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Jeffrey A. Medin PhD

Jeffrey A. Medin PhD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology and Oncology - Pediatrics
Program: Oncology

Member of the Cancer Center


Publications

  • Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system. (Nomura R, Sato T, Sato Y, Medin JA, Kushimoto S, Yanagisawa T) Redox Biol 2017 Oct;13:407-417 PMID: 28683400 PMCID: PMC5498287 07/07/2017
  • Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease. (Huang J, Khan A, Au BC, Barber DL, López-Vásquez L, Prokopishyn NL, Boutin M, Rothe M, Rip JW, Abaoui M, Nagree MS, Dworski S, Schambach A, Keating A, West ML, Klassen J, Turner PV, Sirrs S, Rupar CA, Auray-Blais C, Foley R, Medin JA) Mol Ther Methods Clin Dev 2017 Jun 16;5:241-258 PMID: 28603745 PMCID: PMC5453867 06/13/2017
  • Practical considerations for chimeric antigen receptor design and delivery. (Oldham RAA, Medin JA) Expert Opin Biol Ther 2017 Aug;17(8):961-978 PMID: 28586264 06/07/2017
  • Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. (Sikora J, Dworski S, Jones EE, Kamani MA, Micsenyi MC, Sawada T, Le Faouder P, Bertrand-Michel J, Dupuy A, Dunn CK, Xuan ICY, Casas J, Fabrias G, Hampson DR, Levade T, Drake RR, Medin JA, Walkley SU) Am J Pathol 2017 Apr;187(4):864-883 PMID: 28342444 PMCID: PMC5397689 03/28/2017
  • Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice. (He X, Dworski S, Zhu C, DeAngelis V, Solyom A, Medin JA, Simonaro CM, Schuchman EH) BBA Clin 2017 Jun;7:85-96 PMID: 28275553 PMCID: PMC5338723 03/10/2017
  • Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion. (Kamani MA, Provençal P, Boutin M, Pacienza N, Fan X, Novak A, Huang TC, Binnington B, Au BC, Auray-Blais C, Lingwood CA, Medin JA) Future Sci OA 2016 Dec;2(4):FSO147 PMID: 28116130 PMCID: PMC5242178 01/25/2017
  • Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML. (Huang J, Liu Y, Au BC, Barber DL, Arruda A, Schambach A, Rothe M, Minden MD, Paige CJ, Medin JA) Mol Ther Methods Clin Dev 2016;3:16074 PMID: 27933304 PMCID: PMC5142463 12/10/2016
  • Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy. (Dworski S, Lu P, Khan A, Maranda B, Mitchell JJ, Parini R, Di Rocco M, Hugle B, Yoshimitsu M, Magnusson B, Makay B, Arslan N, Guelbert N, Ehlert K, Jarisch A, Gardner-Medwin J, Dagher R, Terreri MT, Lorenco CM, Barillas-Arias L, Tanpaiboon P, Solyom A, Norris JS, He X, Schuchman EH, Levade T, Medin JA) Biochim Biophys Acta 2017 Feb;1863(2):386-394 PMID: 27915031 12/05/2016
  • Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues. (Desnick RJ, Barton NW, Furbish S, Grabowski GA, Karlsson S, Kolodny EH, Medin JA, Murray GJ, Mistry PK, Patterson MC, Schiffmann R, Weinreb NJ) Mol Genet Metab 2017 Jan - Feb;120(1-2):1-7 PMID: 27866832 11/22/2016
  • Roscoe Owen Brady: Passion for patients. (Medin JA) Proc Natl Acad Sci U S A 2016 Oct 18;113(42):11644-11645 PMID: 27791045 PMCID: PMC5081591 10/30/2016
  • Development of Novel Immunotherapies for Multiple Myeloma. (Al-Hujaily EM, Oldham RA, Hari P, Medin JA) Int J Mol Sci 2016 Sep 08;17(9) PMID: 27618026 PMCID: PMC5037783 09/13/2016
  • Relative distribution of Gb3 isoforms/analogs in NOD/SCID/Fabry mice tissues determined by tandem mass spectrometry. (Provençal P, Boutin M, Dworski S, Au B, Medin JA, Auray-Blais C) Bioanalysis 2016 Sep;8(17):1793-807 PMID: 27523577 PMCID: PMC4992964 08/16/2016
  • Engineering Hematopoietic Cells for Cancer Immunotherapy: Strategies to Address Safety and Toxicity Concerns. (Resetca D, Neschadim A, Medin JA) J Immunother 2016 Sep;39(7):249-59 PMID: 27488725 08/05/2016
