Faculty Collaboration Database

Medical College of Wisconsin

CTSI Cores Search Research Informatics REDCap

Joseph T. Barbieri PhD

Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Center for Immunology
Member of the Center for Microbiome Research

Send Message

Request Meeting

View Curriculum Vitae

Publications (182)

Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines. (Oldrini D, Di Benedetto R, Carducci M, De Simone D, Massai L, Alfini R, Galli B, Brunelli B, Przedpelski A, Barbieri JT, Rossi O, Giannelli C, Rappuoli R, Berti F, Micoli F) Vaccines (Basel) 2023 Nov 28;11(12) PMID: 38140177 PMCID: PMC10747096 SCOPUS ID: 2-s2.0-85180674026 12/23/2023 2 Citations

Botulinum Neurotoxin A4 Has a 1000-Fold Reduced Potency Due to Three Single Amino Acid Alterations in the Protein Receptor Binding Domain. (Tepp WH, Bradshaw M, Gardner AP, Kaufman RL, Barbieri JT, Pellett S) Int J Mol Sci 2023 Mar 16;24(6) PMID: 36982762 PMCID: PMC10055998 SCOPUS ID: 2-s2.0-85151111423 03/30/2023 3 Citations

Light Chain Role in Action of Botulinum Toxins/Clostridial Neurotoxins (Gardner A, Barbieri JT) Handbook of Neurotoxicity Second Edition 1 January 2023;2:1145-1154 SCOPUS ID: 2-s2.0-85153667632 01/01/2023

How Botulinum Neurotoxin Light Chain A1 Maintains Stable Association with the Intracellular Neuronal Plasma Membrane. (Gardner AP, Barbieri JT, Pellett S) Toxins (Basel) 2022 Nov 22;14(12) PMID: 36548711 PMCID: PMC9783275 SCOPUS ID: 2-s2.0-85144580787 12/23/2022 4 Citations

Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein. (Chang MJ, Ollivault-Shiflett M, Schuman R, Ngoc Nguyen S, Kaltashov IA, Bobst C, Rajagopal SP, Przedpelski A, Barbieri JT, Lees A) Vaccine 2022 Aug 19;40(35):5103-5113 PMID: 35871872 PMCID: PMC10336728 SCOPUS ID: 2-s2.0-85134728035 07/26/2022 10 Citations

Bacterial toxins in disease production (Barbieri JT, Pederson KJ) Virulence Mechanisms of Bacterial Pathogens 1 June 2022:163-174 SCOPUS ID: 2-s2.0-0008571823 06/01/2022 3 Citations

Multiple Domains of Staphylococcal Superantigen-like Protein 11 (SSL11) Contribute to Neutrophil Inhibition. (Yang C, Barbieri JT, Dahms NM, Chen C) Biochemistry 2022 Apr 05;61(7):616-624 PMID: 35285627 PMCID: PMC9817067 SCOPUS ID: 2-s2.0-85127145605 03/15/2022 5 Citations

Resolution of Two Steps in Botulinum Neurotoxin Serotype A1 Light Chain Localization to the Intracellular Plasma Membrane. (Gardner A, Tepp WH, Bradshaw M, Barbieri JT, Pellett S) Int J Mol Sci 2021 Oct 15;22(20) PMID: 34681775 PMCID: PMC8539409 SCOPUS ID: 2-s2.0-85116984877 10/24/2021 3 Citations

Resolving the Molecular Steps in Clostridial Neurotoxin Light Chain Translocation. (Zuverink M, Barbieri JT) J Exp Neurol 2020;1(4):123-134 PMID: 33615314 PMCID: PMC7894615 02/23/2021

A Novel High-Potency Tetanus Vaccine. (Przedpelski A, Tepp WH, Pellett S, Johnson EA, Barbieri JT) mBio 2020 Aug 11;11(4) PMID: 32788381 PMCID: PMC7439469 SCOPUS ID: 2-s2.0-85089602052 08/14/2020 17 Citations

Tetanus Toxin cis-Loop Contributes to Light-Chain Translocation. (Zuverink M, Bluma M, Barbieri JT) mSphere 2020 May 06;5(3) PMID: 32376703 PMCID: PMC7203457 SCOPUS ID: 2-s2.0-85084398090 05/08/2020 9 Citations

Staphylococcal Superantigen-like protein 11 mediates neutrophil adhesion and motility arrest, a unique bacterial toxin action. (Chen C, Yang C, Barbieri JT) Sci Rep 2019 Mar 12;9(1):4211 PMID: 30862940 PMCID: PMC6414612 SCOPUS ID: 2-s2.0-85062821069 03/14/2019 13 Citations

Exotoxins (Blum FC, Barbieri JT) Encyclopedia of Microbiology 1 January 2019:197-205 SCOPUS ID: 2-s2.0-85079533166 01/01/2019 1 Citation

Detection of ADP-Ribosylating Bacterial Toxins. (Chen C, Barbieri JT) Methods Mol Biol 2018;1813:287-295 PMID: 30097876 SCOPUS ID: 2-s2.0-85051506237 08/12/2018 3 Citations

Light Chain Diversity among the Botulinum Neurotoxins. (Gardner AP, Barbieri JT) Toxins (Basel) 2018 Jul 02;10(7) PMID: 30004421 PMCID: PMC6070880 SCOPUS ID: 2-s2.0-85049650896 07/14/2018 30 Citations

Protein Toxins That Utilize Gangliosides as Host Receptors. (Zuverink M, Barbieri JT) Prog Mol Biol Transl Sci 2018;156:325-354 PMID: 29747819 PMCID: PMC6243200 SCOPUS ID: 2-s2.0-85043989897 05/12/2018 40 Citations

The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes. (Pellett S, Bradshaw M, Tepp WH, Pier CL, Whitemarsh RCM, Chen C, Barbieri JT, Johnson EA) mBio 2018 Mar 27;9(2) PMID: 29588398 PMCID: PMC5874905 SCOPUS ID: 2-s2.0-85046411664 03/29/2018 56 Citations

Enhancing toxin-based vaccines against botulism. (Przedpelski A, Tepp WH, Zuverink M, Johnson EA, Pellet S, Barbieri JT) Vaccine 2018 Feb 01;36(6):827-832 PMID: 29307477 PMCID: PMC5820173 SCOPUS ID: 2-s2.0-85039912971 01/09/2018 26 Citations

Protein Structure Facilitates High-Resolution Immunological Mapping. (Zuverink M, Barbieri JT) Clin Vaccine Immunol 2017 Dec;24(12) PMID: 29046310 PMCID: PMC5717179 SCOPUS ID: 2-s2.0-85040041257 10/20/2017 1 Citation

When Escherichia coli doesn't fit the mold: A pertussis-like toxin with altered specificity. (Chen C, Barbieri JT) J Biol Chem 2017 Sep 08;292(36):15159-15160 PMID: 28887436 PMCID: PMC5592690 SCOPUS ID: 2-s2.0-85029216082 09/10/2017 2 Citations

Vaccines against Botulism. (Sundeen G, Barbieri JT) Toxins (Basel) 2017 Sep 02;9(9) PMID: 28869493 PMCID: PMC5618201 SCOPUS ID: 2-s2.0-85028746538 09/05/2017 38 Citations

Entry of Botulinum Neurotoxin Subtypes A1 and A2 into Neurons. (Kroken AR, Blum FC, Zuverink M, Barbieri JT) Infect Immun 2017 Jan;85(1) PMID: 27795365 PMCID: PMC5203649 SCOPUS ID: 2-s2.0-85009126852 11/01/2016 30 Citations

