Medical College of Wisconsin
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Ranjan K. Dash PhD

Ranjan K. Dash PhD

Professor

Institution: Medical College of Wisconsin
Department: Biomedical Engineering
Program: Biomedical Engineering Program

Member of the Cardiovascular Center


Publications

  • Detection of hydrogen peroxide production in the isolated rat lung using Amplex red. (Audi SH, Friedly N, Dash RK, Beyer AM, Clough AV, Jacobs ER) Free Radic Res 2018 Sep 02:1-221 PMID: 30175632 09/04/2018    
  • Integrated computational model of the bioenergetics of isolated lung mitochondria. (Zhang X, Dash RK, Jacobs ER, Camara AKS, Clough AV, Audi SH) PLoS One 2018;13(6):e0197921 PMID: 29889855 PMCID: PMC5995348 06/12/2018    
  • Can Mathematical Modeling Explain the Measured Magnitude of the Second Gas Effect? (Korman B, Dash RK, Peyton PJ) Anesthesiology 2018 Jun;128(6):1075-1083 PMID: 29481374 PMCID: PMC5953815 02/27/2018    
  • Modeling the detailed kinetics of mitochondrial cytochrome c oxidase: Catalytic mechanism and nitric oxide inhibition. (Pannala VR, Camara AK, Dash RK) J Appl Physiol (1985) 2016 11 01;121(5):1196-1207 PMID: 27633738 PMCID: PMC5142251 09/17/2016       4 Citations
  • Optical Cryoimaging Reveals a Heterogeneous Distribution of Mitochondrial Redox State in ex vivo Guinea Pig Hearts and Its Alteration During Ischemia and Reperfusion. (Ranji M, Motlagh MM, Salehpour F, Sepehr R, Heisner JS, Dash RK, Camara AK) IEEE J Transl Eng Health Med 2016;4:1800210 PMID: 27574574 PMCID: PMC4993131 08/31/2016    
  • Mg(2+) differentially regulates two modes of mitochondrial Ca(2+) uptake in isolated cardiac mitochondria: implications for mitochondrial Ca(2+) sequestration. (Blomeyer CA, Bazil JN, Stowe DF, Dash RK, Camara AK) J Bioenerg Biomembr 2016 06;48(3):175-88 PMID: 26815005 PMCID: PMC5098337 01/28/2016       7 Citations
  • The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion: The Pathway for Oxygen. (Bassingthwaighte JB, Raymond GM, Dash RK, Beard DA, Nolan M) Adv Exp Med Biol 2016;876:103-110 PMID: 26782201 PMCID: PMC4828238 01/20/2016    
  • Simple accurate mathematical models of blood HbO2 and HbCO2 dissociation curves at varied physiological conditions: evaluation and comparison with other models. (Dash RK, Korman B, Bassingthwaighte JB) Eur J Appl Physiol 2016 Jan;116(1):97-113 PMID: 26298270 PMCID: PMC4699875 08/25/2015       7 Citations
  • Letter to the Editor: Mitochondrial cytochrome c oxidase: mechanism of action and role in regulating oxidative phosphorylation. (Pannala VR, Beard DA, Dash RK) J Appl Physiol (1985) 2015 Jul 15;119(2):157 PMID: 26177971 PMCID: PMC4504981 07/17/2015       6 Citations
  • Effects of p67phox on the mitochondrial oxidative state in the kidney of Dahl salt-sensitive rats: optical fluorescence 3-D cryoimaging. (Salehpour F, Ghanian Z, Yang C, Zheleznova NN, Kurth T, Dash RK, Cowley AW Jr, Ranji M) Am J Physiol Renal Physiol 2015 Aug 15;309(4):F377-82 PMID: 26062875 PMCID: PMC4596732 06/13/2015       8 Citations
  • Markov chain Monte Carlo based analysis of post-translationally modified VDAC gating kinetics. (Tewari SG, Zhou Y, Otto BJ, Dash RK, Kwok WM, Beard DA) Front Physiol 2014;5:513 PMID: 25628567 PMCID: PMC4292549 01/30/2015    
  • Mechanistic characterization of the thioredoxin system in the removal of hydrogen peroxide. (Pannala VR, Dash RK) Free Radic Biol Med 2015 Jan;78:42-55 PMID: 25451645 PMCID: PMC4280359 12/03/2014       13 Citations
  • Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury. (Agarwal B, Stowe DF, Dash RK, Bosnjak ZJ, Camara AK) Front Physiol 2014;5:341 PMID: 25278902 PMCID: PMC4165278 10/04/2014    
  • Determining the origins of superoxide and hydrogen peroxide in the mammalian NADH:ubiquinone oxidoreductase. (Bazil JN, Pannala VR, Dash RK, Beard DA) Free Radic Biol Med 2014 Dec;77:121-9 PMID: 25236739 PMCID: PMC4258523 09/23/2014       9 Citations
  • Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake. (Tewari SG, Camara AK, Stowe DF, Dash RK) J Physiol 2014 May 01;592(9):1917-30 PMID: 24591571 PMCID: PMC4230769 03/05/2014       8 Citations
  • A mechanistic mathematical model for the catalytic action of glutathione peroxidase. (Pannala VR, Bazil JN, Camara AK, Dash RK) Free Radic Res 2014 Apr;48(4):487-502 PMID: 24456207 PMCID: PMC4068149 01/25/2014       10 Citations
  • Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes. (Agarwal B, Dash RK, Stowe DF, Bosnjak ZJ, Camara AK) Biochim Biophys Acta 2014 Mar;1837(3):354-65 PMID: 24355434 PMCID: PMC4084852 12/21/2013       17 Citations
  • Effect of P2X4 and P2X7 receptor antagonism on the pressure diuresis relationship in rats. (Menzies RI, Unwin RJ, Dash RK, Beard DA, Cowley AW Jr, Carlson BE, Mullins JJ, Bailey MA) Front Physiol 2013;4:305 PMID: 24187541 PMCID: PMC3807716 11/05/2013    
  • A biophysically based mathematical model for the catalytic mechanism of glutathione reductase. (Pannala VR, Bazil JN, Camara AKS, Dash RK) Free Radic Biol Med 2013 Dec;65:1385-1397 PMID: 24120751 PMCID: PMC3870161 10/15/2013       12 Citations
  • Carrier-Mediated Transport through Biomembranes (Pradhan RK, Vinnakota KC, Beard DA, Dash RK) Transport in Biological Media (Edited by Kuznetsov AV and Becker SM) Chapter 5, 182-213, Elsevier (Academic Press), San Diego, 2013 10/01/2013    
  • An online model composition tool for system biology models. (Coskun SA, Cicek AE, Lai N, Dash RK, Ozsoyoglu ZM, Ozsoyoglu G) BMC Syst Biol 2013 Sep 05;7:88 PMID: 24006914 PMCID: PMC3846440 09/07/2013       3 Citations
  • Numerical Methods and Simulations of Partial Differential Equations (Pradhan RK, Dash RK) Encyclopedia of Systems Biology (Edited by Dubitzky W, Wolkenhauer O, Cho KH, Yokota H) 1641-1645, Springer Verlag, New York, 2013 07/01/2013    
  • Extra-matrix Mg2+ limits Ca2+ uptake and modulates Ca2+ uptake-independent respiration and redox state in cardiac isolated mitochondria. (Boelens AD, Pradhan RK, Blomeyer CA, Camara AK, Dash RK, Stowe DF) J Bioenerg Biomembr 2013 Jun;45(3):203-18 PMID: 23456198 PMCID: PMC3670670 03/05/2013       9 Citations
  • Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. (Blomeyer CA, Bazil JN, Stowe DF, Pradhan RK, Dash RK, Camara AK) J Bioenerg Biomembr 2013 Jun;45(3):189-202 PMID: 23225099 PMCID: PMC4065551 12/12/2012       13 Citations
  • Modeling the calcium sequestration system in isolated guinea pig cardiac mitochondria. (Bazil JN, Blomeyer CA, Pradhan RK, Camara AK, Dash RK) J Bioenerg Biomembr 2013 Jun;45(3):177-88 PMID: 23180139 PMCID: PMC3615037 11/28/2012       8 Citations
  • A biophysical model of the mitochondrial ATP-Mg/P(i) carrier. (Tewari SG, Dash RK, Beard DA, Bazil JN) Biophys J 2012 Oct 03;103(7):1616-25 PMID: 23062354 PMCID: PMC3471468 10/16/2012       5 Citations