  • Direct Lymph Node Vaccination of Lentivector/Prostate-Specific Antigen is Safe and Generates Tissue-Specific Responses in Rhesus Macaques. (Au BC, Lee CJ, Lopez-Perez O, Foltz W, Felizardo TC, Wang JCM, Huang J, Fan X, Madden M, Goldstein A, Jaffray DA, Moloo B, McCart JA, Medin JA) Biomedicines 2016 Feb 19;4(1) PMID: 28536373 PMCID: PMC5344243 02/19/2016
  • Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy. (Nagree MS, López-Vásquez L, Medin JA) World J Stem Cells 2015 Dec 26;7(11):1233-50 PMID: 26730268 PMCID: PMC4691692 01/06/2016
  • Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis. (Sato T, Neschadim A, Nakagawa R, Yanagisawa T, Medin JA) Methods Mol Biol 2015;1317:55-67 PMID: 26072401 06/15/2015
  • Lentiviral vectors in cancer immunotherapy. (Oldham RA, Berinstein EM, Medin JA) Immunotherapy 2015;7(3):271-84 PMID: 25804479 03/26/2015
  • Markedly perturbed hematopoiesis in acid ceramidase deficient mice. (Dworski S, Berger A, Furlonger C, Moreau JM, Yoshimitsu M, Trentadue J, Au BC, Paige CJ, Medin JA) Haematologica 2015 May;100(5):e162-5 PMID: 25682603 PMCID: PMC4420221 02/16/2015
  • Advances in haplo-identical stem cell transplantation in adults with high-risk hematological malignancies. (Ricci MJ, Medin JA, Foley RS) World J Stem Cells 2014 Sep 26;6(4):380-90 PMID: 25258660 PMCID: PMC4172667 09/27/2014
  • Murine splenic CD4⁺ T cells, induced by innate immune cell interactions and secreted factors, develop antileukemia cytotoxicity. (Nelles ME, Moreau JM, Furlonger CL, Berger A, Medin JA, Paige CJ) Cancer Immunol Res 2014 Nov;2(11):1113-24 PMID: 25154710 08/27/2014
  • On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. (Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR) Anal Chem 2014 Aug 19;86(16):8303-11 PMID: 25072097 PMCID: PMC4139181 07/30/2014
  • Localized interleukin-12 delivery for immunotherapy of solid tumours. (Wei LZ, Xu Y, Nelles EM, Furlonger C, Wang JC, Di Grappa MA, Khokha R, Medin JA, Paige CJ) J Cell Mol Med 2013 Nov;17(11):1465-74 PMID: 24251770 PMCID: PMC4117559 11/21/2013
  • The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer. (Sato T, Neschadim A, Lavie A, Yanagisawa T, Medin JA) PLoS One 2013;8(10):e78711 PMID: 24194950 PMCID: PMC3806853 11/07/2013
  • Engineering lentiviral vectors for modulation of dendritic cell apoptotic pathways. (Wang JC, Felizardo TC, Au BC, Fowler DH, Dekaban GA, Medin JA) Virol J 2013 Jul 20;10:240 PMID: 23870437 PMCID: PMC3723442 07/23/2013
  • Systemic ceramide accumulation leads to severe and varied pathological consequences. (Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA) EMBO Mol Med 2013 Jun;5(6):827-42 PMID: 23681708 PMCID: PMC3779446 05/18/2013
  • Harnessing autophagy for cell fate control gene therapy. (Felizardo TC, Foley J, Steed K, Dropulic B, Amarnath S, Medin JA, Fowler DH) Autophagy 2013 Jul;9(7):1069-79 PMID: 23633667 PMCID: PMC3722316 05/02/2013
  • Lentivirus IL-10 gene therapy down-regulates IL-17 and attenuates mouse orthotopic lung allograft rejection. (Hirayama S, Sato M, Loisel-Meyer S, Matsuda Y, Oishi H, Guan Z, Saito T, Yeung J, Cypel M, Hwang DM, Medin JA, Liu M, Keshavjee S) Am J Transplant 2013 Jun;13(6):1586-93 PMID: 23601206 04/23/2013
  • Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity. (Payne NL, Sun G, McDonald C, Moussa L, Emerson-Webber A, Loisel-Meyer S, Medin JA, Siatskas C, Bernard CC) Brain Behav Immun 2013 May;30:103-14 PMID: 23369732 02/02/2013
  • Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia. (Sun Z, Lee CJ, Mejia-Guerrero S, Zhang Y, Higuchi K, Li RK, Medin JA) Hum Gene Ther 2012 Dec;23(12):1280-9 PMID: 22998370 09/25/2012
  • Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer. (Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T) Mol Cell Proteomics 2012 Dec;11(12):1870-84 PMID: 22986220 PMCID: PMC3518113 09/19/2012
