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Medical College of Wisconsin

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Heather A. Himburg PhD

Professor

Institution: Medical College of Wisconsin
Department: Radiation Oncology

Member of the Cancer Center
Member of the Cardiovascular Research Center

I am willing to collaborate on research projects.

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Publications (78)

Patterns of response in head and neck cancer subregions using daily Quantitative MRI from MR-guided radiation therapy (Bonate R, Awan M, Himburg H, Wong S, Shukla M, Zenga J, Paulson ES) Clinical and Translational Radiation Oncology January 2026;56 SCOPUS ID: 2-s2.0-105019339875 01/01/2026

Radiation-Induced Loss of Tumor-Reactive T Cells Calls for More Rationally Designed Radioimmunotherapy Approaches. (Said I, Awan MJ, Wong SJ, Memon AA, Kearl T, Hematti P, Massey B, Bruening J, Akakpo K, Zenga J, Himburg HA) Int J Radiat Oncol Biol Phys 2026 Jan 01;124(1):190-193 PMID: 41391923 PMCID: PMC12939519 SCOPUS ID: 2-s2.0-105024206020 12/15/2025

Multiomic Selection of Cancer-Testis Antigens as Precision Immuno-oncologic Targets in Head and Neck Cancer. (Memon AA, Awan MJ, Espinosa OV, Kuehn R, Frei A, Foeckler J, Bruening J, Akakpo K, Massey B, Stadler M, Wong S, Himburg HA, Zenga J) JAMA Otolaryngol Head Neck Surg 2025 Dec 01;151(12):1196-1207 PMID: 41129177 PMCID: PMC12550742 SCOPUS ID: 2-s2.0-105022204542 10/23/2025

Tumoral Skin Invasion Is an Independent Predictor of Rapid Recurrence in Head and Neck Cancer. (Memon AA, Khalil M, Espinosa OV, Said I, Yang E, Adams JA, Friedland DR, Khani M, Luo J, Kuehn R, Frei A, Foeckler J, Akakpo K, Massey B, Stadler M, Wong S, Himburg HA, Awan MJ, Bruening J, Zenga J) Head Neck 2026 Feb;48(2):535-542 PMID: 41054923 SCOPUS ID: 2-s2.0-105018525815 10/07/2025

Activation of Angiotensin-Converting Enzyme 2 Mitigates Gastrointestinal Acute Radiation Syndrome. (Sharma GP, Nissen A, Gasperetti T, Foeckler J, Frei AC, Kuehn R, Gerhartz M, Heinzelman P, Romero PA, Zenga J, Himburg HA) Int J Radiat Oncol Biol Phys 2026 Feb 01;124(2):488-503 PMID: 40967372 PMCID: PMC12797870 SCOPUS ID: 2-s2.0-105019379840 09/19/2025

Advances in noninvasive imaging for detecting radiation-induced lung injury (RILI). (Nissen A, Audi SH, Clough AV, Fish B, Joshi A, Medhora M, Sidabras JW, Himburg HA) Int J Radiat Biol 2025 Jul 15:1-13 PMID: 40663440 PMCID: PMC12344586 SCOPUS ID: 2-s2.0-105010955919 07/15/2025 3 Citations

Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer. (Zenga J, Awan MJ, Frei A, Foeckler J, Kuehn R, Kasprzak J, Massey B, Bruening J, Akakpo K, Shukla M, Wong SJ, Mathison AJ, Wendt Andrae J, Hunt B, Puzyrenko A, Jin VX, Memon AA, Villarreal Espinosa O, Chen F, Shaheduzzaman M, Kearl T, Hematti P, Himburg HA) Nat Commun 2025 Jul 01;16(1):5660 PMID: 40593620 PMCID: PMC12219838 SCOPUS ID: 2-s2.0-105009625716 07/02/2025 4 Citations

Radiation-Induced Cardiotoxicity in Hypertensive Salt-Sensitive Rats: A Feasibility Study (An D, Kriegel A, Kumar S, Himburg H, Fish B, Klawikowski S, Rowe D, Lenarczyk M, Baker J, Ibrahim ES) Life June 2025;15(6) SCOPUS ID: 2-s2.0-105009049617 06/01/2025

