Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Publications indexed to the term Mutagenesis

FacultyTitle
1Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. (Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, Taliun SAG, Corvelo A, Gogarten SM, Kang HM, Pitsillides AN, LeFaive J, Lee SB, Tian X, Browning BL, Das S, Emde AK, Clarke WE, Loesch DP, Shetty AC, Blackwell TW, Smith AV, Wong Q, Liu X, Conomos MP, Bobo DM, Aguet F, Albert C, Alonso A, Ardlie KG, Arking DE, Aslibekyan S, Auer PL, Barnard J, Barr RG, Barwick L, Becker LC, Beer RL, Benjamin EJ, Bielak LF, Blangero J, Boehnke M, Bowden DW, Brody JA, Burchard EG, Cade BE, Casella JF, Chalazan B, Chasman DI, Chen YI, Cho MH, Choi SH, Chung MK, Clish CB, Correa A, Curran JE, Custer B, Darbar D, Daya M, de Andrade M, DeMeo DL, Dutcher SK, Ellinor PT, Emery LS, Eng C, Fatkin D, Fingerlin T, Forer L, Fornage M, Franceschini N, Fuchsberger C, Fullerton SM, Germer S, Gladwin MT, Gottlieb DJ, Guo X, Hall ME, He J, Heard-Costa NL, Heckbert SR, Irvin MR, Johnsen JM, Johnson AD, Kaplan R, Kardia SLR, Kelly T, Kelly S, Kenny EE, Kiel DP, Klemmer R, Konkle BA, Kooperberg C, Köttgen A, Lange LA, Lasky-Su J, Levy D, Lin X, Lin KH, Liu C, Loos RJF, Garman L, Gerszten R, Lubitz SA, Lunetta KL, Mak ACY, Manichaikul A, Manning AK, Mathias RA, McManus DD, McGarvey ST, Meigs JB, Meyers DA, Mikulla JL, Minear MA, Mitchell BD, Mohanty S, Montasser ME, Montgomery C, Morrison AC, Murabito JM, Natale A, Natarajan P, Nelson SC, North KE, O'Connell JR, Palmer ND, Pankratz N, Peloso GM, Peyser PA, Pleiness J, Post WS, Psaty BM, Rao DC, Redline S, Reiner AP, Roden D, Rotter JI, Ruczinski I, Sarnowski C, Schoenherr S, Schwartz DA, Seo JS, Seshadri S, Sheehan VA, Sheu WH, Shoemaker MB, Smith NL, Smith JA, Sotoodehnia N, Stilp AM, Tang W, Taylor KD, Telen M, Thornton TA, Tracy RP, Van Den Berg DJ, Vasan RS, Viaud-Martinez KA, Vrieze S, Weeks DE, Weir BS, Weiss ST, Weng LC, Willer CJ, Zhang Y, Zhao X, Arnett DK, Ashley-Koch AE, Barnes KC, Boerwinkle E, Gabriel S, Gibbs R, Rice KM, Rich SS, Silverman EK, Qasba P, Gan W, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Papanicolaou GJ, Nickerson DA, Browning SR, Zody MC, Zöllner S, Wilson JG, Cupples LA, Laurie CC, Jaquish CE, Hernandez RD, O'Connor TD, Abecasis GR) Nature 2021 Feb;590(7845):290-299       724 Citations
1UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. (Chen YG, Ciecko AE, Khaja S, Grzybowski M, Geurts AM, Lieberman SM) Sci Rep 2020 Jul 21;10(1):12019       9 Citations
1Role of ultraviolet mutational signature versus tumor mutation burden in predicting response to immunotherapy. (Pham TV, Boichard A, Goodman A, Riviere P, Yeerna H, Tamayo P, Kurzrock R) Mol Oncol 2020 Aug;14(8):1680-1694       27 Citations
2Pan-cancer analysis of whole genomes. (ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium) Nature 2020 Feb;578(7793):82-93       1554 Citations
1Cyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model. (Lam PY, Kutchukian P, Anand R, Imbriglio J, Andrews C, Padilla H, Vohra A, Lane S, Parker DL Jr, Cornella Taracido I, Johns DG, Beerens M, MacRae CA, Caldwell JP, Sorota S, Asnani A, Peterson RT) Chembiochem 2020 Jul 01;21(13):1905-1910       15 Citations
1Developing zebrafish disease models for in vivo small molecule screens. (Lam PY, Peterson RT) Curr Opin Chem Biol 2019 Jun;50:37-44       57 Citations
1Pigment Epithelium-Derived Factor and its Phosphomimetic Mutant Induce JNK-Dependent Apoptosis and P38-Mediated Migration Arrest. (Konson A, Pradeep S, D'Acunto CW, Seger R) Cell Physiol Biochem 2018;49(2):512-529       11 Citations
1Structural determinants of 5-HT2B receptor activation and biased agonism. (McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL) Nat Struct Mol Biol 2018 Sep;25(9):787-796       93 Citations