  • Lentivector transduction improves outcomes over transplantation of human HSCs alone in NOD/SCID/Fabry mice. (Pacienza N, Yoshimitsu M, Mizue N, Au BC, Wang JC, Fan X, Takenaka T, Medin JA) Mol Ther 2012 Jul;20(7):1454-61 PMID: 22472949 PMCID: PMC3393855 04/05/2012
  • Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer. (Neschadim A, Wang JC, Lavie A, Medin JA) Cancer Gene Ther 2012 May;19(5):320-7 PMID: 22388453 03/06/2012
  • Identification of prostate-enriched proteins by in-depth proteomic analyses of expressed prostatic secretions in urine. (Principe S, Kim Y, Fontana S, Ignatchenko V, Nyalwidhe JO, Lance RS, Troyer DA, Alessandro R, Semmes OJ, Kislinger T, Drake RR, Medin JA) J Proteome Res 2012 Apr 06;11(4):2386-96 PMID: 22339264 PMCID: PMC3642074 02/22/2012
  • Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase. (Neschadim A, Wang JC, Sato T, Fowler DH, Lavie A, Medin JA) Mol Ther 2012 May;20(5):1002-13 PMID: 22273576 PMCID: PMC3345984 01/26/2012
  • Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model. (Swift BE, Williams BA, Kosaka Y, Wang XH, Medin JA, Viswanathan S, Martinez-Lopez J, Keating A) Haematologica 2012 Jul;97(7):1020-8 PMID: 22271890 PMCID: PMC3396673 01/25/2012
  • Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes. (Scaife M, Pacienza N, Au BC, Wang JC, Devine S, Scheid E, Lee CJ, Lopez-Perez O, Neschadim A, Fowler DH, Foley R, Medin JA) Gene Ther 2013 Jan;20(1):24-34 PMID: 22241175 01/14/2012
  • The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. (Amarnath S, Mangus CW, Wang JC, Wei F, He A, Kapoor V, Foley JE, Massey PR, Felizardo TC, Riley JL, Levine BL, June CH, Medin JA, Fowler DH) Sci Transl Med 2011 Nov 30;3(111):111ra120 PMID: 22133721 PMCID: PMC3235958 12/03/2011
  • Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro. (Berthod F, Symes J, Tremblay N, Medin JA, Auger FA) J Cell Physiol 2012 May;227(5):2130-7 PMID: 21769871 07/20/2011
  • Local long-term expression of lentivirally delivered IL-10 in the lung attenuates obliteration of intrapulmonary allograft airways. (Hirayama S, Sato M, Liu M, Loisel-Meyer S, Yeung JC, Wagnetz D, Cypel M, Zehong G, Medin JA, Keshavjee S) Hum Gene Ther 2011 Nov;22(11):1453-60 PMID: 21568692 05/17/2011
  • Differential immune responses mediated by adenovirus- and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model. (Felizardo TC, Wang JC, McGray RA, Evelegh C, Spaner DE, Fowler DH, Bramson JL, Medin JA) Gene Ther 2011 Oct;18(10):986-95 PMID: 21490686 04/15/2011
  • A novel tissue-engineered approach to problems of the postpneumonectomy space. (Tsunooka N, Hirayama S, Medin JA, Liles WC, Keshavjee S, Waddell TK) Ann Thorac Surg 2011 Mar;91(3):880-6 PMID: 21353020 03/01/2011
  • Identification of novel mutations in the α-galactosidase A gene in patients with Fabry disease: pitfalls of mutation analyses in patients with low α-galactosidase A activity. (Yoshimitsu M, Higuchi K, Miyata M, Devine S, Mattman A, Sirrs S, Medin JA, Tei C, Takenaka T) J Cardiol 2011 May;57(3):345-53 PMID: 21333496 02/22/2011
  • Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells. (Siegers GM, Dhamko H, Wang XH, Mathieson AM, Kosaka Y, Felizardo TC, Medin JA, Tohda S, Schueler J, Fisch P, Keating A) Cytotherapy 2011 Jul;13(6):753-64 PMID: 21314241 02/15/2011
  • Anti-leukemia activity of in vitro-expanded human gamma delta T cells in a xenogeneic Ph+ leukemia model. (Siegers GM, Felizardo TC, Mathieson AM, Kosaka Y, Wang XH, Medin JA, Keating A) PLoS One 2011 Feb 03;6(2):e16700 PMID: 21304898 PMCID: PMC3033392 02/10/2011
  • Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates. (Walia JS, Neschadim A, Lopez-Perez O, Alayoubi A, Fan X, Carpentier S, Madden M, Lee CJ, Cheung F, Jaffray DA, Levade T, McCart JA, Medin JA) Hum Gene Ther 2011 Jun;22(6):679-87 PMID: 21280983 PMCID: PMC3155125 02/02/2011
  • Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production. (Wang AY, Crome SQ, Jenkins KM, Medin JA, Bramson JL, Levings MK) Cancer Immunol Immunother 2011 Mar;60(3):381-8 PMID: 21153637 12/15/2010
  • Mesenchymal stromal cells expressing ErbB-2/neu elicit protective antibreast tumor immunity in vivo, which is paradoxically suppressed by IFN-gamma and tumor necrosis factor-alpha priming. (Romieu-Mourez R, François M, Abate A, Boivin MN, Birman E, Bailey D, Bramson JL, Forner K, Young YK, Medin JA, Galipeau J) Cancer Res 2010 Oct 15;70(20):7742-7 PMID: 20924101 10/07/2010
  • Promoter-specific lentivectors for long-term, cardiac-directed therapy of Fabry disease. (Lee CJ, Fan X, Guo X, Medin JA) J Cardiol 2011 Jan;57(1):115-22 PMID: 20846825 09/18/2010
  • A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs. (Likar Y, Zurita J, Dobrenkov K, Shenker L, Cai S, Neschadim A, Medin JA, Sadelain M, Hricak H, Ponomarev V) J Nucl Med 2010 Sep;51(9):1395-403 PMID: 20810757 PMCID: PMC4405132 09/03/2010
  • Alpha-galactosidase A-Tat fusion enhances storage reduction in hearts and kidneys of Fabry mice. (Higuchi K, Yoshimitsu M, Fan X, Guo X, Rasaiah VI, Yen J, Tei C, Takenaka T, Medin JA) Mol Med 2010 May-Jun;16(5-6):216-21 PMID: 20454522 PMCID: PMC2864812 05/11/2010
  • In-depth proteomic analyses of direct expressed prostatic secretions. (Drake RR, Elschenbroich S, Lopez-Perez O, Kim Y, Ignatchenko V, Ignatchenko A, Nyalwidhe JO, Basu G, Wilkins CE, Gjurich B, Lance RS, Semmes OJ, Medin JA, Kislinger T) J Proteome Res 2010 May 07;9(5):2109-16 PMID: 20334419 PMCID: PMC2869496 03/26/2010
  • Induction of human blood group a antigen expression on mouse cells, using lentiviral gene transduction. (Fan X, Lang H, Zhou X, Zhang L, Yin R, Maciejko J, Giannitsos V, Motyka B, Medin JA, Platt JL, West LJ) Hum Gene Ther 2010 Jul;21(7):877-90 PMID: 20163247 PMCID: PMC2938359 02/19/2010
  • Sequencing and characterization of the porcine α-galactosidase A gene: towards the generation of a porcine model for Fabry disease. (Yoshimitsu M, Higuchi K, Fan X, Takao S, Medin JA, Tei C, Takenaka T) Mol Biol Rep 2011 Jun;38(5):3145-52 PMID: 20131008 02/05/2010
  • Isolation of cell surface proteins for mass spectrometry-based proteomics. (Elschenbroich S, Kim Y, Medin JA, Kislinger T) Expert Rev Proteomics 2010 Feb;7(1):141-54 PMID: 20121483 02/04/2010
  • Comparative impact of trastuzumab and cyclophosphamide on HER-2-positive human breast cancer xenografts. (Francia G, Man S, Lee CJ, Lee CR, Xu P, Mossoba ME, Emmenegger U, Medin JA, Kerbel RS) Clin Cancer Res 2009 Oct 15;15(20):6358-66 PMID: 19825954 PMCID: PMC2788792 10/15/2009
  • Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection. (Sato T, Ramsubir S, Higuchi K, Yanagisawa T, Medin JA) J Cardiol 2009 Oct;54(2):245-54 PMID: 19782262 09/29/2009
  • Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. (Silvertown JD, Neschadim A, Liu HN, Shannon P, Walia JS, Kao JC, Robertson J, Summerlee AJ, Medin JA) Regul Pept 2010 Jan 08;159(1-3):44-53 PMID: 19778557 09/26/2009
  • Survival and cardiac remodeling after myocardial infarction are critically dependent on the host innate immune interleukin-1 receptor-associated kinase-4 signaling: a regulator of bone marrow-derived dendritic cells. (Maekawa Y, Mizue N, Chan A, Shi Y, Liu Y, Dawood S, Chen M, Dawood F, de Couto G, Li GH, Suzuki N, Yeh WC, Gramolini A, Medin JA, Liu PP) Circulation 2009 Oct 06;120(14):1401-14 PMID: 19770394 09/23/2009
  • Novel application of lentiviral vectors towards treatment of graft-versus-host disease. (Scaife MD, Neschadim A, Fowler DH, Medin JA) Expert Opin Biol Ther 2009 Jun;9(6):749-61 PMID: 19456209 05/22/2009