Quantitative magnetic resonance imaging responses in head and neck cancer patients treated with magnetic resonance-guided hypofractionated radiation therapy. (Bonate R, Awan MJ, Himburg HA, Wong S, Shukla M, Tarima S, Zenga J, Paulson ES) Phys Imaging Radiat Oncol 2025 Jan;33:100693 PMID: 39877149 PMCID: PMC11772986 SCOPUS ID: 2-s2.0-85214566416 01/29/2025 2 Citations

Quantitative magnetic resonance imaging responses in head and neck cancer patients treated with magnetic resonance-guided hypofractionated radiation therapy (Bonate R, Awan MJ, Himburg HA, Wong S, Shukla M, Tarima S, Zenga J, Paulson ES) Physics and Imaging in Radiation Oncology January 2025;33 SCOPUS ID: 2-s2.0-85214566416 01/01/2025 2 Citations

Locked Dimerized CXCL12 Exerts Radiosensitizing Effects in Head and Neck Cancer. (Espinosa OV, Awan M, Memon AA, Frei A, Foeckler J, Kuehn R, Bruening J, Massey B, Wong S, Shukla M, Kasprzak J, Joshi A, Dwinell MB, Himburg HA, Zenga J) Head Neck 2025 May;47(5):1379-1391 PMID: 39722591 PMCID: PMC12040585 SCOPUS ID: 2-s2.0-85212965471 12/26/2024 1 Citation

IEPA, a novel radiation countermeasure, alleviates acute radiation syndrome in rodents. (Wesolowski R, Fish BL, Eibl M, Bähr S, Munjal Mehta S, Czajkowski MT, Gasperetti T, Orschell CM, Asang C, Singh N, Himburg HA, Pleimes D) Int J Radiat Biol 2025;101(1):1-14 PMID: 39531584 PMCID: PMC11698650 SCOPUS ID: 2-s2.0-85209667085 11/13/2024 1 Citation

Dynamic multispectral NIR/SWIR for in vivo lymphovascular architectural and functional quantification. (Hansen C, Jagtap J, Parchur A, Sharma G, Shafiee S, Sinha S, Himburg H, Joshi A) J Biomed Opt 2024 Oct;29(10):106001 PMID: 39347012 PMCID: PMC11425400 SCOPUS ID: 2-s2.0-85205336601 09/30/2024 1 Citation

In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations (Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ) Oral Oncology September 2024;156 SCOPUS ID: 2-s2.0-85198374252 09/01/2024 1 Citation

Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells. (Chang VY, He Y, Grohe S, Brady MR, Chan A, Kadam RS, Fang T, Pang A, Pohl K, Tran E, Li M, Kan J, Zhang Y, Lu JJ, Sasine JP, Himburg HA, Yue P, Chute JP) iScience 2024 Jul 19;27(7):110306 PMID: 39055915 PMCID: PMC11269946 SCOPUS ID: 2-s2.0-85197589903 07/26/2024 3 Citations

In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations. (Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ) Oral Oncol 2024 Sep;156:106947 PMID: 39009483 SCOPUS ID: 2-s2.0-85198374252 07/16/2024 1 Citation

Type I interferon signaling promotes radioresistance in head and neck cancer. (Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA) Transl Cancer Res 2024 May 31;13(5):2535-2543 PMID: 38881922 PMCID: PMC11170510 SCOPUS ID: 2-s2.0-85195040296 06/17/2024 5 Citations

Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture. (Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA) Transl Oncol 2024 Apr;42:101899 PMID: 38320395 PMCID: PMC10851216 SCOPUS ID: 2-s2.0-85184507548 02/07/2024 5 Citations

Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis. (Sasine JP, Kozlova NY, Valicente L, Dukov J, Tran DH, Himburg HA, Kumar S, Khorsandi S, Chan A, Grohe S, Li M, Kan J, Sehl ME, Schiller GJ, Reinhardt B, Singh BK, Ho R, Yue P, Pasquale EB, Chute JP) Cancer Res 2024 Mar 15;84(6):919-934 PMID: 38231476 PMCID: PMC10940855 SCOPUS ID: 2-s2.0-85187955711 01/17/2024 6 Citations