  • Mitochondrial handling of excess Ca2+ is substrate-dependent with implications for reactive oxygen species generation. (Aldakkak M, Stowe DF, Dash RK, Camara AK) Free Radic Biol Med 2013 Mar;56:193-203 PMID: 23010495 PMCID: PMC3542420 09/27/2012       15 Citations
  • Modeling to link regional myocardial work, metabolism and blood flows. (Bassingthwaighte JB, Beard DA, Carlson BE, Dash RK, Vinnakota K) Ann Biomed Eng 2012 Nov;40(11):2379-98 PMID: 22915334 PMCID: PMC3471663 08/24/2012       9 Citations
  • PathCase-SB: integrating data sources and providing tools for systems biology research. (Coskun SA, Qi X, Cakmak A, Cheng E, Cicek AE, Yang L, Jadeja R, Dash RK, Lai N, Ozsoyoglu G, Ozsoyoglu ZM) BMC Syst Biol 2012 Jun 14;6(1):67 PMID: 22697505 PMCID: PMC3410775 06/16/2012       3 Citations
  • PathCase-SB: Database-enabled tools for regulatory metabolic networks (Qi X, Coskun SA, Cakmak A, Cheng E, Cicek EA, Yang L, Jadeja R, Syed S, Dash RK, Lai N, Ozsoyoglu G, Ozsoyoglu ZM) ACM SIGBioinformatics Record 2(3): 19-25, 2012 03/01/2012    
  • Enhanced charge-independent mitochondrial free Ca(2+) and attenuated ADP-induced NADH oxidation by isoflurane: Implications for cardioprotection. (Agarwal B, Camara AK, Stowe DF, Bosnjak ZJ, Dash RK) Biochim Biophys Acta 2012 Mar;1817(3):453-65 PMID: 22155157 PMCID: PMC3269543 12/14/2011       14 Citations
  • Characterization of Mg2+ inhibition of mitochondrial Ca2+ uptake by a mechanistic model of mitochondrial Ca2+ uniporter. (Pradhan RK, Qi F, Beard DA, Dash RK) Biophys J 2011 Nov 02;101(9):2071-81 PMID: 22067144 PMCID: PMC3207172 11/10/2011       15 Citations
  • Detailed kinetics and regulation of mammalian 2-oxoglutarate dehydrogenase. (Qi F, Pradhan RK, Dash RK, Beard DA) BMC Biochem 2011 Sep 26;12:53 PMID: 21943256 PMCID: PMC3195097 09/29/2011       15 Citations
  • Stimulatory effects of calcium on respiration and NAD(P)H synthesis in intact rat heart mitochondria utilizing physiological substrates cannot explain respiratory control in vivo. (Vinnakota KC, Dash RK, Beard DA) J Biol Chem 2011 Sep 02;286(35):30816-22 PMID: 21757763 PMCID: PMC3162442 07/16/2011       15 Citations
  • A minimal model for the mitochondrial rapid mode of Ca¬≤+ uptake mechanism. (Bazil JN, Dash RK) PLoS One 2011;6(6):e21324 PMID: 21731705 PMCID: PMC3121760 07/07/2011       13 Citations
  • Characterization of membrane potential dependency of mitochondrial Ca2+ uptake by an improved biophysical model of mitochondrial Ca2+ uniporter. (Pradhan RK, Qi F, Beard DA, Dash RK) PLoS One 2010 Oct 08;5(10):e13278 PMID: 20949039 PMCID: PMC2951907 10/16/2010       15 Citations
  • Kinetics and regulation of mammalian NADH-ubiquinone oxidoreductase (Complex I). (Chen X, Qi F, Dash RK, Beard DA) Biophys J 2010 Sep 08;99(5):1426-36 PMID: 20816054 PMCID: PMC2931722 09/08/2010    
  • Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: exploration of mechanisms. (Haumann J, Dash RK, Stowe DF, Boelens AD, Beard DA, Camara AK) Biophys J 2010 Aug 09;99(4):997-1006 PMID: 20712982 PMCID: PMC2920628 08/18/2010       18 Citations
  • A database of thermodynamic quantities for the reactions of glycolysis and the tricarboxylic acid cycle. (Li X, Dash RK, Pradhan RK, Qi F, Thompson M, Vinnakota KC, Wu F, Yang F, Beard DA) J Phys Chem B 2010 Dec 16;114(49):16068-82 PMID: 20446702 PMCID: PMC3299200 05/08/2010    
  • A biophysically based mathematical model for the kinetics of mitochondrial Na+-Ca2+ antiporter. (Pradhan RK, Beard DA, Dash RK) Biophys J 2010 Jan 20;98(2):218-30 PMID: 20338843 PMCID: PMC2808480 03/27/2010    
