winder DG) Physiol Genomics 2008 Feb 19;32(3):283-98 PMID: 17911379 10/04/2007       12 Citations
  • Experience-dependent effects of cocaine self-administration/conditioning on prefrontal and accumbens dopamine responses. (Ikegami A, Olsen CM, D'Souza MS, Duvauchelle CL) Behav Neurosci 2007 Apr;121(2):389-400 PMID: 17469929 PMCID: PMC2565684 05/02/2007       13 Citations
  • A method for single-session cocaine self-administration in the mouse. (Olsen CM, Winder DG) Psychopharmacology (Berl) 2006 Jul;187(1):13-21 PMID: 16767412 06/13/2006       10 Citations
  • Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. (Grueter BA, Gosnell HB, Olsen CM, Schramm-Sapyta NL, Nekrasova T, Landreth GE, Winder DG) J Neurosci 2006 Mar 22;26(12):3210-9 PMID: 16554472 03/24/2006       80 Citations
  • Prefrontal cortex D1 modulation of the reinforcing properties of cocaine. (Olsen CM, Duvauchelle CL) Brain Res 2006 Feb 23;1075(1):229-35 PMID: 16460710 02/08/2006       16 Citations
  • Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. (Schramm-Sapyta NL, Olsen CM, Winder DG) Neuropsychopharmacology 2006 Jul;31(7):1444-51 PMID: 16205778 10/06/2005       35 Citations
  • Serotonergic neurotoxic metabolites of ecstasy identified in rat brain. (Jones DC, Duvauchelle C, Ikegami A, Olsen CM, Lau SS, de la Torre R, Monks TJ) J Pharmacol Exp Ther 2005 Apr;313(1):422-31 PMID: 15634943 01/07/2005       102 Citations
  • Chronic D1 agonist and ethanol coadministration facilitate ethanol-mediated behaviors. (D'Souza MS, Ikegami A, Olsen CM, Duvauchelle CL) Pharmacol Biochem Behav 2003 Sep;76(2):335-42 PMID: 14592686 11/01/2003       17 Citations
  • Cholinergic interneurons of the nucleus accumbens and dorsal striatum are activated by the self-administration of cocaine. (Berlanga ML, Olsen CM, Chen V, Ikegami A, Herring BE, Duvauchelle CL, Alcantara AA) Neuroscience 2003;120(4):1149-56 PMID: 12927219 08/21/2003       41 Citations
  • Intravenous ethanol/cocaine self-administration initiates high intake of intravenous ethanol alone. (Ikegami A, Olsen CM, Fleming SM, Guerra EE, Bittner MA, Wagner J, Duvauchelle CL) Pharmacol Biochem Behav 2002 Jul;72(4):787-94 PMID: 12062567 06/14/2002       13 Citations
  • Intra-prefrontal cortex injections of SCH 23390 influence nucleus accumbens dopamine levels 24 h post-infusion. (Olsen CM, Duvauchelle CL) Brain Res 2001 Dec 13;922(1):80-6 PMID: 11730704 12/04/2001       13 Citations
  • alpha-melanocyte-stimulating hormone and habituation of prey-catching behavior in the Texas toad, Bufo speciosus. (Olsen CM, Lovering AT, Carr JA) Horm Behav 1999 Aug;36(1):62-9 PMID: 10433887 08/06/1999       12 Citations
  • Last update: 12/28/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796