From GFP to β-lactamase: advancing intact cell imaging for toxins and effectors. (Zuverink M, Barbieri JT) Pathog Dis 2015 Dec;73(9):ftv097 PMID: 26500183 PMCID: PMC4732026 SCOPUS ID: 2-s2.0-85021388978 10/27/2015 6 Citations

Solubility of the catalytic domains of Botulinum neurotoxin serotype E subtypes. (Chen S, Barbieri JT) Protein Expr Purif 2016 Feb;118:18-24 PMID: 26477500 SCOPUS ID: 2-s2.0-84945292499 10/20/2015 2 Citations

Heat-Labile Enterotoxin IIa, a Platform To Deliver Heterologous Proteins into Neurons. (Chen C, Przedpelski A, Tepp WH, Pellett S, Johnson EA, Barbieri JT) mBio 2015 Aug 11;6(4):e00734 PMID: 26265718 PMCID: PMC4542185 SCOPUS ID: 2-s2.0-84940833015 08/13/2015 17 Citations

Pseudomonas aeruginosa toxins (Rolsma S, Frank DW, Barbieri JT) Comprehensive Sourcebook of Bacterial Protein Toxins 5 June 2015:133-160 SCOPUS ID: 2-s2.0-85053197841 06/05/2015 5 Citations

Mutations of the functional ARH1 allele in tumors from ARH1 heterozygous mice and cells affect ARH1 catalytic activity, cell proliferation and tumorigenesis. (Kato J, Vekhter D, Heath J, Zhu J, Barbieri JT, Moss J) Oncogenesis 2015 Jun 01;4(6):e151 PMID: 26029825 PMCID: PMC4753525 SCOPUS ID: 2-s2.0-84931267838 06/02/2015 15 Citations

A Heterologous Reporter Defines the Role of the Tetanus Toxin Interchain Disulfide in Light-Chain Translocation. (Zuverink M, Chen C, Przedpelski A, Blum FC, Barbieri JT) Infect Immun 2015 Jul;83(7):2714-24 PMID: 25895970 PMCID: PMC4468531 SCOPUS ID: 2-s2.0-84930989049 04/22/2015 16 Citations

Nonenzymatic conversion of ADP-ribosylated arginines to ornithine alters the biological activities of human neutrophil peptide-1. (Stevens LA, Barbieri JT, Piszczek G, Otuonye AN, Levine RL, Zheng G, Moss J) J Immunol 2014 Dec 15;193(12):6144-51 PMID: 25392530 PMCID: PMC6291843 SCOPUS ID: 2-s2.0-84916886837 11/14/2014 5 Citations

Multiple domains of tetanus toxin direct entry into primary neurons. (Blum FC, Tepp WH, Johnson EA, Barbieri JT) Traffic 2014 Oct;15(10):1057-65 PMID: 25040808 PMCID: PMC4167930 SCOPUS ID: 2-s2.0-84908507447 07/22/2014 16 Citations

Novel bacterial ADP-ribosylating toxins: structure and function. (Simon NC, Aktories K, Barbieri JT) Nat Rev Microbiol 2014 Sep;12(9):599-611 PMID: 25023120 PMCID: PMC5846498 SCOPUS ID: 2-s2.0-84906320189 07/16/2014 181 Citations

Bacillus cereus Certhrax ADP-ribosylates vinculin to disrupt focal adhesion complexes and cell adhesion. (Simon NC, Barbieri JT) J Biol Chem 2014 Apr 11;289(15):10650-10659 PMID: 24573681 PMCID: PMC4036183 SCOPUS ID: 2-s2.0-84898669505 02/28/2014 18 Citations

Entry of a recombinant, full-length, atoxic tetanus neurotoxin into Neuro-2a cells. (Blum FC, Przedpelski A, Tepp WH, Johnson EA, Barbieri JT) Infect Immun 2014 Feb;82(2):873-81 PMID: 24478100 PMCID: PMC3911378 SCOPUS ID: 2-s2.0-84892996722 01/31/2014 18 Citations

The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. (Schuld NJ, Vervacke JS, Lorimer EL, Simon NC, Hauser AD, Barbieri JT, Distefano MD, Williams CL) J Biol Chem 2014 Mar 07;289(10):6862-6876 PMID: 24415755 PMCID: PMC3945348 SCOPUS ID: 2-s2.0-84896783691 01/15/2014 37 Citations

Protease activity of the botulinum neurotoxins (Chen S, Barbieri JT) Molecular Aspects of Botulinum Neurotoxin 1 January 2014:171-189 SCOPUS ID: 2-s2.0-85028293409 01/01/2014 1 Citation

Exoenzyme S ADP-ribosylates Rab5 effector sites to uncouple intracellular trafficking. (Simon NC, Barbieri JT) Infect Immun 2014 Jan;82(1):21-8 PMID: 24101692 PMCID: PMC3911848 SCOPUS ID: 2-s2.0-84890832844 10/09/2013 9 Citations

Pseudomonas aeruginosa utilizes the type III secreted toxin ExoS to avoid acidified compartments within epithelial cells. (Heimer SR, Evans DJ, Stern ME, Barbieri JT, Yahr T, Fleiszig SM) PLoS One 2013;8(9):e73111 PMID: 24058462 PMCID: PMC3776860 SCOPUS ID: 2-s2.0-84884268574 09/24/2013 48 Citations

Damage by microbial toxins (Barbieri JT) Schaechter S Mechanisms of Microbial Disease Fifth Edition 8 July 2013:127-140 SCOPUS ID: 2-s2.0-84971255188 07/08/2013 1 Citation

Enhancing the protective immune response against botulism. (Przedpelski A, Tepp WH, Kroken AR, Fu Z, Kim JJ, Johnson EA, Barbieri JT) Infect Immun 2013 Jul;81(7):2638-44 PMID: 23670557 PMCID: PMC3697623 SCOPUS ID: 2-s2.0-84879446130 05/15/2013 23 Citations

The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft. (Silhár P, Lardy MA, Hixon MS, Shoemaker CB, Barbieri JT, Struss AK, Lively JM, Javor S, Janda KD) ACS Med Chem Lett 2013 Feb 14;4(2):283-287 PMID: 23565325 PMCID: PMC3615567 SCOPUS ID: 2-s2.0-84874079018 04/09/2013 16 Citations

General aspects and recent advances on bacterial protein toxins. (Lemichez E, Barbieri JT) Cold Spring Harb Perspect Med 2013 Feb 01;3(2):a013573 PMID: 23378599 PMCID: PMC3552341 SCOPUS ID: 2-s2.0-84878961049 02/05/2013 43 Citations

Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry. (Karalewitz AP, Fu Z, Baldwin MR, Kim JJ, Barbieri JT) J Biol Chem 2012 Nov 23;287(48):40806-16 PMID: 23027864 PMCID: PMC3504792 SCOPUS ID: 2-s2.0-84870028543 10/03/2012 43 Citations

Pseudomonas aeruginosa serology and risk for re-isolation in the EPIC trial. (Anstead M, Heltshe SL, Khan U, Barbieri JT, Langkamp M, Döring G, Dharia S, Gibson RL, Treggiari MM, Lymp J, Rosenfeld M, Ramsey B) J Cyst Fibros 2013 Mar;12(2):147-53 PMID: 22944725 PMCID: PMC3696392 SCOPUS ID: 2-s2.0-84878014012 09/05/2012 32 Citations

Host cell cytotoxicity and cytoskeleton disruption by CerADPr, an ADP-ribosyltransferase of Bacillus cereus G9241. (Simon NC, Vergis JM, Ebrahimi AV, Ventura CL, O'Brien AD, Barbieri JT) Biochemistry 2013 Apr 02;52(13):2309-18 PMID: 22934824 PMCID: PMC3661007 SCOPUS ID: 2-s2.0-84875797158 09/01/2012 13 Citations