1Transmembrane Segment XI of the Na+/H+ Antiporter of S. pombe is a Critical Part of the Ion Translocation Pore. (Dutta D, Shin K, Rainey JK, Fliegel L) Sci Rep 2017 Oct 16;7(1):12793       4 Citations
2Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation. (Petrou VI, Herrera CM, Schultz KM, Clarke OB, Vendome J, Tomasek D, Banerjee S, Rajashankar KR, Belcher Dufrisne M, Kloss B, Kloppmann E, Rost B, Klug CS, Trent MS, Shapiro L, Mancia F) Science 2016 Feb 05;351(6273):608-12       84 Citations
1Neurogranin restores amyloid β-mediated synaptic transmission and long-term potentiation deficits. (Kaleka KS, Gerges NZ) Exp Neurol 2016 Mar;277:115-123       19 Citations
1Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. (Zhang H, Unal H, Gati C, Han GW, Liu W, Zatsepin NA, James D, Wang D, Nelson G, Weierstall U, Sawaya MR, Xu Q, Messerschmidt M, Williams GJ, Boutet S, Yefanov OM, White TA, Wang C, Ishchenko A, Tirupula KC, Desnoyer R, Coe J, Conrad CE, Fromme P, Stevens RC, Katritch V, Karnik SS, Cherezov V) Cell 2015 May 07;161(4):833-44       299 Citations
1Genetic Confirmation that the H5 Protein Is Required for Vaccinia Virus DNA Replication. (Boyle KA, Greseth MD, Traktman P) J Virol 2015 Jun;89(12):6312-27       16 Citations
1Complex cooperative functions of heparan sulfate proteoglycans shape nervous system development in Caenorhabditis elegans. (Díaz-Balzac CA, Lázaro-Peña MI, Tecle E, Gomez N, Bülow HE) G3 (Bethesda) 2014 Aug 05;4(10):1859-70       31 Citations
1Bacillus cereus Certhrax ADP-ribosylates vinculin to disrupt focal adhesion complexes and cell adhesion. (Simon NC, Barbieri JT) J Biol Chem 2014 Apr 11;289(15):10650-10659       18 Citations
1Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics. (Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR) PLoS Pathog 2013 Aug;9(8):e1003565       314 Citations
2Structural basis for molecular recognition at serotonin receptors. (Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, Stevens RC, Xu HE) Science 2013 May 03;340(6132):610-4       428 Citations
1Genetic and biochemical dissection of a HisKA domain identifies residues required exclusively for kinase and phosphatase activities. (Willett JW, Kirby JR) PLoS Genet 2012;8(11):e1003084       80 Citations
2A flagellar A-kinase anchoring protein with two amphipathic helices forms a structural scaffold in the radial spoke complex. (Sivadas P, Dienes JM, St Maurice M, Meek WD, Yang P) J Cell Biol 2012 Nov 12;199(4):639-51       27 Citations
1Natural Products Genomics: A novel approach for the discovery of anti-cancer therapeutics. (Monks NR, Li B, Gunjan S, Rogers DT, Kulshrestha M, Falcone DL, Littleton JM) J Pharmacol Toxicol Methods 2011;64(3):217-25       11 Citations
1Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signaling. (Wang W, Zhu J, Springer TA, Luo BH) J Biol Chem 2011 Jan 21;286(3):1860-7       15 Citations
1Molecular determinants dictating cell surface expression of the human sodium-dependent vitamin C transporter-2 in human liver cells. (Subramanian VS, Marchant JS, Said HM) Am J Physiol Gastrointest Liver Physiol 2010 Feb;298(2):G267-74       17 Citations
1Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. (Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, Roth BL) Biochemistry 2009 Jul 28;48(29):6898-908       67 Citations
1Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation. (Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB) J Med Chem 2008 Nov 13;51(21):6808-28       34 Citations
1The metallo-beta-lactamase GOB is a mono-Zn(II) enzyme with a novel active site. (Morán-Barrio J, González JM, Lisa MN, Costello AL, Peraro MD, Carloni P, Bennett B, Tierney DL, Limansky AS, Viale AM, Vila AJ) J Biol Chem 2007 Jun 22;282(25):18286-18293       72 Citations
1Genetics and genetic manipulation in Francisella tularensis. (Frank DW, Zahrt TC) Ann N Y Acad Sci 2007 Jun;1105:67-97       22 Citations
1Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons. (Fu Z, Lee SH, Simonetta A, Hansen J, Sheng M, Pak DT) J Neurochem 2007 Jan;100(1):118-31       71 Citations
1Unique substrate recognition by botulinum neurotoxins serotypes A and E. (Chen S, Barbieri JT) J Biol Chem 2006 Apr 21;281(16):10906-11       86 Citations
1Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. (Mogil JS, Breese NM, Witty MF, Ritchie J, Rainville ML, Ase A, Abbadi N, Stucky CL, Séguéla P) J Neurosci 2005 Oct 26;25(43):9893-901       110 Citations
1A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? (Dulubova I, Lou X, Lu J, Huryeva I, Alam A, Schneggenburger R, Südhof TC, Rizo J) EMBO J 2005 Aug 17;24(16):2839-50       204 Citations
1Exopolysaccharide sugars contribute to biofilm formation by Salmonella enterica serovar typhimurium on HEp-2 cells and chicken intestinal epithelium. (Ledeboer NA, Jones BD) J Bacteriol 2005 May;187(9):3214-26       104 Citations
1Genome sequence of the Brown Norway rat yields insights into mammalian evolution. (Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Simons R, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium) Nature 2004 Apr 01;428(6982):493-521       1729 Citations
1Moderate hypermutability of a transgenic lacZ reporter gene in Myc-dependent inflammation-induced plasma cell tumors in mice. (Felix K, Polack A, Pretsch W, Jackson SH, Feigenbaum L, Bornkamm GW, Janz S) Cancer Res 2004 Jan 15;64(2):530-7       5 Citations
1Predicting the genotoxicity of thiophene derivatives from molecular structure. (Mosier PD, Jurs PC, Custer LL, Durham SK, Pearl GM) Chem Res Toxicol 2003 Jun;16(6):721-32       46 Citations
1Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1. (Lanning CC, Ruiz-Velasco R, Williams CL) J Biol Chem 2003 Apr 04;278(14):12495-506       82 Citations
1Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. (Felix K, Rockwood LD, Pretsch W, Bornkamm GW, Janz S) Free Radic Biol Med 2003 Jan 15;34(2):226-32       8 Citations
1Bcl-2 reduces mutant rates in a transgenic lacZ reporter gene in mouse pre-B lymphocytes. (Felix K, Rolink A, Melchers F, Janz S) Mutat Res 2003 Jan 28;522(1-2):135-44       3 Citations
1Transgenic shuttle vector assays for determining genetic differences in oxidative B cell mutagenesis in vivo. (Felix K, Rockwood LD, Janz S) Methods Enzymol 2002;353:434-48       3 Citations
1Basolateral sorting signal of the 300-kDa mannose 6-phosphate receptor. (Wick DA, Seetharam B, Dahms NM) Am J Physiol Gastrointest Liver Physiol 2002 Jan;282(1):G51-60       9 Citations
1The perplexed and confused mutations affect distinct stages during the transition from proliferating to post-mitotic cells within the zebrafish retina. (Link BA, Kainz PM, Ryou T, Dowling JE) Dev Biol 2001 Aug 15;236(2):436-53       25 Citations
1Inducible mutagenesis in TEPC 2372, a mouse plasmacytoma cell line that harbors the transgenic shuttle vector lambdaLIZ. (Felix K, Kovalchuk AL, Park SS, Coleman AE, Ramsay ES, Qian M, Kelliher KA, Jones GM, Ried T, Bornkamm GW, Janz S) Mutat Res 2001 Jan 25;473(1):121-36       1 Citation
1Small molecule developmental screens reveal the logic and timing of vertebrate development. (Peterson RT, Link BA, Dowling JE, Schreiber SL) Proc Natl Acad Sci U S A 2000 Nov 21;97(24):12965-9       456 Citations
1A (GATA)(7) motif located in the 5' boundary area of the human beta-globin locus control region exhibits silencer activity in erythroid cells. (Ramchandran R, Bengra C, Whitney B, Lanclos K, Tuan D) Am J Hematol 2000 Sep;65(1):14-24       18 Citations
1The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding. (Blöcker D, Barth H, Maier E, Benz R, Barbieri JT, Aktories K) Infect Immun 2000 Aug;68(8):4566-73       61 Citations
