Medical College of Wisconsin
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David M. Gourlay MD

David M. Gourlay MD

Chief, Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Pediatric Surgery

Member of the Comprehensive Injury Center


Leadership Positions

  • Wisconsin State Trauma Advisory Committee
  • American Pediatric Surgical Association - Trauma Committee
  • Medical Director - Trauma Program Children's Hopsital of Wisconsin
  • Association of American Medical Colleges – MCW Key Contact for Joining Forces Program
  • Publications

  • Efficacy of surveillance ultrasound for venous thromboembolism diagnosis in critically ill children after trauma. (Landisch RM, Hanson SJ, Punzalan RC, Braun K, Cassidy LD, Gourlay DM) J Pediatr Surg 2018 Nov;53(11):2195-2201 PMID: 29997028 07/13/2018    
  • Factors Known to Influence the Development of Necrotizing Enterocolitis to Modify Expression and Activity of Intestinal Alkaline Phosphatase in a Newborn Neonatal Rat Model. (Rentea RM, Rentea MJ, Biesterveld B, Liedel JL, Gourlay DM) Eur J Pediatr Surg 2018 May 03 PMID: 29723880 05/04/2018    
  • Regarding global pediatric surgery training opportunities. (Baird R, Pandya K, Lal DR, Calkins CM, Oldham KT, Tsai A, Naik-Mathuria B, St-Louis E, Luc MK, LaRusso K, Petroze R, Lofberg KM, Biller CK, Villalona GA, Gourlay DM, Klein M, DeUgarte D, Cleary M, Berdan EA, Siddiqui S, Lo A, Langer M, Duffy D, Blair G, Beres A, Laberge JM, Berdan EA, Radulescu A, Holterman A, Hoover JD, Fitzgerald T, Ganey M, Krishnaswami S, Ozgediz D) J Pediatr Surg 2018 Jun;53(6):1256-1258 PMID: 29605263 04/02/2018    
  • Pediatric and Congenital Colorectal Diseases in the Adult Patient. (Gourlay DM) Clin Colon Rectal Surg 2018 Mar;31(2):49-50 PMID: 29487486 PMCID: PMC5825857 03/01/2018    
  • Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2. (Rentea RM, Guo Y, Zhu X, Musch MW, Chang EB, Gourlay DM, Liedel JL) Pediatr Surg Int 2018 Mar;34(3):323-330 PMID: 29196880 12/03/2017    
  • Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model. (Fawley J, Cuna A, Menden HL, McElroy S, Umar S, Welak SR, Gourlay DM, Li X, Sampath V) Pediatr Res 2018 01;83(1-1):164-174 PMID: 28846670 08/29/2017    
  • Evaluation of guidelines for injured children at high risk for venous thromboembolism: A prospective observational study. (Landisch RM, Hanson SJ, Cassidy LD, Braun K, Punzalan RC, Gourlay DM) J Trauma Acute Care Surg 2017 05;82(5):836-844 PMID: 28430759 04/22/2017       5 Citations
  • Evaluation of guidelines for injured children at high risk for VTE: A prospective observational study. (Landisch RM, Hanson SJ, Cassidy LD, Braun K, Punzalan RC, Gourlay DM) J Trauma Acute Care Surg 2017 Mar 02 PMID: 28257391 03/04/2017    
  • Pediatric Trauma Assessment and Management Database: Leveraging Existing Data Systems to Predict Mortality and Functional Status after Pediatric Injury. (Flynn-O'Brien KT, Fallat ME, Rice TB, Gall CM, Nance ML, Upperman JS, Gourlay DM, Crow JP, Rivara FP) J Am Coll Surg 2017 May;224(5):933-944.e5 PMID: 28235647 02/27/2017       1 Citations
  • Letter to the Editor: "Post-traumatic liver and splenic pseudoaneurysms in children: Diagnosis, management, and follow-up screening using contrast enhanced ultrasound (CEUS)" by Durkin et al J Pediatr Surg 51 (2016) 289-292. (Letton RW Jr, Campbell BT, Falcone RA Jr, Gaines BA, Gourlay DM, Groner JI, Mooney DP, Nance ML, Notrica DM, Petty JK, Sartorelli KH) J Pediatr Surg 2017 02;52(2):367-368 PMID: 27889065 11/28/2016       1 Citations