Vaccines against botulism. (Karalewitz AP, Barbieri JT) Curr Opin Microbiol 2012 Jun;15(3):317-24 PMID: 22694934 SCOPUS ID: 2-s2.0-84864050116 06/15/2012 35 Citations

Damage by microbial toxins (Barbieri JT) Schaechter S Mechanisms of Microbial Disease Fifth Edition 15 May 2012:127-139 SCOPUS ID: 2-s2.0-84971219332 05/15/2012

Insights into the different catalytic activities of Clostridium neurotoxins. (Chen S, Karalewitz AP, Barbieri JT) Biochemistry 2012 May 08;51(18):3941-7 PMID: 22510015 PMCID: PMC3542401 SCOPUS ID: 2-s2.0-84860759738 04/19/2012 21 Citations

Tetanus toxin and botulinum toxin a utilize unique mechanisms to enter neurons of the central nervous system. (Blum FC, Chen C, Kroken AR, Barbieri JT) Infect Immun 2012 May;80(5):1662-9 PMID: 22392932 PMCID: PMC3347426 SCOPUS ID: 2-s2.0-84861169060 03/07/2012 57 Citations

Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. (Zhao J, Du Y, Horton JR, Upadhyay AK, Lou B, Bai Y, Zhang X, Du L, Li M, Wang B, Zhang L, Barbieri JT, Khuri FR, Cheng X, Fu H) Proc Natl Acad Sci U S A 2011 Sep 27;108(39):16212-6 PMID: 21908710 PMCID: PMC3182712 SCOPUS ID: 2-s2.0-80053645046 09/13/2011 96 Citations

Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence. (Hritonenko V, Mun JJ, Tam C, Simon NC, Barbieri JT, Evans DJ, Fleiszig SM) Microb Pathog 2011 Nov;51(5):305-12 PMID: 21843628 PMCID: PMC3213052 SCOPUS ID: 2-s2.0-80052433053 08/17/2011 32 Citations

Subunit vaccine efficacy against Botulinum neurotoxin subtypes. (Henkel JS, Tepp WH, Przedpelski A, Fritz RB, Johnson EA, Barbieri JT) Vaccine 2011 Oct 13;29(44):7688-95 PMID: 21839134 PMCID: PMC3209516 SCOPUS ID: 2-s2.0-80053597280 08/16/2011 13 Citations

Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons. (Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT) J Biol Chem 2011 Jul 29;286(30):26828-37 PMID: 21632541 PMCID: PMC3143643 SCOPUS ID: 2-s2.0-79960680902 06/03/2011 35 Citations

Unique ganglioside binding by botulinum neurotoxins C and D-SA. (Kroken AR, Karalewitz AP, Fu Z, Baldwin MR, Kim JJ, Barbieri JT) FEBS J 2011 Dec;278(23):4486-96 PMID: 21554541 PMCID: PMC3170675 SCOPUS ID: 2-s2.0-81555216752 05/11/2011 23 Citations

Association of botulinum neurotoxin serotype A light chain with plasma membrane-bound SNAP-25. (Chen S, Barbieri JT) J Biol Chem 2011 Apr 29;286(17):15067-72 PMID: 21378164 PMCID: PMC3083167 SCOPUS ID: 2-s2.0-79955433958 03/08/2011 37 Citations

Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1. (Pier CL, Chen C, Tepp WH, Lin G, Janda KD, Barbieri JT, Pellett S, Johnson EA) FEBS Lett 2011 Jan 03;585(1):199-206 PMID: 21126520 PMCID: PMC3041152 SCOPUS ID: 2-s2.0-78650885033 12/04/2010 72 Citations

Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease. (Eubanks LM, Silhár P, Salzameda NT, Zakhari JS, Xiaochuan F, Barbieri JT, Shoemaker CB, Hixon MS, Janda KD) ACS Med Chem Lett 2010;1(6):268-272 PMID: 20959871 PMCID: PMC2955888 SCOPUS ID: 2-s2.0-77956548287 10/21/2010 45 Citations

The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells. (Angus AA, Evans DJ, Barbieri JT, Fleiszig SM) Infect Immun 2010 Nov;78(11):4500-10 PMID: 20732998 PMCID: PMC2976358 SCOPUS ID: 2-s2.0-78049431931 08/25/2010 53 Citations

Identification of a unique ganglioside binding loop within botulinum neurotoxins C and D-SA . (Karalewitz AP, Kroken AR, Fu Z, Baldwin MR, Kim JJ, Barbieri JT) Biochemistry 2010 Sep 21;49(37):8117-26 PMID: 20731382 PMCID: PMC2939319 SCOPUS ID: 2-s2.0-77956591091 08/25/2010 51 Citations

Structural analysis of botulinum neurotoxin type G receptor binding . (Schmitt J, Karalewitz A, Benefield DA, Mushrush DJ, Pruitt RN, Spiller BW, Barbieri JT, Lacy DB) Biochemistry 2010 Jun 29;49(25):5200-5 PMID: 20507178 PMCID: PMC2894633 SCOPUS ID: 2-s2.0-77953881240 05/29/2010 33 Citations

Toxins from bacteria. (Henkel JS, Baldwin MR, Barbieri JT) EXS 2010;100:1-29 PMID: 20358680 PMCID: PMC3564551 SCOPUS ID: 2-s2.0-77950880789 04/03/2010 81 Citations

Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors. (Silhár P, Capková K, Salzameda NT, Barbieri JT, Hixon MS, Janda KD) J Am Chem Soc 2010 Mar 10;132(9):2868-9 PMID: 20158239 PMCID: PMC2832098 SCOPUS ID: 2-s2.0-77950343388 02/18/2010 47 Citations

Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease. (Stowe GN, Silhár P, Hixon MS, Silvaggi NR, Allen KN, Moe ST, Jacobson AR, Barbieri JT, Janda KD) Org Lett 2010 Feb 19;12(4):756-9 PMID: 20092262 PMCID: PMC2821465 SCOPUS ID: 2-s2.0-76849114940 01/23/2010 31 Citations

Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase. (Capková K, Hixon MS, Pellett S, Barbieri JT, Johnson EA, Janda KD) Bioorg Med Chem Lett 2010 Jan 01;20(1):206-8 PMID: 19914829 PMCID: PMC2818383 SCOPUS ID: 2-s2.0-72049088765 11/17/2009 29 Citations

Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors. (Salzameda NT, Barbieri JT, Janda KD) Bioorg Med Chem Lett 2009 Oct 15;19(20):5848-50 PMID: 19747823 PMCID: PMC2753755 SCOPUS ID: 2-s2.0-70349218029 09/15/2009 9 Citations

Gangliosides as high affinity receptors for tetanus neurotoxin. (Chen C, Fu Z, Kim JJ, Barbieri JT, Baldwin MR) J Biol Chem 2009 Sep 25;284(39):26569-77 PMID: 19602728 PMCID: PMC2785345 SCOPUS ID: 2-s2.0-70350371732 07/16/2009 108 Citations

Proteomic identification of OprL as a seromarker for initial diagnosis of Pseudomonas aeruginosa infection of patients with cystic fibrosis. (Rao AR, Laxova A, Farrell PM, Barbieri JT) J Clin Microbiol 2009 Aug;47(8):2483-8 PMID: 19553571 PMCID: PMC2725635 SCOPUS ID: 2-s2.0-68549088793 06/26/2009 11 Citations

