Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Michael Kron MD

Michael Kron MD

Director, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Infectious Disease
Program: Administration

Member of the Cancer Center


Clinical Expertise

  • Parasitology
  • Tropical Medicine
  • MCW Program / Core Facilities

  • Program in International Health
    Biotechnology and Bioengineering Center
  • Publications

  • Field-Effect Transistor Biosensor for Rapid Detection of Ebola Antigen. (Chen Y, Ren R, Pu H, Guo X, Chang J, Zhou G, Mao S, Kron M, Chen J) Sci Rep 2017 Sep 08;7(1):10974 PMID: 28887479 PMCID: PMC5591202 09/10/2017    
  • Correction: Brugia malayi Asparaginyl-tRNA Synthetase Stimulates Endothelial Cell Proliferation, Vasodilation and Angiogenesis. (D JJ, Dhanraj M, Solaiappan S, Sivanesan S, Kron M, Dhanasekaran A) PLoS One 2017;12(2):e0171402 PMID: 28152101 PMCID: PMC5289596 02/06/2017    
  • Brugia malayi Asparaginyl-tRNA Synthetase Stimulates Endothelial Cell Proliferation, Vasodilation and Angiogenesis. (D JJ, Dhanraj M, Solaiappan S, Sivanesan S, Kron M, Dhanasekaran A) PLoS One 2016;11(1):e0146132 PMID: 26751209 PMCID: PMC4709172 01/12/2016       1 Citations
  • Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites. (Rateb ME, Yang D, Vodanovic-Jankovic S, Yu Z, Kron MA, Shen B) J Antibiot (Tokyo) 2015 Aug;68(8):540-2 PMID: 25735843 03/05/2015       3 Citations
  • Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J. (Rateb ME, Yu Z, Yan Y, Yang D, Huang T, Vodanovic-Jankovic S, Kron MA, Shen B) J Antibiot (Tokyo) 2014 Jan;67(1):127-32 PMID: 23715040 PMCID: PMC3773001 05/30/2013       13 Citations
  • Nematode asparaginyl-tRNA synthetase resolves intestinal inflammation in mice with T-cell transfer colitis. (Kron MA, Metwali A, Vodanovic-Jankovic S, Elliott D) Clin Vaccine Immunol 2013 Feb;20(2):276-81 PMID: 23254300 PMCID: PMC3571265 12/21/2012       18 Citations
  • New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase. (Yu Z, Vodanovic-Jankovic S, Kron M, Shen B) Org Lett 2012 Sep 21;14(18):4946-9 PMID: 22967068 PMCID: PMC3460372 09/13/2012       21 Citations
  • Interleukin-8-like activity in a filarial asparaginyl-tRNA synthetase. (Kron MA, Wang C, Vodanovic-Jankovic S, Howard OM, Kuhn LA) Mol Biochem Parasitol 2012 Sep;185(1):66-9 PMID: 22710390 06/20/2012       10 Citations
  • Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase. (Yu Z, Vodanovic-Jankovic S, Ledeboer N, Huang SX, Rajski SR, Kron M, Shen B) Org Lett 2011 Apr 15;13(8):2034-7 PMID: 21405052 PMCID: PMC3074013 03/17/2011       34 Citations
  • In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi. (Wenkert D, Ramirez B, Shen Y, Kron MA) J Parasitol Res 2010;2010:716498 PMID: 21253549 PMCID: PMC3021863 01/22/2011    
  • A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase. (Crepin T, Peterson F, Haertlein M, Jensen D, Wang C, Cusack S, Kron M) J Mol Biol 2011 Jan 28;405(4):1056-69 PMID: 21134380 12/08/2010       23 Citations
  • Asparaginyl-tRNA synthetase pre-transfer editing assay. (Danel F, Caspers P, Nuoffer C, Härtlein M, Kron MA, Page MG) Curr Drug Discov Technol 2011 Mar;8(1):66-75 PMID: 21091430 11/26/2010       11 Citations