  • Potent induction of B- and T-cell immunity against human carcinoembryonic antigen-expressing tumors in human carcinoembryonic antigen transgenic mice mediated by direct lentivector injection. (Loisel-Meyer S, Felizardo T, Mariotti J, Mossoba ME, Foley JE, Kammerer R, Mizue N, Keefe R, McCart JA, Zimmermann W, Dropulic B, Fowler DH, Medin JA) Mol Cancer Ther 2009 Mar;8(3):692-702 PMID: 19276164 PMCID: PMC2846382 03/12/2009
  • Multidimensional protein identification technology analysis highlights mitoxantrone-induced expression modulations in the primary prostate cancer cell proteome. (Symes J, Evangelou A, Ignatchenko A, Fleshner N, Kislinger T, Medin JA) Proteomics Clin Appl 2009 Mar;3(3):347-58 PMID: 26238752 03/01/2009
  • Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells. (Symes JC, Siatskas C, Fowler DH, Medin JA) Cancer Gene Ther 2009 May;16(5):439-52 PMID: 19096446 PMCID: PMC2857530 12/20/2008
  • Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction. (Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA) Mol Ther 2009 Feb;17(2):262-8 PMID: 19002160 PMCID: PMC2835055 11/13/2008
  • Long-term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using beta-human choriogonadotropin secreting tumor cell lines. (Francia G, Emmenegger U, Lee CR, Shaked Y, Folkins C, Mossoba M, Medin JA, Man S, Zhu Z, Witte L, Kerbel RS) Mol Cancer Ther 2008 Oct;7(10):3452-9 PMID: 18852148 10/15/2008
  • In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease. (Ramsubir S, Nonaka T, Girbés CB, Carpentier S, Levade T, Medin JA) Mol Genet Metab 2008 Nov;95(3):133-41 PMID: 18805722 PMCID: PMC2614354 09/23/2008
  • Fas-mediated killing of primary prostate cancer cells is increased by mitoxantrone and docetaxel. (Symes JC, Kurin M, Fleshner NE, Medin JA) Mol Cancer Ther 2008 Sep;7(9):3018-28 PMID: 18790782 09/16/2008
  • IL-10 secretion increases signal persistence of HEMA-MMA-microencapsulated luciferase-modified CHO fibroblasts in mice. (Surzyn M, Symes J, Medin JA, Sefton MV) Tissue Eng Part A 2009 Jan;15(1):127-36 PMID: 18710337 08/20/2008
  • Transduction and transplantation of spermatogonia into the testis of ram lambs through the extra-testicular rete. (Rodriguez-Sosa JR, Silvertown JD, Foster RA, Medin JA, Hahnel A) Reprod Domest Anim 2009 Aug;44(4):612-20 PMID: 18694428 08/13/2008
  • IL-12 immunotherapy of murine leukaemia: comparison of systemic versus gene modified cell therapy. (Labbe A, Nelles M, Walia J, Jia L, Furlonger C, Nonaka T, Medin JA, Paige CJ) J Cell Mol Med 2009 Aug;13(8B):1962-76 PMID: 18624776 07/16/2008
  • Immuno-gene therapy approaches for cancer: from in vitro studies to clinical trials. (Loisel-Meyer S, Foley R, Medin JA) Front Biosci 2008 May 01;13:3202-14 PMID: 18508428 05/30/2008
  • Implementation of high-throughput screening for Fabry disease in Toronto dialysis patients. (Rasaiah VI, Underwood JP, Oreopoulos DG, Medin JA) NDT Plus 2008 Apr;1(2):129-130 PMID: 28657021 PMCID: PMC5477914 04/01/2008
  • Tumor protection following vaccination with low doses of lentivirally transduced DCs expressing the self-antigen erbB2. (Mossoba ME, Walia JS, Rasaiah VI, Buxhoeveden N, Head R, Ying C, Foley JE, Bramson JL, Fowler DH, Medin JA) Mol Ther 2008 Mar;16(3):607-17 PMID: 18180774 01/09/2008
  • A roadmap to safe, efficient, and stable lentivirus-mediated gene therapy with hematopoietic cell transplantation. (Neschadim A, McCart JA, Keating A, Medin JA) Biol Blood Marrow Transplant 2007 Dec;13(12):1407-16 PMID: 18022569 11/21/2007
  • Lentivirally Transduced Recipient-derived Dendritic Cells Serve to Ex Vivo Expand Functional FcRγ-sufficient Double-negative Regulatory T Cells. (Thomson CW, Mossoba ME, Siatskas C, Chen W, Sung A, Medin JA, Zhang L) Mol Ther 2007 Apr;15(4):818-824 PMID: 28192704 04/01/2007
