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Melinda R. Dwinell PhD Online Profile

Melinda R. Dwinell PhD

Associate Professor
Medical College of Wisconsin
Department: Physiology
Program: Genetics


Research Experience

  • Cardiovascular Physiology
  • Circulatory and Respiratory Physiology
  • Phenotype
  • Respiratory Physiology

    • Methodologies and Techniques

  • Airway Resistance
  • Monitoring, Physiologic
  • Plethysmography, Whole Body

    • Publications

  • PhenoMiner: quantitative phenotype curation at the rat genome database. (Laulederkind SJ, Liu W, Smith JR, Hayman GT, Wang SJ, Nigam R, Petri V, Lowry TF, de Pons J, Dwinell MR, Shimoyama M) Database (Oxford) 2013;2013:bat015 PMID 23603846
  • Comparison of 2 rat breeding schemes using conventional caging. (Allen KP, Dwinell MR, Zappa A, Temple A, Thulin J) J Am Assoc Lab Anim Sci 2013;52(2):142-5 PMID 23562096
  • The Rat Genome Database 2013--data, tools and users. (Laulederkind SJ, Hayman GT, Wang SJ, Smith JR, Lowry TF, Nigam R, Petri V, de Pons J, Dwinell MR, Shimoyama M) Brief Bioinform 2013 Feb 22: PMID 23434633
  • The updated RGD Pathway Portal utilizes increased curation efficiency and provides expanded pathway information. (Hayman GT, Jayaraman P, Petri V, Tutaj M, Liu W, De Pons J, Dwinell MR, Shimoyama M) Hum Genomics 2013;7:4 PMID 23379628
  • Exploring genetic, genomic, and phenotypic data at the rat genome database. (Laulederkind SJ, Hayman GT, Wang SJ, Lowry TF, Nigam R, Petri V, Smith JR, Dwinell MR, Jacob HJ, Shimoyama M) Curr Protoc Bioinformatics 2012 Dec;Chapter 1:Unit1.14 PMID 23255149
  • Chromosome substitution modulates resistance to ischemia reperfusion injury in Brown Norway rats. (Basile DP, Dwinell MR, Wang SJ, Shames BD, Donohoe DL, Chen S, Sreedharan R, Van Why SK) Kidney Int 2013 Feb;83(2):242-50 PMID 23235564
  • Gene Ontology annotations and resources. (Gene Ontology Consortium) Nucleic Acids Res 2013 Jan;41(Database issue):D530-5 PMID 23161678
  • Three ontologies to define phenotype measurement data. (Shimoyama M, Nigam R, McIntosh LS, Nagarajan R, Rice T, Rao DC, Dwinell MR) Front Genet 2012;3:87 PMID 22654893
  • Ontology searching and browsing at the Rat Genome Database. (Laulederkind SJ, Tutaj M, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, de Pons J, Dwinell MR, Jacob HJ) Database (Oxford) 2012;2012:bas016 PMID 22434847
  • The Gene Ontology: enhancements for 2011. (Gene Ontology Consortium) Nucleic Acids Res 2012 Jan;40(Database issue):D559-64 PMID 22102568
  • The emerging role for rat models in gene discovery. (Dwinell MR, Lazar J, Geurts AM) Mamm Genome 2011 Aug;22(7-8):466-75 PMID 21732192
  • The Rat Genome Database pathway portal. (Petri V, Shimoyama M, Hayman GT, Smith JR, Tutaj M, de Pons J, Dwinell MR, Munzenmaier DH, Twigger SN, Jacob HJ, RGD Team) Database (Oxford) 2011;2011:bar010 PMID 21478484
  • The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. (Laulederkind SJ, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, de Pons J, Kowalski G, Liu W, Rood W, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ, RGD Team) Database (Oxford) 2011;2011:bar002 PMID 21321022
  • Gene targeting in the rat: advances and opportunities. (Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM) Trends Genet 2010 Dec;26(12):510-8 PMID 20869786
  • Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain. (Kunert MP, Dwinell MR, Lombard JH) Physiol Genomics 2010 Nov 29;42A(4):244-58 PMID 20841496
  • Postnatal ventilatory response to CO₂ in awake piglets. (Dwinell MR, Hogan GE, Sirlin E, Mayhew DL, Forster HV) Respir Physiol Neurobiol 2011 Jan 31;175(1):49-54 PMID 20837167
  • Online tools for understanding rat physiology. (Dwinell MR) Brief Bioinform 2010 Jul;11(4):431-9 PMID 20056729
  • The rat genome database curators: who, what, where, why. (Shimoyama M, Hayman GT, Laulederkind SJ, Nigam R, Lowry TF, Petri V, Smith JR, Wang SJ, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ, RGD Team) PLoS Comput Biol 2009 Nov;5(11):e1000582 PMID 19956751
  • Differences between three inbred rat strains in number of K+ channel-immunoreactive neurons in the medullary raphé nucleus. (Riley D, Dwinell M, Qian B, Krause KL, Bonis JM, Neumueller S, Marshall BD, Hodges MR, Forster HV) J Appl Physiol 2010 Apr;108(4):1003-10 PMID 19926827
  • The Rat Genome Database 2009: variation, ontologies and pathways. (Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, DePons J, Laulederkind S, Lowry T, Nigram R, Petri V, Smith J, Stoddard A, Twigger SN, Jacob HJ, RGD Team) Nucleic Acids Res 2009 Jan;37(Database issue):D744-9 PMID 18996890
  • Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr) Am J Physiol Renal Physiol 2008 Sep;295(3):F837-42 PMID 18653478
  • Sex-specific differences in chromosome-dependent regulation of vascular reactivity in female consomic rat strains from a SSxBN cross. (Kunert MP, Dwinell MR, Drenjancevic Peric I, Lombard JH) Am J Physiol Regul Integr Comp Physiol 2008 Aug;295(2):R516-27 PMID 18509103
  • Physiological genomics: from bench to bedside. (Dwinell MR) Exp Physiol 2007 Nov;92(6):987 PMID 17938419
  • Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ) Am J Physiol Renal Physiol 2007 Dec;293(6):F1905-14 PMID 17898042
  • Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. (Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW Jr, Greene AS, Kwitek AE, Jacob HJ) Physiol Genomics 2006 Aug 16;26(3):218-25 PMID 16772359
  • BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID 16478827
  • Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains. (Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW Jr, Jacob HJ) J Appl Physiol 2005 May;98(5):1630-8 PMID 15661838
  • Do genes on rat chromosomes 9, 13, 16, 18, and 20 contribute to regulation of breathing? (Forster HV, Dwinell MR, Hodges MR, Brozoski D, Hogan GE) Respir Physiol Neurobiol 2003 May 30;135(2-3):247-61 PMID 12809624
  • Ventilatory phenotypes among four strains of adult rats. (Hodges MR, Forster HV, Papanek PE, Dwinell MR, Hogan GE) J Appl Physiol 2002 Sep;93(3):974-83 PMID 12183493
  • Central amino acid neurotransmitters, ventilatory output and metabolism during acute hypoxia in anesthetized rats. (Dwinell MR, Kazemi H, Lam JT, Powell FL) Adv Exp Med Biol 2001;499:291-6 PMID 11729894
  • Ventilatory long-term facilitation in unanesthetized rats. (Olson EB Jr, Bohne CJ, Dwinell MR, Podolsky A, Vidruk EH, Fuller DD, Powell FL, Mitchel GS) J Appl Physiol 2001 Aug;91(2):709-16 PMID 11457785
