Medical College of Wisconsin
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David M. Gourlay MD

David M. Gourlay MD

Chief, Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Pediatric Surgery

Member of the Comprehensive Injury Center


Leadership Positions

  • Wisconsin State Trauma Advisory Committee
  • American Pediatric Surgical Association - Trauma Committee
  • Medical Director - Trauma Program Children's Hopsital of Wisconsin
  • Association of American Medical Colleges – MCW Key Contact for Joining Forces Program
  • Publications (59)

  • Esophagojejunal Anastomosis by Circular Stapler in Pediatric Patients: Size Minima Defined by Experience and Geometry. (Jamshidi R, Densmore JC, Gourlay DM, Lal DR, Calkins CM) J Laparoendosc Adv Surg Tech A 2019 Oct;29(10):1311-1314 PMID: 31549898 SCOPUS ID: 2-s2.0-85073490967 09/25/2019    
  • A tiered approach to optimize pediatric laparoscopic appendectomy outcomes (Bence CM, Wu R, Somers KK, Szabo A, Arca MJ, Calkins CM, Gourlay DM, Oldham KT, Sato TT, Siddiqui SM, Densmore JC) Journal of Pediatric Surgery 2019 SCOPUS ID: 2-s2.0-85071982482 01/01/2019    
  • Efficacy of surveillance ultrasound for venous thromboembolism diagnosis in critically ill children after trauma. (Landisch RM, Hanson SJ, Punzalan RC, Braun K, Cassidy LD, Gourlay DM) J Pediatr Surg 2018 Nov;53(11):2195-2201 PMID: 29997028 SCOPUS ID: 2-s2.0-85049479648 07/13/2018    
  • Factors Known to Influence the Development of Necrotizing Enterocolitis to Modify Expression and Activity of Intestinal Alkaline Phosphatase in a Newborn Neonatal Rat Model. (Rentea RM, Rentea MJ, Biesterveld B, Liedel JL, Gourlay DM) Eur J Pediatr Surg 2019 Jun;29(3):290-297 PMID: 29723880 SCOPUS ID: 2-s2.0-85047363575 05/04/2018    
  • Regarding global pediatric surgery training opportunities. (Baird R, Pandya K, Lal DR, Calkins CM, Oldham KT, Tsai A, Naik-Mathuria B, St-Louis E, Luc MK, LaRusso K, Petroze R, Lofberg KM, Biller CK, Villalona GA, Gourlay DM, Klein M, DeUgarte D, Cleary M, Berdan EA, Siddiqui S, Lo A, Langer M, Duffy D, Blair G, Beres A, Laberge JM, Berdan EA, Radulescu A, Holterman A, Hoover JD, Fitzgerald T, Ganey M, Krishnaswami S, Ozgediz D) J Pediatr Surg 2018 06;53(6):1256-1258 PMID: 29605263 SCOPUS ID: 2-s2.0-85047989560 04/02/2018       1 Citation
  • Pediatric and Congenital Colorectal Diseases in the Adult Patient. (Gourlay DM) Clin Colon Rectal Surg 2018 Mar;31(2):49-50 PMID: 29487486 PMCID: PMC5825857 03/01/2018    
  • Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2. (Rentea RM, Guo Y, Zhu X, Musch MW, Chang EB, Gourlay DM, Liedel JL) Pediatr Surg Int 2018 Mar;34(3):323-330 PMID: 29196880 SCOPUS ID: 2-s2.0-85035774795 12/03/2017    
  • Intestinal alkaline phosphatase deficiency leads to dysbiosis and bacterial translocation in the newborn intestine. (Fawley J, Koehler S, Cabrera S, Lam V, Fredrich K, Hessner M, Salzman N, Gourlay D) J Surg Res 2017 10;218:35-42 PMID: 28985873 SCOPUS ID: 2-s2.0-85020395721 10/08/2017       8 Citations
  • Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model. (Fawley J, Cuna A, Menden HL, McElroy S, Umar S, Welak SR, Gourlay DM, Li X, Sampath V) Pediatr Res 2018 01;83(1-1):164-174 PMID: 28846670 SCOPUS ID: 2-s2.0-85042040164 08/29/2017       3 Citations