  • Crystallization and preliminary X-ray diffraction analysis of human cytosolic seryl-tRNA synthetase. (Artero JB, Teixeira SC, Mitchell EP, Kron MA, Forsyth VT, Haertlein M) Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Nov 01;66(Pt 11):1521-4 PMID: 21045311 PMCID: PMC3001664 11/04/2010    
  • Using structural analysis to generate parasite-selective monoclonal antibodies. (Kron MA, Cichanowicz S, Hendrick A, Liu A, Leykam J, Kuhn LA) Protein Sci 2008 Jun;17(6):983-9 PMID: 18411421 PMCID: PMC2386738 04/16/2008       4 Citations
  • Interconversion between two unrelated protein folds in the lymphotactin native state. (Tuinstra RL, Peterson FC, Kutlesa S, Elgin ES, Kron MA, Volkman BF) Proc Natl Acad Sci U S A 2008 Apr 01;105(13):5057-62 PMID: 18364395 PMCID: PMC2278211 03/28/2008    
  • Capacity building in anthelmintic drug discovery. (Kron M, Yousif F, Ramirez B) Expert Opin Drug Discov 2007 Oct;2(s1):S75-82 PMID: 23489035 10/01/2007    
  • Identification of diadenosine triphosphate in Brugia malayi by reverse phase high performance liquid chromatography and MALDI mass spectrometry. (Kron M, Leykam J, Kopaczewski J, Matus I) J Chromatogr B Analyt Technol Biomed Life Sci 2007 Sep 01;856(1-2):234-8 PMID: 17631429 PMCID: PMC2044565 07/17/2007       9 Citations
  • Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change. (Sukuru SC, Crepin T, Milev Y, Marsh LC, Hill JB, Anderson RJ, Morris JC, Rohatgi A, O'Mahony G, Grøtli M, Danel F, Page MG, Härtlein M, Cusack S, Kron MA, Kuhn LA) J Comput Aided Mol Des 2006 Mar;20(3):159-78 PMID: 16645791 04/29/2006       35 Citations
  • Brugia malayi asparaginyl-transfer RNA synthetase induces chemotaxis of human leukocytes and activates G-protein-coupled receptors CXCR1 and CXCR2. (Ramirez BL, Howard OM, Dong HF, Edamatsu T, Gao P, Hartlein M, Kron M) J Infect Dis 2006 Apr 15;193(8):1164-71 PMID: 16544258 03/18/2006       21 Citations
  • Do tissue levels of autoantigenic aminoacyl-tRNA synthetase predict clinical disease? (Kron MA, Petridis M, Haertlein M, Libranda-Ramirez B, Scaffidi LE) Med Hypotheses 2005;65(6):1124-7 PMID: 16085368 08/09/2005       6 Citations
  • Synthesis and activity of substituted anthraquinones against a human filarial parasite, Brugia malayi. (Dhananjeyan MR, Milev YP, Kron MA, Nair MG) J Med Chem 2005 Apr 21;48(8):2822-30 PMID: 15828820 04/15/2005       46 Citations
  • Contrasting Wuchereria bancrofti microfilaria rates in two Mangyan-populated Philippine villages. (Ramirez BL, Hernandez L, Alberto FF, Collins M, Nfonsam V, Punsalan T, Kron MA) Am J Trop Med Hyg 2004 Jul;71(1):17-23 PMID: 15238683 07/09/2004       2 Citations
  • Genotypic characterization of Kaposi's sarcoma-associated herpesvirus in asymptomatic infected subjects from isolated populations. (Whitby D, Marshall VA, Bagni RK, Wang CD, Gamache CJ, Guzman JR, Kron M, Ebbesen P, Biggar RJ) J Gen Virol 2004 Jan;85(Pt 1):155-63 PMID: 14718630 01/14/2004       66 Citations
  • Expression, localization and alternative function of cytoplasmic asparaginyl-tRNA synthetase in Brugia malayi. (Kron M, Petridis M, Milev Y, Leykam J, Härtlein M) Mol Biochem Parasitol 2003 Jun;129(1):33-9 PMID: 12798504 06/12/2003       18 Citations
  • Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. (Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, Casciola-Rosen L, Härtlein M, Kron M, Yang D, Yiadom K, Dwivedi S, Plotz PH, Oppenheim JJ) J Exp Med 2002 Sep 16;196(6):781-91 PMID: 12235211 PMCID: PMC2194054 09/18/2002       197 Citations
  • Human anti-asparaginyl-tRNA synthetase autoantibodies (anti-KS) increase the affinity of the enzyme for its tRNA substrate. (Beaulande M, Kron M, Hirakata M, Härtlein M) FEBS Lett 2001 Apr 13;494(3):170-4 PMID: 11311235 04/20/2001       9 Citations
  • Hyperimmunoglobulinemia E in the absence of atopy and filarial infection: the Huaorani of Ecuador. (Kron MA, Ammunariz M, Pandey J, Guzman JR) Allergy Asthma Proc 2000 Nov-Dec;21(6):335-41 PMID: 11191097 02/24/2001       9 Citations
  • Lymphatic filariasis in the Philippines. (Kron M, Walker E, Hernandez L, Torres E, Libranda-Ramirez B) Parasitol Today 2000 Aug;16(8):329-33 PMID: 10900480 07/20/2000       15 Citations
  • New molecular targets for filariasis drug discovery. (Lazdins J, Kron M) Parasitol Today 1999 Aug;15(8):305-6 PMID: 10407372 07/17/1999       19 Citations
  • Immunoglobulin allotypes among the Bicolanos of Sorsogon province, Luzon, Philippines: implications of phenotypes for filariasis. (Kron MA, Ramirez B, Belizario V Jr, Pandey JP) Exp Clin Immunogenet 1999;16(2):65-71 PMID: 10343157 05/27/1999       4 Citations
  • Anti-KS: identification of autoantibodies to asparaginyl-transfer RNA synthetase associated with interstitial lung disease. (Hirakata M, Suwa A, Nagai S, Kron MA, Trieu EP, Mimori T, Akizuki M, Targoff IN) J Immunol 1999 Feb 15;162(4):2315-20 PMID: 9973509 02/11/1999       132 Citations
  • Bartonellosis in Ecuador: serosurvey and current status of cutaneous verrucous disease. (Amano Y, Rumbea J, Knobloch J, Olson J, Kron M) Am J Trop Med Hyg 1997 Aug;57(2):174-9 PMID: 9288812 08/01/1997       35 Citations
  • The 75-kilodalton antigen of Bartonella bacilliformis is a structural homolog of the cell division protein FtsZ. (Padmalayam I, Anderson B, Kron M, Kelly T, Baumstark B) J Bacteriol 1997 Jul;179(14):4545-52 PMID: 9226264 PMCID: PMC179290 07/01/1997       20 Citations
  • Threat of dengue haemorrhagic fever after yellow fever vaccination. (Guzman JR, Kron MA) Lancet 1997 Jun 21;349(9068):1841 PMID: 9269239 06/21/1997       4 Citations
  • Substandard primaquine phosphate for US Peace Corps personnel. (Kron MA) Lancet 1996 Nov 23;348(9039):1453-4 PMID: 8937304 11/23/1996       15 Citations
  • An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase. (Kron M, Marquard K, Härtlein M, Price S, Leberman R) FEBS Lett 1995 Oct 23;374(1):122-4 PMID: 7589498 10/23/1995       27 Citations
  • Infectious Disease in Ecuador. (Guzman JR, Jurado HM, Kron MA) J Travel Med 1995 Jun 01;2(2):89-95 PMID: 9815368 06/01/1995    
  • Immunoglobulin allotypes in Ecuadorian Cayapa Indians. (Kron MA, Gately L, Pandey JP, Jurado MH, Rumbea Guzman J) Hum Genet 1994 May;93(5):517-9 PMID: 8168827 05/01/1994       2 Citations
  • Antibody responses to Onchocerca volvulus in Ecuadorian Indians and blacks. (Kron MA, Sisley B, Guderian RH, Mackenzie CD, Chico M, Jurado H, Rumbea Guzman J) Trop Med Parasitol 1993 Sep;44(3):152-4 PMID: 8256087 09/01/1993       6 Citations