  • Erratum to: Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels. (Dash RK, Bassingthwaighte JB) Ann Biomed Eng 2010 Apr;38(4):1683-701 PMID: 20162361 PMCID: PMC2862600 02/18/2010       22 Citations
  • An Improved Algorithm and Its Parallel Implementation for Solving a General Blood-Tissue Transport and Metabolism Model. (Xie D, Dash RK, Beard DA) J Comput Phys 2009 Nov 01;228(20):7850-7861 PMID: 20161089 PMCID: PMC2744406 02/18/2010    
  • Design of experiments for identification of complex biochemical systems with applications to mitochondrial bioenergetics. (Vinnakota KC, Beard DA, Dash RK) Conf Proc IEEE Eng Med Biol Soc 2009;2009:4171-4 PMID: 19964622 PMCID: PMC2810972 12/08/2009    
  • Generating rate equations for complex enzyme systems by a computer-assisted systematic method. (Qi F, Dash RK, Han Y, Beard DA) BMC Bioinformatics 2009 Aug 04;10:238 PMID: 19653903 PMCID: PMC2729780 08/06/2009       25 Citations
  • BISEN: Biochemical Simulation Environment. (Vanlier J, Wu F, Qi F, Vinnakota KC, Han Y, Dash RK, Yang F, Beard DA) Bioinformatics 2009 Mar 15;25(6):836-7 PMID: 19244386 PMCID: PMC2732302 02/27/2009       11 Citations
  • A biophysically based mathematical model for the kinetics of mitochondrial calcium uniporter. (Dash RK, Qi F, Beard DA) Biophys J 2009 Feb 18;96(4):1318-32 PMID: 19217850 PMCID: PMC2717240 02/17/2009       29 Citations
  • Role of NADH/NAD+ transport activity and glycogen store on skeletal muscle energy metabolism during exercise: in silico studies. (Li Y, Dash RK, Kim J, Saidel GM, Cabrera ME) Am J Physiol Cell Physiol 2009 Jan;296(1):C25-46 PMID: 18829894 PMCID: PMC2636997 10/03/2008       17 Citations
  • Metabolic dynamics in skeletal muscle during acute reduction in blood flow and oxygen supply to mitochondria: in-silico studies using a multi-scale, top-down integrated model. (Dash RK, Li Y, Kim J, Beard DA, Saidel GM, Cabrera ME) PLoS One 2008 Sep 09;3(9):e3168 PMID: 18779864 PMCID: PMC2526172 09/10/2008       18 Citations
  • Modeling of cellular metabolism and microcirculatory transport. (Beard DA, Wu F, Cabrera ME, Dash RK) Microcirculation 2008 Nov;15(8):777-93 PMID: 18608987 07/09/2008       14 Citations
  • Analysis of cardiac mitochondrial Na+-Ca2+ exchanger kinetics with a biophysical model of mitochondrial Ca2+ handling suggests a 3:1 stoichiometry. (Dash RK, Beard DA) J Physiol 2008 Jul 01;586(13):3267-85 PMID: 18467367 PMCID: PMC2538784 05/10/2008       50 Citations
  • Modeling cellular metabolism and energetics in skeletal muscle: large-scale parameter estimation and sensitivity analysis. (Dash RK, Li Y, Kim J, Saidel GM, Cabrera ME) IEEE Trans Biomed Eng 2008 Apr;55(4):1298-318 PMID: 18390321 04/09/2008       23 Citations
  • Modeling oxygen and carbon dioxide transport and exchange using a closed loop circulatory system. (Carlson BE, Anderson JC, Raymond GM, Dash RK, Bassingthwaighte JB) Adv Exp Med Biol 2008;614:353-60 PMID: 18290346 PMCID: PMC3377501 02/23/2008       4 Citations
  • A computational model of skeletal muscle metabolism linking cellular adaptations induced by altered loading states to metabolic responses during exercise. (Dash RK, Dibella JA 2nd, Cabrera ME) Biomed Eng Online 2007 Apr 20;6:14 PMID: 17448235 PMCID: PMC1868741 04/24/2007       19 Citations
  • Linking pulmonary oxygen uptake, muscle oxygen utilization and cellular metabolism during exercise. (Lai N, Camesasca M, Saidel GM, Dash RK, Cabrera ME) Ann Biomed Eng 2007 Jun;35(6):956-69 PMID: 17380394 PMCID: PMC4124918 03/24/2007       15 Citations