Engineering botulinum neurotoxin to extend therapeutic intervention. (Chen S, Barbieri JT) Proc Natl Acad Sci U S A 2009 Jun 09;106(23):9180-4 PMID: 19487672 PMCID: PMC2695098 SCOPUS ID: 2-s2.0-67249103849 06/03/2009 71 Citations

Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F. (Fu Z, Chen C, Barbieri JT, Kim JJ, Baldwin MR) Biochemistry 2009 Jun 23;48(24):5631-41 PMID: 19476346 PMCID: PMC2709598 SCOPUS ID: 2-s2.0-67649210455 05/30/2009 133 Citations

Association of botulinum neurotoxins with synaptic vesicle protein complexes. (Baldwin MR, Barbieri JT) Toxicon 2009 Oct;54(5):570-4 PMID: 19362106 PMCID: PMC2730980 SCOPUS ID: 2-s2.0-68949167926 04/14/2009 29 Citations

Catalytic properties of botulinum neurotoxin subtypes A3 and A4. (Henkel JS, Jacobson M, Tepp W, Pier C, Johnson EA, Barbieri JT) Biochemistry 2009 Mar 24;48(11):2522-8 PMID: 19256469 PMCID: PMC2701208 SCOPUS ID: 2-s2.0-64849090643 03/05/2009 59 Citations

Exotoxins (Barbieri JT) Encyclopedia of Microbiology Third Edition 1 January 2009:355-364 SCOPUS ID: 2-s2.0-85069223639 01/01/2009 7 Citations

Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins. (Deng Q, Barbieri JT) Annu Rev Microbiol 2008;62:271-88 PMID: 18785839 SCOPUS ID: 2-s2.0-53849133471 09/13/2008 144 Citations

Modulation of host cell endocytosis by the type III cytotoxin, Pseudomonas ExoS. (Deng Q, Barbieri JT) Traffic 2008 Nov;9(11):1948-57 PMID: 18778330 PMCID: PMC2574883 SCOPUS ID: 2-s2.0-53849135540 09/10/2008 28 Citations

Molecular basis for tetanus toxin coreceptor interactions. (Chen C, Baldwin MR, Barbieri JT) Biochemistry 2008 Jul 08;47(27):7179-86 PMID: 18543947 SCOPUS ID: 2-s2.0-46849085158 06/12/2008 53 Citations

Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin. (Chen S, Hall C, Barbieri JT) J Biol Chem 2008 Jul 25;283(30):21153-9 PMID: 18511417 PMCID: PMC2475686 SCOPUS ID: 2-s2.0-51049112074 05/31/2008 61 Citations

Subunit vaccine against the seven serotypes of botulism. (Baldwin MR, Tepp WH, Przedpelski A, Pier CL, Bradshaw M, Johnson EA, Barbieri JT) Infect Immun 2008 Mar;76(3):1314-8 PMID: 18070903 PMCID: PMC2258812 SCOPUS ID: 2-s2.0-40749123001 12/12/2007 113 Citations

Recombinant holotoxoid vaccine against botulism. (Pier CL, Tepp WH, Bradshaw M, Johnson EA, Barbieri JT, Baldwin MR) Infect Immun 2008 Jan;76(1):437-42 PMID: 17967862 PMCID: PMC2223665 SCOPUS ID: 2-s2.0-37749009074 10/31/2007 50 Citations

Intracellular trafficking of Pseudomonas ExoS, a type III cytotoxin. (Deng Q, Zhang Y, Barbieri JT) Traffic 2007 Oct;8(10):1331-45 PMID: 17714437 SCOPUS ID: 2-s2.0-34548590305 08/24/2007 15 Citations

Multiple pocket recognition of SNAP25 by botulinum neurotoxin serotype E. (Chen S, Barbieri JT) J Biol Chem 2007 Aug 31;282(35):25540-7 PMID: 17609207 SCOPUS ID: 2-s2.0-34548509453 07/05/2007 43 Citations

Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS. (Zhang Y, Deng Q, Porath JA, Williams CL, Pederson-Gulrud KJ, Barbieri JT) Cell Microbiol 2007 Sep;9(9):2192-201 PMID: 17490406 SCOPUS ID: 2-s2.0-34547913066 05/11/2007 19 Citations

Erratum: An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 8, (2602-2607) DOI: 10.1073/pnas.0611213104) (Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, Baldwin MR, Malizio CJ, Goodnough MC, Barbieri JT, Johnson EA, Boger DL, Dickerson TJ, Janda KD) Proceedings of the National Academy of Sciences of the United States of America 10 April 2007;104(15):6490 SCOPUS ID: 2-s2.0-34547506296 04/10/2007 3 Citations

Intracellular localization of type III-delivered Pseudomonas ExoS with endosome vesicles. (Zhang Y, Deng Q, Barbieri JT) J Biol Chem 2007 Apr 27;282(17):13022-32 PMID: 17311921 SCOPUS ID: 2-s2.0-34250351513 02/22/2007 25 Citations

Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes. (Baldwin MR, Barbieri JT) Biochemistry 2007 Mar 20;46(11):3200-10 PMID: 17311420 SCOPUS ID: 2-s2.0-33947392128 02/22/2007 53 Citations

An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. (Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, Baldwin MR, Malizio CJ, Goodnough MC, Barbieri JT, Johnson EA, Boger DL, Dickerson TJ, Janda KD) Proc Natl Acad Sci U S A 2007 Feb 20;104(8):2602-7 PMID: 17293454 PMCID: PMC1815229 SCOPUS ID: 2-s2.0-33847323110 02/13/2007 110 Citations

Mechanism of substrate recognition by botulinum neurotoxin serotype A. (Chen S, Kim JP, Barbieri JT) J Biol Chem 2007 Mar 30;282(13):9621-9627 PMID: 17244603 SCOPUS ID: 2-s2.0-34248213125 01/25/2007 81 Citations

Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango. (Baldwin MR, Kim JJ, Barbieri JT) Nat Struct Mol Biol 2007 Jan;14(1):9-10 PMID: 17203068 SCOPUS ID: 2-s2.0-33846065566 01/05/2007 25 Citations

Pseudomonas aeruginosa toxins (Maresso AW, Frank DW, Barbieri JT) Comprehensive Sourcebook of Bacterial Protein Toxins 2006:257-269 SCOPUS ID: 2-s2.0-35348958777 12/01/2006 5 Citations

Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation. (Maresso AW, Deng Q, Pereckas MS, Wakim BT, Barbieri JT) Cell Microbiol 2007 Jan;9(1):97-105 PMID: 16889625 SCOPUS ID: 2-s2.0-33845382946 08/08/2006 33 Citations

Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate. (Fu Z, Chen S, Baldwin MR, Boldt GE, Crawford A, Janda KD, Barbieri JT, Kim JJ) Biochemistry 2006 Jul 25;45(29):8903-11 PMID: 16846233 SCOPUS ID: 2-s2.0-33746268620 07/19/2006 52 Citations

Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors. (Boldt GE, Kennedy JP, Hixon MS, McAllister LA, Barbieri JT, Tzipori S, Janda KD) J Comb Chem 2006;8(4):513-21 PMID: 16827563 PMCID: PMC2644723 SCOPUS ID: 2-s2.0-33746184737 07/11/2006 71 Citations

A yeast assay probes the interaction between botulinum neurotoxin serotype B and its SNARE substrate. (Fang H, Luo W, Henkel J, Barbieri J, Green N) Proc Natl Acad Sci U S A 2006 May 02;103(18):6958-63 PMID: 16636286 PMCID: PMC1447522 SCOPUS ID: 2-s2.0-33646476127 04/26/2006 13 Citations