  • Measuring ventilatory acclimatization to hypoxia: comparative aspects. (Powell FL, Dwinell MR, Aaron EA) Respir Physiol 2000 Sep;122(2-3):271-84 PMID 10967350
  • Central nervous system mechanisms of ventilatory acclimatization to hypoxia. (Powell FL, Huey KA, Dwinell MR) Respir Physiol 2000 Jul;121(2-3):223-36 PMID 10963777
  • Chronic hypoxia induces changes in the central nervous system processing of arterial chemoreceptor input. (Dwinell MR, Huey KA, Powell FL) Adv Exp Med Biol 2000;475:477-84 PMID 10849688
  • Chronic hypoxia enhances the phrenic nerve response to arterial chemoreceptor stimulation in anesthetized rats. (Dwinell MR, Powell FL) J Appl Physiol 1999 Aug;87(2):817-23 PMID 10444644
  • Differential respiratory muscle recruitment induced by clonidine in awake goats. (Hedrick MS, Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) J Appl Physiol 1998 Apr;84(4):1198-207 PMID 9516185
  • Intracarotid dopamine infusion does not prevent acclimatization to hypoxia. (Janssen PL, Dwinell MR, Pizarro J, Bisgard GE) Respir Physiol 1998 Jan;111(1):33-43 PMID 9496470
  • Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats. (Janssen PL, O'Halloran KD, Pizarro J, Dwinell MR, Bisgard GE) Respir Physiol 1998 Jan;111(1):25-32 PMID 9496469
  • Lack of long-term facilitation of ventilation after exposure to hypoxia in goats. (Dwinell MR, Janssen PL, Bisgard GE) Respir Physiol 1997 Apr;108(1):1-9 PMID 9178372
  • Effects of carotid body hypocapnia during ventilatory acclimatization to hypoxia. (Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) J Appl Physiol 1997 Jan;82(1):118-24 PMID 9029206
  • Effects of continuous intracarotid infusion of dopamine during long-term hypoxia in awake goats. (Janssen PL, Dwinell MR, Pizarro DJ, Bisgard GE) Adv Exp Med Biol 1996;410:383-6 PMID 9030329
  • Mitochondrial division, blood vessel dilation, and large intercellular space expansion of goat carotid body during hypoxia. (Xue D, Keith IM, Dwinell MR, Bisgard GE) Adv Exp Med Biol 1996;410:55-8 PMID 9030276
  • The role of carotid body CO2 during ventilatory acclimatization to hypoxia in the goat. (Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) Adv Exp Med Biol 1996;410:387-90 PMID 9030330
  • Recurrent laryngeal nerve activation by alpha 2 adrenergic agonists in goats. (Hedrick MS, Ryan ML, Bisgard GE) Respir Physiol 1995 Aug;101(2):129-37 PMID 8570915
  • Intracarotid substance P infusion inhibits ventilation in the goat. (Pizarro J, Ryan ML, Hedrick MS, Xue DH, Keith IM, Bisgard GE) Respir Physiol 1995 Jul;101(1):11-22 PMID 8525117
  • Effects of carotid body sympathetic denervation on ventilatory acclimatization to hypoxia in the goat. (Ryan ML, Hedrick MS, Pizarro J, Bisgard GE) Respir Physiol 1995 Feb;99(2):215-24 PMID 7777704
  • Modulation of respiratory rhythm by alpha 2-adrenoceptors in awake and anesthetized goats. (Hedrick MS, Ryan ML, Pizarro J, Bisgard GE) J Appl Physiol 1994 Aug;77(2):742-50 PMID 8002523
  • Carotid body noradrenergic sensitivity in ventilatory acclimatization to hypoxia. (Ryan ML, Hedrick MS, Pizarro J, Bisgard GE) Respir Physiol 1993 Apr;92(1):77-90 PMID 8390087

    • Grants and Awards

  • Integration of Phenotype Data from Multiple Centers Using Ontologies (#9206371 07/15/2010 - 06/30/2013) Sponsor: NIH Heart Lung and Blood Institute