Differential Response in Quantitative MRI Parameters Detected in Head and Neck Cancer Patients Treated with Concurrent Immunotherapy during Hypo-Fractionated MR-gRT. (Bonate R, Paulson ES, Frei A, Shukla ME, Tarima S, Wong S, Himburg HA, Zenga J, Awan MJ) Int J Radiat Oncol Biol Phys 2023 Oct 01;117(2S):S65 PMID: 37784546 10/03/2023

Differential Response to Radiation Fractionation in Head and Neck Cancer Patient-Derived Xenografts. (Musaddiq A, Zenga J, Frei A, Shukla ME, Himburg HA) Int J Radiat Oncol Biol Phys 2023 Oct 01;117(2S):e253 PMID: 37784980 10/03/2023

2^nd Window NIR Imaging of Radiation Injury Mitigation Provided by Reduced Notch-Dll4 Expression on Vasculature. (Kondelaji MHR, Sharma GP, Jagtap J, Shafiee S, Hansen C, Gasperetti T, Frei A, Veley D, Narayanan J, Fish BL, Parchur AK, Ibrahim EH, Medhora M, Himburg HA, Joshi A) Mol Imaging Biol 2024 Feb;26(1):124-137 PMID: 37530966 PMCID: PMC11188939 SCOPUS ID: 2-s2.0-85166543488 08/02/2023 7 Citations

X-ray and MR Contrast Bearing Nanoparticles Enhance the Therapeutic Response of Image-Guided Radiation Therapy for Oral Cancer. (Sharma G, Razeghi Kondelaji MH, Sharma GP, Hansen C, Parchur AK, Shafiee S, Jagtap JM, Fish B, Bergom C, Paulson E, Hall WA, Himburg HA, Joshi A) Technol Cancer Res Treat 2023;22:15330338231189593 PMID: 37469184 PMCID: PMC10363893 SCOPUS ID: 2-s2.0-85165292958 07/20/2023 7 Citations

Photoactivated HPPH-Liposomal therapy for the treatment of HPV-Negative head and neck cancer. (Zenga J, Awan M, Hadi Razeghi Kondelaji M, Hansen C, Shafiee S, Frei A, Foeckler J, Kuehn R, Bruening J, Massey B, Wong S, Joshi A, Himburg HA) Oral Oncol 2023 Sep;144:106487 PMID: 37423200 PMCID: PMC10413333 SCOPUS ID: 2-s2.0-85164978149 07/10/2023 6 Citations

Biological sex differences in renin angiotensin system enzymes ACE and ACE2 regulate normal tissue response to radiation injury. (Sharma GP, Frei A, Fish B, Gasperetti T, Veley D, Szalewski N, Nissen A, Himburg HA) Front Physiol 2023;14:1191237 PMID: 37275232 PMCID: PMC10235526 SCOPUS ID: 2-s2.0-85161056291 06/05/2023 12 Citations

Biomarkers to Predict Lethal Radiation Injury to the Rat Lung. (Medhora M, Gao F, Gasperetti T, Narayanan J, Himburg H, Jacobs ER, Clough AV, Fish BL, Szabo A) Int J Mol Sci 2023 Mar 15;24(6) PMID: 36982722 PMCID: PMC10053311 SCOPUS ID: 2-s2.0-85152016549 03/30/2023 7 Citations

Autologous CD34+ stem cell humanization in head and neck cancer modeling: The translational importance of T cell maturation (Zenga J, Awan MJ, Frei A, Shukla M, Shreenivas A, Wong SJ, Himburg HA) Oral Oncology Reports March 2023;5 SCOPUS ID: 2-s2.0-85181215896 03/01/2023

Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity. (Bansal S, Bansal S, Fish BL, Li Y, Xu X, Fernandez JA, Griffin JH, Himburg HA, Boerma M, Medhora M, Cheema AK) Int J Radiat Biol 2023;99(7):1109-1118 PMID: 36827630 PMCID: PMC10330346 SCOPUS ID: 2-s2.0-85148957703 02/25/2023 1 Citation

IPW-5371 mitigates the delayed effects of acute radiation exposure in WAG/RijCmcr rats when started 15 days after PBI with bone marrow sparing. (Fish BL, Hart B, Gasperetti T, Narayanan J, Gao F, Veley D, Pierce L, Himburg HA, MacVittie T, Medhora M) Int J Radiat Biol 2023;99(7):1119-1129 PMID: 36794325 PMCID: PMC10330589 SCOPUS ID: 2-s2.0-85148532473 02/17/2023 7 Citations