1The zebrafish young mutation acts non-cell-autonomously to uncouple differentiation from specification for all retinal cells. (Link BA, Fadool JM, Malicki J, Dowling JE) Development 2000 May;127(10):2177-88       98 Citations
1Identification of a conserved N-terminal sequence involved in transmembrane signal transduction in EnvZ. (Waukau J, Forst S) J Bacteriol 1999 Sep;181(17):5534-8       10 Citations
1Elevated mutant frequencies in lymphoid tissues persist throughout plasmacytoma development in BALB/c.lambdaLIZ mice. (Felix K, Kelliher KA, Bornkamm GW, Janz S) Cancer Res 1999 Aug 01;59(15):3621-6       10 Citations
1Basic fibroblast growth factor activates serum response factor gene expression by multiple distinct signaling mechanisms. (Spencer JA, Major ML, Misra RP) Mol Cell Biol 1999 Jun;19(6):3977-88       22 Citations
2CheY-dependent methylation of the asparagine receptor, McpB, during chemotaxis in Bacillus subtilis. (Kirby JR, Saulmon MM, Kristich CJ, Ordal GW) J Biol Chem 1999 Apr 16;274(16):11092-100       31 Citations
1Localization of ASH1 mRNA particles in living yeast. (Bertrand E, Chartrand P, Schaefer M, Shenoy SM, Singer RH, Long RM) Mol Cell 1998 Oct;2(4):437-45       1244 Citations
1Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains. (Ahern-Djamali SM, Comer AR, Bachmann C, Kastenmeier AS, Reddy SK, Beckerle MC, Walter U, Hoffmann FM) Mol Biol Cell 1998 Aug;9(8):2157-71       94 Citations
1An RNA splicing enhancer-like sequence is a component of a splicing inhibitor element from Rous sarcoma virus. (McNally LM, McNally MT) Mol Cell Biol 1998 Jun;18(6):3103-11       39 Citations
1Association of elevated mutagenesis in the spleen with genetic susceptibility to induced plasmacytoma development in mice. (Felix K, Kelliher K, Bornkamm GW, Janz S) Cancer Res 1998 Apr 15;58(8):1616-9       4 Citations
1Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. (Yang G, Sigmund CD) Hypertension 1998 Mar;31(3):734-40       21 Citations
1Elevated mutant frequencies in gene lacI in splenic lipopolysaccharide blasts after exposure to activated phagocytes in vitro. (Felix K, Lin S, Janz S) Eur J Immunol 1997 Sep;27(9):2160-4       5 Citations
1Integrin-mediated activation of focal adhesion kinase is independent of focal adhesion formation or integrin activation. Studies with activated and inhibitory beta3 cytoplasmic domain mutants. (Lyman S, Gilmore A, Burridge K, Gidwitz S, White GC 2nd) J Biol Chem 1997 Sep 05;272(36):22538-47       71 Citations
1The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons. (Stucky CL, Koltzenburg M) J Neurosci 1997 Jun 01;17(11):4398-405       61 Citations
1Role of His243 in the phosphatase activity of EnvZ in Escherichia coli. (Skarphol K, Waukau J, Forst SA) J Bacteriol 1997 Feb;179(4):1413-6       33 Citations
1Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway. (Yahr TL, Goranson J, Frank DW) Mol Microbiol 1996 Dec;22(5):991-1003       242 Citations
1G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. (van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ) J Biol Chem 1996 Jan 19;271(3):1266-9       190 Citations
1Regulation of expression of Pseudomonas exotoxin A by iron. (Frank DW, Storey DG) Methods Enzymol 1994;235:502-17       4 Citations
1Response to influenza infection in mice with a targeted disruption in the interferon gamma gene. (Graham MB, Dalton DK, Giltinan D, Braciale VL, Stewart TA, Braciale TJ) J Exp Med 1993 Nov 01;178(5):1725-32       225 Citations
1Chemotactic methylesterase promotes adaptation to high concentrations of attractant in Bacillus subtilis. (Kirsch ML, Peters PD, Hanlon DW, Kirby JR, Ordal GW) J Biol Chem 1993 Sep 05;268(25):18610-6       49 Citations
1Biochemical and biophysical characterization of the reovirus cell attachment protein sigma 1: evidence that it is a homotrimer. (Strong JE, Leone G, Duncan R, Sharma RK, Lee PW) Virology 1991 Sep;184(1):23-32       64 Citations