  • Anti-CD25 targeted killing of bicistronically transduced cells: a novel safety mechanism against retroviral genotoxicity. (Ramsubir S, Yoshimitsu M, Medin JA) Mol Ther 2007 Jun;15(6):1174-81 PMID: 17387334 03/28/2007
  • Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy. (Sato T, Neschadim A, Konrad M, Fowler DH, Lavie A, Medin JA) Mol Ther 2007 May;15(5):962-70 PMID: 17375075 03/22/2007
  • Lentiviral vectors for gene therapy of heart disease. (Higuchi K, Medin JA) J Cardiol 2007 Jan;49(1):1-11 PMID: 17269208 02/03/2007
  • Lentivirally transduced recipient-derived dendritic cells serve to ex vivo expand functional FcRgamma-sufficient double-negative regulatory T cells. (Thomson CW, Mossoba ME, Siatskas C, Chen W, Sung A, Medin JA, Zhang L) Mol Ther 2007 Apr;15(4):818-24 PMID: 17264854 02/01/2007
  • Multiple reduced-intensity conditioning regimens facilitate correction of Fabry mice after transplantation of transduced cells. (Liang SB, Yoshimitsu M, Poeppl A, Rasaiah VI, Cai J, Fowler DH, Medin JA) Mol Ther 2007 Mar;15(3):618-27 PMID: 17228315 01/18/2007
  • Analog of H2 relaxin exhibits antagonistic properties and impairs prostate tumor growth. (Silvertown JD, Symes JC, Neschadim A, Nonaka T, Kao JC, Summerlee AJ, Medin JA) FASEB J 2007 Mar;21(3):754-65 PMID: 17197386 01/02/2007
  • Cancer immunotherapy using virally transduced dendritic cells: animal studies and human clinical trials. (Mossoba ME, Medin JA) Expert Rev Vaccines 2006 Oct;5(5):717-32 PMID: 17181444 12/22/2006
  • Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A. (Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA) Circ J 2006 Nov;70(11):1503-8 PMID: 17062978 10/26/2006
  • Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells. (Yoshimitsu M, Higuchi K, Ramsubir S, Nonaka T, Rasaiah VI, Siatskas C, Liang SB, Murray GJ, Brady RO, Medin JA) Gene Ther 2007 Feb;14(3):256-65 PMID: 16929352 08/25/2006
  • Functional expression of mouse relaxin and mouse relaxin-3 in the lung from an Ebola virus glycoprotein-pseudotyped lentivirus via tracheal delivery. (Silvertown JD, Walia JS, Summerlee AJ, Medin JA) Endocrinology 2006 Aug;147(8):3797-808 PMID: 16709614 05/20/2006
  • Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts. (du Manoir JM, Francia G, Man S, Mossoba M, Medin JA, Viloria-Petit A, Hicklin DJ, Emmenegger U, Kerbel RS) Clin Cancer Res 2006 Feb 01;12(3 Pt 1):904-16 PMID: 16467105 02/10/2006
  • Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. (Ayach BB, Yoshimitsu M, Dawood F, Sun M, Arab S, Chen M, Higuchi K, Siatskas C, Lee P, Lim H, Zhang J, Cukerman E, Stanford WL, Medin JA, Liu PP) Proc Natl Acad Sci U S A 2006 Feb 14;103(7):2304-9 PMID: 16467148 PMCID: PMC1413746 02/10/2006
  • Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus. (Lund N, Branch DR, Sakac D, Lingwood CA, Siatskas C, Robinson CJ, Brady RO, Medin JA) AIDS 2005 Sep 23;19(14):1543-6 PMID: 16135910 09/02/2005
  • Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms. (Siatskas C, Underwood J, Ramezani A, Hawley RG, Medin JA) FASEB J 2005 Oct;19(12):1752-4 PMID: 16076962 08/04/2005
  • H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. (Silvertown JD, Ng J, Sato T, Summerlee AJ, Medin JA) Int J Cancer 2006 Jan 01;118(1):62-73 PMID: 16049981 07/29/2005
  • Cloning, sequencing and characterization of lentiviral-mediated expression of rhesus macaque (Macaca mulatta) interleukin-2 receptor alpha cDNA. (Silvertown JD, Walia JS, Medin JA) Dev Comp Immunol 2005;29(11):989-1002 PMID: 15935473 06/07/2005
  • Efficient transfer of PSA and PSMA cDNAs into DCs generates antibody and T cell antitumor responses in vivo. (Medin JA, Liang SB, Hou JW, Kelley LS, Peace DJ, Fowler DH) Cancer Gene Ther 2005 Jun;12(6):540-51 PMID: 15678150 01/29/2005
