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David M. Gourlay MD

David M. Gourlay MD

Associate Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Pediatric Surgery


Leadership Positions

  • Wisconsin State Trauma Advisory Committee
  • American Pediatric Surgical Association - Trauma Committee
  • Medical Director - Trauma Program Children's Hopsital of Wisconsin
  • Association of American Medical Colleges – MCW Key Contact for Joining Forces Program
  • Publications

  • Interleukin-23 Increases Intestinal Epithelial Cell Permeability In Vitro. (Heinzerling NP, Donohoe D, Fredrich K, Gourlay DM, Liedel JL) Eur J Pediatr Surg 2015 May 22: PMID: 26007691 05/27/2015
  • Intestinal alkaline phosphatase to treat necrotizing enterocolitis. (Biesterveld BE, Koehler SM, Heinzerling NP, Rentea RM, Fredrich K, Welak SR, Gourlay DM) J Surg Res 2015 Jun 15;196(2):235-40 PMID: 25840489 04/05/2015
  • A consensus-based criterion standard definition for pediatric patients who needed the highest-level trauma team activation. (Lerner EB, Drendel AL, Falcone RA Jr, Weitze KC, Badawy MK, Cooper A, Cushman JT, Drayna PC, Gourlay DM, Gray MP, Shah MI, Shah MN) J Trauma Acute Care Surg 2015 Mar;78(3):634-8 PMID: 25710438 PMCID: PMC4341956 02/25/2015
  • Intestinal NADPH oxidase 2 activity increases in a neonatal rat model of necrotizing enterocolitis. (Welak SR, Rentea RM, Teng RJ, Heinzerling N, Biesterveld B, Liedel JL, Pritchard KA Jr, Fredrich KM, Gourlay DM) PLoS One 2014;9(12):e115317 PMID: 25517730 PMCID: PMC4269454 12/18/2014
  • Intestinal alkaline phosphatase is protective to the preterm rat pup intestine. (Heinzerling NP, Liedel JL, Welak SR, Fredrich K, Biesterveld BE, Pritchard KA Jr, Gourlay DM) J Pediatr Surg 2014 Jun;49(6):954-60; discussion 960 PMID: 24888842 PMCID: PMC4130394 06/04/2014
  • A consensus-based criterion standard for trauma center need. (Lerner EB, Willenbring BD, Pirrallo RG, Brasel KJ, Cady CE, Colella MR, Cooper A, Cushman JT, Gourlay DM, Jurkovich GJ, Newgard CD, Salomone JP, Sasser SM, Shah MN, Swor RA, Wang SC) J Trauma Acute Care Surg 2014 Apr;76(4):1157-63 PMID: 24662885 03/26/2014
  • Is the Trauma Mortality Prediction Model (TMPM-ICD-9) a valid predictor of mortality in pediatric trauma patients? (Cassidy LD, Cook A, Ertl A, Gourlay D, Osler T) J Pediatr Surg 2014 Jan;49(1):189-92; discussions 192 PMID: 24439607 01/21/2014
  • Operative vs nonoperative management for blunt pancreatic transection in children: multi-institutional outcomes. (Iqbal CW, St Peter SD, Tsao K, Cullinane DC, Gourlay DM, Ponsky TA, Wulkan ML, Adibe OO, Pancreatic Trauma in Children (PATCH) Study Group) J Am Coll Surg 2014 Feb;218(2):157-62 PMID: 24440062 01/21/2014
  • Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice. (Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3009-15 PMID: 23956444 PMCID: PMC3793605 08/21/2013
  • N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. (Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3016-29 PMID: 23883583 PMCID: PMC3793606 07/26/2013
  • Health disparities analysis of critically ill pediatric trauma patients in Milwaukee, Wisconsin. (Cassidy LD, Lambropoulos D, Enters J, Gourlay D, Farahzad M, Lal DR) J Am Coll Surg 2013 Aug;217(2):233-9 PMID: 23664140 PMCID: PMC4126201 05/15/2013
  • Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Fredrich K, Pritchard K Jr, Oldham KT, Simpson PM, Gourlay DM) J Pediatr Surg 2013 Jan;48(1):124-8 PMID: 23331804 01/22/2013
  • Colorectal considerations in pediatric patients. (Gourlay DM) Surg Clin North Am 2013 Feb;93(1):251-72 PMID: 23177075 11/28/2012
  • Early enteral stressors in newborns increase inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Welak SR, Fredrich K, Donohoe D, Pritchard KA, Oldham KT, Gourlay DM, Liedel JL) Eur J Pediatr Surg 2013 Feb;23(1):39-47 PMID: 23165517 11/21/2012
  • Intestinal alkaline phosphatase prevents the systemic inflammatory response associated with necrotizing enterocolitis. (Riggle KM, Rentea RM, Welak SR, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2013 Mar;180(1):21-6 PMID: 23158403 11/20/2012
  • A ductus remnant confounding the diagnosis of blunt thoracic aortic injury in a 13-year-old adolescent boy. (Chang HL, Savo AM, Seabrook GR, Gourlay DM) J Pediatr Surg 2012 Aug;47(8):1614-7 PMID: 22901928 08/21/2012