  • Evaluation of guidelines for injured children at high risk for venous thromboembolism: A prospective observational study. (Landisch RM, Hanson SJ, Cassidy LD, Braun K, Punzalan RC, Gourlay DM) J Trauma Acute Care Surg 2017 05;82(5):836-844 PMID: 28430759 SCOPUS ID: 2-s2.0-85014172433 04/22/2017       7 Citations
  • Evaluation of guidelines for injured children at high risk for VTE: A prospective observational study. (Landisch RM, Hanson SJ, Cassidy LD, Braun K, Punzalan RC, Gourlay DM) J Trauma Acute Care Surg 2017 Mar 02 PMID: 28257391 03/04/2017    
  • Validation of a hand-held point of care device for lactate in adult and pediatric patients using traditional and locally-smoothed median and maximum absolute difference curves. (Colon-Franco JM, Lo SF, Tarima SS, Gourlay D, Drendel AL, Brook Lerner E) Clin Chim Acta 2017 May;468:145-149 PMID: 28235428 SCOPUS ID: 2-s2.0-85014381454 02/27/2017       3 Citations
  • Pediatric Trauma Assessment and Management Database: Leveraging Existing Data Systems to Predict Mortality and Functional Status after Pediatric Injury. (Flynn-O'Brien KT, Fallat ME, Rice TB, Gall CM, Nance ML, Upperman JS, Gourlay DM, Crow JP, Rivara FP) J Am Coll Surg 2017 May;224(5):933-944.e5 PMID: 28235647 PMCID: PMC6475528 SCOPUS ID: 2-s2.0-85016070243 02/27/2017       1 Citation
  • Letter to the Editor: "Post-traumatic liver and splenic pseudoaneurysms in children: Diagnosis, management, and follow-up screening using contrast enhanced ultrasound (CEUS)" by Durkin et al J Pediatr Surg 51 (2016) 289-292. (Letton RW Jr, Campbell BT, Falcone RA Jr, Gaines BA, Gourlay DM, Groner JI, Mooney DP, Nance ML, Notrica DM, Petty JK, Sartorelli KH) J Pediatr Surg 2017 02;52(2):367-368 PMID: 27889065 SCOPUS ID: 2-s2.0-85007198105 11/28/2016       1 Citation
  • Effects of anticipated neonatal surgical intervention on maternal milk cytokine production. (Rentea RM, Wagner AJ, Gourlay DM, Christensen M, Liedel JL) J Pediatr Surg 2017 Jan;52(1):45-49 PMID: 27836369 SCOPUS ID: 2-s2.0-85006269815 11/12/2016       1 Citation
  • Radiation-induced changes in intestinal and tissue-nonspecific alkaline phosphatase: implications for recovery after radiation therapy. (Rentea RM, Lam V, Biesterveld B, Fredrich KM, Callison J, Fish BL, Baker JE, Komorowski R, Gourlay DM, Otterson MF) Am J Surg 2016 Oct;212(4):602-608 PMID: 27501776 SCOPUS ID: 2-s2.0-84991709365 08/10/2016       5 Citations
  • Intestinal alkaline phosphatase: a summary of its role in clinical disease. (Fawley J, Gourlay DM) J Surg Res 2016 May 01;202(1):225-34 PMID: 27083970 PMCID: PMC4834149 SCOPUS ID: 2-s2.0-84960954017 04/17/2016       25 Citations
  • Helicopter interfacility transport of pediatric trauma patients: Are we overusing a costly resource? (Meyer MT, Gourlay DM, Weitze KC, Ship MD, Drayna PC, Werner C, Lerner EB) J Trauma Acute Care Surg 2016 Feb;80(2):313-7 PMID: 26491808 SCOPUS ID: 2-s2.0-84957433698 10/23/2015       8 Citations
  • Interleukin-23 Increases Intestinal Epithelial Cell Permeability In Vitro. (Heinzerling NP, Donohoe D, Fredrich K, Gourlay DM, Liedel JL) Eur J Pediatr Surg 2016 Jun;26(3):260-6 PMID: 26007691 SCOPUS ID: 2-s2.0-84930079309 05/27/2015       1 Citation
  • Intestinal alkaline phosphatase to treat necrotizing enterocolitis. (Biesterveld BE, Koehler SM, Heinzerling NP, Rentea RM, Fredrich K, Welak SR, Gourlay DM) J Surg Res 2015 Jun 15;196(2):235-40 PMID: 25840489 PMCID: PMC4578817 SCOPUS ID: 2-s2.0-84930384574 04/05/2015       6 Citations