  • Effects of anticipated neonatal surgical intervention on maternal milk cytokine production. (Rentea RM, Wagner AJ, Gourlay DM, Christensen M, Liedel JL) J Pediatr Surg 2017 Jan;52(1):45-49 PMID: 27836369 11/12/2016       1 Citations
  • Radiation-induced changes in intestinal and tissue-nonspecific alkaline phosphatase: implications for recovery after radiation therapy. (Rentea RM, Lam V, Biesterveld B, Fredrich KM, Callison J, Fish BL, Baker JE, Komorowski R, Gourlay DM, Otterson MF) Am J Surg 2016 Oct;212(4):602-608 PMID: 27501776 08/10/2016       1 Citations
  • Intestinal alkaline phosphatase: a summary of its role in clinical disease. (Fawley J, Gourlay DM) J Surg Res 2016 May 01;202(1):225-34 PMID: 27083970 PMCID: PMC4834149 04/17/2016       14 Citations
  • Helicopter interfacility transport of pediatric trauma patients: Are we overusing a costly resource? (Meyer MT, Gourlay DM, Weitze KC, Ship MD, Drayna PC, Werner C, Lerner EB) J Trauma Acute Care Surg 2016 Feb;80(2):313-7 PMID: 26491808 10/23/2015       4 Citations
  • Interleukin-23 Increases Intestinal Epithelial Cell Permeability In Vitro. (Heinzerling NP, Donohoe D, Fredrich K, Gourlay DM, Liedel JL) Eur J Pediatr Surg 2016 Jun;26(3):260-6 PMID: 26007691 05/27/2015       1 Citations
  • Intestinal alkaline phosphatase to treat necrotizing enterocolitis. (Biesterveld BE, Koehler SM, Heinzerling NP, Rentea RM, Fredrich K, Welak SR, Gourlay DM) J Surg Res 2015 Jun 15;196(2):235-40 PMID: 25840489 PMCID: PMC4578817 04/05/2015       5 Citations
  • A consensus-based criterion standard definition for pediatric patients who needed the highest-level trauma team activation. (Lerner EB, Drendel AL, Falcone RA Jr, Weitze KC, Badawy MK, Cooper A, Cushman JT, Drayna PC, Gourlay DM, Gray MP, Shah MI, Shah MN) J Trauma Acute Care Surg 2015 Mar;78(3):634-8 PMID: 25710438 PMCID: PMC4341956 02/25/2015       13 Citations
  • Intestinal NADPH oxidase 2 activity increases in a neonatal rat model of necrotizing enterocolitis. (Welak SR, Rentea RM, Teng RJ, Heinzerling N, Biesterveld B, Liedel JL, Pritchard KA Jr, Fredrich KM, Gourlay DM) PLoS One 2014;9(12):e115317 PMID: 25517730 PMCID: PMC4269454 12/18/2014       3 Citations
  • Intestinal alkaline phosphatase is protective to the preterm rat pup intestine. (Heinzerling NP, Liedel JL, Welak SR, Fredrich K, Biesterveld BE, Pritchard KA Jr, Gourlay DM) J Pediatr Surg 2014 Jun;49(6):954-60; discussion 960 PMID: 24888842 PMCID: PMC4130394 06/04/2014       12 Citations
  • A consensus-based criterion standard for trauma center need. (Lerner EB, Willenbring BD, Pirrallo RG, Brasel KJ, Cady CE, Colella MR, Cooper A, Cushman JT, Gourlay DM, Jurkovich GJ, Newgard CD, Salomone JP, Sasser SM, Shah MN, Swor RA, Wang SC) J Trauma Acute Care Surg 2014 Apr;76(4):1157-63 PMID: 24662885 03/26/2014       23 Citations
  • Operative vs nonoperative management for blunt pancreatic transection in children: multi-institutional outcomes. (Iqbal CW, St Peter SD, Tsao K, Cullinane DC, Gourlay DM, Ponsky TA, Wulkan ML, Adibe OO, Pancreatic Trauma in Children (PATCH) Study Group) J Am Coll Surg 2014 Feb;218(2):157-62 PMID: 24440062 01/21/2014       35 Citations
  • Is the Trauma Mortality Prediction Model (TMPM-ICD-9) a valid predictor of mortality in pediatric trauma patients? (Cassidy LD, Cook A, Ertl A, Gourlay D, Osler T) J Pediatr Surg 2014 Jan;49(1):189-92; discussions 192 PMID: 24439607 01/21/2014       6 Citations
  • Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice. (Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3009-15 PMID: 23956444 PMCID: PMC3793605 08/21/2013       19 Citations
  • N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. (Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3016-29 PMID: 23883583 PMCID: PMC3793606 07/26/2013       15 Citations
  • Health disparities analysis of critically ill pediatric trauma patients in Milwaukee, Wisconsin. (Cassidy LD, Lambropoulos D, Enters J, Gourlay D, Farahzad M, Lal DR) J Am Coll Surg 2013 Aug;217(2):233-9 PMID: 23664140 PMCID: PMC4126201 05/15/2013       11 Citations
  • Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Fredrich K, Pritchard K Jr, Oldham KT, Simpson PM, Gourlay DM) J Pediatr Surg 2013 Jan;48(1):124-8 PMID: 23331804 PMCID: PMC5664149 01/22/2013       12 Citations
  • Colorectal considerations in pediatric patients. (Gourlay DM) Surg Clin North Am 2013 Feb;93(1):251-72 PMID: 23177075 11/28/2012       5 Citations
  • Early enteral stressors in newborns increase inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Welak SR, Fredrich K, Donohoe D, Pritchard KA, Oldham KT, Gourlay DM, Liedel JL) Eur J Pediatr Surg 2013 Feb;23(1):39-47 PMID: 23165517 PMCID: PMC5664148 11/21/2012       11 Citations
  • Intestinal alkaline phosphatase prevents the systemic inflammatory response associated with necrotizing enterocolitis. (Riggle KM, Rentea RM, Welak SR, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2013 Mar;180(1):21-6 PMID: 23158403 PMCID: PMC5664146 11/20/2012       17 Citations
  • A ductus remnant confounding the diagnosis of blunt thoracic aortic injury in a 13-year-old adolescent boy. (Chang HL, Savo AM, Seabrook GR, Gourlay DM) J Pediatr Surg 2012 Aug;47(8):1614-7 PMID: 22901928 08/21/2012    
  • A multicenter prospective analysis of pediatric trauma activation criteria routinely used in addition to the six criteria of the American College of Surgeons. (Falcone RA Jr, Haas L, King E, Moody S, Crow J, Moss A, Gaines B, McKenna C, Gourlay DM, Werner C, Meagher DP Jr, Schwing L, Garcia N, Brown D, Groner JI, Haley K, Deross A, Cizmar L, Armola R) J Trauma Acute Care Surg 2012 Aug;73(2):377-84; discussion 384 PMID: 22846943 08/01/2012       22 Citations
  • Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Welak SR, Cassidy LD, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Pediatr Surg 2012 Jun;47(6):1135-42 PMID: 22703783 06/19/2012       27 Citations
  • Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Fredrich K, Welak SR, Pritchard KA Jr, Oldham KT, Simpson PM, Gourlay DM) J Surg Res 2012 Oct;177(2):228-34 PMID: 22687880 PMCID: PMC5664150 06/13/2012       8 Citations
  • The good and the bad of the innate immune response in necrotizing enterocolitis. (Gourlay DM) J Surg Res 2012 Jun 01;175(1):51-3 PMID: 21920553 09/17/2011       2 Citations
  • Endothelial microparticles induce inflammation in acute lung injury. (Buesing KL, Densmore JC, Kaul S, Pritchard KA Jr, Jarzembowski JA, Gourlay DM, Oldham KT) J Surg Res 2011 Mar;166(1):32-9 PMID: 20828748 PMCID: PMC4731030 09/11/2010       35 Citations
  • Is it safe to discharge intussusception patients after successful hydrostatic reduction? (Whitehouse JS, Gourlay DM, Winthrop AL, Cassidy LD, Arca MJ) J Pediatr Surg 2010 Jun;45(6):1182-6 PMID: 20620317 07/14/2010       13 Citations