Unique substrate recognition by botulinum neurotoxins serotypes A and E. (Chen S, Barbieri JT) J Biol Chem 2006 Apr 21;281(16):10906-11 PMID: 16478727 SCOPUS ID: 2-s2.0-33744952947 02/16/2006 86 Citations

A leucine-rich motif targets Pseudomonas aeruginosa ExoS within mammalian cells. (Zhang Y, Barbieri JT) Infect Immun 2005 Dec;73(12):7938-45 PMID: 16299285 PMCID: PMC1307044 SCOPUS ID: 2-s2.0-28444479483 11/22/2005 28 Citations

Characterization of the antibody response to the receptor binding domain of botulinum neurotoxin serotypes A and E. (Baldwin MR, Tepp WH, Pier CL, Bradshaw M, Ho M, Wilson BA, Fritz RB, Johnson EA, Barbieri JT) Infect Immun 2005 Oct;73(10):6998-7005 PMID: 16177380 PMCID: PMC1230911 SCOPUS ID: 2-s2.0-25444446822 09/24/2005 58 Citations

Uncoupling Crk signal transduction by Pseudomonas exoenzyme T. (Deng Q, Sun J, Barbieri JT) J Biol Chem 2005 Oct 28;280(43):35953-60 PMID: 16123042 SCOPUS ID: 2-s2.0-27744597068 08/27/2005 34 Citations

Early immune response to the components of the type III system of Pseudomonas aeruginosa in children with cystic fibrosis. (Corech R, Rao A, Laxova A, Moss J, Rock MJ, Li Z, Kosorok MR, Splaingard ML, Farrell PM, Barbieri JT) J Clin Microbiol 2005 Aug;43(8):3956-62 PMID: 16081936 PMCID: PMC1233990 SCOPUS ID: 2-s2.0-23744484047 08/06/2005 28 Citations

The type III cytotoxins of Yersinia and Pseudomonas aeruginosa that modulate the actin cytoskeleton. (Baldwin MR, Barbieri JT) Curr Top Microbiol Immunol 2005;291:147-66 PMID: 15984080 SCOPUS ID: 2-s2.0-18744411524 06/30/2005 17 Citations

Bacterial cytotoxins: targeting eukaryotic switches. (Aktories K, Barbieri JT) Nat Rev Microbiol 2005 May;3(5):397-410 PMID: 15821726 SCOPUS ID: 2-s2.0-17844406602 04/12/2005 203 Citations

Detection of Pseudomonas aeruginosa type III antibodies in children with tracheostomies. (Rao AR, Splaingard MS, Gershan WM, Havens PL, Thill A, Barbieri JT) Pediatr Pulmonol 2005 May;39(5):402-7 PMID: 15666370 SCOPUS ID: 2-s2.0-17444394492 01/25/2005 7 Citations

Pseudomonas aeruginosa ExoS and ExoT. (Barbieri JT, Sun J) Rev Physiol Biochem Pharmacol 2004;152:79-92 PMID: 15375697 SCOPUS ID: 2-s2.0-15944420126 09/18/2004 205 Citations

How bacterial ADP-ribosylating toxins recognize substrates. (Sun J, Maresso AW, Kim JJ, Barbieri JT) Nat Struct Mol Biol 2004 Sep;11(9):868-76 PMID: 15311272 SCOPUS ID: 2-s2.0-4344717785 08/18/2004 64 Citations

The C-terminus of botulinum neurotoxin type A light chain contributes to solubility, catalysis, and stability. (Baldwin MR, Bradshaw M, Johnson EA, Barbieri JT) Protein Expr Purif 2004 Sep;37(1):187-95 PMID: 15294297 SCOPUS ID: 2-s2.0-3543058813 08/06/2004 73 Citations

ExoS Rho GTPase-activating protein activity stimulates reorganization of the actin cytoskeleton through Rho GTPase guanine nucleotide disassociation inhibitor. (Sun J, Barbieri JT) J Biol Chem 2004 Oct 08;279(41):42936-44 PMID: 15292224 SCOPUS ID: 2-s2.0-5644229545 08/05/2004 30 Citations

Ezrin/radixin/moesin proteins are high affinity targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS. (Maresso AW, Baldwin MR, Barbieri JT) J Biol Chem 2004 Sep 10;279(37):38402-8 PMID: 15252013 SCOPUS ID: 2-s2.0-4644363572 07/15/2004 55 Citations

Molecular heterogeneity of a type III cytotoxin, Pseudomonas aeruginosa exoenzyme S. (Maresso AW, Riese MJ, Barbieri JT) Biochemistry 2003 Dec 09;42(48):14249-57 PMID: 14640693 SCOPUS ID: 2-s2.0-0344629874 12/04/2003 4 Citations

Intracellular membrane localization of pseudomonas ExoS and Yersinia YopE in mammalian cells. (Krall R, Zhang Y, Barbieri JT) J Biol Chem 2004 Jan 23;279(4):2747-53 PMID: 14597627 SCOPUS ID: 2-s2.0-1642535429 11/05/2003 59 Citations

Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 regulator of kinase (Crk) proteins. (Sun J, Barbieri JT) J Biol Chem 2003 Aug 29;278(35):32794-800 PMID: 12807879 SCOPUS ID: 2-s2.0-0041355556 06/17/2003 140 Citations

Expression and purification of two recombinant forms of the type-III cytotoxin, Pseudomonas aeruginosa ExoS. (Maresso AW, Barbieri JT) Protein Expr Purif 2002 Dec;26(3):432-7 PMID: 12460767 SCOPUS ID: 2-s2.0-0036910606 12/04/2002 7 Citations

Intracellular localization modulates targeting of ExoS, a type III cytotoxin, to eukaryotic signalling proteins. (Pederson KJ, Krall R, Riese MJ, Barbieri JT) Mol Microbiol 2002 Dec;46(5):1381-90 PMID: 12453223 SCOPUS ID: 2-s2.0-0036887054 11/28/2002 42 Citations

Bacterial toxins that modify the actin cytoskeleton. (Barbieri JT, Riese MJ, Aktories K) Annu Rev Cell Dev Biol 2002;18:315-44 PMID: 12142277 SCOPUS ID: 2-s2.0-0036437349 07/27/2002 141 Citations

ADP-ribosylation and functional effects of Pseudomonas exoenzyme S on cellular RalA. (Fraylick JE, Riese MJ, Vincent TS, Barbieri JT, Olson JC) Biochemistry 2002 Jul 30;41(30):9680-7 PMID: 12135390 SCOPUS ID: 2-s2.0-0037199493 07/24/2002 32 Citations

Membrane localization contributes to the in vivo ADP-ribosylation of Ras by Pseudomonas aeruginosa ExoS. (Riese MJ, Barbieri JT) Infect Immun 2002 Apr;70(4):2230-2 PMID: 11895993 PMCID: PMC127869 SCOPUS ID: 2-s2.0-0036131313 03/16/2002 19 Citations

Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS. (Riese MJ, Goehring UM, Ehrmantraut ME, Moss J, Barbieri JT, Aktories K, Schmidt G) J Biol Chem 2002 Apr 05;277(14):12082-8 PMID: 11821389 SCOPUS ID: 2-s2.0-0037023740 02/01/2002 53 Citations

Children with cystic fibrosis produce an immune response against exoenzyme S, a type III cytotoxin of Pseudomonas aeruginosa. (Banwart B, Splaingard ML, Farrell PM, Rock MJ, Havens PL, Moss J, Ehrmantraut ME, Frank DW, Barbieri JT) J Infect Dis 2002 Jan 15;185(2):269-70 PMID: 11807706 SCOPUS ID: 2-s2.0-0037080359 01/25/2002 21 Citations