Cord Blood-Derived Endothelial Progenitor Cells Promote In Vivo Regeneration of Human Hematopoietic Bone Marrow. (Doan PL, Frei AC, Piryani SO, Szalewski N, Fan E, Himburg HA) Int J Radiat Oncol Biol Phys 2023 Aug 01;116(5):1163-1174 PMID: 36792018 PMCID: PMC11086728 SCOPUS ID: 2-s2.0-85150303948 02/16/2023 7 Citations

Delayed renal injury in survivors of hematologic acute radiation syndrome. (Gasperetti T, Frei A, Prasad Sharma G, Pierce L, Veley D, Szalewski N, Munjal Mehta S, Fish BL, Pleimes D, Himburg HA) Int J Radiat Biol 2023;99(7):1130-1138 PMID: 36688956 PMCID: PMC10313734 SCOPUS ID: 2-s2.0-85147298374 01/24/2023 4 Citations

Autologous CD34+ stem cell humanization in head and neck cancer modeling: The translational importance of T cell maturation (Zenga J, Awan MJ, Frei A, Shukla M, Shreenivas A, Wong SJ, Himburg HA) Oral Oncology Reports 2022, 100010. ISSN 2772-9060, https://doi.org/10.1016/j.oor.2022.100010. 12/30/2022

Organ-Specific Endothelial Dysfunction Following Total Body Irradiation Exposure. (Sharma GP, Himburg HA) Toxics 2022 Dec 01;10(12) PMID: 36548580 PMCID: PMC9781710 SCOPUS ID: 2-s2.0-85144737806 12/23/2022 8 Citations

Mitigation of Multi-Organ Radiation Injury with ACE2 Agonist Diminazene Aceturate. (Gasperetti T, Sharma GP, Frei AC, Pierce L, Veley D, Szalewski N, Narayanan J, Fish BL, Himburg HA) Radiat Res 2022 Oct 01;198(4):325-335 PMID: 35904437 PMCID: PMC9641750 SCOPUS ID: 2-s2.0-85139804264 07/30/2022 8 Citations

Chronic stress promotes an immunologic inflammatory state and head and neck cancer growth in a humanized murine model. (Zenga J, Awan MJ, Frei A, Petrie E, Sharma GP, Shreenivas A, Shukla M, Himburg HA) Head Neck 2022 Jun;44(6):1324-1334 PMID: 35261119 PMCID: PMC9081149 SCOPUS ID: 2-s2.0-85125920861 03/10/2022 7 Citations

Pharmacologic ACE-Inhibition Mitigates Radiation-Induced Pneumonitis by Suppressing ACE-Expressing Lung Myeloid Cells. (Sharma GP, Fish BL, Frei AC, Narayanan J, Gasperetti T, Scholler D, Pierce L, Szalewski N, Blue N, Medhora M, Himburg HA) Int J Radiat Oncol Biol Phys 2022 May 01;113(1):177-191 PMID: 35093482 PMCID: PMC9018504 SCOPUS ID: 2-s2.0-85125928392 01/31/2022 27 Citations

Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution. (Termini CM, Pang A, Fang T, Roos M, Chang VY, Zhang Y, Setiawan NJ, Signaevskaia L, Li M, Kim MM, Tabibi O, Lin PK, Sasine JP, Chatterjee A, Murali R, Himburg HA, Chute JP) Nat Commun 2021 Nov 30;12(1):6990 PMID: 34848712 PMCID: PMC8635308 SCOPUS ID: 2-s2.0-85120176028 12/02/2021 38 Citations

Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells. (Sharma GP, Frei AC, Narayanan J, Gasperetti T, Veley D, Amjad A, Albano K, Fish BL, Himburg HA) PLoS One 2021;16(10):e0259042 PMID: 34695155 PMCID: PMC8544859 SCOPUS ID: 2-s2.0-85117930366 10/26/2021 14 Citations

Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation. (Fish BL, MacVittie TJ, Gao F, Narayanan J, Gasperetti T, Scholler D, Sheinin Y, Himburg HA, Hart B, Medhora M) Health Phys 2021 Oct 01;121(4):419-433 PMID: 34546222 PMCID: PMC8577554 SCOPUS ID: 2-s2.0-85117425987 09/22/2021 35 Citations

Epidermal growth factor receptor-dependent DNA repair promotes murine and human hematopoietic regeneration. (Fang T, Zhang Y, Chang VY, Roos M, Termini CM, Signaevskaia L, Quarmyne M, Lin PK, Pang A, Kan J, Yan X, Javier A, Pohl K, Zhao L, Scott P, Himburg HA, Chute JP) Blood 2020 Jul 23;136(4):441-454 PMID: 32369572 PMCID: PMC7378456 SCOPUS ID: 2-s2.0-85088499146 05/06/2020 22 Citations

Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling. (Himburg HA, Roos M, Fang T, Zhang Y, Termini CM, Schlussel L, Kim M, Pang A, Kan J, Zhao L, Suh H, Sasine JP, Sapparapu G, Bowers PM, Schiller G, Chute JP) J Clin Invest 2020 Jan 02;130(1):315-328 PMID: 31613796 PMCID: PMC6934217 SCOPUS ID: 2-s2.0-85077404546 10/16/2019 12 Citations

PTPσ inhibitors promote hematopoietic stem cell regeneration. (Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP) Nat Commun 2019 Aug 14;10(1):3667 PMID: 31413255 PMCID: PMC6694155 SCOPUS ID: 2-s2.0-85070740613 08/16/2019 29 Citations

Dickkopf-1 Treatment Stimulates Hematopoietic Regenerative Function in Infused Endothelial Progenitor Cells. (Kim MM, Schlussel L, Zhao L, Himburg HA) Radiat Res 2019 Jul;192(1):53-62 PMID: 31081743 PMCID: PMC6668624 SCOPUS ID: 2-s2.0-85068359875 05/14/2019 11 Citations

Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration. (Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP) Cell Stem Cell 2018 Sep 06;23(3):370-381.e5 PMID: 30100167 PMCID: PMC6482945 SCOPUS ID: 2-s2.0-85056484773 08/14/2018 116 Citations

Wild-type Kras expands and exhausts hematopoietic stem cells. (Sasine JP, Himburg HA, Termini CM, Roos M, Tran E, Zhao L, Kan J, Li M, Zhang Y, de Barros SC, Rao DS, Counter CM, Chute JP) JCI Insight 2018 Jun 07;3(11) PMID: 29875320 PMCID: PMC6124423 SCOPUS ID: 2-s2.0-85056627323 06/08/2018 17 Citations

Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. (Himburg HA, Doan PL, Quarmyne M, Yan X, Sasine J, Zhao L, Hancock GV, Kan J, Pohl KA, Tran E, Chao NJ, Harris JR, Chute JP) Nat Med 2017 Jan;23(1):91-99 PMID: 27918563 PMCID: PMC5592969 SCOPUS ID: 2-s2.0-85001889482 12/06/2016 71 Citations

Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. (Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP) Cell Rep 2016 Nov 01;17(6):1584-1594 PMID: 27806297 PMCID: PMC5963255 SCOPUS ID: 2-s2.0-84995621461 11/03/2016 22 Citations

Discussion: "Comparison of Statistical Methods for Assessing Spatial Correlations Between Maps of Different Arterial Properties" (Rowland, E. M., Mohamied, Y., Chooi, K. Y., Bailey, E. L., and Weinberg, P. D., 2015, ASME J. Biomech. Eng., 137(10), p. 101003): An Alternative Approach Using Segmentation Based on Local Hemodynamics. (Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Friedman MH) J Biomech Eng 2016 Sep 01;138(9):0955011-2 PMID: 27437909 PMCID: PMC4993249 SCOPUS ID: 2-s2.0-85009400030 07/21/2016

A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation. (Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP) Radiat Res 2016 Aug;186(2):141-52 PMID: 27387861 PMCID: PMC6016841 SCOPUS ID: 2-s2.0-84982263977 07/09/2016 29 Citations

Ionizing Radiation: Toxicologic Action (Himburg HA, Chute JP) Mammalian Toxicology 27 March 2015:309-321 SCOPUS ID: 2-s2.0-84976562539 03/27/2015