  • Characterization of a variant tandem repeat from Sudanese Onchocerca volvulus. (Kron MA, Ali MH) Trop Med Parasitol 1993 Jun;44(2):113-5 PMID: 8367658 06/01/1993       4 Citations
  • Human infestation with Cochliomyia hominivorax, the New World screwworm. (Kron MA) J Am Acad Dermatol 1992 Aug;27(2 Pt 1):264-5 PMID: 1430370 08/01/1992       11 Citations
  • Characterization of a possible tRNA synthetase gene from Onchocerca volvulus. (Kron MA, Erttmann K, Greene BM, Unnasch T) Mol Biochem Parasitol 1992 Jun;52(2):289-92 PMID: 1620168 06/01/1992       3 Citations
  • Identification of related DNA sequences in Borrelia burgdorferi and two strains of Leptospira interrogans by using polymerase chain reaction. (Kron MA, Gupta A, Mackenzie CD) J Clin Microbiol 1991 Oct;29(10):2338-40 PMID: 1939594 PMCID: PMC270326 10/01/1991       2 Citations
  • Surface area calculation for Onchocerca volvulus microfilariae. (Kron MA, Mackenzie CD) Trop Med Parasitol 1991 Jun;42(2):151-2 PMID: 1896774 06/01/1991       1 Citations
  • Abdominal sparganosis in Ecuador: a case report. (Kron MA, Guderian R, Guevara A, Hidalgo A) Am J Trop Med Hyg 1991 Feb;44(2):146-50 PMID: 1826415 02/01/1991       14 Citations
  • OHIO-1 beta-lactamase is part of the SHV-1 family. (Shlaes DM, Currie-McCumber C, Hull A, Behlau I, Kron M) Antimicrob Agents Chemother 1990 Aug;34(8):1570-6 PMID: 2121093 PMCID: PMC171875 08/01/1990       22 Citations
  • Onchocerca volvulus recombinant antigen: physical characterization and clinical correlates with serum reactivity. (Gallin MY, Tan M, Kron MA, Rechnitzer D, Greene BM, Newland HS, White AT, Taylor HR, Unnasch TR) J Infect Dis 1989 Sep;160(3):521-9 PMID: 2760503 09/01/1989       22 Citations
  • Buffer's belly. (Kron MA, Ellner JJ) N Engl J Med 1988 Mar 03;318(9):584 PMID: 3340142 03/03/1988       4 Citations
  • Molecular epidemiology of OHIO-1 beta-lactamase. (Kron MA, Shlaes DM, Currie-McCumber C, Medeiros AA) Antimicrob Agents Chemother 1987 Dec;31(12):2007-9 PMID: 2830844 PMCID: PMC175845 12/01/1987       6 Citations
  • Severe onchocercal dermatitis in the Ethiopian border region of Sudan. (Ghalib HW, MacKenzie CD, Kron MA, Williams JF, el Khalifa M, el Sheikh H) Ann Trop Med Parasitol 1987 Aug;81(4):405-19 PMID: 3446029 08/01/1987       27 Citations
  • Cell adherence to microfilariae of Onchocerca volvulus: a comparative study. (Williams JF, Ghalib HW, Mackenzie CD, Elkhalifa MY, Ayuya JM, Kron MA) Ciba Found Symp 1987;127:146-63 PMID: 3595320 01/01/1987       15 Citations
  • Novel plasmid-mediated beta-lactamase in members of the family Enterobacteriaceae from Ohio. (Shlaes DM, Medeiros AA, Kron MA, Currie-McCumber C, Papa E, Vartian CV) Antimicrob Agents Chemother 1986 Aug;30(2):220-4 PMID: 3490215 PMCID: PMC180522 08/01/1986    
  • Pentamidine: a review. (Sands M, Kron MA, Brown RB) Rev Infect Dis 1985 Sep-Oct;7(5):625-34 PMID: 3903942 09/01/1985       247 Citations
  • Clonorchiasis and praziquantel. (Hsu CC, Kron MA) Arch Intern Med 1985 Jun;145(6):1002-3 PMID: 4004423 06/01/1985    
  • Hepatitis A-induced remission of minimal change nephropathy. (Kron MA, Hedger R) Arch Intern Med 1984 Nov;144(11):2279-80 PMID: 6497535 11/01/1984       4 Citations
  • Last update: 03/28/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796