  • Conservative management of giant omphalocele with topical povidone-iodine and its effect on thyroid function. (Whitehouse JS, Gourlay DM, Masonbrink AR, Aiken JJ, Calkins CM, Sato TT, Arca MJ) J Pediatr Surg 2010 Jun;45(6):1192-7 PMID: 20620319 07/14/2010       24 Citations
  • The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. (Whitehouse JS, Riggle KM, Purpi DP, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Sep;163(1):79-85 PMID: 20599220 07/06/2010       30 Citations
  • The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. (Whitehouse JS et al.) J Surg Res 2010 Feb;158(2):201 PMID: 20105777 01/29/2010    
  • Endothelial microparticles induce myeloperoxidase-mediated lung injury. (Buesing K et al.) J Surg Res 2010 Feb;158(2):349 PMID: 20106140 01/29/2010    
  • Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis. (Whitehouse JS, Xu H, Shi Y, Noll L, Kaul S, Jones DW, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Jun 01;161(1):1-8 PMID: 19922948 PMCID: PMC3196648 11/20/2009       28 Citations
  • Beyond feasibility: a comparison of newborns undergoing thoracoscopic and open repair of congenital diaphragmatic hernias. (Gourlay DM, Cassidy LD, Sato TT, Lal DR, Arca MJ) J Pediatr Surg 2009 Sep;44(9):1702-7 PMID: 19735811 09/09/2009       64 Citations
  • Pelvic angiography for recurrent traumatic pelvic arterial hemorrhage. (Gourlay D, Hoffer E, Routt M, Bulger E) J Trauma 2005 Nov;59(5):1168-73; discussion 1173-4 PMID: 16385296 12/31/2005       43 Citations
  • Implications of proteasome inhibition: an enhanced macrophage phenotype. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) Cell Immunol 2004 Feb;227(2):140-7 PMID: 15135296 05/12/2004       29 Citations
  • Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation. (Cuschieri J, Bulmus V, Gourlay D, Garcia I, Hoffman A, Stayton P, Maier RV) Shock 2004 Feb;21(2):182-8 PMID: 14752294 01/31/2004       22 Citations
  • Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinase. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) Shock 2003 Aug;20(2):176-82 PMID: 12865664 07/17/2003       16 Citations
  • Platelet-activating factor acetylhydrolase inhibits alveolar macrophage activation in vivo. (Bulger EM, Gourlay D, Cuschieri J, Jelacic S, Staudenmeyer K, Garcia I, Maier RV) Shock 2003 Jul;20(1):17-22 PMID: 12813363 06/19/2003       10 Citations
  • Endotoxin-induced endothelial cell proinflammatory phenotypic differentiation requires stress fiber polymerization. (Cuschleri J, Gourlay D, Garcia I, Jelacic S, Maier RV) Shock 2003 May;19(5):433-9 PMID: 12744486 05/15/2003       21 Citations
  • Modulation of endotoxin-induced endothelial activity by microtubule depolymerization. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) J Trauma 2003 Jan;54(1):104-12; discussion 112-3 PMID: 12544905 01/25/2003       16 Citations
  • Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. (Cuschieri J, Gourlay D, Bulger E, Garcia I, Jelacic S, Maier RV) Surgery 2002 Aug;132(2):157-66 PMID: 12219006 09/10/2002       7 Citations
  • Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) J Trauma 2002 Mar;52(3):434-42 PMID: 11901316 03/20/2002       33 Citations
  • Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin. (Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV) J Immunol 2002 Feb 01;168(3):1389-96 PMID: 11801680 01/22/2002       62 Citations
  • Last update: 11/29/2018
    jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad