Pui Ying Lam PhD
Assistant Professor
Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration
Member of the
Center for Immunology
I am willing to collaborate on research projects.
Send Message
Request Meeting
Research Areas of Interest
CalciumDisease Models, AnimalInflammationMacrophagesNeutrophilsOptogeneticsSignal TransductionTime-Lapse ImagingZebrafishneuroinflammationDanionella cerebrumPhotopharmacologyResearch Experience
ActinsAnimals, Genetically ModifiedCalciumCell MovementCell PolarityChemotaxisDisease Models, AnimalGene Expression RegulationIn Situ HybridizationMacrophagesMicrotubulesNeutrophilsOptogeneticsSignal TransductionTRPA1 Cation ChannelTime-Lapse ImagingZebrafishDanionella cerebrumMethodologies and Techniques
Time-Lapse ImagingZebrafishEducational Expertise
MacrophagesNeutrophilsTime-Lapse ImagingZebrafishPublications (26)
The conducting state of TRPA1 modulates channel lateral mobility (Sampieri A, Padilla-Flores T, Thawani AR, Lam PY, Fuchter MJ, Peterson R, Vaca L) Cell Calcium December 2023;116 SCOPUS ID: 2-s2.0-85172678285 12/01/2023 Longitudinal in vivo imaging of adult Danionella cerebrum using standard confocal microscopy. (Lam PY) Dis Model Mech 2022 Dec 01;15(12) PMID: 36398624 PMCID: PMC9844135 SCOPUS ID: 2-s2.0-85144499718 11/19/2022 3 CitationsCell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. (Houseright RA, Rosowski EE, Lam PY, Tauzin SJM, Mulvaney O, Dewey CN, Huttenlocher A) Sci Rep 2020 Sep 24;10(1):15716 PMID: 32973200 PMCID: PMC7518243 SCOPUS ID: 2-s2.0-85091432160 09/26/2020 12 CitationsTRPswitch-A Step-Function Chemo-optogenetic Ligand for the Vertebrate TRPA1 Channel. (Lam PY, Thawani AR, Balderas E, White AJP, Chaudhuri D, Fuchter MJ, Peterson RT) J Am Chem Soc 2020 Oct 14;142(41):17457-17468 PMID: 32966062 PMCID: PMC8011302 SCOPUS ID: 2-s2.0-85092945882 09/24/2020 16 CitationsBoholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide. (Torres JP, Lin Z, Fenton DS, Leavitt LU, Niu C, Lam PY, Robes JM, Peterson RT, Concepcion GP, Haygood MG, Olivera BM, Schmidt EW) J Nat Prod 2020 Apr 24;83(4):1249-1257 PMID: 32186874 PMCID: PMC10172148 SCOPUS ID: 2-s2.0-85082040097 03/19/2020 9 CitationsCyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model. (Lam PY, Kutchukian P, Anand R, Imbriglio J, Andrews C, Padilla H, Vohra A, Lane S, Parker DL Jr, Cornella Taracido I, Johns DG, Beerens M, MacRae CA, Caldwell JP, Sorota S, Asnani A, Peterson RT) Chembiochem 2020 Jul 01;21(13):1905-1910 PMID: 32003101 PMCID: PMC7500981 SCOPUS ID: 2-s2.0-85080951472 02/01/2020 15 CitationsEfficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. (Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA) Dev Cell 2019 Apr 22;49(2):189-205.e6 PMID: 31014479 PMCID: PMC6708378 SCOPUS ID: 2-s2.0-85064090810 04/25/2019 44 CitationsDeveloping zebrafish disease models for in vivo small molecule screens. (Lam PY, Peterson RT) Curr Opin Chem Biol 2019 Jun;50:37-44 PMID: 30928773 PMCID: PMC6800242 SCOPUS ID: 2-s2.0-85063391592 04/01/2019 56 CitationsFilopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis. (Fischer RS, Lam PY, Huttenlocher A, Waterman CM) Dev Biol 2019 Jul 01;451(1):86-95 PMID: 30193787 PMCID: PMC7082808 SCOPUS ID: 2-s2.0-85053325520 09/09/2018 43 CitationsNoncanonical translation via deadenylated 3' UTRs maintains primordial germ cells. (Jin YN, Schlueter PJ, Jurisch-Yaksi N, Lam PY, Jin S, Hwang WY, Yeh JJ, Yoshigi M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT) Nat Chem Biol 2018 Sep;14(9):844-852 PMID: 29988067 PMCID: PMC6800240 SCOPUS ID: 2-s2.0-85049618175 07/11/2018 7 CitationsLive imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. (Barros-Becker F, Lam PY, Fisher R, Huttenlocher A) J Cell Sci 2017 Nov 15;130(22):3801-3808 PMID: 28972134 PMCID: PMC5702045 SCOPUS ID: 2-s2.0-85034080622 10/04/2017 64 CitationsA high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. (Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT) Sci