  • Enhanced filter paper enzyme assay for high-throughput population screening for Fabry disease. (Poeppl AG, Murray GJ, Medin JA) Anal Biochem 2005 Feb 01;337(1):161-3 PMID: 15649390 01/15/2005
  • Bioluminescent imaging of a marking transgene and correction of Fabry mice by neonatal injection of recombinant lentiviral vectors. (Yoshimitsu M, Sato T, Tao K, Walia JS, Rasaiah VI, Sleep GT, Murray GJ, Poeppl AG, Underwood J, West L, Brady RO, Medin JA) Proc Natl Acad Sci U S A 2004 Nov 30;101(48):16909-14 PMID: 15550536 PMCID: PMC534735 11/20/2004
  • Enhanced effect of vascular endothelial growth factor, thrombopoietin peptide agonist, SCF, and Flt3-L on LTC-IC and reporter gene transduction from umbilical cord blood CD34+ cells. (Smith SL, Kiss J, Siatskas C, Medin JA, Moldwin RL) Transfusion 2004 Mar;44(3):438-49 PMID: 14996204 03/05/2004
  • The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs. (Veldman RJ, Mita A, Cuvillier O, Garcia V, Klappe K, Medin JA, Campbell JD, Carpentier S, Kok JW, Levade T) FASEB J 2003 Jun;17(9):1144-6 PMID: 12692077 04/15/2003
  • Post-transduction events in retrovirus-mediated gene therapy involving hematopoietic stem cells: beyond efficiency issues. (Medin JA, Fowler DH) J Cell Biochem Suppl 2002;38:46-54 PMID: 12046849 06/06/2002
  • Gene therapy for Fabry disease. (Siatskas C, Medin JA) J Inherit Metab Dis 2001;24 Suppl 2:25-41; discussion 11-2 PMID: 11758676 01/05/2002
  • Gene transfer in the cardiovascular system: update 2000. (Medin JA, Buttrick PM) Heart Dis 2000 Nov-Dec;2(6):409-21 PMID: 11728292 12/01/2001
  • A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling. (Veldman RJ, Maestre N, Aduib OM, Medin JA, Salvayre R, Levade T) Biochem J 2001 May 01;355(Pt 3):859-68 PMID: 11311151 PMCID: PMC1221804 04/20/2001
  • Preselective gene therapy for Fabry disease. (Qin G, Takenaka T, Telsch K, Kelley L, Howard T, Levade T, Deans R, Howard BH, Malech HL, Brady RO, Medin JA) Proc Natl Acad Sci U S A 2001 Mar 13;98(6):3428-33 PMID: 11248095 PMCID: PMC30670 03/15/2001
  • Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells. (Takenaka T, Murray GJ, Qin G, Quirk JM, Ohshima T, Qasba P, Clark K, Kulkarni AB, Brady RO, Medin JA) Proc Natl Acad Sci U S A 2000 Jun 20;97(13):7515-20 PMID: 10840053 PMCID: PMC16577 06/07/2000
  • Stress-induced apoptosis is not mediated by endolysosomal ceramide. (Ségui B, Bezombes C, Uro-Coste E, Medin JA, Andrieu-Abadie N, Augé N, Brouchet A, Laurent G, Salvayre R, Jaffrézou JP, Levade T) FASEB J 2000 Jan;14(1):36-47 PMID: 10627278 01/08/2000
  • Circulating alpha-galactosidase A derived from transduced bone marrow cells: relevance for corrective gene transfer for Fabry disease. (Takenaka T, Qin G, Brady RO, Medin JA) Hum Gene Ther 1999 Aug 10;10(12):1931-9 PMID: 10466627 08/31/1999
  • Enzymatic and functional correction along with long-term enzyme secretion from transduced bone marrow hematopoietic stem/progenitor and stromal cells derived from patients with Fabry disease. (Takenaka T, Hendrickson CS, Tworek DM, Tudor M, Schiffmann R, Brady RO, Medin JA) Exp Hematol 1999 Jul;27(7):1149-59 PMID: 10390190 07/02/1999
  • Ex vivo expansion and genetic marking of primitive human and baboon hematopoietic cells. (Medin JA, Brandt JE, Rozler E, Nelson M, Bartholomew A, Li C, Turian J, Chute J, Chung T, Hoffman R) Ann N Y Acad Sci 1999 Apr 30;872:233-40; discussion 240-2 PMID: 10372126 06/18/1999
  • Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells. (Medin JA, Takenaka T, Carpentier S, Garcia V, Basile JP, Segui B, Andrieu-Abadie N, Auge N, Salvayre R, Levade T) Hum Gene Ther 1999 May 20;10(8):1321-9 PMID: 10365663 06/12/1999