In vivo rho GTPase-activating protein activity of Pseudomonas aeruginosa cytotoxin ExoS. (Krall R, Sun J, Pederson KJ, Barbieri JT) Infect Immun 2002 Jan;70(1):360-7 PMID: 11748202 PMCID: PMC127644 SCOPUS ID: 2-s2.0-0036137206 12/19/2001 81 Citations

Variations in site and levels of expression of chondrocyte nucleotide pyrophosphohydrolase with aging. (Masuda I, Iyama KI, Halligan BD, Barbieri JT, Haas AL, McCarty DJ, Ryan LM) J Bone Miner Res 2001 May;16(5):868-75 PMID: 11341331 SCOPUS ID: 2-s2.0-0035055433 05/09/2001 13 Citations

ADP ribosylation of Arg41 of Rap by ExoS inhibits the ability of Rap to interact with its guanine nucleotide exchange factor, C3G. (Riese MJ, Wittinghofer A, Barbieri JT) Biochemistry 2001 Mar 20;40(11):3289-94 PMID: 11258948 SCOPUS ID: 2-s2.0-0035916917 03/22/2001 36 Citations

Structure of the ExoS GTPase activating domain. (Würtele M, Renault L, Barbieri JT, Wittinghofer A, Wolf E) FEBS Lett 2001 Feb 23;491(1-2):26-9 PMID: 11226412 SCOPUS ID: 2-s2.0-0035936895 02/28/2001 37 Citations

Sera from adult patients with cystic fibrosis contain antibodies to Pseudomonas aeruginosa type III apparatus. (Moss J, Ehrmantraut ME, Banwart BD, Frank DW, Barbieri JT) Infect Immun 2001 Feb;69(2):1185-8 PMID: 11160019 PMCID: PMC98003 SCOPUS ID: 2-s2.0-0035143703 02/13/2001 41 Citations

How the Pseudomonas aeruginosa ExoS toxin downregulates Rac. (Würtele M, Wolf E, Pederson KJ, Buchwald G, Ahmadian MR, Barbieri JT, Wittinghofer A) Nat Struct Biol 2001 Jan;8(1):23-6 PMID: 11135665 SCOPUS ID: 2-s2.0-0035171524 01/03/2001 101 Citations

Pseudomonas aeruginosa exoenzyme S, a bifunctional type-III secreted cytotoxin. (Barbieri JT) Int J Med Microbiol 2000 Oct;290(4-5):381-7 PMID: 11111915 SCOPUS ID: 2-s2.0-0033752839 12/09/2000 69 Citations

Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein. (Krall R, Schmidt G, Aktories K, Barbieri JT) Infect Immun 2000 Oct;68(10):6066-8 PMID: 10992524 PMCID: PMC101576 SCOPUS ID: 2-s2.0-0033796738 09/19/2000 143 Citations

Intracellular localization and processing of Pseudomonas aeruginosa ExoS in eukaryotic cells. (Pederson KJ, Pal S, Vallis AJ, Frank DW, Barbieri JT) Mol Microbiol 2000 Jul;37(2):287-99 PMID: 10931325 SCOPUS ID: 2-s2.0-0033913828 08/10/2000 34 Citations

The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding. (Blöcker D, Barth H, Maier E, Benz R, Barbieri JT, Aktories K) Infect Immun 2000 Aug;68(8):4566-73 PMID: 10899856 PMCID: PMC98375 SCOPUS ID: 2-s2.0-0038208865 07/19/2000 63 Citations

The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases. (Goehring UM, Schmidt G, Pederson KJ, Aktories K, Barbieri JT) J Biol Chem 1999 Dec 17;274(51):36369-72 PMID: 10593930 SCOPUS ID: 2-s2.0-0033579479 12/14/1999 247 Citations

Residues of 14-3-3 zeta required for activation of exoenzyme S of Pseudomonas aeruginosa. (Zhang L, Wang H, Masters SC, Wang B, Barbieri JT, Fu H) Biochemistry 1999 Sep 14;38(37):12159-64 PMID: 10508420 SCOPUS ID: 2-s2.0-0033554398 10/03/1999 38 Citations

Pseudomonas aeruginosa exoenzyme S disrupts Ras-mediated signal transduction by inhibiting guanine nucleotide exchange factor-catalyzed nucleotide exchange. (Ganesan AK, Vincent TS, Olson JC, Barbieri JT) J Biol Chem 1999 Jul 30;274(31):21823-9 PMID: 10419499 SCOPUS ID: 2-s2.0-0033618308 07/27/1999 72 Citations

Expression of FAS-independent ADP-ribosyltransferase activity by a catalytic deletion peptide of Pseudomonas aeruginosa exoenzyme S. (Knight DA, Barbieri JT) Biochemistry 1999 May 04;38(18):5858-63 PMID: 10231537 SCOPUS ID: 2-s2.0-0033522426 05/08/1999 5 Citations

The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins. (Pederson KJ, Vallis AJ, Aktories K, Frank DW, Barbieri JT) Mol Microbiol 1999 Apr;32(2):393-401 PMID: 10231494 SCOPUS ID: 2-s2.0-0032931551 05/07/1999 123 Citations

Interaction of 14-3-3 with a nonphosphorylated protein ligand, exoenzyme S of Pseudomonas aeruginosa. (Masters SC, Pederson KJ, Zhang L, Barbieri JT, Fu H) Biochemistry 1999 Apr 20;38(16):5216-21 PMID: 10213629 SCOPUS ID: 2-s2.0-0033586783 04/23/1999 134 Citations

Intracellular expression of the ADP-ribosyltransferase domain of Pseudomonas exoenzyme S is cytotoxic to eukaryotic cells. (Pederson KJ, Barbieri JT) Mol Microbiol 1998 Nov;30(4):751-9 PMID: 10094623 SCOPUS ID: 2-s2.0-0031735291 03/27/1999 65 Citations

Pseudomonas aeruginosa exoenzyme S, a double ADP-ribosyltransferase, resembles vertebrate mono-ADP-ribosyltransferases. (Ganesan AK, Mende-Mueller L, Selzer J, Barbieri JT) J Biol Chem 1999 Apr 02;274(14):9503-8 PMID: 10092634 SCOPUS ID: 2-s2.0-0033515484 03/27/1999 33 Citations

Pseudomonas aeruginosa exoenzyme S is a biglutamic acid ADP-ribosyltransferase. (Radke J, Pederson KJ, Barbieri JT) Infect Immun 1999 Mar;67(3):1508-10 PMID: 10024602 PMCID: PMC96488 SCOPUS ID: 2-s2.0-0032974751 02/20/1999 43 Citations

Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions. (Vallis AJ, Yahr TL, Barbieri JT, Frank DW) Infect Immun 1999 Feb;67(2):914-20 PMID: 9916108 PMCID: PMC96404 SCOPUS ID: 2-s2.0-0032962344 01/23/1999 124 Citations

ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system. (Yahr TL, Vallis AJ, Hancock MK, Barbieri JT, Frank DW) Proc Natl Acad Sci U S A 1998 Nov 10;95(23):13899-904 PMID: 9811898 PMCID: PMC24955 SCOPUS ID: 2-s2.0-0032506004 11/13/1998 388 Citations

Pertussis toxin abolishes the cardioprotective effect of ischemic preconditioning in intact rat heart. (Schultz JE, Hsu AK, Barbieri JT, Li PL, Gross GJ) Am J Physiol 1998 Aug;275(2):H495-500 PMID: 9683437 SCOPUS ID: 2-s2.0-0031852654 07/31/1998 48 Citations

Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites. (Ganesan AK, Frank DW, Misra RP, Schmidt G, Barbieri JT) J Biol Chem 1998 Mar 27;273(13):7332-7 PMID: 9516428 SCOPUS ID: 2-s2.0-0032571385 04/29/1998 102 Citations

Glycosphingolipids as novel targets for T-cell suppression by the B subunit of recombinant heat-labile enterotoxin. (Truitt RL, Hanke C, Radke J, Mueller R, Barbieri JT) Infect Immun 1998 Apr;66(4):1299-308 PMID: 9529046 PMCID: PMC108053 SCOPUS ID: 2-s2.0-0032036427 04/07/1998 35 Citations

Molecular cloning and expression of a porcine chondrocyte nucleotide pyrophosphohydrolase. (Masuda I, Halligan BD, Barbieri JT, Haas AL, Ryan LM, McCarty DJ) Gene 1997 Sep 15;197(1-2):277-87 PMID: 9332376 SCOPUS ID: 2-s2.0-0030845712 10/23/1997 26 Citations

Ecto-ADP-ribosyltransferase activity of Pseudomonas aeruginosa exoenzyme S. (Knight DA, Barbieri JT) Infect Immun 1997 Aug;65(8):3304-9 PMID: 9234791 PMCID: PMC175468 SCOPUS ID: 2-s2.0-0030858819 08/01/1997 30 Citations

Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa. (Liu S, Yahr TL, Frank DW, Barbieri JT) J Bacteriol 1997 Mar;179(5):1609-13 PMID: 9045820 PMCID: PMC178873 SCOPUS ID: 2-s2.0-0031046668 03/01/1997 48 Citations

Pseudomonas aeruginosa nucleic acids encoding exoenzymes activity and use thereof in detecting pseudomonas aeruginosa infection (Barbieri JT, Frank DW, Kulich SM) Biotechnology Advances 1997;15(3-4):723 SCOPUS ID: 2-s2.0-0030662886 01/01/1997

Preferential processing of the S1 subunit of pertussis toxin that is bound to eukaryotic cells. (Finck-Barbançon V, Barbieri JT) Mol Microbiol 1996 Oct;22(1):87-95 PMID: 8899711 SCOPUS ID: 2-s2.0-0029820244 10/01/1996 5 Citations

Genetic relationship between the 53- and 49-kilodalton forms of exoenzyme S from Pseudomonas aeruginosa. (Yahr TL, Barbieri JT, Frank DW) J Bacteriol 1996 Mar;178(5):1412-9 PMID: 8631719 PMCID: PMC177816 SCOPUS ID: 2-s2.0-0029914812 03/01/1996 113 Citations

Identification of glutamic acid 381 as a candidate active site residue of Pseudomonas aeruginosa exoenzyme S. (Liu S, Kulich SM, Barbieri JT) Biochemistry 1996 Feb 27;35(8):2754-8 PMID: 8611582 SCOPUS ID: 2-s2.0-0029969391 02/27/1996 47 Citations

Pertussis toxin-catalyzed ADP-ribosylation of Gi-2 and Gi-3 in CHO cells is modulated by inhibitors of intracellular trafficking. (Xu Y, Barbieri JT) Infect Immun 1996 Feb;64(2):593-9 PMID: 8550212 PMCID: PMC173806 SCOPUS ID: 2-s2.0-0030034114 02/01/1996 30 Citations

Functional domains of Pseudomonas aeruginosa exoenzyme S. (Knight DA, Finck-Barbançon V, Kulich SM, Barbieri JT) Infect Immun 1995 Aug;63(8):3182-6 PMID: 7622246 PMCID: PMC173434 SCOPUS ID: 2-s2.0-0029099069 08/01/1995 62 Citations

Pertussis toxin-mediated ADP-ribosylation of target proteins in Chinese hamster ovary cells involves a vesicle trafficking mechanism. (Xu Y, Barbieri JT) Infect Immun 1995 Mar;63(3):825-32 PMID: 7868253 PMCID: PMC173077 SCOPUS ID: 2-s2.0-0028905448 03/01/1995 46 Citations

ADP-ribosylation of alpha i3C20 by the S1 subunit and deletion peptides of S1 of pertussis toxin. (Finck-Barbançon V, Barbieri JT) Biochemistry 1995 Jan 24;34(3):1070-5 PMID: 7827022 SCOPUS ID: 2-s2.0-0028986692 01/24/1995 10 Citations

Expression of recombinant exoenzyme S of Pseudomonas aeruginosa. (Kulich SM, Frank DW, Barbieri JT) Infect Immun 1995 Jan;63(1):1-8 PMID: 7806344 PMCID: PMC172950 SCOPUS ID: 2-s2.0-0028796549 01/01/1995 47 Citations

The family of bacterial ADP-ribosylating exotoxins. (Krueger KM, Barbieri JT) Clin Microbiol Rev 1995 Jan;8(1):34-47 PMID: 7704894 PMCID: PMC172848 SCOPUS ID: 2-s2.0-0028981421 01/01/1995 144 Citations

Assignment of functional domains involved in ADP-ribosylation and B-oligomer binding within the carboxyl terminus of the S1 subunit of pertussis toxin. (Krueger KM, Barbieri JT) Infect Immun 1994 May;62(5):2071-8 PMID: 8168972 PMCID: PMC186468 SCOPUS ID: 2-s2.0-0028230250 05/01/1994 17 Citations

Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388. (Kulich SM, Yahr TL, Mende-Mueller LM, Barbieri JT, Frank DW) J Biol Chem 1994 Apr 08;269(14):10431-7 PMID: 8144626 SCOPUS ID: 2-s2.0-0028308703 04/08/1994 78 Citations

Role of histidine 35 of the S1 subunit of pertussis toxin in the ADP-ribosylation of transducin. (Xu Y, Barbançon-Finck V, Barbieri JT) J Biol Chem 1994 Apr 01;269(13):9993-9 PMID: 8144593 SCOPUS ID: 2-s2.0-0028364247 04/01/1994 18 Citations

Biochemical analysis of mutations at tyrosine-98 of the S1 subunit of pertussis toxin. (Xu Y, Barbieri JT) Biochemistry 1994 Feb 15;33(6):1573-9 PMID: 8312278 SCOPUS ID: 2-s2.0-0028296777 02/15/1994

Molecular characterization of the in vitro activation of pertussis toxin by ATP. (Krueger KM, Barbieri JT) J Biol Chem 1993 Jun 15;268(17):12570-8 PMID: 8509398 SCOPUS ID: 2-s2.0-0027233731 06/15/1993 10 Citations

Purification and characterization of exoenzyme S from Pseudomonas aeruginosa 388. (Kulich SM, Frank DW, Barbieri JT) Infect Immun 1993 Jan;61(1):307-13 PMID: 8418052 PMCID: PMC302720 SCOPUS ID: 2-s2.0-0027464118 01/01/1993 44 Citations

Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin. (Barbieri JT, Armellini D, Molkentin J, Rappuoli R) Infect Immun 1992 Dec;60(12):5071-7 PMID: 1452339 PMCID: PMC258279 SCOPUS ID: 2-s2.0-0026459612 12/01/1992 25 Citations

Identification of the phosphoribulokinase sugar phosphate binding domain. (Sandbaken MG, Runquist JA, Barbieri JT, Miziorko HM) Biochemistry 1992 Apr 14;31(14):3715-9 PMID: 1314650 SCOPUS ID: 2-s2.0-0026636948 04/14/1992 23 Citations