  • A consensus-based criterion standard definition for pediatric patients who needed the highest-level trauma team activation. (Lerner EB, Drendel AL, Falcone RA Jr, Weitze KC, Badawy MK, Cooper A, Cushman JT, Drayna PC, Gourlay DM, Gray MP, Shah MI, Shah MN) J Trauma Acute Care Surg 2015 Mar;78(3):634-8 PMID: 25710438 PMCID: PMC4341956 SCOPUS ID: 2-s2.0-84924137781 02/25/2015       16 Citations
  • Intestinal NADPH oxidase 2 activity increases in a neonatal rat model of necrotizing enterocolitis. (Welak SR, Rentea RM, Teng RJ, Heinzerling N, Biesterveld B, Liedel JL, Pritchard KA Jr, Fredrich KM, Gourlay DM) PLoS One 2014;9(12):e115317 PMID: 25517730 PMCID: PMC4269454 SCOPUS ID: 2-s2.0-84919466804 12/18/2014       5 Citations
  • Intestinal alkaline phosphatase is protective to the preterm rat pup intestine. (Heinzerling NP, Liedel JL, Welak SR, Fredrich K, Biesterveld BE, Pritchard KA Jr, Gourlay DM) J Pediatr Surg 2014 Jun;49(6):954-60; discussion 960 PMID: 24888842 PMCID: PMC4130394 SCOPUS ID: 2-s2.0-84901801080 06/04/2014       13 Citations
  • A consensus-based criterion standard for trauma center need. (Lerner EB, Willenbring BD, Pirrallo RG, Brasel KJ, Cady CE, Colella MR, Cooper A, Cushman JT, Gourlay DM, Jurkovich GJ, Newgard CD, Salomone JP, Sasser SM, Shah MN, Swor RA, Wang SC) J Trauma Acute Care Surg 2014 Apr;76(4):1157-63 PMID: 24662885 SCOPUS ID: 2-s2.0-84897045324 03/26/2014       24 Citations
  • Is the Trauma Mortality Prediction Model (TMPM-ICD-9) a valid predictor of mortality in pediatric trauma patients? (Cassidy LD, Cook A, Ertl A, Gourlay D, Osler T) J Pediatr Surg 2014 Jan;49(1):189-92; discussions 192 PMID: 24439607 SCOPUS ID: 2-s2.0-84892585772 01/21/2014       6 Citations
  • Operative vs nonoperative management for blunt pancreatic transection in children: multi-institutional outcomes. (Iqbal CW, St Peter SD, Tsao K, Cullinane DC, Gourlay DM, Ponsky TA, Wulkan ML, Adibe OO, Pancreatic Trauma in Children (PATCH) Study Group) J Am Coll Surg 2014 Feb;218(2):157-62 PMID: 24440062 SCOPUS ID: 2-s2.0-84892623642 01/21/2014       40 Citations
  • Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice. (Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3009-15 PMID: 23956444 PMCID: PMC3793605 SCOPUS ID: 2-s2.0-84886071622 08/21/2013       19 Citations
  • N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. (Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3016-29 PMID: 23883583 PMCID: PMC3793606 SCOPUS ID: 2-s2.0-84885993885 07/26/2013       15 Citations
  • Health disparities analysis of critically ill pediatric trauma patients in Milwaukee, Wisconsin. (Cassidy LD, Lambropoulos D, Enters J, Gourlay D, Farahzad M, Lal DR) J Am Coll Surg 2013 Aug;217(2):233-9 PMID: 23664140 PMCID: PMC4126201 SCOPUS ID: 2-s2.0-84880570583 05/15/2013       12 Citations
  • Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Fredrich K, Pritchard K Jr, Oldham KT, Simpson PM, Gourlay DM) J Pediatr Surg 2013 Jan;48(1):124-8 PMID: 23331804 PMCID: PMC5664149 SCOPUS ID: 2-s2.0-84872391628 01/22/2013       13 Citations
  • Colorectal considerations in pediatric patients. (Gourlay DM) Surg Clin North Am 2013 Feb;93(1):251-72 PMID: 23177075 SCOPUS ID: 2-s2.0-84869749121 11/28/2012       5 Citations
  • Early enteral stressors in newborns increase inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Welak SR, Fredrich K, Donohoe D, Pritchard KA, Oldham KT, Gourlay DM, Liedel JL) Eur J Pediatr Surg 2013 Feb;23(1):39-47 PMID: 23165517 PMCID: PMC5664148 SCOPUS ID: 2-s2.0-84873592351 11/21/2012       15 Citations