  • An efficient deconvolution algorithm for estimating oxygen consumption during muscle activities. (Dash RK, Somersalo E, Cabrera ME, Calvetti D) Comput Methods Programs Biomed 2007 Mar;85(3):247-56 PMID: 17275136 PMCID: PMC1994789 02/06/2007       2 Citations
  • Local regularization method applied to estimating oxygen consumption during muscle activities (Calvetti D, Dash RK, Somersalo E, Cabrera ME) Inverse Problems 22: 229-243, 2006 10/01/2006    
  • Simultaneous blood-tissue exchange of oxygen, carbon dioxide, bicarbonate, and hydrogen ion. (Dash RK, Bassingthwaighte JB) Ann Biomed Eng 2006 Jul;34(7):1129-48 PMID: 16775761 PMCID: PMC4232240 06/16/2006       54 Citations
  • Relating pulmonary oxygen uptake to muscle oxygen consumption at exercise onset: in vivo and in silico studies. (Lai N, Dash RK, Nasca MM, Saidel GM, Cabrera ME) Eur J Appl Physiol 2006 Jul;97(4):380-94 PMID: 16636861 PMCID: PMC4124916 04/26/2006       24 Citations
  • Estimating in vitro mitochondrial oxygen consumption during muscle contraction and recovery: a novel approach that accounts for diffusion. (Dash RK, Bell BM, Kushmerick MJ, Vicini P) Ann Biomed Eng 2005 Mar;33(3):343-55 PMID: 15868725 05/05/2005       5 Citations
  • Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels. (Dash RK, Bassingthwaighte JB) Ann Biomed Eng 2004 Dec;32(12):1676-93 PMID: 15682524 02/03/2005       42 Citations
  • On a class of Boussinesq equations for shallow water waves (Daripa P, Dash RK) Lect Notes Comp Sci 2668: 764-773, 2003 07/01/2003    
  • A class of model equations for bi-directional propagation of capillary-gravity waves (Daripa P, Dash RK) Int J Eng Sci 41(2): 201-218, 2003 02/01/2003    
  • A numerical study of pulsatile blood flow in an eccentric catheterized artery using a fast algorithm (Daripa P, Dash RK) J Eng Math 42(1): 1-22, 2002 04/01/2002    
  • Analytical and numerical studies of a singularly perturbed Boussinesq equation (Dash RK, Daripa P) Appl Math Comput 126(1): 1-30, 2002 01/01/2002    
  • Numerical study of flow in a constricted curved annulus: an application to flow in a catheterized artery (Jayaraman G, Dash RK) J Eng Math 40(4): 355-376, 2001 04/01/2001    
  • Weakly non-local solitary wave solutions of a singularly perturbed Boussinesq equation (Daripa P, Dash RK) Math Comp Simul 55: 393-405, 2001 04/01/2001    
  • Shear augmented dispersion of a solute in a casson fluid flowing in a conduit. (Dash RK, Jayaraman G, Mehta KN) Ann Biomed Eng 2000 Apr;28(4):373-85 PMID: 10870894 06/28/2000       28 Citations
  • Flow in a catheterized curved artery with stenosis. (Dash RK, Jayaraman G, Mehta KN) J Biomech 1999 Jan;32(1):49-61 PMID: 10050951 03/02/1999       69 Citations
  • Effect of yield stress on the flow of a Casson fluid in a homogeneous porous medium bounded by a circular tube (Dash RK, Mehta KN, Jayaraman G) Appl Sci Res 57(1): 133-149, 1997 01/01/1997    
  • Casson fluid flow in a pipe filled with a homogeneous porous medium (Dash RK, Mehta KN, Jayaraman G) Int J Eng Sci 34(10): 1145-1156, 1996 10/01/1996    
  • Estimation of increased flow resistance in a narrow catheterized artery--a theoretical model. (Dash RK, Jayaraman G, Mehta KN) J Biomech 1996 Jul;29(7):917-30 PMID: 8809622 07/01/1996       65 Citations
  • Last update: 09/11/2018
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