The carboxyl terminus of the S1 subunit of pertussis toxin confers high affinity binding to transducin. (Cortina G, Krueger KM, Barbieri JT) J Biol Chem 1991 Dec 15;266(35):23810-4 PMID: 1748655 SCOPUS ID: 2-s2.0-0026344820 12/15/1991 21 Citations

Protease treatment of pertussis toxin identifies the preferential cleavage of the S1 subunit. (Krueger KM, Mende-Mueller LM, Barbieri JT) J Biol Chem 1991 May 05;266(13):8122-8 PMID: 1850738 SCOPUS ID: 2-s2.0-0025807970 05/05/1991 11 Citations

Localization of a region of the S1 subunit of pertussis toxin required for efficient ADP-ribosyltransferase activity. (Cortina G, Barbieri JT) J Biol Chem 1991 Feb 15;266(5):3022-30 PMID: 1993675 SCOPUS ID: 2-s2.0-0025805672 02/15/1991 10 Citations

Biochemical and biological activities of recombinant S1 subunit of pertussis toxin. (Barbieri JT, Pizza M, Cortina G, Rappuoli R) Infect Immun 1990 Apr;58(4):999-1003 PMID: 2108094 PMCID: PMC258573 SCOPUS ID: 2-s2.0-0025228813 04/01/1990 12 Citations

Photolabeling of Glu-129 of the S-1 subunit of pertussis toxin with NAD. (Barbieri JT, Mende-Mueller LM, Rappuoli R, Collier RJ) Infect Immun 1989 Nov;57(11):3549-54 PMID: 2807535 PMCID: PMC259866 SCOPUS ID: 2-s2.0-0024418570 11/01/1989 47 Citations

Mutants of pertussis toxin suitable for vaccine development. (Pizza M, Covacci A, Bartoloni A, Perugini M, Nencioni L, De Magistris MT, Villa L, Nucci D, Manetti R, Bugnoli M) Science 1989 Oct 27;246(4929):497-500 PMID: 2683073 SCOPUS ID: 2-s2.0-0024470848 10/27/1989 252 Citations

Role of tryptophan 26 in the NAD glycohydrolase reaction of the S-1 subunit of pertussis toxin. (Cortina G, Barbieri JT) J Biol Chem 1989 Oct 15;264(29):17322-8 PMID: 2551899 SCOPUS ID: 2-s2.0-0024330332 10/15/1989 18 Citations

Expression and secretion of the S-1 subunit and C180 peptide of pertussis toxin in Escherichia coli. (Barbieri JT, Moloney BK, Mende-Mueller LM) J Bacteriol 1989 Aug;171(8):4362-9 PMID: 2546919 PMCID: PMC210213 SCOPUS ID: 2-s2.0-0024315868 08/01/1989 24 Citations

ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin. (Barbieri JT, Cortina G) Infect Immun 1988 Aug;56(8):1934-41 PMID: 3135265 PMCID: PMC259504 SCOPUS ID: 2-s2.0-0023801974 08/01/1988 44 Citations

Diphtheria toxin: purification and properties. (Carroll SF, Barbieri JT, Collier RJ) Methods Enzymol 1988;165:68-76 PMID: 3148099 SCOPUS ID: 2-s2.0-0024215156 01/01/1988 48 Citations

Expression of a mutant, full-length form of diphtheria toxin in Escherichia coli. (Barbieri JT, Collier RJ) Infect Immun 1987 Jul;55(7):1647-51 PMID: 3110068 PMCID: PMC260572 SCOPUS ID: 2-s2.0-0023238618 07/01/1987 47 Citations

Expression of the S-1 catalytic subunit of pertussis toxin in Escherichia coli. (Barbieri JT, Rappuoli R, Collier RJ) Infect Immun 1987 May;55(5):1321-3 PMID: 2883125 PMCID: PMC260508 SCOPUS ID: 2-s2.0-0023277841 05/01/1987 17 Citations

Diphtheria toxin can simultaneously bind to its receptor and adenylyl-(3',5')-uridine 3'-monophosphate. (Barbieri JT, Collins CM, Collier RJ) Biochemistry 1986 Oct 21;25(21):6608-11 PMID: 3790545 SCOPUS ID: 2-s2.0-0022977028 10/21/1986 5 Citations

Dimeric form of diphtheria toxin: purification and characterization. (Carroll SF, Barbieri JT, Collier RJ) Biochemistry 1986 May 06;25(9):2425-30 PMID: 3718959 SCOPUS ID: 2-s2.0-0022511852 05/06/1986 44 Citations

Diphtheria toxin. Effect of substituting aspartic acid for glutamic acid 148 on ADP-ribosyltransferase activity. (Tweten RK, Barbieri JT, Collier RJ) J Biol Chem 1985 Sep 05;260(19):10392-4 PMID: 2863266 SCOPUS ID: 2-s2.0-0022205447 09/05/1985 61 Citations

Intracellular transport and processing of diptheria toxin (DT) in BSC-1 cells (Fedde K, Barbieri J, Collier RJ, Sly WS) Federation Proceedings 1985;44(5):6123 SCOPUS ID: 2-s2.0-0021883047 01/01/1985

Interaction of diphtheria toxin with adenylyl-(3',5')-uridine 3'-monophosphate. I. Equilibrium and kinetic measurements. (Collins CM, Barbieri JT, Collier RJ) J Biol Chem 1984 Dec 25;259(24):15154-8 PMID: 6511788 SCOPUS ID: 2-s2.0-0021733873 12/25/1984 10 Citations

An endogenous dinucleotide bound to diphtheria toxin. Adenylyl-(3',5')-uridine 3'-monophosphate. (Barbieri JT, Carroll SF, Collier RJ, McCloskey JA) J Biol Chem 1981 Dec 10;256(23):12247-51 PMID: 7298656 SCOPUS ID: 2-s2.0-0019804211 12/10/1981 17 Citations

Distribution of superoxide dismutase, catalase, and peroxidase activities among Treponema pallidum and other spirochetes. (Austin FE, Barbieri JT, Corin RE, Grigas KE, Cox CD) Infect Immun 1981 Aug;33(2):372-9 PMID: 7024127 PMCID: PMC350708 SCOPUS ID: 2-s2.0-0019467001 08/01/1981 29 Citations

Influence of oxygen on respiration and glucose catabolism by Treponema pallidum. (Barbieri JT, Cox CD) Infect Immun 1981 Mar;31(3):992-7 PMID: 7014470 PMCID: PMC351416 SCOPUS ID: 2-s2.0-0019460639 03/01/1981 5 Citations

Distribution of glucose incorporated into macromolecular material by treponema pallidum. (Barbieri JT, Austin FE, Cox CD) Infect Immun 1981 Mar;31(3):1071-7 PMID: 7014454 PMCID: PMC351426 SCOPUS ID: 2-s2.0-0019506205 03/01/1981 12 Citations

Pyruvate oxidation by Treponema pallidum. (Barbieri JT, Cox CD) Infect Immun 1979 Jul;25(1):157-63 PMID: 383612 PMCID: PMC414432 SCOPUS ID: 2-s2.0-0018776273 07/01/1979 5 Citations

Glucose incorporation by Treponema pallidum. (Barbieri JT, Cox CD) Infect Immun 1979 Apr;24(1):291-3 PMID: 378845 PMCID: PMC414297 SCOPUS ID: 2-s2.0-0018410264 04/01/1979 3 Citations

Last update: 04/25/2024

© 2025 Clinical & Translational Science Institute
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53223

Publication and ontology data from NCBI | Disclaimer and Copyright

This site is a collaborative effort of the Medical College of Wisconsin and the Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number 2UL1TR001436) at the National Institutes of Health (NIH).

selective

Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Joseph T. Barbieri PhD

Professor

Publications (182)