Rep 2017 Sep 19;7(1):11839 PMID: 28928472 PMCID: PMC5605526 SCOPUS ID: 2-s2.0-85029827979 09/21/2017 14 CitationsMacrophages mediate flagellin induced inflammasome activation and host defense in zebrafish. (Vincent WJ, Freisinger CM, Lam PY, Huttenlocher A, Sauer JD) Cell Microbiol 2016 Apr;18(4):591-604 PMID: 26468080 PMCID: PMC5027955 SCOPUS ID: 2-s2.0-84961207801 10/16/2015 58 CitationsIn vivo imaging and characterization of actin microridges. (Lam PY, Mangos S, Green JM, Reiser J, Huttenlocher A) PLoS One 2015;10(1):e0115639 PMID: 25629723 PMCID: PMC4309568 SCOPUS ID: 2-s2.0-84961306974 01/30/2015 38 CitationsRedox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. (Tauzin S, Starnes TW, Becker FB, Lam PY, Huttenlocher A) J Cell Biol 2014 Dec 08;207(5):589-98 PMID: 25488917 PMCID: PMC4259815 SCOPUS ID: 2-s2.0-84920019093 12/10/2014 101 CitationsSpinning disk confocal imaging of neutrophil migration in zebrafish. (Lam PY, Fischer RS, Shin WD, Waterman CM, Huttenlocher A) Methods Mol Biol 2014;1124:219-33 PMID: 24504955 PMCID: PMC4087032 SCOPUS ID: 2-s2.0-84898932691 02/08/2014 19 CitationsHeat shock modulates neutrophil motility in zebrafish. (Lam PY, Harvie EA, Huttenlocher A) PLoS One 2013;8(12):e84436 PMID: 24367659 PMCID: PMC3868611 SCOPUS ID: 2-s2.0-84893180470 12/25/2013 23 Citationsodd-skipped related 2 is required for fin chondrogenesis in zebrafish. (Lam PY, Kamei CN, Mangos S, Mudumana S, Liu Y, Drummond IA) Dev Dyn 2013 Nov;242(11):1284-92 PMID: 23913342 PMCID: PMC4041527 SCOPUS ID: 2-s2.0-84886234377 08/06/2013 8 CitationsInterstitial leukocyte migration in vivo. (Lam PY, Huttenlocher A) Curr Opin Cell Biol 2013 Oct;25(5):650-8 PMID: 23797028 PMCID: PMC3782709 SCOPUS ID: 2-s2.0-84882926459 06/26/2013 29 CitationsThe role of microtubules in neutrophil polarity and migration in live zebrafish. (Yoo SK, Lam PY, Eichelberg MR, Zasadil L, Bement WM, Huttenlocher A) J Cell Sci 2012 Dec 01;125(Pt 23):5702-10 PMID: 22992461 PMCID: PMC3575705 SCOPUS ID: 2-s2.0-84874698036 09/21/2012 64 CitationsThe SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish. (Lam PY, Yoo SK, Green JM, Huttenlocher A) J Cell Sci 2012 Nov 01;125(Pt 21):4973-8 PMID: 22946052 PMCID: PMC3533387 SCOPUS ID: 2-s2.0-84872254649 09/05/2012 37 CitationsThe ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. (Mangos S, Lam PY, Zhao A, Liu Y, Mudumana S, Vasilyev A, Liu A, Drummond IA) Dis Model Mech 2010;3(5-6):354-65 PMID: 20335443 PMCID: PMC2860853 SCOPUS ID: 2-s2.0-77952128984 03/26/2010 108 CitationsErratum: Inhibition of stored Ca2+ release disrupts convergencerelated cell movements in the lateral intermediate mesoderm resulting in abnormal positioning and morphology of the pronephric anlagen in intact zebrafish embryos (Development Growth and Differentiation (2009) 51 (429442)) (Lam PY, Webb SE, Leclerc C, Moreau M, Miller AL) Development Growth and Differentiation June 2009;51(5):520 SCOPUS ID: 2-s2.0-66949148362 06/01/2009 Inhibition of stored Ca2+ release disrupts convergence-related cell movements in the lateral intermediate mesoderm resulting in abnormal positioning and morphology of the pronephric anlagen in intact zebrafish embryos. (Lam PY, Webb SE, Leclerc C, Moreau M, Miller AL) Dev Growth Differ 2009 May;51(4):429-42 PMID: 19382938 SCOPUS ID: 2-s2.0-65349175207 04/23/2009 10 CitationsCollective cell migration drives morphogenesis of the kidney nephron. (Vasilyev A, Liu Y, Mudumana S, Mangos S, Lam PY, Majumdar A, Zhao J, Poon KL, Kondrychyn I, Korzh V, Drummond IA) PLoS Biol 2009 Jan 06;7(1):e9 PMID: 19127979 PMCID: PMC2613420 SCOPUS ID: 2-s2.0-58849125300 01/09/2009 155 CitationsDownregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. (Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P) EMBO J 2008 Jun 04;27(11):1537-48 PMID: 18480843 PMCID: PMC2426729 SCOPUS ID: 2-s2.0-44649099112 05/16/2008 134 Citations Last update: 11/06/2023