Medical College of Wisconsin
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Renren Wen PhD

Associate Investigator

Institution: BloodCenter of Wisconsin
Department: Blood Research Institute

Member of the Cancer Center


Publications

  • PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. (Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, Broeckel U, Aggarwal P, Turner A, Neale G, Guy C, Zhu N, Chi H, Wen R, Wang D) Nat Commun 2017 11 13;8(1):1457 PMID: 29133930 PMCID: PMC5684131 11/15/2017       1 Citations
  • IVIg for Treatment of Severe Refractory Heparin-Induced Thrombocytopenia. (Padmanabhan A, Jones CG, Pechauer SM, Curtis BR, Bougie DW, Irani MS, Bryant BJ, Alperin JB, Deloughery TG, Mulvey KP, Dhakal B, Wen R, Wang D, Aster RH) Chest 2017 09;152(3):478-485 PMID: 28427966 PMCID: PMC5812774 04/22/2017       15 Citations
  • Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development. (Fu G, Yu M, Chen Y, Zheng Y, Zhu W, Newman DK, Wang D, Wen R) Eur J Immunol 2017 01;47(1):74-83 PMID: 27759161 PMCID: PMC5559087 10/21/2016    
  • Evaluation of nestin or osterix promoter-driven cre/loxp system in studying the biological functions of murine osteoblastic cells. (Su X, Yu M, Qiu G, Zheng Y, Chen Y, Wen R, Fu G, Zhu W, Chen J, Wu N, Ma P, Chen W, Wu Z, Wang D) Am J Transl Res 2016;8(3):1447-59 PMID: 27186271 PMCID: PMC4859630 05/18/2016    
  • Kras Is Critical for B Cell Lymphopoiesis. (Chen Y, Zheng Y, You X, Yu M, Fu G, Su X, Zhou F, Zhu W, Wu Z, Zhang J, Wen R, Wang D) J Immunol 2016 Feb 15;196(4):1678-85 PMID: 26773157 PMCID: PMC4744498 01/17/2016       4 Citations
  • A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control. (Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W) Cell Rep 2015 Nov 10;13(6):1118-1124 PMID: 26527008 PMCID: PMC4859432 11/04/2015       18 Citations
  • Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. (Zheng Y, Adams T, Zhi H, Yu M, Wen R, Newman PJ, Wang D, Newman DK) PLoS One 2015;10(3):e0119739 PMID: 25793864 PMCID: PMC4368822 03/21/2015       5 Citations
  • Critical role of CD4 T cells in PF4/heparin antibody production in mice. (Zheng Y, Yu M, Padmanabhan A, Aster RH, Yuan L, Wen R, Wang D) Blood 2015 Mar 12;125(11):1826-9 PMID: 25595736 PMCID: PMC4357587 01/18/2015       10 Citations
  • B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia. (Zheng Y, Wang AW, Yu M, Padmanabhan A, Tourdot BE, Newman DK, White GC, Aster RH, Wen R, Wang D) Blood 2014 Feb 06;123(6):931-4 PMID: 24357731 PMCID: PMC3916881 12/21/2013       16 Citations
  • Critical role for mouse marginal zone B cells in PF4/heparin antibody production. (Zheng Y, Yu M, Podd A, Yuan L, Newman DK, Wen R, Arepally G, Wang D) Blood 2013 Apr 25;121(17):3484-92 PMID: 23460609 PMCID: PMC3637017 03/06/2013       22 Citations
  • Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection. (Fu G, Chen Y, Schuman J, Wang D, Wen R) J Immunol 2012 Sep 01;189(5):2326-32 PMID: 22837484 PMCID: PMC3528184 07/28/2012       9 Citations
  • Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. (Chen Y, Yu M, Dai X, Zogg M, Wen R, Weiler H, Wang D) J Exp Med 2011 May 09;208(5):923-35 PMID: 21502331 PMCID: PMC3092340 04/20/2011       23 Citations
  • Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. (Fu G, Chen Y, Yu M, Podd A, Schuman J, He Y, Di L, Yassai M, Haribhai D, North PE, Gorski J, Williams CB, Wang D, Wen R) J Exp Med 2010 Feb 15;207(2):309-18 PMID: 20123962 PMCID: PMC2822604 02/04/2010       66 Citations