  • Characterization of the chimeric retinoic acid receptor RARalpha/VDR. (Pemrick SM, Abarzúa P, Kratzeisen C, Marks MS, Medin JA, Ozato K, Grippo JF) Leukemia 1998 Apr;12(4):554-62 PMID: 9557614 04/29/1998
  • Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor. (Nuñez SB, Medin JA, Braissant O, Kemp L, Wahli W, Ozato K, Segars JH) Mol Cell Endocrinol 1997 Mar 14;127(1):27-40 PMID: 9099898 03/14/1997
  • Viral vectors for gene therapy of hematopoietic cells. (Medin JA, Karlsson S) Immunotechnology 1997 Mar;3(1):3-19 PMID: 9154464 03/01/1997
  • Selection of retrovirally transduced cells to enhance the efficiency of gene therapy. (Medin JA, Karlsson S) Proc Assoc Am Physicians 1997 Mar;109(2):111-9 PMID: 9069579 03/01/1997
  • Correction in trans for Fabry disease: expression, secretion and uptake of alpha-galactosidase A in patient-derived cells driven by a high-titer recombinant retroviral vector. (Medin JA, Tudor M, Simovitch R, Quirk JM, Jacobson S, Murray GJ, Brady RO) Proc Natl Acad Sci U S A 1996 Jul 23;93(15):7917-22 PMID: 8755577 PMCID: PMC38849 07/23/1996
  • A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients. (Medin JA, Migita M, Pawliuk R, Jacobson S, Amiri M, Kluepfel-Stahl S, Brady RO, Humphries RK, Karlsson S) Blood 1996 Mar 01;87(5):1754-62 PMID: 8634421 03/01/1996
  • Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors. (Migita M, Medin JA, Pawliuk R, Jacobson S, Nagle JW, Anderson S, Amiri M, Humphries RK, Karlsson S) Proc Natl Acad Sci U S A 1995 Dec 19;92(26):12075-9 PMID: 8618847 PMCID: PMC40299 12/19/1995
  • Transfer of the human glucocerebrosidase gene into hematopoietic stem cells of nonablated recipients: successful engraftment and long-term expression of the transgene. (Schiffmann R, Medin JA, Ward JM, Stahl S, Cottler-Fox M, Karlsson S) Blood 1995 Aug 01;86(3):1218-27 PMID: 7620175 08/01/1995
  • Retinoid X receptor beta and peroxisome proliferator-activated receptor activate an estrogen response element. (Nunez SB, Medin JA, Keller H, Wang K, Ozato K, Wahli W, Segars J) Recent Prog Horm Res 1995;50:409-16 PMID: 7740175 01/01/1995
  • Expression of foreign proteins in Trichoplusia ni larvae. (Medin JA, Gathy K, Coleman MS) Methods Mol Biol 1995;39:265-75 PMID: 7620555 01/01/1995
  • Quantitative increases in DNA binding affinity and positional effects determine 9-cis retinoic acid induced activation of the retinoid X receptor beta homodimer. (Medin JA, Minucci S, Driggers PH, Lee IJ, Ozato K) Mol Cell Endocrinol 1994 Oct;105(1):27-35 PMID: 7821715 10/01/1994
  • Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. (Bovolenta C, Driggers PH, Marks MS, Medin JA, Politis AD, Vogel SN, Levy DE, Sakaguchi K, Appella E, Coligan JE) Proc Natl Acad Sci U S A 1994 May 24;91(11):5046-50 PMID: 8197182 PMCID: PMC43928 05/24/1994
  • Recombinant thyroid hormone receptor and retinoid X receptor stimulate ligand-dependent transcription in vitro. (Lee IJ, Driggers PH, Medin JA, Nikodem VM, Ozato K) Proc Natl Acad Sci U S A 1994 Mar 01;91(5):1647-51 PMID: 8127860 PMCID: PMC43220 03/01/1994
  • Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers. (Segars JH, Nagata T, Bours V, Medin JA, Franzoso G, Blanco JC, Drew PD, Becker KG, An J, Tang T) Mol Cell Biol 1993 Oct;13(10):6157-69 PMID: 8413217 PMCID: PMC364675 10/01/1993
  • Lack of functional significance of Cys227 and Cys234 in terminal deoxynucleotidyltransferase. (Medin JA, Coleman MS) J Biol Chem 1992 Mar 15;267(8):5199-201 PMID: 1544903 03/15/1992
  • Efficient, low-cost protein factories: expression of human adenosine deaminase in baculovirus-infected insect larvae. (Medin JA, Hunt L, Gathy K, Evans RK, Coleman MS) Proc Natl Acad Sci U S A 1990 Apr;87(7):2760-4 PMID: 2181448 PMCID: PMC53770 04/01/1990
  • Last update: 09/14/2017
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