  • Intestinal alkaline phosphatase prevents the systemic inflammatory response associated with necrotizing enterocolitis. (Riggle KM, Rentea RM, Welak SR, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2013 Mar;180(1):21-6 PMID: 23158403 PMCID: PMC5664146 SCOPUS ID: 2-s2.0-84873702533 11/20/2012       21 Citations
  • A ductus remnant confounding the diagnosis of blunt thoracic aortic injury in a 13-year-old adolescent boy. (Chang HL, Savo AM, Seabrook GR, Gourlay DM) J Pediatr Surg 2012 Aug;47(8):1614-7 PMID: 22901928 SCOPUS ID: 2-s2.0-84865082329 08/21/2012    
  • A multicenter prospective analysis of pediatric trauma activation criteria routinely used in addition to the six criteria of the American College of Surgeons. (Falcone RA Jr, Haas L, King E, Moody S, Crow J, Moss A, Gaines B, McKenna C, Gourlay DM, Werner C, Meagher DP Jr, Schwing L, Garcia N, Brown D, Groner JI, Haley K, Deross A, Cizmar L, Armola R) J Trauma Acute Care Surg 2012 Aug;73(2):377-84; discussion 384 PMID: 22846943 SCOPUS ID: 2-s2.0-84864592576 08/01/2012       25 Citations
  • Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Welak SR, Cassidy LD, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Pediatr Surg 2012 Jun;47(6):1135-42 PMID: 22703783 06/19/2012       27 Citations
  • Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Fredrich K, Welak SR, Pritchard KA Jr, Oldham KT, Simpson PM, Gourlay DM) J Surg Res 2012 Oct;177(2):228-34 PMID: 22687880 PMCID: PMC5664150 SCOPUS ID: 2-s2.0-84866042288 06/13/2012       9 Citations
  • The good and the bad of the innate immune response in necrotizing enterocolitis. (Gourlay DM) J Surg Res 2012 Jun 01;175(1):51-3 PMID: 21920553 SCOPUS ID: 2-s2.0-84860332445 09/17/2011       3 Citations
  • Discussion (Gourlay D, Pasquale MA, McQuay N, Yelon J) Journal of Trauma - Injury, Infection and Critical Care November 2010;69(5):1099-1100 SCOPUS ID: 2-s2.0-78549278054 11/01/2010    
  • Endothelial microparticles induce inflammation in acute lung injury. (Buesing KL, Densmore JC, Kaul S, Pritchard KA Jr, Jarzembowski JA, Gourlay DM, Oldham KT) J Surg Res 2011 Mar;166(1):32-9 PMID: 20828748 PMCID: PMC4731030 SCOPUS ID: 2-s2.0-79951678163 09/11/2010       38 Citations
  • Is it safe to discharge intussusception patients after successful hydrostatic reduction? (Whitehouse JS, Gourlay DM, Winthrop AL, Cassidy LD, Arca MJ) J Pediatr Surg 2010 Jun;45(6):1182-6 PMID: 20620317 SCOPUS ID: 2-s2.0-77953854009 07/14/2010       17 Citations
  • Conservative management of giant omphalocele with topical povidone-iodine and its effect on thyroid function. (Whitehouse JS, Gourlay DM, Masonbrink AR, Aiken JJ, Calkins CM, Sato TT, Arca MJ) J Pediatr Surg 2010 Jun;45(6):1192-7 PMID: 20620319 SCOPUS ID: 2-s2.0-77953831898 07/14/2010       28 Citations
  • The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. (Whitehouse JS, Riggle KM, Purpi DP, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Sep;163(1):79-85 PMID: 20599220 SCOPUS ID: 2-s2.0-77955927943 07/06/2010       32 Citations
  • The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. (Whitehouse JS et al.) J Surg Res 2010 Feb;158(2):201 PMID: 20105777 01/29/2010    
  • Endothelial microparticles induce myeloperoxidase-mediated lung injury. (Buesing K et al.) J Surg Res 2010 Feb;158(2):349 PMID: 20106140 01/29/2010    