  • A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. (Schuman J, Chen Y, Podd A, Yu M, Liu HH, Wen R, Chen ZJ, Wang D) Blood 2009 May 07;113(19):4566-74 PMID: 19196865 PMCID: PMC2680363 02/07/2009       50 Citations
  • A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development. (Chen Y, Yu M, Podd A, Wen R, Chrzanowska-Wodnicka M, White GC, Wang D) Blood 2008 May 01;111(9):4627-36 PMID: 18319399 PMCID: PMC2343596 03/06/2008       31 Citations
  • Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing. (Bai L, Chen Y, He Y, Dai X, Lin X, Wen R, Wang D) Mol Cell Biol 2007 Sep;27(17):5957-67 PMID: 17591700 PMCID: PMC1952164 06/27/2007       17 Citations
  • Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation. (Zeng H, Di L, Fu G, Chen Y, Gao X, Xu L, Lin X, Wen R) Mol Cell Biol 2007 Jul;27(14):5235-45 PMID: 17502353 PMCID: PMC1951946 05/16/2007       29 Citations
  • B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells. (Chen Y, Pappu BP, Zeng H, Xue L, Morris SW, Lin X, Wen R, Wang D) J Immunol 2007 Jan 01;178(1):49-57 PMID: 17182539 12/22/2006       17 Citations
  • Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. (Wen R, Chen Y, Bai L, Fu G, Schuman J, Dai X, Zeng H, Yang C, Stephan RP, Cleveland JL, Wang D) Mol Cell Biol 2006 Dec;26(24):9364-76 PMID: 17030619 PMCID: PMC1698523 10/13/2006       23 Citations
  • Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells. (Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, Wang D, Malarkannan S) J Immunol 2006 Oct 15;177(8):5365-76 PMID: 17015722 10/04/2006       36 Citations
  • Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction. (Dai X, Chen Y, Schuman J, Hua Z, Adamson JW, Wen R, Wang D) Mol Cell Biol 2006 Jan;26(1):88-99 PMID: 16354682 PMCID: PMC1317611 12/16/2005       10 Citations
  • An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. (Wen R, Chen Y, Schuman J, Fu G, Yang S, Zhang W, Newman DK, Wang D) EMBO J 2004 Oct 13;23(20):4007-17 PMID: 15372077 PMCID: PMC524341 09/17/2004       28 Citations
  • Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. (Wen R, Chen Y, Xue L, Schuman J, Yang S, Morris SW, Wang D) J Biol Chem 2003 Oct 31;278(44):43654-62 PMID: 12928432 08/21/2003       35 Citations
  • Identification of Shp-2 as a Stat5A phosphatase. (Chen Y, Wen R, Yang S, Schuman J, Zhang EE, Yi T, Feng GS, Wang D) J Biol Chem 2003 May 09;278(19):16520-7 PMID: 12615921 03/05/2003       87 Citations
  • Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R. (Wen R, Jou ST, Chen Y, Hoffmeyer A, Wang D) J Immunol 2002 Dec 15;169(12):6743-52 PMID: 12471105 12/10/2002       48 Citations
  • Biological variation of blood acid-base status: consequences for analytical goal-setting and interpretation of results. (Harding PJ, Fraser CG) Clin Chem 1987 Aug;33(8):1416-8 PMID: 3111750 08/01/1987       7 Citations
  • Replication of the adeno-associated virus DNA termini in vitro. (Srivastava A) Intervirology 1987;27(3):138-47 PMID: 2822604 01/01/1987       30 Citations
  • Are measurements of intensity of infection or morbidity necessary to evaluate schistosomiasis control within PHC? (Wilkins HA) Trop Med Parasitol 1986 Jun;37(2):223-5 PMID: 3092340 06/01/1986       3 Citations
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