Mammalian Toxicology Chapter 15: Ionizing Radiation: Toxicologic Action (Himburg HA, Chute JP Editor: Abou‐Donia Mohamed B.) 02/27/2015

Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. (Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, Diehl AM) Gut 2016 Apr;65(4):683-92 PMID: 25596181 PMCID: PMC4504836 SCOPUS ID: 2-s2.0-84929919170 01/18/2015 30 Citations

Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. (Quarmyne M, Doan PL, Himburg HA, Yan X, Nakamura M, Zhao L, Chao NJ, Chute JP) J Clin Invest 2015 Jan;125(1):177-82 PMID: 25415437 PMCID: PMC4382260 SCOPUS ID: 2-s2.0-84920461717 11/22/2014 22 Citations

A translatable predictor of human radiation exposure. (Lucas J, Dressman HK, Suchindran S, Nakamura M, Chao NJ, Himburg H, Minor K, Phillips G, Ross J, Abedi M, Terbrueggen R, Chute JP) PLoS One 2014;9(9):e107897 PMID: 25255453 PMCID: PMC4177872 SCOPUS ID: 2-s2.0-84907588604 09/26/2014 47 Citations

Pleiotrophin mediates hematopoietic regeneration via activation of RAS. (Himburg HA, Yan X, Doan PL, Quarmyne M, Micewicz E, McBride W, Chao NJ, Slamon DJ, Chute JP) J Clin Invest 2014 Nov;124(11):4753-8 PMID: 25250571 PMCID: PMC4347246 SCOPUS ID: 2-s2.0-84908636760 09/25/2014 48 Citations

Imatinib tackles lymphoma via the PDGFRβ+ pericyte. (Chute JP, Himburg HA) Blood 2013 Jun 27;121(26):5107-8 PMID: 23813934 SCOPUS ID: 2-s2.0-84884171117 07/03/2013 9 Citations

Epidermal growth factor regulates hematopoietic regeneration after radiation injury. (Doan PL, Himburg HA, Helms K, Russell JL, Fixsen E, Quarmyne M, Harris JR, Deoliviera D, Sullivan JM, Chao NJ, Kirsch DG, Chute JP) Nat Med 2013 Mar;19(3):295-304 PMID: 23377280 PMCID: PMC3594347 SCOPUS ID: 2-s2.0-84875228640 02/05/2013 154 Citations

Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche (Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP) Cell Reports 27 December 2012;2(6):1774 SCOPUS ID: 2-s2.0-84871699237 12/27/2012 31 Citations

Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. (Doan PL, Russell JL, Himburg HA, Helms K, Harris JR, Lucas J, Holshausen KC, Meadows SK, Daher P, Jeffords LB, Chao NJ, Kirsch DG, Chute JP) Stem Cells 2013 Feb;31(2):327-37 PMID: 23132593 PMCID: PMC3580267 SCOPUS ID: 2-s2.0-84874327921 11/08/2012 67 Citations

Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. (Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP) Cell Rep 2012 Oct 25;2(4):964-75 PMID: 23084748 PMCID: PMC3696585 SCOPUS ID: 2-s2.0-84868107930 10/23/2012 93 Citations

Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. (Meadows SK, Dressman HK, Daher P, Himburg H, Russell JL, Doan P, Chao NJ, Lucas J, Nevins JR, Chute JP) PLoS One 2010 Jul 12;5(7):e11535 PMID: 20634956 PMCID: PMC2902517 SCOPUS ID: 2-s2.0-77955375162 07/17/2010 52 Citations

Endothelial gene expression in regions of defined shear exposure in the porcine iliac arteries. (LaMack JA, Himburg HA, Zhang J, Friedman MH) Ann Biomed Eng 2010 Jul;38(7):2252-62 PMID: 20387120 SCOPUS ID: 2-s2.0-77954659301 04/14/2010 10 Citations

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. (Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP) Nat Med 2010 Apr;16(4):475-82 PMID: 20305662 PMCID: PMC3689427 SCOPUS ID: 2-s2.0-77950543499 03/23/2010 245 Citations

Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. (Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP) Stem Cells 2010 Mar 31;28(3):523-34 PMID: 20054864 PMCID: PMC3909217 SCOPUS ID: 2-s2.0-77950589175 01/08/2010 64 Citations

Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. (Salter AB, Meadows SK, Muramoto GG, Himburg H, Doan P, Daher P, Russell L, Chen B, Chao NJ, Chute JP) Blood 2009 Feb 26;113(9):2104-7 PMID: 19141867 PMCID: PMC2651019 SCOPUS ID: 2-s2.0-61849092556 01/15/2009 135 Citations

Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. (Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP) Mol Endocrinol 2009 Feb;23(2):188-201 PMID: 19106195 PMCID: PMC2646618 SCOPUS ID: 2-s2.0-58849113213 12/25/2008 24 Citations

Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. (Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg GS, Chao NJ, Nevins JR, Chute JP) PLoS One 2008 Apr 02;3(4):e1912 PMID: 18382685 PMCID: PMC2271127 SCOPUS ID: 2-s2.0-44849110695 04/03/2008 107 Citations

Distinct profiles of endothelial gene expression in hyperpermeable regions of the porcine aortic arch and thoracic aorta. (LaMack JA, Himburg HA, Friedman MH) Atherosclerosis 2007 Dec;195(2):e35-41 PMID: 17588585 PMCID: PMC2683674 SCOPUS ID: 2-s2.0-36049003109 06/26/2007 11 Citations

Frequency-dependent response of the vascular endothelium to pulsatile shear stress. (Himburg HA, Dowd SE, Friedman MH) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H645-53 PMID: 17322417 SCOPUS ID: 2-s2.0-34547148984 02/27/2007 119 Citations

Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo. (Friedman MH, Himburg HA, LaMack JA) J Biomech Eng 2006 Dec;128(6):965-8 PMID: 17154699 SCOPUS ID: 2-s2.0-33846424238 12/13/2006 6 Citations

Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. (Himburg HA, Friedman MH) J Biomech Eng 2006 Dec;128(6):852-6 PMID: 17154685 SCOPUS ID: 2-s2.0-33846443970 12/13/2006 35 Citations

Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. (Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, Himburg HA, Chao NJ) Blood 2007 Mar 15;109(6):2365-72 PMID: 17095624 PMCID: PMC1852197 SCOPUS ID: 2-s2.0-33947265398 11/11/2006 87 Citations

The effect of waveform frequency and amplitude on vascular endothelial gene expresssion (Himburg HA, Friedman MH) Proceedings of the 2005 Summer Bioengineering Conference 2005;2005:327-328 SCOPUS ID: 2-s2.0-33646570860 12/01/2005

A CFD-based method to evaluate the effect of shear stress on endothelial gene expression in vivo (Himburg HA, Lamack JA, Friedman MH) Proceedings of the 2005 Summer Bioengineering Conference 2005;2005:1392-1393 SCOPUS ID: 2-s2.0-33646546929 12/01/2005

Effect of hypercholesterolemia on transendothelial EBD-albumin permeability and lipid accumulation in porcine iliac arteries. (Lamack JA, Himburg HA, Friedman MH) Atherosclerosis 2006 Feb;184(2):255-63 PMID: 15935354 SCOPUS ID: 2-s2.0-30044439227 06/07/2005 10 Citations

Interaction of wall shear stress magnitude and gradient in the prediction of arterial macromolecular permeability. (LaMack JA, Himburg HA, Li XM, Friedman MH) Ann Biomed Eng 2005 Apr;33(4):457-64 PMID: 15909651 SCOPUS ID: 2-s2.0-18244382054 05/25/2005 41 Citations

Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability. (Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Li XM, Friedman MH) Am J Physiol Heart Circ Physiol 2004 May;286(5):H1916-22 PMID: 14715506 SCOPUS ID: 2-s2.0-1942533437 01/13/2004 515 Citations

Model-based shear stress gradient in realistic vascular flows and its relation to arterial macromolecular permeability (LaMack JA, Himburg HA, Li XM, Friedman MH) American Society of Mechanical Engineers Bioengineering Division Publication BED 2003;55:89-90 SCOPUS ID: 2-s2.0-1842457052 01/01/2003

Last update: 03/05/2026

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Heather A. Himburg PhD

Professor

Publications (78)