  • Erratum to "Beyond feasibility: a comparison of newborns undergoing thoracoscopic and open repair of congenital diaphragmatic hernias" (DOI:10.1016/j.jpedsurg.2008.11.030) (Gourlay DM) Journal of Pediatric Surgery December 2009;44(12):2440 SCOPUS ID: 2-s2.0-71649114345 12/01/2009    
  • Congenital malformations of the lung (Gourlay DM, Oldham KT) Pediatric Surgery: Diagnosis and Management 2009:293-305 SCOPUS ID: 2-s2.0-84889770674 12/01/2009    
  • Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis. (Whitehouse JS, Xu H, Shi Y, Noll L, Kaul S, Jones DW, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Jun 01;161(1):1-8 PMID: 19922948 PMCID: PMC3196648 SCOPUS ID: 2-s2.0-77951621050 11/20/2009       32 Citations
  • Beyond feasibility: a comparison of newborns undergoing thoracoscopic and open repair of congenital diaphragmatic hernias. (Gourlay DM, Cassidy LD, Sato TT, Lal DR, Arca MJ) J Pediatr Surg 2009 Sep;44(9):1702-7 PMID: 19735811 SCOPUS ID: 2-s2.0-69549096080 09/09/2009       65 Citations
  • Pelvic angiography for recurrent traumatic pelvic arterial hemorrhage. (Gourlay D, Hoffer E, Routt M, Bulger E) J Trauma 2005 Nov;59(5):1168-73; discussion 1173-4 PMID: 16385296 SCOPUS ID: 2-s2.0-30344466957 12/31/2005       43 Citations
  • Implications of proteasome inhibition: an enhanced macrophage phenotype. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) Cell Immunol 2004 Feb;227(2):140-7 PMID: 15135296 SCOPUS ID: 2-s2.0-2342630414 05/12/2004       30 Citations
  • Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation. (Cuschieri J, Bulmus V, Gourlay D, Garcia I, Hoffman A, Stayton P, Maier RV) Shock 2004 Feb;21(2):182-8 PMID: 14752294 SCOPUS ID: 2-s2.0-4644275127 01/31/2004       22 Citations
  • Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinase. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) Shock 2003 Aug;20(2):176-82 PMID: 12865664 SCOPUS ID: 2-s2.0-1542541983 07/17/2003       16 Citations
  • Platelet-activating factor acetylhydrolase inhibits alveolar macrophage activation in vivo. (Bulger EM, Gourlay D, Cuschieri J, Jelacic S, Staudenmeyer K, Garcia I, Maier RV) Shock 2003 Jul;20(1):17-22 PMID: 12813363 SCOPUS ID: 2-s2.0-0041384469 06/19/2003       10 Citations
  • Endotoxin-induced endothelial cell proinflammatory phenotypic differentiation requires stress fiber polymerization. (Cuschleri J, Gourlay D, Garcia I, Jelacic S, Maier RV) Shock 2003 May;19(5):433-9 PMID: 12744486 SCOPUS ID: 2-s2.0-4444331746 05/15/2003       21 Citations
  • Modulation of endotoxin-induced endothelial activity by microtubule depolymerization. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) J Trauma 2003 Jan;54(1):104-12; discussion 112-3 PMID: 12544905 SCOPUS ID: 2-s2.0-0037237407 01/25/2003       15 Citations
  • Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. (Cuschieri J, Gourlay D, Bulger E, Garcia I, Jelacic S, Maier RV) Surgery 2002 Aug;132(2):157-66 PMID: 12219006 SCOPUS ID: 2-s2.0-0036674393 09/10/2002       7 Citations
  • Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) J Trauma 2002 Mar;52(3):434-42 PMID: 11901316 SCOPUS ID: 2-s2.0-0036119664 03/20/2002       34 Citations
  • Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) J Immunol 2002 Feb 01;168(3):1389-96 PMID: 11801680 SCOPUS ID: 2-s2.0-0036467350 01/22/2002       64 Citations
  • Last update: 10/25/2019
    jenkins-FCD Prod-409 d1e206b0be345926047b0d9c353c78a4cce4058b