  • A multicenter prospective analysis of pediatric trauma activation criteria routinely used in addition to the six criteria of the American College of Surgeons. (Falcone RA Jr, Haas L, King E, Moody S, Crow J, Moss A, Gaines B, McKenna C, Gourlay DM, Werner C, Meagher DP Jr, Schwing L, Garcia N, Brown D, Groner JI, Haley K, Deross A, Cizmar L, Armola R) J Trauma Acute Care Surg 2012 Aug;73(2):377-84; discussion 384 PMID: 22846943 08/01/2012
  • Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Welak SR, Cassidy LD, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Pediatr Surg 2012 Jun;47(6):1135-42 PMID: 22703783 06/19/2012
  • Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Fredrich K, Welak SR, Pritchard KA Jr, Oldham KT, Simpson PM, Gourlay DM) J Surg Res 2012 Oct;177(2):228-34 PMID: 22687880 06/13/2012
  • The good and the bad of the innate immune response in necrotizing enterocolitis. (Gourlay DM) J Surg Res 2012 Jun 1;175(1):51-3 PMID: 21920553 09/17/2011
  • Endothelial microparticles induce inflammation in acute lung injury. (Buesing KL, Densmore JC, Kaul S, Pritchard KA Jr, Jarzembowski JA, Gourlay DM, Oldham KT) J Surg Res 2011 Mar;166(1):32-9 PMID: 20828748 09/11/2010
  • Is it safe to discharge intussusception patients after successful hydrostatic reduction? (Whitehouse JS, Gourlay DM, Winthrop AL, Cassidy LD, Arca MJ) J Pediatr Surg 2010 Jun;45(6):1182-6 PMID: 20620317 07/14/2010
  • Conservative management of giant omphalocele with topical povidone-iodine and its effect on thyroid function. (Whitehouse JS, Gourlay DM, Masonbrink AR, Aiken JJ, Calkins CM, Sato TT, Arca MJ) J Pediatr Surg 2010 Jun;45(6):1192-7 PMID: 20620319 07/14/2010
  • The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. (Whitehouse JS, Riggle KM, Purpi DP, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Sep;163(1):79-85 PMID: 20599220 07/06/2010
  • The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. (Whitehouse JS et al.) J Surg Res 2010 Feb;158(2):201 PMID: 20105777 01/29/2010
  • Endothelial microparticles induce myeloperoxidase-mediated lung injury. (Buesing K et al.) J Surg Res 2010 Feb;158(2):349 PMID: 20106140 01/29/2010
  • Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis. (Whitehouse JS, Xu H, Shi Y, Noll L, Kaul S, Jones DW, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Jun 1;161(1):1-8 PMID: 19922948 PMCID: PMC3196648 11/20/2009
  • Beyond feasibility: a comparison of newborns undergoing thoracoscopic and open repair of congenital diaphragmatic hernias. (Gourlay DM, Cassidy LD, Sato TT, Lal DR, Arca MJ) J Pediatr Surg 2009 Sep;44(9):1702-7 PMID: 19735811 09/09/2009
  • Pelvic angiography for recurrent traumatic pelvic arterial hemorrhage. (Gourlay D, Hoffer E, Routt M, Bulger E) J Trauma 2005 Nov;59(5):1168-73; discussion 1173-4 PMID: 16385296 12/31/2005
  • Implications of proteasome inhibition: an enhanced macrophage phenotype. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) Cell Immunol 2004 Feb;227(2):140-7 PMID: 15135296 05/12/2004
  • Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation. (Cuschieri J, Bulmus V, Gourlay D, Garcia I, Hoffman A, Stayton P, Maier RV) Shock 2004 Feb;21(2):182-8 PMID: 14752294 01/31/2004
  • Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinase. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) Shock 2003 Aug;20(2):176-82 PMID: 12865664 07/17/2003
  • Platelet-activating factor acetylhydrolase inhibits alveolar macrophage activation in vivo. (Bulger EM, Gourlay D, Cuschieri J, Jelacic S, Staudenmeyer K, Garcia I, Maier RV) Shock 2003 Jul;20(1):17-22 PMID: 12813363 06/19/2003
  • Endotoxin-induced endothelial cell proinflammatory phenotypic differentiation requires stress fiber polymerization. (Cuschleri J, Gourlay D, Garcia I, Jelacic S, Maier RV) Shock 2003 May;19(5):433-9 PMID: 12744486 05/15/2003
  • Modulation of endotoxin-induced endothelial activity by microtubule depolymerization. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) J Trauma 2003 Jan;54(1):104-12; discussion 112-3 PMID: 12544905 01/25/2003
  • Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. (Cuschieri J, Gourlay D, Bulger E, Garcia I, Jelacic S, Maier RV) Surgery 2002 Aug;132(2):157-66 PMID: 12219006 09/10/2002
  • Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) J Trauma 2002 Mar;52(3):434-42 PMID: 11901316 03/20/2002
  • Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) J Immunol 2002 Feb 1;168(3):1389-96 PMID: 11801680 01/22/2002
  • Last update: 07/29/2015